Chemmart Meloxicam

Total Page:16

File Type:pdf, Size:1020Kb

Chemmart Meloxicam Chemmart Meloxicam Capsules Meloxicam Consumer Medicine Information For a copy of a large print leaflet, Ph: 1800 195 055 What is in this leaflet Ask your doctor if you have any swelling of the feet or lips due to questions about why this medicine fluid build-up Read this leaflet carefully before has been prescribed for you. · You experience bleeding from the taking your medicine. Your doctor may have prescribed this stomach, gut or any other This leaflet answers some common medicine for another reason. bleeding questions about meloxicam. It does This medicine is available only with · You have had a stroke resulting not contain all the available a doctor©s prescription. from a bleed in the brain or have information. It does not take the a bleeding disorder place of talking to your doctor or How it works · You currently have a peptic pharmacist. Meloxicam belongs to a family of (stomach) ulcer All medicines have risks and medicines called Non-Steroidal Anti- · You are lactose intolerant (this benefits. Your doctor has weighed inflammatory Drugs (NSAIDs). medicine contains lactose) the risks of you using this medicine These medicines work by relieving · You have Crohn©s Disease or against the benefits they expect it pain and inflammation. Ulcerative Colitis will have for you. There is no evidence that this · You have severe liver or kidney Keep this leaflet with your medicine is addictive. problems medicine. · You are currently taking other You may want to read it again. medicines known as: sulfinpyrazone (used to treat Before you take this gout), fluconazole (used to treat medicine fungal infections) or certain What this medicine is sulfur antibiotics (e.g. used for When you must not take it sulfaphenazole or sulfamethoxazole) The name of your medicine is Do not take this medicine if you Chemmart Meloxicam. It contains have an allergy to: Do not breastfeed if you are taking this medicine the active ingredient meloxicam. · meloxicam Meloxicam may pass into breast milk It is used to treat the symptoms of · any of the ingredients listed at the and affect your baby. · osteoarthritis end of this leaflet Do not give meloxicam to children · rheumatoid arthritis · aspirin or any other NSAIDs and adolescents under 18 years of Both diseases mainly affect the joints Do not take this medicine if: age. causing pain and swelling. · You are about to undergo a Safety and effectiveness in children Although meloxicam can relieve coronary artery bypass graft younger than 18 years have not been symptoms such as pain and surgery established. inflammation, it will not cure your · You have a disease of the heart Do not take this medicine after the condition. with shortness of breath, and expiry date (EXP) printed on the CHEMMART MELOXICAM CAPSULES 1 pack or if the packaging is torn or Taking other medicines · some medicines used to treat shows signs of tampering. irregular heartbeats (such as Tell your doctor or pharmacist if amiodarone and quinidine) If it has expired or damaged, return it you are taking any other to your pharmacist for disposal. medicines, including any that you · some medicines used to treat If you are not sure whether you get without a prescription from fungal infections (such as should be taking this medicine, talk your pharmacy, supermarket or fluconazole, ketoconazole, to your doctor. health food shop. itraconazole) Some medicines may interact with · some sulfur antibiotics (such as Before you start to take it meloxicam. These include: sulfaphenazole and sulfamethoxazole) Before you start taking this · any other medicines used to treat medicine, tell your doctor if you high blood pressure and some If you are taking any of these you have allergies to any other other heart problems, such as may need a different dose or you medicines, food, preservatives or ACE inhibitors, angiotensin may need to take different medicines. dyes. receptor antagonists and diuretics Other medicines not listed above Tell your doctor if you have or (also called fluid or water may also interact with meloxicam. tablets). When taken together have had any medical conditions, Your doctor and pharmacist have these medicines can cause kidney especially the following: more information on medicines to be problems · high blood pressure or fluid careful with or avoid while taking retention · aspirin, salicylates or other this medicine. NSAID medicines · diabetes · medicines used to thin your blood · high cholesterol or other risk (such as warfarin, heparin and factors for heart disease ticlopidine) How to take this · heartburn, indigestion, ulcers or · lithium, a medicine used to treat medicine other stomach problems some types of mood disorders · kidney or liver disease Follow carefully all directions · antidepressants called selective given to you by your doctor or · asthma or any other breathing serotonin reuptake inhibitors pharmacist. problems (SSRIs) Their instructions may be different to Tell your doctor if you are · methotrexate, a medicine used to the information in this leaflet. pregnant or intend to become treat rheumatoid arthritis (a pregnant. painful joint disease) and some How much to take This medicine is not recommended types of cancer Your doctor or pharmacist will tell for use during pregnancy. Do not · cyclosporin, a medicine used to you how much of this medicine you take this medicine whilst pregnant treat rheumatoid arthritis and should take. This will depend on until you and your doctor have certain problems with the your condition and whether you are discussed the risks and benefits immune system taking any other medicines. involved. · terfenadine and astemizole, For the treatment of osteoarthritis Tell your doctor if you are using an medicines used to prevent or IUD (intrauterine device) for birth relieve the symptoms of allergy, The usual dose of meloxicam is 7.5 control. such as hay fever or insect stings mg, taken as a single dose each day. This medicine may decrease the · pemetrexed, used to treat lung However, your doctor will prescribe effectiveness of IUDs. cancer a dose suitable for your condition. Tell your doctor if you currently · medicines used to treat diabetes For the treatment of rheumatoid have an infection. arthritis · cholestyramine, a medicine used This medicine may hide some of the to treat high cholesterol levels in The usual dose of meloxicam is 15 signs of an infection. This may make the blood mg taken as a single dose each day. you think, mistakenly, that you are · corticosteroids (drugs usually Depending on your response, your better, or it is not serious. used to treat inflammatory doctor may reduce this dose to 7.5 If you have not told your doctor or conditions, such as skin rash and mg taken as a single dose each day. pharmacist about any of the above, asthma) The maximum recommended daily tell them before you start taking dose of meloxicam is 15 mg. this medicine. CHEMMART MELOXICAM CAPSULES 2 For patients with kidney problems Alternatively go to the Accident Go to your doctor regularly for a undergoing dialysis, the maximum and Emergency Department at check-up. recommended daily dose is 7.5 mg. your nearest hospital. Do not stop taking your medicine or Do this even if there are no signs of Things you must not do change your dosage without first discomfort or poisoning. You may Do not give this medicine to anyone checking with your doctor. need urgent medical attention. else, even if their symptoms seem Signs of an overdose with meloxicam similar to yours. How to take it may include: Do not take this medicine to treat Swallow meloxicam capsules whole, · nausea and/or vomiting any other condition unless your with a full glass of water. doctor tells you to. · headache Do not stop taking your medicine, · drowsiness When to take it or change the dosage, without · blurred vision It is best to take meloxicam checking with your doctor. immediately after food to avoid the · dizziness chance of an upset stomach. · fits or seizures Things to be careful of Take this medicine at the same time · low blood pressure Be careful when driving or each day, either morning or evening. operating machinery until you · difficulty in breathing Taking it at the same time each day know how meloxicam affects you. · impaired consciousness will have the best effect and will also As with other NSAID medicines, help you remember when to take it. · kidney failure. meloxicam may cause dizziness, drowsiness or blurred vision in some How long to take it for people. Continue taking your medicine for Make sure you know how you as long as your doctor tells you. While you are taking react to meloxicam before you Make sure you have enough to last this medicine drive a car, operate machinery, or over weekends and holidays. do anything else that could be Things you must do dangerous. If you forget to take it Tell your doctor or pharmacist If it is almost time to take your next that you are taking this medicine if dose, skip the missed dose and take you are about to be started on any your next dose at the usual time. new medicine. Side effects Otherwise take it as soon as you Tell any other doctors, dentists and Tell your doctor or pharmacist as remember and then go back to taking pharmacists who treat you that soon as possible if you do not feel your medicine as you would you are taking this medicine. well while you are taking normally. If you are going to have surgery, meloxicam, or if you have any Do not take a double dose to make tell the surgeon or anaesthetist that questions or concerns. up for missed doses. you are taking this medicine. All medicines can have side effects. This may increase the chance of side Meloxicam can slow down blood Sometimes they are serious but most effects.
Recommended publications
  • Sulfinpyrazone 100Mg and 200Mg Tablets (Sulfinpyrazone)
    Prescribing information sulfinpyrazone 100mg and 200mg tablets (sulfinpyrazone) Presentation: Coated tablets agents, sulphonamides, penicillin, theophylline, phenytoin, non- indication: Chronic, including tophaceous gout; recurrent gouty steroidal antirheumatic drugs. arthritis; hyperuricaemia Pregnancy and lactation: Used with caution in pregnant women, Dosage and administration: Route of administration: Oral. Adults: weighing the potential risk against the possible benefits. It is not known 100-200mg daily increasing gradually (over the first two or three whether the active substance or its metabolite(s) pass into breast milk. weeks) to 600mg daily (rarely 800mg), and maintained until the For safety reasons mothers should refrain from taking the drug. serum urate level has fallen within the normal range. Maintenance Undesirable effects: Mild transient gastro-intestinal upsets, such dose may be as low as 200mg daily. Children: Paediatric usage as nausea, vomiting, diarrhea, gastro-intestinal bleeding and not established. ulcers, acute renal failure, salt and water retention, allergic skin contraindications: Acute attacks of gout. Gastric and duodenal reactions, leucopenia, thrombocytopenia, agranulocytosis, aplastic ulcer. Known hypersensitivity to sulfinpyrazone and other pyrazolone anaemia, hepatic dysfunction, jaundice and hepatitis. derivatives. Contra-indicated in patients with asthma, urticaria, or (Please refer to the Summary of Product Characteristics for acute rhinitis, severe parenchymal lesions of the liver or kidneys, detailed information) porphyria, blood dyscrasias, haemorrhagic diatheses overdose: Nausea, vomiting, abdominal pains, diarrhoea, Precautions and warnings: Used with caution in patients with hypotension, cardiac arrhythmias, hyperventilation, respiratory hyperuricaemia or gout, episodes of urolithiasis or renal colic, disorders, impairment of consciousness, coma, epileptic seizures, ensure adequate fluid intake and alkalinisation of the urine during oliguria or anuria, acute renal failure, renal colic.
    [Show full text]
  • New Zealand Data Sheet
    NEW ZEALAND DATA SHEET 1 PRODUCT NAME DICLOFENAC SANDOZ 25mg enteric coated tablet 50mg enteric coated tablet 2 QUALITATIVE AND QUANTITATIVE COMPOSITION Each Diclofenac Sandoz 25 mg tablet contains Diclofenac Sodium 25mg Each Diclofenac Sandoz 50 mg tablet contains Diclofenac Sodium 50mg Tablets contain lactose. For the full list of excipients, see section 6.1. 3 PHARMACEUTICAL FORM 25 mg Brown-yellow gastro-resistant film coated tablets, round, biconvex faced with a plain rim. Approximate tablet dimensions: diameter 6.1 to 6.3 mm; thickness 2.9 to 3.2 mm. Each tablet contains Diclofenac Sodium Ph Eur 25 mg. 50 mg Brown-yellow gastro-resistant film coated tablets, round, biconvex faced with a banded rim. Approximate tablet dimensions: diameter 8.0 to 8.3 mm; thickness 3.5 to 3.8 mm. Each tablet contains Diclofenac Sodium Ph Eur 50 mg. 4 CLINICAL PARTICULARS 4.1 Therapeutic indications Treatment of: • Inflammatory and degenerative forms of rheumatism - rheumatoid arthritis, juvenile rheumatoid arthritis, ankylosing spondylitis, osteoarthritis and spondylarthritis, painful syndromes of the vertebral column, non-articular rheumatism; • Acute attacks of gout; • Post-traumatic and post-operative pain, inflammation, and swelling, e.g. following dental or orthopaedic surgery; • Painful and/or inflammatory conditions in gynaecology, e.g. primary dysmenorrhoea or adnexitis; • As an adjuvant in severe painful inflammatory infections of the ear, nose, or throat, e.g. pharyngotonsillitis, otitis. In keeping with general therapeutic principles, the underlying Page 1 of 18 NEW ZEALAND DATA SHEET disease should be treated with basic therapy, as appropriate. Fever alone is not an indication. 4.2 Dose and method of administration Dosage Diclofenac Sandoz should only be prescribed when the benefits are considered to outweigh the potential risks.
    [Show full text]
  • Nonsteroidal Antiinflammatory Drugs and Acute Renal Failure in Elderly Persons
    American Journal of Epidemiology Vol. 151, No. 5 Copyright © 2000 by The Johns Hopkins University School of Hygiene and Public Health Printed In U.S.A. Ail rights reserved Nonsteroidal Antiinflammatory Drugs and Acute Renal Failure in Elderly Persons Marie R. Griffin,1'2 Aida Yared,3 and Wayne A. Ray1 Renal prostaglandin inhibition by nonsteroidal antiinflammatory drugs (NSAIDs) may decrease renal function, Downloaded from https://academic.oup.com/aje/article/151/5/488/117194 by guest on 27 September 2021 especially under conditions of low effective circulating volume. To evaluate the risk of important deterioration of renal function due to this effect, the authors performed a nested case-control study using Tennessee Medicaid enrollees aged £65 years in 1987-1991. Cases were patients who had been hospitalized with community- acquired acute renal failure; they were selected on the basis of medical record review of Medicaid enrollees with selected discharge diagnoses. Information on the timing, duration, and dose of prescription NSAIDs used, demographic factors, and comorbidity was gathered from computerized Medicaid-Medicare data files. Of the 1,799 patients with acute renal failure (4.51 hospitalizations per 1,000 person-years), 18.1% were current users of prescription NSAIDs as compared with 11.3% of 9,899 randomly selected population controls. After control for demographic factors and comorbidity, use of NSAIDs increased the risk of acute renal failure 58% (adjusted odds ratio = 1.58; 95% confidence interval (Cl): 1.34, 1.86). For ibuprofen, which accounted for 35% of NSAID use, odds ratios associated with dosages of £1,200 mg/day, >1,200-<2,400 mg/day, and £2,400 mg/day were 0.94 (95% Cl: 0.58, 1.51), 1.89 (95% Cl: 1.34, 2.67), and 2.32 (95% Cl: 1.45, 3.71), respectively (test for linear trend: p = 0.009).
    [Show full text]
  • WO 2010/099522 Al
    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date 2 September 2010 (02.09.2010) WO 2010/099522 Al (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 45/06 (2006.01) A61K 31/4164 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 31/4045 (2006.01) A61K 31/00 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, (21) International Application Number: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/US2010/025725 HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, (22) International Filing Date: KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, 1 March 2010 (01 .03.2010) ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, (25) Filing Language: English SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, (26) Publication Language: English TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 61/156,129 27 February 2009 (27.02.2009) US kind of regional protection available): ARIPO (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, (71) Applicant (for all designated States except US): ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, HELSINN THERAPEUTICS (U.S.), INC.
    [Show full text]
  • S Salsalate Tablets
    SALSALATE TABLETS CARDIOVASCULAR EFFECTS renal disease. If SALSALATE TABLETS therapy must be initiated, Rx Only Cardiovascular Thrombotic Events close monitoring of the patient’s renal function is advisable. Cardiovascular Risk Clinical trials of several COX-2 selective and nonselective NSAIDs Anaphylactoid Reactions • NSAIDs may cause an increased risk of serious cardiovascular of up to three years duration have shown an increased risk of As with other NSAIDs, anaphylactoid reactions may occur in thrombotic events, myocardial infarction, and stroke, which can serious cardiovascular (CV) thrombotic events, myocardial patients without known prior exposure to SALSALATE TABLETS. be fatal. This risk may increase with duration of use. Patients infarction, and stroke, which can be fatal. All NSAIDs, both COX-2 SALSALATE TABLETS should not be given to patients with the with cardiovascular disease or risk factors for cardiovascular selective and nonselective, may have a similar risk. Patients with aspirin triad. This symptom complex typically occurs in asthmatic disease may be at greater risk. (See WARNINGS and CLINICAL known CV disease or risk factors for CV disease may be at greater patients who experience rhinitis with or without nasal polyps, or TRIALS). risk. To minimize the potential risk for an adverse CV event in who exhibit severe, potentially fatal bronchospasm after taking • SALSALATE TABLETS is contraindicated for the treatment of patients treated with an NSAID, the lowest effective dose should be aspirin or other NSAIDs (see CONTRAINDICATIONS and perioperative pain in the setting of coronary artery bypass graft used for the shortest duration possible. Physicians and patients PRECAUTIONS - Preexisting Asthma). Emergency help should be (CABG) surgery (see WARNINGS Gastrointestinal Risk) should remain alert for the development of such events, even in sought in cases where an anaphylactoid reaction occurs.
    [Show full text]
  • Highlights of Prescribing Information
    HIGHLIGHTS OF PRESCRIBING INFORMATION -----------------------------CONTRAINDICATIONS-------------------------------------­ These highlights do not include all the information needed to use Patients with known hypersensitivity to natural or recombinant hirudins, IPRIVASK safely and effectively. See full prescribing information for and in patients with active bleeding and/or irreversible coagulation IPRIVASK. disorders (4). IPRIVASK® 15 mg (desirudin for injection), for subcutaneous injection -----------------------WARNINGS AND PRECAUTIONS-----------------------------­ Initial U.S. approval: 2003 • Hemorrhage: Bleeding can occur at any site during therapy with WARNING: SPINAL/EPIDURAL HEMATOMAS Iprivask. An unexplained fall in hematocrit or blood pressure should See Full Prescribing Information for complete boxed warning. lead to a search for a bleeding site. Avoid intramuscular injection as When neuraxial anesthesia (epidural/spinal anesthesia) or local bleeding and hematoma formation may result. (5.3). spinal puncture is employed, patients anticoagulated or • Increased Risk of bleeding with Renal Impairment: Dose reductions scheduled to be anticoagulated with selective inhibitors of by factors of three and nine are recommended for patients with thrombin such as Iprivask may be at risk of developing an moderate and severe renal impairment respectively (2.2). In addition, epidural or spinal hematoma which can result in long-term or daily aPTT and serum creatinine monitoring are recommended for permanent paralysis (5.1). patients with moderate
    [Show full text]
  • Information for the User Diclofenac / Omeprazole Modified-Release
    Package Leaflet: Information for the User Diclofenac / Omeprazole modified-release capsules, hard, 75 mg / 20 mg diclofenac sodium/omeprazole Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. Keep this leaflet. You may need to read it again. If you have any further questions, please ask your doctor or pharmacist. This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours. If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4. What is in this leaflet 1. What Diclofenac / Omeprazole modified-release capsules, hard, 75 mg / 20 mg is and what it is used for 2. What you need to know before you take Diclofenac / Omeprazole modified-release capsules, hard, 75 mg / 20 mg 3. How to take Diclofenac / Omeprazole modified-release capsules, hard, 75 mg / 20 mg 4. Possible side effects 5. How to store Diclofenac / Omeprazole modified-release capsules, hard, 75 mg / 20 mg 6. Contents of the pack and other information 1. What Diclofenac / Omeprazole modified-release capsules, hard, 75 mg / 20 mg is and what it is used for Diclofenac / Omeprazole modified-release capsules, hard, 75 mg / 20 mg contains two active ingredients in a single capsule. These active ingredients are diclofenac sodium (75 mg) and omeprazole (20 mg). Diclofenac is one of a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs) and is used to reduce pain and inflammation of joint disorders.
    [Show full text]
  • Gastro-Duodenal Ulcers Associated with the Use of Non-Steroidal Anti-Inflammatory Drugs: a Systematic Review of Preventive Pharmacological Interventions
    Gastro-duodenal Ulcers Associated with the Use of Technology Non-steroidal Anti- inflammatory Drugs: A Systematic Review Report of Preventive Issue 38 September 2003 Pharmacological Interventions Publications can be requested from: CCOHTA 600-865 Carling Avenue Ottawa, Ontario, Canada K1S 5S8 Tel. (613) 226-2553 Fax. (613) 226-5392 Email: [email protected] or download from CCOHTA’s web site: http://www.ccohta.ca Cite as: Rostom A, Dubé C, Jolicoeur E, Boucher M, Joyce J. Gastro-duodenal ulcers associated with the use of non-steroidal anti-inflammatory drugs: a systematic review of preventive pharmacological interventions. Ottawa: Canadian Coordinating Office for Health Technology Assessment; 2003. Technology report no 38. Reproduction of this document for non-commercial purposes is permitted provided appropriate credit is given to CCOHTA. CCOHTA is a non-profit organization funded by the federal, provincial and territorial governments. Legal Deposit - 2003 National Library of Canada ISBN: 1-894620-92-5 (print) ISBN: 1-894620-93-3 (electronic version) Publications Mail Agreement Number: 40026386 Canadian Coordinating Office for Health Technology Assessment Gastro-duodenal Ulcers Associated with the Use of Non-steroidal Anti-inflammatory Drugs: A Systematic Review of Preventive Pharmacological Interventions Alaa Rostom MD MSc FRCPC1 1 Catherine Dubé MD MSc FRCPC 1 Emilie Jolicoeur MD 2 Michel Boucher BPharm MSc 2 Janet Joyce MLS September 2003 ________________________ 1 University of Ottawa, Ottawa, Ontario 2 Canadian Coordinating Office for Health Technology Assessment, Ottawa, Ontario Reviewers These individuals kindly provided comments on this report. External Reviewers Isabelle Chabot, PhD Betsy Miller, BScPharm MSc Manager, Health Economics and Executive Director Outcomes Research Patient Access and Outcomes Research Merck Frosst Canada & Co.
    [Show full text]
  • New Zealand Data Sheet IBUPROFEN LIQUID CAPSULES
    New Zealand Data Sheet IBUPROFEN LIQUID CAPSULES Neo Health Ibuprofen liquid capsules 400mg 1 PRODUCT NAME Ibuprofen 400mg Liquid capsules 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Each capsule contains Ibuprofen 400 mg. For full list of excipients, see section 6.1 3.PHARMACEUTICAL FORM Capsule, soft Natural transparent, oval shaped, soft gelatin capsule containing clear colourless liquid. imprinted with L 160 in Black edible ink. 4.CLINICAL PARTICULARS 4.1 Therapeutic indications This medical product is indicated in adults and children & adolescents 12 years of age and over for the symptomatic treatment of mild to moderate pain and/or inflammation associated with headache, migraine, tension headache, muscular pain, dental pain, period pain, sinus pain, back pain, arthritis pain, cold and flu symptoms. 4.2 Dosage and administration For oral use and short-term use only. Capsules should not be chewed. Undesirable effects may be minimized by using the lowest effective dose for the shortest possible duration necessary to control symptoms (see section 4.4) Adults and children & adolescents 12 years of age and over. Initial dose, one capsule with water. Then, if necessary, one capsule every six hours. Do not exceed six capsules (2400 mg) in any 24-hour period. If in children and adolescents between 12 and 18 years this medicinal product is required for 3 days, or if symptoms worsen a doctor should be consulted. If in adults the product is required for more than 3 days in the case of fever and 4 days for treatment of pain, or if the symptoms worsen the patient is advised to consult a doctor.
    [Show full text]
  • Vinblastine and Sulfinpyrazone Export by the Multidrug Resistance Protein MRP2 Is Associated with Glutathione Export
    British Journal of Cancer (2000) 83(3), 375–383 © 2000 Cancer Research Campaign doi: 10.1054/ bjoc.2000.1262, available online at http://www.idealibrary.com on Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export R Evers1,4, M de Haas1, R Sparidans2, J Beijnen2, PR Wielinga3, J Lankelma3 and P Borst1 1Division of Molecular Biology and Center of Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands; 2Department of Pharmacy, Slotervaart Hospital, Louwesweg 6, 1066 EC Amsterdam, The Netherlands; 3Academic Hospital Vrije Universiteit, Department of Medical Oncology, Room BR232, PO Box 7057, 1007 MB Amsterdam, The Netherlands; 4Present address Georg-Speyer-Haus, Paul Ehrlich straße 42–44, 60596 Frankfurt am, Germany Summary The multidrug resistance proteins MRP1 and MRP2 are members of the same subfamily of ATP-binding cassette transporters. Besides organic molecules conjugated to negatively charged ligands, these proteins also transport cytotoxic drugs for which no negatively charged conjugates are known to exist. In polarized MDCKII cells, MRP1 routes to the lateral plasma membrane, and MRP2 to the apical plasma membrane. In these cells MRP1 transports daunorubicin, and MRP2 vinblastine; both transporters export reduced glutathione (GSH) into the medium. We demonstrate that glutathione transport in MDCKII-MRP1 cells is inhibited by the inhibitors of organic anion transporters sulfinpyrazone, indomethacin, probenecid and benzbromarone. In MDCKII-MRP2 cells, GSH export is stimulated by low concentrations of sulfinpyrazone or indomethacin, whereas export is inhibited down to control levels at high concentrations. We find that unmodified sulfinpyrazone is a substrate for MRP2, also at concentrations where GSH export is inhibited.
    [Show full text]
  • Ibuprofen 600 Mg Film- Coated Tablets
    Package leaflet: Information for the user You should discuss your treatment with your doctor or pharmacist before taking Ibuprofen if Ibuprofen 600 mg film- you: • have heart problems including heart failure, coated tablets angina (chest pain), or if you have had a heart attack, bypass surgery, peripheral Read all of this leaflet carefully before artery disease (poor circulation in the legs you start taking this medicine because it or feet due to narrow or blocked arteries), or contains important information for you. any kind of stroke (including ‘mini-stroke’ or - Keep this leaflet. You may need to read it transient ischaemic attack “TIA”). again. • have high blood pressure, diabetes, high - If you have any further questions, ask your cholesterol, or have a family history of heart doctor or pharmacist. disease or stroke, or if you are a smoker. - This medicine has been prescribed for you Effects on the kidneys only. Do not pass it on to others. It may Ibuprofen may cause problems with kidney harm them, even if their signs of illness are function even in patients who have not had the same as yours. kidney problems before. This may result in - If you get any side effects, talk to your swelling of the legs and may even lead to heart doctor or pharmacist. This includes any failure or high blood pressure in predisposed possible side effects not listed in this leaflet. individuals. See section 4. Ibuprofen may cause kidney damage especially What is in this leaflet in patients who already have kidney, heart or 1. What Ibuprofen is and what it is used for liver problems, or are taking diuretics or ACE 2.
    [Show full text]
  • Salicylic Acid 6% Foam
    Salicylic Acid 6% Foam (salicylic acid in a water and lipid based foam, 6%) Rx Only DESCRIPTION Salicylic Acid 6% Foam is applied topically and used in the removal of excessive keratin in hyperkeratotic skin disorders. Active Ingredient: Salicylic Acid 6% Inactive Ingredients: Butane, Carthamus Tinctorius (Safflower) Seed Oil, Cocamidopropyl Dimethylamine, Diazolidinyl Urea, Ethylhexylglycerin, Glycerin, Methylparaben, Olea Europaea (Olive) Fruit Oil, Phenoxyethanol, Polysorbate 20, Polysorbate 80, Propane, Propylene Glycol, Propylparaben, Sodium C14-16 Olefin Sulfonate, Sodium Hydroxide, Water. CHEMICAL STRUCTURE Salicylic acid is a 2-hydroxy derivative of benzoic acid having the following chemical structure: CO2H OH CLINICAL PHARMACOLOGY Salicylic acid has been shown to produce desquamation of the horny layer of skin while not affecting qualitative or quantitative changes in structure of the viable epidermis. The mechanism of action has been attributed to dissolution of intercellular cement substance. In a study of the percutaneous absorption of salicylic acid from Salicylic Acid 6% Foam in four patients with extensive active psoriasis, Taylor and Halprin showed that peak serum levels never exceeded 5 mg/100 mL even though more than 60% of the applied salicylic acid was absorbed. Systemic toxic reactions are usually associated with much higher serum levels (30 to 40 mg/100mL). Peak serum levels occurred within 5 hours of the topical application under occlusion. The sites were occluded for 10 hours over the entire body surface below the neck. Since salicylates are distributed in the extracellular space, patients with a contracted extracellular space due to dehydration or diuretics have higher salicylate levels than those with a normal extracellular space.
    [Show full text]