Andreas Zirlik Curriculum Vitae

Birth Place and Date Schweinfurt, 1974 Nationality German

Education - Training

1984- 1993 Grammar school “Celtis Gymnasium”, Schweinfurt, Germany. Final exam (Abitur) with an average of 1.0. Scholarship of the Bavarian State for highly talented students („Bayerische Bayerischen Hochbegabtenprüfung“).

1993- 1999 Medical Studies at the University of Leipzig, Germany. Trimesters at the University of Alabama, Birmingham, USA, and the University of Montpellier, France. Final medical exam (3. Staatsexamen) with an average of 1.0

1999 State medical license (Approbation)

2001 Academic degree “Dr. med.” with “summa cum laude” from University of Leipzig, Leipzig, Germany

2008 State Board („Facharzt“) for Internal Medicine (WBO 2003)

2009 Habilitation on the topic „Modulation of inflammatory signaling pathways as therapeutic target in atherosclerosis“, Venia legendi for Internal Medicine/Cardiology

2012 State Board („Facharzt“) for Internal Medicine and Cardiology (WBO 2006)

2012 Professor for Medicine/Cardiology of the Medical Faculty of the University of Freiburg, Germany

2015 Listing in the appointment procedure for the Chief of Cardiology and University Professorship/Ordinariat („W3 Professor“) Internal Medicine/ Cardiology at the University of Jena, Germany

2015 Designated President of the German Society of Atherosclerosis Research (DGAF)

2017 Listing in the appointment procedure for the Chief of Cardiology and University Professorship/Ordinariat („W3 Professor“) Internal Medicine/ Cardiology at the University of Halle, Germany

2018 Call to the Professorship for Internal Medicine and Cardiology at the University Graz, Austria

2018 President of the German Society of Atherosclerosis Research (DGAF)

2018 Professor for Internal Medicine and Cardiology at the Medical University of Graz and Head of the Department of Cardiology

Positions and clinical/academic development:

2000- 2003 Residency in Internal Medicine at the University Hospital of the University of Freiburg, Germany, Department of Cardiology and Angiology (Prof. Dr. Christoph Bode), scientific work on the regulation of the expression of Plasminogen Activator Inhibitor-1 (PAI-1) in adipose tissue

2003- 2005 Postdoctoral Fellowship at the Brigham and Women’s Hospital, Cardiovascular Medicine (Prof. Dr. Peter Libby), Harvard Medical School, Boston, USA, scientific work on CD40/CD40L-dependent functions in atherosclerosis

2005- 2009 Continuation of clinical and scientific work as Fellow in Internal Medicine/Cardiology at the University Hospital Freiburg, Germany, Department of Cardiology and Angiology (Prof. Dr. Christoph Bode), scientific work on inflammatory signaling pathways in atherosclerosis and metabolic syndrome

Since 2005 Principal Investigator/Leader of the Atherogenesis Research Group Freiburg with currently 2 medical technicians, 1 junior group leader, 4 Post-Docs, 2 PhD student and 3 MD students

Since 2009 Attending/Consultant („Oberarzt“) in Internal Medicine/Cardiology at the University Hospital Freiburg, Germany, Department of Cardiology and Angiology (Prof. Dr. Christoph Bode, since 4/2012 transformed into the Department of Cardiology/Angiology at the University Heart Center Freiburg • Bad Krozingen)

Since 2013 Deputy Medical Director of the Department of Cardiology and Angiology I of the University Heart Center Freiburg (Prof. Dr. Christoph Bode) with full clinical and administrative authorities

Clinical Responsibilities and interventional performance numbers:

since 2009 Head of the Heart Failure and Heart Transplantation Unit since 2010 Member of the 24h PCI team of Attendings/Consultants since 2010 Head of the Interventional Valve Team (ISAH), specialized on Mitraclip implantations since 2011 Member of the 24h on call team of Attendings/Consultants for the ICU since 2011 Head of the Interventional Hypertensiology/Renal Denervation Unit since 2013 Research Coordinator of the Department since 2016 Head of the cardiovascular high risk outpatient service

> 4000 Left Heart Catheterizations and PCIs > 500 Right Heart Catheterizations > 200 Myocardial Biopsies > 150 Renal Denervations > 150 Mitraclip Implantations > 100 ECLS and Impella Implantations > 50 Pericardiocentises > 40 TAVI > 15 CardioMEMS Implantations

Prizes and Awards

1993 -1999 Scholarship of the Bavarian State for highly talented students after passing the High Talent Exam („Hochbegabtenprüfung“), approx. 70.000,- DM in 6 years

10/1998 Wolfgang-Natonek-Award“ for outstanding study results and special dedication for students’ interests by the Association of Sponsors and Friends of the University of Leipzig, 5,000.- DM

2003- 2004 Research Fellowship by the German Research Foundation („Deutsche Forschungsgemeinschaft“). Topic: The role of CD40-deficiency in atheroma-associated endothelial cells, smooth muscle cells, and monocytes/macrophages with special respect to cell type-specific signaling functions, DFG-ZI-743/1-1, approx. 35,000.- Euro

2005- 2006 Returning from Post-Doc Fellowship by the Medical Faculty of the University of Freiburg, approx. 30,000.- Euro

2007 MSD Award for Atherosclerosis/Hypertension 2007, 10,000.- Euro

2018 Albert-Fraenkel-Prize of the German Cardiac Society (DGK), 5.200,- Euro

Patents

2011 European Patent Application on „Selective Targeting of the CD40L/Mac-1 interaction by small peptide inhibitors and its use for the treatment of inflammation and atherogenesis” (PCT/EP2011/064132 (WO2012005225 A1))

2016 European Patent Application on “Antibodies for the selective inhibition of inflammation and pharmaceutical compositions containing such antibodies (EP 16175382.7)

Teaching / Lecturing Experience

1993- 1999 As MD student leader of newly founded POL (Problem oriented Lerning) Groups, student representative in various academic and university committees (Faculty Board, Senate, Konzil, Appointment Committees for Professors)

2000- 2003 Clinical Examination Courses in Internal Medicine

since 2005 Various Courses and Lectures Internal Medicine and Cardiology (e.g., Bedside Teaching, Differential Diagnostics of Thoracic Pain, Syncope, Casuistics)

since 2009 Pathophysiology Lecture (Heart Failure, Atherosclerosis), Main Lecture in Internal Medicine (Acute Coronary Syndrome, Heart Failure, Heart Transplantation, Hypertension), Lecture Molecular Cardiology (Inflammatory mechanisms in atherosclerosis, myocardial infarction, and metabolic syndrome)

since 2010 Member of the Faculty of the International Master Program in Biomedical Sciences (IMBS), a joint Master/PhD program of the University of Buenos Aires, Argentina and the University of Freiburg, Germany

since 2013 Head of the Internal Medicine Module of the Molecular Medicine Study Program (Prof. Dr. Christoph Peters) of the University of Freiburg

Academic Activities

a) Membership in Clinical and Scientific Associations since 2001 Member of the German Association of Cardiology (DKG) since 2001 Member of the European Society of Cardiology (ESC) since 2002 Member of the German Society of Atherosclerosis Research (DGAF) since 2004 Member of the American Heart Association (AHA) since 2011 Member of the International Society for Heart and Lung Transplantation (ISHLT) since 2011 Member of the Society of Thrombosis and Hemostaseology (GTH) since 2013 Fellow of the European Society of Cardiology (FESC) since 2013 Member of the German Society of Internal Medicine (DGIM)

since 2014 Fellow of the American College of Cardiology (FACC) since 2016 Member of the Southwest German Society for Internal Medicine (SwGIM) Member of the since 2017 European Atherosclerosis Society (EAS) since 2017 Fellow of the American Heart Association (FAHA)

a) Reviewer for Scientific Journals since 2003 ad hoc reviewer for Thrombosis Heamostasis, Heart since 2006 ad hoc reviewer for ATVB, British Journal Haematology, Circulation since 2008 ad hoc reviewer for Atherosclersosis, American Heart Journal since 2009 ad hoc reviewer for American Journal Cardiology since 2010 ad hoc reviewer for PLoS One, Circulation Research since 2012 ad hoc reviewer for European Journal of Endocrinology, Hypertension since 2013 ad hoc reviewer for Experimental Physiology, Cardiovascular Diabetology, Clinical Research in Cardiology, Arthritis Research and Therapy since 2014 ad hoc reviewer für FEBS Journal, Hämostaseologie

b) Special Academic Activities: 2007-2011 Member of the Board of Principle Investigators of the Speman Graduate School of Biology and Medicine, Excellence Initiative of the German Research Foundation (DFG) Member of the Faculty of the International Master Program in Biomedical since 2010 Sciences (IMBS), a joint Master/PhD Program of the University of Buenos Aires, Argentina nad the University of Freiburg, Germany Member of the Local Editorial Team of the European Editor of Circulation, since 2010 Prof. Dr. Christoph Bode Organization of the Summer School of the Department, a scientific retreat since 2010 (approx. 80-100 participants) Editorial Board Member of Case Reports in Vascular Medicine since 2011 Editorial Board Member of PlosOne (IF 3.5) since 2012 Ad hoc reviewer for the German Science Foundation (DFG), member of the review since 2012 committee of SFB688 Member of the Advisory Board of the German Society of Atherosclersis Research (DGAF) 2012-2015 Member of the Steering Committee of the Pre-TRUST Study (Trial of Ularitide for the since 2013 prevention of renal worsening in patients at risk for radiocontrast induced nephropathy), Sponsor Cardiorentis AG, Zug, Schweiz Congress Secretary of the Annual Meeting of the Soviety of Thrombosis and 2013-2015 Hemasteseology (GTH) in 2015 in Düsseldorf (Congress Presidents: Profs. Bode und Scharf) since 2015 Designated President of the German Society of Atherosclerosis Research (DGAF) since 2016 Co-chairman of the working group “Heart and Diabetes” (AG23) of the German Cardiac Society (DGK) since 2017 Editor of the German Journal “Cardiology up2date” since 2017 Editorial Board Member of Atherosclerosis since 2018 President of the German Society of Atherosclerosis Research (DGAF)