The Man Who Thought of Everything Algis Valiunas
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The Theorist Ridley Makes No Mention of a Meeting She Had Then with the Physicist Alexander Stokes and a Half a Dozen Scientists and Laboratories to Solve
NATURE|Vol 443|26 October 2006 AUTUMN BOOKS the spring of 1950 (not in December, as Ridley writes). She joined the lab in January 1951, and The theorist Ridley makes no mention of a meeting she had then with the physicist Alexander Stokes and a half a dozen scientists and laboratories to solve. graduate student, Raymond Gosling, at which Francis Crick: Discoverer of the Crick himself did very little of the laboratory John Randall, the lab’s director, gave her a sup- Genetic Code work. Rather, he was the explicator, the arbiter, ply of the best DNA they had and appointed by Matt Ridley the taskmaster. Gosling her assistant. Crucially, Wilkins was HarperCollins: 2006. 213 pp. £12.95, $19.95 Crick was above all the theorist — and that’s away on vacation. Franklin had every reason Horace Freeland Judson the unifying thread. Not just with the coding to think the DNA was exclusively hers. When Any biographer of Francis Crick faces a dif- problem but throughout his career, Crick was Wilkins returned and expected to collabo- ficult problem: he was the greatest biologist the one who put other scientists’ thoughts in rate with her, she shut him out. He grumbled of the latter half of the twentieth century, yet order. He soaked up data, mostly other people’s, about her to Crick and Watson, and in Feb- his life was curiously one-dimensional. It was but saw beyond the data to their meaning, their ruary 1953 he notoriously showed Watson an intensely concentrated but narrowly focused. shape, their implications. He found principles, X-ray diagram she had obtained — which they By far the most important part of his life was and did it with a preternatural clarity of mind interpreted as she had failed to do. -
Europe's Favorite Chemists?
ability and on uncertainty evaluation of chemical mea- surement results. Participants can take this expertise back to their home countries and/or become regional coordinators for IMEP in their respective countries. In collaboration with EUROMET and CCQM, IMEP samples are offered for the organization of EUROMET key or supplementary comparisons and, where appro- priate, for the organization of CCQM key comparisons or pilot studies. In its role as a neutral, impartial international evalu- ation program, IMEP displays existing problems in chemical measurement. IRMM is dedicated to tackling this problem and will, where possible, collaborate with international bodies, education and accreditation au- thorities, and NMIs to achieve more reliable measure- ments and contribute to setting up an internationally structured measurement system. Ellen Poulsen (Denmark) preparing graphs for the IMEP-9 participants’ report on trace elements in water. Europe’s Favorite Chemists? Choosing Europe’s Top 100 Chemists: birth of Christ is quite forgotten in general. An addi- A Difficult Task tional irony lies in the fact that recent evidence from history, archaeology, and astronomy suggests a birthdate This article by Prof. Colin Russell (Department of His- about seven years earlier, so the real millennium came tory of Science and Technology, Open University, and went unnoticed in the early 1990s. However that Milton Keynes, England MK6 7AA, UK) was com- may be, the grand spirit of revelry and bonhomie can- missioned by Chemistry in Britain and published by not be quenched by such mundane considerations, and that magazine in Vol. 36, pp. 50–52, February 2000. celebration there shall be. Nor are societies to be left The list of Europe’s 100 distinguished chemists was behind in the general euphoria. -
Copyright by Paul Harold Rubinson 2008
Copyright by Paul Harold Rubinson 2008 The Dissertation Committee for Paul Harold Rubinson certifies that this is the approved version of the following dissertation: Containing Science: The U.S. National Security State and Scientists’ Challenge to Nuclear Weapons during the Cold War Committee: —————————————————— Mark A. Lawrence, Supervisor —————————————————— Francis J. Gavin —————————————————— Bruce J. Hunt —————————————————— David M. Oshinsky —————————————————— Michael B. Stoff Containing Science: The U.S. National Security State and Scientists’ Challenge to Nuclear Weapons during the Cold War by Paul Harold Rubinson, B.A.; M.A. Dissertation Presented to the Faculty of the Graduate School of The University of Texas at Austin in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy The University of Texas at Austin August 2008 Acknowledgements Thanks first and foremost to Mark Lawrence for his guidance, support, and enthusiasm throughout this project. It would be impossible to overstate how essential his insight and mentoring have been to this dissertation and my career in general. Just as important has been his camaraderie, which made the researching and writing of this dissertation infinitely more rewarding. Thanks as well to Bruce Hunt for his support. Especially helpful was his incisive feedback, which both encouraged me to think through my ideas more thoroughly, and reined me in when my writing overshot my argument. I offer my sincerest gratitude to the Smith Richardson Foundation and Yale University International Security Studies for the Predoctoral Fellowship that allowed me to do the bulk of the writing of this dissertation. Thanks also to the Brady-Johnson Program in Grand Strategy at Yale University, and John Gaddis and the incomparable Ann Carter-Drier at ISS. -
The Gene in the Twenty-First Century
CGA_C01.qxd 4/24/07 10:16 Page 1 1 CHAPTER 1 The gene in the twenty-first century Choong-Chin Liew, PhD, & Victor J. Dzau, MD Vries named the transmitted substances “pangens”; Introduction he later coined the term “mutation” to signify the When the word was first used in 1909, “gene” was a appearance of a new pangen [5]. hypothesis necessary to explain puzzling observa- Cambridge evolutionist William Bateson (1861– tions about heredity. As the century progressed, the 1926) translated Mendel into English and worked hypothesis began to acquire reality as the structure vigourously to promote Mendel’s ideas in the and functions of the gene were gradually elucidated. English-speaking scientific world. Bateson himself Earlier and simpler concepts became superseded as coined the term “genetics” in 1906 [6]. The word evidence led to better understanding of the gene. “gene” was not introduced until 1909, when Wilhelm Today the gene is recognized to be a highly complex Johannsen (1857–1927), a Danish botanist, offered entity. The genomics revolution is well underway this term in preference to earlier terms [7]. but there is much that remains for twenty-first cen- A next major step towards an elucidation of tury science to learn before the potential of molec- the gene came with the discovery that genes have ular biology and technology can be fully realized. physical locations on chromosomes in studies on Drosophila carried out by Thomas Hunt Morgan (1866–1945) and his colleagues at the zoology de- The search for the gene partment of Columbia University [8,9]. Morgan’s Much of the science that laid the foundation for the student, Alfred Sturtevant (1891–1970) was able to genetics and genomics revolution took place in the show that the gene for a trait was localized in a fixed very near past; 1900 is the date often considered to location or locus arranged “like beads on a string” be the beginning of modern genetics. -
THEODOR Ft5rster 1910
THEODOR Ft5RSTER 1910 - 19714 Journal of Luminescence 12/13 (1976) 8—12 © North-Holland Publishing Company MEMORIAL FOR THE LATE PROFESSOR THEODOR FORSTER A. WELLER Max-Planck-Institut für Biophysikalische Chemie Göttingen, Fed. Rep. Germany On the 20th of May 1974 Theodor Forster died of a heart attack at the age of 64 while he was on his way to the Institute of Physical Chemistry at the University of Stuttgart whose director he had been for 23 years. In view of his numerous important and fundamental contributions to almost all aspects of luminescence, it is indeed appropriate to pay honour to the man and his work today. Theodor Forster was born on May 15, 1910, in Frankfurt, Germany. He went to school there (the same school which about 30 years before Otto Hahn had attended), and after completing his Abitur in 1929, he became a student of physics and mathe- matics at Frankfurt University. At that time there was very little red tape at German Universities. It was for in- stance possible to study physics and/or mathematics without an examination except for the final oral examination after having finished the PhD thesis. As a consequence the good student, in general, was able to finish the University in surprisingly short time; and so in 1933 at the age of 23 Theodor Förster was promoted to Dr. phil. with a thesis entitled “ZurPolarisation von Elektronen durch Reflexion” under the tutelage of E. Madelung. Still before having finished his thesis he had become an Assistant (scientific co- worker) of ProfessorKarl-Friedrich Bonhoeffer. -
Reflections on the Historiography of Molecular Biology
Reflections on the Historiography of Molecular Biology HORACE FREELAND JUDSON SURELY the time has come to stop applying the word revolution to the rise of new scientific research programmes. Our century has seen many upheavals in scientific ideas--so many and so varied that the notion of scientific revolution has been stretched out of shape and can no longer be made to cover the processes of change characteristic of most sciences these past hundred years. By general consent, two great research pro- grammes arising in this century stand om from the others. The first, of course, was the one in physics that began at the turn of the century with quantum theory and relativity and ran through the working out, by about 1930, of quantum mechanics in its relativistic form. The trans- formation in physics appears to be thoroughly documented. Memoirs and biographies of the physicists have been written. Interviewswith survivors have been recorded and transcribed. The history has been told at every level of detail and difficulty. The second great programme is the one in biology that had its origins in the mid-1930s and that by 1970 had reached, if not a conclusion, a kind of cadence--a pause to regroup. This is the transformation that created molecular biology and latter-day biochemistry. The writing of its history has only recently started and is beset with problems. Accounting for the rise of molecular biology began with brief, partial, fugitive essays by participants. Biographies have been written of two, of the less understood figures in the science, who died even as the field was ripening, Oswald Avery and Rosalind Franklin; other scientists have wri:tten their memoirs. -
The Eighth Day of Creation”: Looking Back Across 40 Years to the Birth of Molecular Biology and the Roots of Modern Cell Biology
“The Eighth Day of Creation”: looking back across 40 years to the birth of molecular biology and the roots of modern cell biology Mark Peifer1 1 Department of Biology and Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, CB#3280, Chapel Hill, NC 27599-3280, USA * To whom correspondence should be addressed Email: [email protected] Phone: (919) 962-2272 1 Forty years ago, Horace Judson’s “The Eight Day of Creation” was published, a book vividly recounting the foundations of modern biology, the molecular biology revolution. This book inspired many in my generation. The anniversary provides a chance for a new generation to take a look back, to see how science has changed and hasn’t changed. Many central players in the book, including Sydney Brenner, Seymour Benzer and Francois Jacob, would go on to be among the founders of modern cell, developmental, and neurobiology. These players come alive via their own words, as complex individuals, both heroes and anti-heroes. The technologies and experimental approaches they pioneered, ranging from cell fractionation to immunoprecipitation to structural biology, and the multidisciplinary approaches they took continue to power and inspire our work today. In the process, Judson brings out of the shadows the central roles played by women in many of the era’s discoveries. He provides us with a vision of how science and scientists have changed, of how many things about our endeavor never change, and how some new ideas are perhaps not as new as we’d like to think. 2 In 1979 Horace Judson completed a ten-year project about cell and molecular biology’s foundations, unveiling “The Eighth Day of Creation”, a book I view as one of the most masterful evocations of a scientific revolution (Judson, 1979). -
THEODORE WILLIAM RICHARDS January 31, 1868-April 2, 1928
NATIONAL ACADEMY OF SCIENCES T H E O D O R E W I L L I A M R ICHARDS 1868—1928 A Biographical Memoir by JAMES BRYANT CONANT Any opinions expressed in this memoir are those of the author(s) and do not necessarily reflect the views of the National Academy of Sciences. Biographical Memoir COPYRIGHT 1974 NATIONAL ACADEMY OF SCIENCES WASHINGTON D.C. THEODORE WILLIAM RICHARDS January 31, 1868-April 2, 1928 BY JAMES BRYANT CONANT HEODORE WILLIAM RICHARDS was a precocious son of distin- Tguished parents. He was born in Philadelphia on January 31, 1868, the third son and fifth child of William Trost Richards and Anna Matlack Richards, who had been married on June 30, 1856. As strict members of the Society of Friends, the Matlack family looked askance at a young man who earned his living painting pictures. Anna was "read out of meeting." The Quaker marriage ceremony took place in the house of a friend. The first months of the honeymoon were devoted to the com- position and illustration of a manuscript volume of poems for the lady who had first brought the young couple together. A mutual interest in Browning and Tennyson had started an acquaintanceship which rapidly became a romance. An old friend and fellow artist of Philadelphia reminiscing long after W. T. Richards had established his reputation as a landscape painter said, "He amazed me by getting married and resigning his position as designer [in a local firm manufacturing gas fixtures] in order to devote himself entirely to his art. -
Wilhelm Ostwald – the Scientist
ARTICLE-IN-A-BOX Wilhelm Ostwald – The Scientist Friedrich Wilhelm Ostwald was born on September 2, 1853 at Riga, Latvia, Russia to Gottfried Ostwald, a master cooper and Elisabeth Leuckel. He was the second son to his parents who both were descended from German immigrants. He had his early education at Riga. His subsequent education was at the University of Dorpat (now Tartu, Estonia) where he enrolled in 1872. At the university he studied chemistry under the tutelage of Carl ErnstHeinrich Schmidt (1822– 1894) who again was a pupil of Justus von Liebig. Besides Schmidt, Johannes Lemberg (1842– 1902) and Arthur von Oettingen (1836–1920) who were his teachers in physical chemistry were also principal influences. It was in 1877 that he defended his thesis ‘Volumchemische Studien über Affinität’. Subsequently he taught as Privatdozent for a couple of years. During this period, his personal life saw some changes as well. He wedded Helene von Reyher (1854–1946) in 1880. With Helene, he had three sons, and two daughters. Amongst his children, Wolfgang went on to become a famous colloid chemist. On the strength of recommendation from Dorpat, Ostwald was appointed as a Professor at Riga Polytechnicum in 1882. He worked on multiple applications of the law of mass action. He also conducted measurements in chemical reaction kinetics as well as conductivity of solutions. To this end, the pyknometer was developed which was used to determine the density of liquids. He also had a thermostat built and both of these were named after him. He was prolific in his teaching and research which helped establish a school of science at the university. -
Hemolytic Anemias
Hemolytic Anemias May 16, 2012 Anand S. Lagoo, MD, PhD Department of Pathology Anand Lagoo/Hereditary Anemias RS/5-12 Anemia Reduced red cell mass below the normal limit for age and sex of patient In practice, a hemoglobin level below the normal limit for age and sex of patient Anand Lagoo/Hereditary Anemias RS/5-12 Classifications of Anemias Morphological classification- Based on size of RBCs and their hemoglobin content Normocytic vs Microcytic vs Macrocytic Normochromic vs Hypochromic NOTE: The morphological classification suggests an etiologic differential which is confirmed by additional tests Etiological Classification 12 - Decreased Hgb and/or RBC production Defects of red cell survival (Hemolytic Anemias) Anand Lagoo/Hereditary AnemiasRS/5 Automated Blood Count Mean cell Hb Mean cell Hb concentration Red cell distribution width Mean cell volume Anand Lagoo/Hereditary Anemias RS/5-12 Platelet Central pallor Normal Decreased below Increased above Range lower limit = upper limit = Hgb g/dL M 14 - 18 Anemia Polycythemia F 12 - 16 MCV in fL 80 - 98 Microcytic Macrocytic MCH in pg 27 - 34 Hypochromic Hyperchromic (usually seen in Reticulocyte: % 0.5 – 1.5 (usually seen in aplastic anemia or hemolytic anemia) Abs /c mm 20k –100k myeoldysplasia) Anand Lagoo/Hereditary Anemias RS/5-12 Use of reticulocyte count in the evaluation of anemias HIGH Retic Index >2% or Low Retic Index <2% or Absolute count >100,000/ul Absolute count <100,000/ul HIGH Production LOW Production Anemias Anemias RESPONSE TO BLOOD HYPOPROLIFERATIVE LOSS MATURATION -
Total Knowledge? Encyclopedic Handbooks in the Twentieth-Century Chemical and Life Sciences
BJHS Themes (2020), 5, 187–203 doi:10.1017/bjt.2020.11 RESEARCH ARTICLE Total knowledge? Encyclopedic handbooks in the twentieth-century chemical and life sciences Mathias Grote* Institut für Geschichtswissenschaften, Unter den Linden 6, 10099 Berlin, Germany *Email: [email protected] Abstract Encyclopedic handbooks have been household names to scientists – Gmelins Handbuch der anorga- nischen Chemie to chemists, Bergey’s Manual of Determinative Bacteriology to microbiologists. Their heavy tomes were consulted for reference, and their contents taken as authoritative. This paper ana- lyses the development of this genre as well as of ‘handbook science’. Handbooks and their claim to provide comprehensive factual knowledge on a subject should be understood as a reaction to the scattering of knowledge in modern periodical print as discussed by Wilhelm Ostwald or Ludwik Fleck. A comparative analysis of the actors, the institutions and practices of compiling and editing a German and an American handbook project around mid-century reveals commonalities and differ- ences in how twentieth-century sciences have attempted to cope with the acceleration and disper- sion of knowledge generation before computing. These attempts have resulted in different conceptions of a book, from compilation to organic whole. Moreover, the handbook’s claim to com- prise lasting facts makes it a fitting case in point to reflect on the temporality of knowledge and the relevance of books to the sciences. In 2018, the shelves dedicated to displaying Gmelins Handbuch der anorganischen Chemie in a science reference section at Berlin’s Staatsbibliothek at Potsdamer Platz were cleared. The hundreds of heavy tomes of this register of inorganic chemistry (detailing the names, properties and uses of thousands of substances) were on their way to the depot. -
Bio-R/Evolution in Historiographic Perspective: Some Reflections on the History and Epistemology of Biomolecular Science
VOLUME 11 ISSUE 1 2007 ISSN: 1833-878X Pages 4-13 Howard HsuehHsueh----HaoHao Chiang Bio-R/Evolution in Historiographic Perspective: Some Reflections on the History and Epistemology of Biomolecular Science ABSTRACT Does the molecular vision of life signify a unique revolution in biology or a more general evolution of the life sciences in the twentieth century? This paper visits this ‘big question’ by reflecting on a series of major debates in the historiography of molecular biology, especially those regarding its origins and the periodization of its development. For instance, while some have suggested that the discipline emerged in the 1930s, others have argued for its birth in the post-WWII era. Above all, the impact of the Rockefeller Foundation and the physical sciences on the formation of molecular biology remains a central topic of discussion among historians of biology. Unlike earlier historians of biomolecular science, recent scholars have also started to pay closer attention to the laboratory and material cultures that had conditioned its historical shaping. This paper argues that, ultimately, these debates all rest upon one fundamental historiographical problem: the absence of a unifying understanding of ‘molecular biology’ among historians (and practitioners) of biological science. This heterogeneous conceptualization of ‘molecular biology’, however, should be viewed as valuable because it allows for multiple approaches to resolving the ‘revolution versus evolution’ debate that together enrich our interpretation of the twentieth-century biomolecular vision of life. 4 BIOGRAPHY Howard Chiang is currently a Ph.D. student in the History of Science Program at Princeton University. He holds a B.S. in Biochemistry and a B.A.