Raphael Mechoulam Ph.D

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Raphael Mechoulam Ph.D. Head, Medicinal Chemistry Lab President, Multidisciplinary Center for Cannabinoid Research Office: +972-2-6758634 [email protected] Raphael Mechoulam is an organic chemist and professor of Medicinal Chemistry at the Hebrew University of Jerusalem in Israel. Ever since his discovery of the human endo-cannabinoid system in the 1960’s, and his subsequent nearly 60 years’ work identifying cannabis’ complementary phyto-cannabinoids, Mechoulam has been widely acknowledged as the ‘father of cannabis research’. Mechoulam is best known for his work (together with Y. Gaoni, C. Trips, and S. Benezra) in the isolation, structure elucidation and total synthesis of Δ9-tetrahydrocannabinol, the main active principle of cannabis, among numerous other phytocannabinoids. Mechoulam also pioneered the isolation and the identification of the endogenous cannabinoids anandamide from the brain and 2-arachidonoyl glycerol (2-AG) from peripheral organs together with his students, postdocs and collaborators. He received his M.Sc. in biochemistry from the Hebrew University of Jerusalem (1952), and his Ph.D. at the Weizmann Institute, Reḥovot (1958), with a thesis on the chemistry of steroids. After postdoctoral studies at the Rockefeller Institute, New York (1959–60), he was on the scientific staff of the Weizmann Institute (1960– 65), before moving to the Hebrew University of Jerusalem, where he became professor (1972) and Lionel Jacobson Professor of Medicinal Chemistry from 1975. In 1994 he was elected a member of the Israel Academy of Sciences, and has been the recipient of numerous other awards and honors, including the Israel Prize in Exact Sciences (2000), the Heinrich Wieland Prize (2004), the Israel Chemical Society Prize for excellence in research (2009), the Rothschild Prize in Chemical Sciences and Physical Sciences (2012), the EMET Prize in Exact Sciences – Chemistry (2012), and the inaugural "Arcview Raphael Mechoulam Lifetime Achievement Award"(2019), an award to carry his name forward for future awardees. Some of his most recent work includes modifying naturally occurring cannabinoids, such as CBDA, to increase stability, as cannabidiolic acid methyl ester (HU-580) and its potential to have better therapeutic effects. He has over 350 publications. .

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Safe Access to Medical Cannabis in New Mexico Schools a Guide Prepared for Tisha Brick by Jason Barker with Safe Access New Mexico
Safe Access To Medical Cannabis in New Mexico Schools A guide prepared for Tisha Brick by Jason Barker with Safe Access New Mexico Safe Access New Mexico ~ A Chapter of Americans For Safe Access UNITE-NETWORK-GROW-INFORM-KNOW-EDUCATE-ACTIVISM-VOTE-HEALTH-WELLNESS (All Rights Reserved 04/20/2018) 1 Program Participants Should Be Able To Use Medical Cannabis At Schools We've come a long way since cannabis was first decriminalized in Oregon in 1973 and then in New Mexico; medical cannabis history started in 1978, after public hearings the legislature enacted H.B. 329, the nation’s first law recognizing the medical value of cannabis…the first law. And it has now been over a decade since the passage of the Lynn and Erin Compassionate Use Act. Safe Access for those patients who will benefit most from medical cannabis treatments; still need to overcome political, social and legal barriers with advocacy by creating policies that improve access to medical cannabis for patients - and that means at school too. Schools already allow children to use all kinds of psychotropic medications—from Ritalin to opioid painkillers—when prescribed by a physician. 2 States That Allow Safe Access To Medical Cannabis In Schools New Jersey - 2015 * Maine - 2015 * Colorado - 2016 (1st Jack’s Law) & 2018 Washington - 2016 Pennsylvania - 2017 Illinois - 2018 (* States Program is Modelled after New Mexico’s Medical Cannabis Program) 3 New Jersey in November 2015 became the first state to do so. Governor Christie signed a bill directing all school districts in New Jersey to adopt rules that permit children with developmental disabilities to consume cannabis oil or another edible cannabis product.
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Mechoulam on Cannabidiol by Fred Gardner a Lipid
O’Shaughnessy’s • Winter/Spring 2008 —31— An Overview at the IACM meeting in Cologne Mechoulam on Cannabidiol By Fred Gardner a lipid. Sophisticated analytical tech- wonder, then, that CBD plays a role in The emerging significance of can- niques and brilliant, dedicated lab work- many clinical conditions. nabis components other than THC was ers (“They should not be married so they Conditions treatable by CBD again a prominent theme when the can work 24 hours a day, seven days a Mechoulam described an experiment International Association of Cannabis week”) enabled Mechoulam to isolate a led by Paul Consroe and colleagues in as Medicine met in Cologne in early cannabinoid produced by the body itself Brazil in which CBD was tested as a October, 2007. The IACM was founded —arachidonoyl-ethanolamide or AEA, treatment for intractable epilepsy. Pa- in 1997 by Franjo Grotenhermen, MD which his colleague William Devane tients stayed on the anticonvulsants they (as the German ACM); it is a smaller dubbed “anandamide,” incorporating the had been on (which hadn’t eliminated organization than the ICRS and its focus Sanskrit word for “bliss.” their seizures) and added 200mg/day of is more clinical, less pharmacological. CBD or a placebo. Of the seven patients “There is almost no physi- getting CBD over the course of several Mechoulam thought his ological system that has been months, only one showed no improve- study of cannabis would be “a ment; three became seizure-free; one looked into in which endocan- experienced only one or two seizures, minor project, it will be finished nabinoids don’t play a certain Mechoulam recalled; and two experi- photo by Alon Weinstock Alon by photo off in six months.” part.” enced reduced severity and occurrence of seizures.
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Cannabis – the Israeli Perspective
J Basic Clin Physiol Pharmacol 2016; 27(3): 181–187 Review Raphael Mechoulam* Cannabis – the Israeli perspective DOI 10.1515/jbcpp-2015-0091 customs. Burning cannabis and inhaling the smoke made Received July 28, 2015; accepted July 29, 2015; previously published them ‘howl in joy’ [1]. online September 30, 2015 Surprisingly, in ancient Judea, cannabis was appar- ently unknown. Or, if it was used as a medicine, it was Abstract: Short overviews are presented on the histori- ignored in the Bible, as it was part of the prevalent Assyr- cal uses of cannabis in the Middle East and on the more ian customs and culture, which after the empire of Assyria recent scientific and medical research on phytocannabi- disintegrated (around 6th century B.C.), the Judean noids and the endocannabinoid system, with emphasis leaders tried to suppress. However, it may be mentioned on research contributions from Israel. These are followed in the Bible as panag – an unidentified product exported by examples of research projects and clinical trials with to Tyre [2]. cannabinoids and by a short report on the regulation of The Greeks and the Romans, who were in the Middle medical marijuana in Israel, which at present is adminis- East for many centuries, were not aware of the psycho- tered to over 22,000 patients. activity of cannabis, but they used it as a medicinal Keywords: anandamide; 2-arachidonoyl glycerol (2-AG); agent, mostly for some types of pain and inflammations. cannabidiol (CBD); tetrahydrocannabinol (THC). However, Galen was aware that it produces ‘senseless talk’ [1]. In medieval Arab society, for over a millennium, In memory of Professor Itai Bab, a close friend and dedicated researcher.
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(12) United States Patent (10) Patent No.: US 9,365,534 B2 Mechoulam Et Al
USOO9365534B2 (12) United States Patent (10) Patent No.: US 9,365,534 B2 Mechoulam et al. (45) Date of Patent: Jun. 14, 2016 (54) ARYLATED CAMPHENES, PROCESSES FOR (56) References Cited THER PREPARATION AND USES THEREOF U.S. PATENT DOCUMENTS (71) Applicant: Yissum Research Development 2,537,647 A 1/1951 Kitchen et al. Company of the Hebrew University of 2,647,152 A 7, 1953 Kitchen et al. Jerusalem Ltd., Jerusalem (IL) 3.284,359 A 11, 1966 Roth 3,800,051 A 3, 1974 Barnhart et al. 3,833,671 A 9/1974 Mardiguian et al. (72) Inventors: Raphael Mechoulam, Jerusalem (IL); 4,061,777 A 12/1977 Mardiguian Lital Magid, Jerusalem (IL); Esther 4,112,000 A 9/1978 Mardiguian Shohami, Mevasseret Zion (IL); Itai 5,648,352 A 7/1997 Bocket al. 6.242,386 B1 6/2001 Lukads et al. Bab, Carmei Yossef (IL) 7,514,583 B2 4/2009 Snow et al. 7,714,170 B2 5, 2010 Snow et al. (73) Assignee: YISSUM RESEARCH 8,722,938 B2* 5/2014 Mechoulam et al. ......... 568.327 DEVELOPMENT COMPANY OF 2007/0225.362 A1 9, 2007 Snow et al. THE HEBREW UNIVERSITY OF 2007/0276034 A1 1 1/2007 Esposito et al. 2011/OO15272 A1 1/2011 Snow et al. JERUSALEM LTD., Jerusalem (IL) 2011/O144124 A1 6, 2011 Snow et al. (*) Notice: Subject to any disclaimer, the term of this FOREIGN PATENT DOCUMENTS patent is extended or adjusted under 35 U.S.C. 154(b) by 0 days. CL 19930O256 2, 1993 CL 2OOOO 1176 5, 2000 CN 18472O7 A 3, 2006 (21) Appl.
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Structure-Activity Relationships of the Cannabinoids
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14:00 Opening Remarks and Greetings Meir Bialer, School Of
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Cannabinoids As Therapeutics.Pdf
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