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Melbourne Health Research Week 2015 Letter from the Executive Director of Research Welcome to Research Week 2015

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Melbourne Health Research Week 2015 Letter from the Executive Director of Research Welcome to Research Week 2015 Melbourne Health Research28 May – 4 June 2015Week Melbourne Health Research Week 2015 Letter from the Executive Director of Research Welcome to Research Week 2015. In this increasingly popular annual event we showcase the advances in health and medical research described through exploration of the research question. This year’s program provides a sample of the abundant number of Melbourne Health research activities. Dr Leonie Walsh, Lead Scientist for Victoria, will open the event at the opening plenary session on Thursday 28 May. Titled “A Brain Storm – RMH Neuroscience Newsmakers”, this session focuses on one of Melbourne Health’s strengths. Each of the three presenters, Helmut Butzkueven, Mark Walterfang and Bruce Campbell, are leaders in their disciplines and we take this opportunity to acknowledge and celebrate the outstanding recent highlights of their work. Activities continue throughout the week with a range of research education and information sessions. The research symposium will have parallel sessions of original research, along with poster viewing, and we encourage you to attend these events to learn more about our research, and support those presenting their work. This year we will host a hypothetical “Developing new therapies: Pipelines or Pipedreams?” which promises to be enlightening and entertaining. The closing plenary on 4 June will showcase the cardiology research at MH, to be presented by Tomos Walters, followed by our prize-giving session. I would like to thank the efforts of those involved in reviewing abstracts and posters and the session chairs during Research Week. Your time and expertise is greatly appreciated. I would also like to thank the Research Week Committee for compiling an exciting program and for all the work that goes into making this event such a success. Research underpins the activities of Melbourne Health, enables us to live our values, and to provide excellent healthcare. Thank you Professor Ingrid Winship Executive Director Research Research Week Committee 2015 Professor Ingrid Winship (Chair) Ms Carol Jewell Ms Angela Bragato Dr Ashley Ng Dr Bruce Campbell Professor Terry O’Brien Ms Ishani Hewage Ms Jacqui Richmond Professor Danny Liew Dr Angela Watt Ms Angela Magira Thursday 28 May 2015 Opening Plenary 1.00 – 2.00 pm, Charles La Trobe Lecture Theatre, Function and Convention Centre, Ground Floor (Lunch at 12.30 pm) “A Brain Storm – RMH Neuroscience Newsmakers” Opening: Professor Ingrid Winship, Executive Director Research, Melbourne Health Guest: Dr Leonie Walsh, Lead Scientist for Victoria Leonie Walsh heads the Office of the Lead Scientist. She has more than 25 years of technology leadership and product development experience with multi-national companies such as Visy, Henkel and Dow Chemical. She is the President and Director of the Fight Cancer Foundation and immediate past President of the Australasian Industrial Research group and a Fellow of the Academy of Technological Sciences and Engineering and the . Leonie is Victoria's representative on the Forum of Australian Chief Scientists. Invited Speakers: Dr Bruce Campbell, Consultant Neurologist, Head of Hyperacute Stroke, The Royal Melbourne Hospital Endovascular therapy for stroke guided by advanced brain imaging: The EXTEND-IA trial Associate Professor Helmut Butzkueven, Joint Head, MS Service, Department of Neurology, The Royal Melbourne Hospital MSBase : 10 years of a global Multiple Sclerosis Registry at the Royal Melbourne Hospital Associate Professor Mark Walterfang, Senior Staff Specialist, Neuropsychiatry Unit, Melbourne Health Searching for illness biomarkers and new treatments in a rare disorder: Niemann Pick Type C Page | 1 Friday 29 May 2015 Research Symposium CONCURRENT SESSIONS: 9 . 1 5 – 1 0 . 1 5 A M Cancer Basic Seminar Room 1 Chair: Professor Geoffrey Lindeman 1 Ashleigh Poh, PhD Student, Walter and Eliza Hall Institute Haematopoietic cell kinase activation promotes gastric cancer progression and invasion by facilitating alternative macrophage polarisation 2 Toby Phesse, Senior Research Officer, Olivia Newton-John Cancer Research Institute Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5+ stem cells 3 Dustin Flanagan, PhD student, The University of Melbourne The role of Frizzled-7 and Myc in gastric tumourigenesis 4 Nisha Narayan, PhD Student, Walter and Eliza Hall Institute Dose-dependent effects of miR-155 in acute myeloid leukemia 5 Stephanie Amiridis, PhD Student, The University of Melbourne Investigating the role of dynamin II in glioblastoma Global Seminar Room 2 Chair: Professor Mike Richards 6 Catherine George, Antimicrobial Stewardship Pharmacist Antimicrobial Stewardship – improving antimicrobial prescribing at The Royal Melbourne Hospital 7 John D Wark, Professor of Medicine, Melbourne Health and The University Of Melbourne Vitamin D status and skin damage in a sunny climate: evaluation in healthy young women 8 Ben Cowie, Epidemiology and Physician, VIDRL, Melbourne Health The impact of overseas hepatitis B vaccination programs on the future burden of hepatitis B in Australia 9 Piero Perucca, Clinical Epilepsy Fellow, The Royal Melbourne Hospital and PhD Candidate, The University of Melbourne Clinical whole-exome sequencing in focal epilepsies of suspected genetic etiology 10 Jennifer MacLachlan, Epidemiologist, The Doherty Institute Mapping progress towards Australia’s National Hepatitis B Strategy targets, 2013 Medicine Charles La Trobe Lecture Theatre Chair: Professor David Russell 11 Austin Lee, Medical Student, Department of Anaesthesia and Pain Management,The Royal Melbourne Hospital Fluid therapy to prevent hypotension in patients having colonoscopy 12 Bhupesh Pathik, Fellow in Cardiac Electrophysiology and Pacing, The Royal Melbourne Hospital Three-dimensional (3D) wavemapping of human persistent atrial fibrillation 13 Judy Savige, The University of Melbourne Use of CRISPR technique to correct a gene defect in X-linked Alport syndrome due to a missense mutation in the COL4A5 gene 14 Cathy Daniel, Consultation Liaison Psychiatry Nurse, The Royal Melbourne Hospital The impact of violence risk screening on code grey responses and access to clinical care 15 Alex McLellan, Fellow, The Royal Melbourne Hospital A minimal or maximal ablation strategy to achieve pulmonary vein isolation for paroxysmal atrial fibrillation: a prospective multi- centre randomized controlled trial (The Minimax Study) Quality of Care Lovell Lecture Theatre Chair: Professor Geoff Hebbard 16 Danielle Hitch, Academic Occupational Therapy Project Worker Attitudes of mental health occupational therapists to evidence based practice 17 Peter Colman, Director, Diabetes and Endocrinology, The Royal Melbourne Hospital Prevalence of diabetes and its impact on the length of hospital stay – relationship to admitting unit and diagnosis 18 Bernarda Cavka, Physiotherapist, The Royal Melbourne Hospital Mixed methods evaluation of a comprehensive osteoarthritis hip and knee service; patient, clinician and administrative perspectives 19 Uyen Phan, Senior Musculoskeletal Physiotherapist, Melbourne Health Back pain assessment clinic (BAC): A feasible new model of hospital/community care 20 Jared Gursanscky, Physician The benefit of targeted pharmacist education in reducing prescribing errors by junior doctors – a controlled trial Page | 2 CONCURRENT SESSIONS: 1 0 . 3 0 – 1 1 . 3 0 A M Cancer – Clinical Research Seminar Room 1 Chair: Professor Mark Rosenthal 21 Radha Ramanan, Hospital Medical Officer, The Royal Melbourne Hospital Causes and effects of methotrexate dose alterations in allogeneic haematopoietic cell transplantation 22 Belinda Lee, Clinical Research Fellow, Walter and Eliza Hall Institute and The Royal Melbourne Hospital Impact of tumour site on bevacizumab efficacy in metastatic colorectal cancer 23 Clare Weeden, PhD Student, Walter and Eliza Hall Institute FGFR inhibition in patient-derived xenograft mouse models of lung squamous cell carcinoma 24 Kathryn Field, Medical Oncologist, Melbourne Health Treatment and outcomes of metastatic colorectal cancer in Australia: defining differences between public and private practice 25 Fary Khan, Director Rehabilitation Services, The Royal Melbourne Hospital Multidisciplinary rehabilitation in persons with primary brain tumour: a controlled clinical trial Infection and Immunity Seminar Room 2 Chair: Associate Professor Joe Sasadeusz 26 Kylie Carville, Epidemiologist, VIDRL, Melbourne Health Seven years of monitoring influenza vaccine effectiveness in Victoria 27 Vanessa Bryant, Senior Research Officer, Walter and Eliza Hall Institute A new genetic aetiology for CVID 28 Shereen Oon, Rheumatologist, The Royal Melbourne Hospital Targeted plasmacytoid dendritic cell depletion with an Anti-CD123 mAb – a potential novel treatment for systemic lupus erythematosus 29 Melinda Hardy, Walter and Eliza Hall Institute The specificity and dominance of the polyclonal T cell response to gluten after wheat ingestion in children with coeliac disease is consistent to that of adults 30 Simon Chatfield, Rheumatologist and PhD student, The Royal Melbourne Hospital Neutrophil extracellular traps (NETS) are present in the joint fluid of inflammatory arthritis patients Mental Health Charles La Trobe Lecture Theatre Chair: Associate Professor Andrew Chanen 31 Rachel Tindall, Registered Psychiatric Nurse, Orygen Youth Health Factors influencing engagement with case-managers: perspectives of young people with a diagnosis of first episode psychosis 32 Frances Bilbao, Senior Project Officer,
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