International Symposium on

Cyclophilins and other Foldases: Signaling Catalysts and Drug Targets

Halle (Saale), Germany, September 19-21, 2013

CONFERENCE MATERIAL

Cyclophilins and other Foldases

CONFERENCE VENUE

The symposium will be held at

the Martin-Luther-University Halle-Wittenberg Lecture hall XXII

Universitätsplatz 1 06108 Halle (Saale) Germany

Conference office telephone: 0157-30056381

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CONFERENCE VENUE LOCATION

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ORGANIZING COMMITTEE

Jochen Balbach (MLU Halle-Wittenberg)

Gunter Fischer (MPI BPC Göttingen, BO Halle)

Franz X. Schmid (University of Bayreuth)

The conference is supported by

SCYNEXIS Inc. Selcia Ltd. AstraZeneca Takeda Pharma Debiopharm Fonds der Chemischen Industrie The City of Halle

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WELCOME TO THE CONFERENCE

We take great pleasure in setting aside our regular lab work and welcoming you all to the International Conference on Cyclophilins and other Foldases - Cell Signaling Catalysts and Drug Targets, which will be held at the Martin-Luther-University Halle- Wittenberg, Germany from September 19th to 22th, 2013.

In the last few years, the scientific and biotechnological communities have become increasingly interested in the challenges involved in conformational regulation of bioactivities by endogenous factors such as foldases. This is reflected in the number of over 600 papers published during 2012 about the addressed in this conference. We are just beginning to understand how catalyzed conformational interconversions of peptide bonds may affect protein functioning under physiological and pathophysiological conditions. This conference is thought to provide an unique forum for researchers to present and exchange new data and to call attention on all aspects of foldase enzymes and their inhibitors. We are pleased to see many prominent scientists come lecturing here in their special fields extending the biochemical studies to biomedicine and potential clinical applications.

Halle, with its 230.000 inhabitants, is situated along the river Saale. Our conference venue belongs to the Martin-Luther University Halle-Wittenberg, which is one the oldest universities in Germany. You will find Germany´s National Academy of Sciences, Leopoldina just a few steps from the conference venue indicating that Halle (Saale) is a good place to discuss and to plan scientific activities.

Also important, along the streets and lanes of the city you will find many coffee shops and restaurants where you can sit and listen to the city's buzz.

We truly hope you will enjoy the conference and your days in Halle (Saale).

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GENERAL INFORMATION

Location The symposium will be held in the Auditorium Maximum (Audimax) at the Martin- Luther-University Halle-Wittenberg, Lecture hall XXII, Universitätsplatz 1, 06108 Halle (Saale), Germany.

Conference Office The conference office is located in the foyer of the Audimax and will be open from 11 am on September 19, 2013 and on the following days of the symposium from 7:30 a.m. till the end of the sessions. Wireless LAN access is available at the conference office.

Registration All participants are kindly requested to visit the conference office after arrival. All necessary conference materials will be distributed together with the conference bag.

Badges All participants are kindly requested to wear their badges throughout the conference for identification and admittance to the sessions and social events. Members of the organization staff will wear yellow badges.

Lunches All participants are kindly requested to arrange for their own lunch. Lunch is available from several different local restaurants and coffee shops within walking distance. At the marketplace and in Große Ullrichstraße, there are also several take-aways. Several lunch opportunities are marked on the map (page 3).

Transportation Halle has a public transportation system operating a tram and bus network. Please be sure to validate your ticket in the tram.

Money Exchange All banks offer money exchange according to the official current exchange rates. Common credit cards are accepted in most shops and restaurants.

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Hotels In case of late arrival please contact the hotels.

Conference hotels are: Dorint Charlottenhof Halle Dorotheenstraße 12 06108 Halle 0345 / 29230 The conference venue can be easily reached from the hotel by foot (20 min walk).

Ankerhof Hotel Ankerstraße 2 06108 Halle 0345 / 2323200 The conference venue can be easily reached from the hotel by foot (20 min walk).

Maritim Hotel Halle Riebeckplatz 4 06110 Halle 0345 / 51010 The conference venue can be reached from the hotel by foot (20 min walk) or by tram (line 2, 4, 5, 7, 9 and 12).

Best Western Grand City Hotel Halle Neustädter Passage 5 06122 Halle (Halle-Neustadt) 0345 / 69310

Guests of this hotel travel free-of-charge on public transport in Halle. To the conference venue it is recommended to go by tram to the market place (line 2 or 10, 11 min). From the market place back to the hotel please use line 2 (direction Soltauer Straße) or line 10 (direction Göttinger Bogen) each departing every 15 min. The tram stop is right in front of the hotel (Zentrum Neustadt).

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SOCIAL PROGRAM

All participants are kindly invited to the following social events:

On Thursday, 19 September 2013, at 8:00 p.m. there will be a Welcome Reception at the Stadthaus Halle. The Stadthaus is the neo-gothic building located at the south side of the market place (Markt 2).

On Saturday, 21 September 2013, at 8:00 p.m. there will be the Conference Dinner at the Maritim Hotel Halle. The Maritim Hotel Halle can be found within walking distance of the conference venue at Riebeckplatz 4.

Special events: On Friday, 20 September 2013, at 8:00 p.m. there will be a Guided Evening Tour in the State Museum of Prehistory. The museum is located at Richard-Wagner-Str. 9. It can be reached most easily by taking tram 7. The tram station directly located in front of the museum is called “Landesmuseum für Vorgeschichte”. or alternatively, a Guided Evening Tour in the Museum Händel-Haus, the birthplace of George Frideric Handel. The museum is located at Große Nikolaistraße 5 and can be found within walking distance of the conference venue. Please sign up for the event of your choice at the conference office.

On Friday, 20 September 2013, at 7:30 p.m. there will be a Sponsor’s Dinner at the Moritzburg Castle Halle. Separate invitations for this event will be presented together with the conference material.

For accompanying guests: For accompanying guests we offer ad hoc arrangements of excursions, guided city tours or museum visits. Please contact the conference office for organization and support.

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SCIENTIFIC PROGRAM

General There will be plenary lectures (45 min), keynote topics (30 min) and oral communications (30 or 20 min). All times include discussion. The program will also include posters. In microsymposia, there will be selected oral presentations in the lecture hall based on posters displayed in the poster area.

Conference Language English is the official language of the symposium.

Lectures and Oral Presentations All lectures will be held at the Auditorium Maximum, Lecture hall XXII, Universitätsplatz 1, Halle. Authors are kindly requested to load and to check their PowerPoint presentations in collaboration with the technical service before the session starts.

Poster sessions Poster sessions will be held in the foyer area of the Auditorium Maximum, Universitätsplatz 1, Halle. Poster authors are recommended to hang all posters on September, 19.

Two poster sessions with discussion at the stands are scheduled for September 20 (posters with odd numbers) and September 21 (posters with even numbers). Each poster will be allotted a panel of size: 90 cm in width and 120 cm in high.

Microsymposia In microsymposia, there will be selected oral presentations in the lecture hall based on posters displayed in the poster area. Oral presentation must be no longer than 8 min. No more than 5 slides are permitted. There will be no time for discussion in the lecture hall after the oral presentation. Please move discussions individually to the poster area.

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Symposium Schedule Thursday, Friday, Saturday, September 19 September 20 September 21 Registration open from 7:30 a.m. Registration open from 7:30 a.m. Session 2 Session 4 8:30 – 8:50 8:30 – 9:15 Plenary Chad Dickey (L-11) Kun Ping Lu (L-27) 8:50 – 9:10 9:15 – 9:45 Felix Hausch (L-12) Steven Hanes (L-28) 9:10 - 9:30 9:45 - 10:05 Tracy Robson (L-13) Len Kritharides (L-29) 9:30 - 9:50 Adina Breiman (L-14) Conference registration 9:50 - 10:20 10:05 - 10:35 Coffee break Coffee break open from 11 a.m. 10:20 - 10:40 10:35 - 11:05 Michael Steinert (L-15) Donald Hamelberg (L-30) 10:40 - 11:00 11:05 - 11:35 Holger Barth (L-16) Dorothee Kern (L-31) Conference posters will be on 11:00 - 11:20 11:35 - 11:55 display for the duration of the Patrizia Nigro (L-17) Xavier Hanoulle (L-32) conference 11:20 - 11:40 11:55 - 12:15 Joan C. Marini (L-18) Valentina Bonetto (L-33) 11:40 - 12:00 12:15 - 12:35 Hans Peter Bächinger (L-19) Paulo A. Ferreira (L-34) 12:00 - 12:20 Yi-Cherng Liou (L-20) 12:20-14:00 12:35-14:00 Lunch break Lunch break Session 1 Session 3 Session 5 14:00-14:20 14:00 – 14:45 Plenary 14:00 – 14:30 Opening remarks and history Bradford C. Berk (L-21) Jun O. Liu (L-35) Gunter Fischer (L-01) 14:20 – 15:05 Plenary 14:45 – 15:15 14:30 – 15:00 Philippe Gallay (L-02) Andreas E. May (L-22) Michael Bukrinsky (L-36) 15:05 – 15:35 15:15 – 17:15 15:00-16:50 Jeremy Luban (L-03) Microsymposium I Microsymposium II and coffee break and coffee break 15:35 – 15:55 17:15 – 17:45 16:50 – 17:20 Peter Probst (L-04) James S. Malter (L-23) Charles Clevenger (L-37) 15:55 – 16:25 17:45 – 18:05 17:20 – 17:40 Coffee break Takafumi Uchida (L-24) Thomas Ratajczak (L-38) 16:25 – 16:45 18:05 – 18:25 17:40 – 18:00 Angus Bell (L-05) Felicia A. Etzkorn (L-25) Eva Obermayr (L-39) 16:45 – 17:15 18:25 – 18:45 18:00 – 18:20 Etienne E. Baulieu (L-06) Guy Lippens (L-26) Kimio Satoh (L-40) 17:15 – 17:35 18:20 – 18:40 Veerle Baekelandt (L-07) Franz X. Schmid (L-41) 17:35 – 17:55 18:40 – 19:00 Mario Galigniana (L-08) Jochen Balbach (L-42) 17:55 – 18:25 Maria Fiammetta Romano (L-09) 18:25 – 18:45 Hans Fliri (L-10)

18:45 End of the session 18:45 End of the session 19:00 End of the session 20:00 Welcome Reception Special events 20:00 Conference Dinner

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LECTURES Thursday, September 19 Session 1 Chair: Gunter Fischer

14:00 L-01 Gunter Fischer MPI BPC Göttingen, BO Halle, Germany OPENING REMARKS AND HISTORY 14:20 L-02 Philippe Gallay Department of Immunology & Microbial Science, La Jolla, CA, USA CYCLOPHILINS, INHIBITORS AND HEPATITIS C VIRUS 15:05 L-03 Jeremy Luban University of Massachusetts Medical School, Worcester, MA, USA THE HIV-1 CAPSID AND CONSERVATION OF AN ANCIENT CYCLOPHILIN A BINDING LOOP 15:35 L-04 Peter Probst1, Sarah Mosier1, Bernard Scorneaux1, Ann Sluder1, Koichi Watashi2, Katyna Borroto-Esoda1 1Scynexis Inc., Durham, NC, USA, 2National Institute of Infectious Diseases, Tokyo, Japan THE IMMUNOMODULATORY ROLE OF THE NON- IMMUNOSUPPRESSIVE CYCLOPHILIN INHIBITOR SCY-635 IN THE TREATMENT OF HEPATITIS C

15:55 Coffee break Session 1 continued Chair: Philippe Gallay

16:25 L-05 Angus Bell, Paul Monaghan, Wesley Shaw Trinity College Dublin, Dublin, Ireland ON THE MECHANISMS OF ANTIMALARIAL ACTION OF FK506, RAPAMYCIN AND NON-IMMUNOSUPPRESSIVE CONGENERS 16:45 L-06 Etienne Emile Baulieu1, Béatrice Chambraud1, Marcel Tawk1, Julien Giustiniani1, Geri Meduri1, Guy Lippens2 Institut National de la Santé et de la Recherche Médicale, Le Kremlin-Bicêtre Cedex, France, 2Université de Lille, Villeneuve d'Ascq, France INTERACTION OF FKBP52 WITH TAU: PATHOPHYSIOLOGICAL ASPECTS

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17:15 L-07 Angelique Deleersnijder, Melanie Gerard, Francesca Macchi, Anke Van der Perren, Chris Van den Haute, Veerle Baekelandt Laboratory for Neurobiology and Gene Therapy, KU Leuven, Belgium UNRAVELING THE ROLE OF FK506 BINDING PROTEINS IN THE AGGREGATION AND NEUROTOXICITY OF α−SYNUCLEIN, A KEY PLAYER IN PARKINSON’S DISEASE 17:35 L-08 Mariana Lagadari1, Cristina Daneri1, Luciana Gallo1, Graciela Piwien- Pilipuk1, Mario Galigniana1,2 1Instituto de Biología y Medicina Experimental (IBYME) Buenos Aires, Argentina, 2University of Buenos Aires, Buenos Aires, Argentina MITOCHONDRIAL LOCALIZATION AND ANTIAPOPTOTIC PROPERTIES OF FKBP51 AND CYCLOPHILIN A 17:55 L-09 Simona Romano, Giovanna Nappo, Maria Fiammetta Romano University Federico II, Naples, Italy FK506 BINDING PROTEIN 51 (FKBP51) PLAYS A ROLE AS TRANSCRIPTIONAL CO-REGULATOR OF MELANOMA STEMNESS 18:25 L-10 Hans Fliri Selcia Ltd., Fyfield Business & Research Park, Ongar, Essex, United Kingdom PROLYL : INDUSTRY’S NEGLECTED CHILD

Friday, September 20 Session 2 Chair: Jochen Balbach

8:30 L-11 Laura Blair1, Shannon Hill2, Matt Scaglione3, Carl Cotman4, Henry Paulson3, Martin Muschol2, Vladimir Uversky2, 6, Torsten Klengel7, Elisabeth Binder7, Rakez Kayed8, Todd Golde5, Nicole Berchtold4, Chad 1 Dickey 1,2University of South Florida, Department of Molecular Medicine, Tampa, FL, USA, 3University of Michigan, Ann Arbor, MI, USA, 4Univeristy of California, Irvine, CA, USA, 5University of Florida, Gainesville, FL, USA, 6Russian Academy of Sciences,Pushchino, Moscow Region, Russia, 7Max Planck Institute of Psychiatry, Munich, Germany, 8The University of Texas Medical Branch, Galveston, TX, USA FKBP51 COORDINATES WITH HSP90 TO FACILITATE NEURO- DEGENERATION THROUGH ALTERING TAU AGGREGATE STRUCTURE 8:50 L-12 Felix Hausch Max Planck Institute of Psychiatry, Munich, Germany THE PROSPECT OF FKBP51 AS A DRUG TARGET

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9:10 L-13 Lana McClements1, Anita Yakkundi1, Angelos Papaspyropoulos4, Hannah Harrison3, Matthew P. Ablett3, Puthen V. Jithesh5, Hayley D. McKeen1, Rachel Bennett1, Christopher Donley1, Adrien Kissenpfennig2, Helen O. McCarthy1, Eric O’Neill4, Robert B. Clarke3, Tracy Robson1 1,2 Queen’s University Belfast, Belfast, United Kingdom, 3University of Manchester, Manchester, United Kingdom, 4University of Oxford, Oxford, United Kingdom, 5University of Liverpool, United Kingdom TARGETING TREATMENT RESISTANT BREAST CANCER STEM CELLS WITH FKBPL AND ITS PEPTIDE DERIVATIVE, AD-01 9:30 L-14 Adina Breiman, David Meiri, Shikma Nachmani, Anat Milgrom Department of Molecular Biology and Ecology of Plants, Tel Aviv University, Tel Aviv, Israel THE PLANT LARGE INTERACT WITH Hsp90 AND ARE INVOLVED IN DEVELOPMENT AND THERMOTOLERANCE

9:50 Coffee break Session 2 continued Chair: Jeremy Luban

10:20 L-15 Michael Steinert1, Can Ünal1, Janine Rasch1, Kai Schwedhelm2, Alexandra Thiele3, Matthias Weiwad3, Kristian Schweimer4, Gunter Fischer6, Cornelius Faber5 1Technische Universität Braunschweig, Braunschweig, Germany, 2University of Würzburg, Würzburg, Germany, 3Martin Luther University Halle-Wittenberg, Halle (Saale), Germany, 4Universität Bayreuth, Bayreuth, Germany,5 Universitätsklinikum Münster, Münster, Germany, 6MPI BPC Göttingen, BO Halle, Germany FUNCTION OF LEGIONELLA PNEUMOPHILA MIP DURING HUMAN INFECTION 10:40 L-16 Katharina Ernst1, Eva Kaiser1, Cordelia Schiene-Fischer2, Holger Barth1 1University of Ulm Medical Center, Ulm, Germany, 2Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany CYCLOPHILINS AND FK506 BINDING PROTEINS BIND TO AND MEDIATE MEMBRANE TRANSPORT OF BACTERIAL ADP- RIBOSYLATING TOXINS 11:00 L-17 Patrizia Nigro1, Stefania Straino2, Giulio Pompilio1, Bradford C. Berk3, Maurizio C. Capogrossi2 1Centro Cardiologico Monzino-IRCCS, Milan, Italy, 2Laboratorio di Patologia Vascolare -IRCCS, Rome, Italy, 3University of Rochester School of Medicine and Dentistry, Rochester, NY, USA ROLE OF CYCLOPHILIN A IN ISCHEMIA AND REGENERATION

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11:20 L-18 Wayne A. Cabral1, Irina Perdivara2, MaryAnn Weis3, Masahiko Terajima4, Angela R. Blissett1, Weizhong Chang1, Elena Makareeva5, Sergey Leikin5, David Eyre3, Mitsuo Yamauchi4, Joan C. Marini1 1NICHD, NIH, USA, 2NIEHS, NIH, USA, 3University of Washington, Seattle, WA, USA 4University of North Carolina, Chapel Hill, NC, USA, 5Physical Biochemistry, NICHD, NIH, USA PPIB KO MOUSE: DIRECT EFFECTS ON COLLAGEN FOLDING AND GLYCOSYLATION, AND INDIRECT EFFECT ON LH1, ALTERING BONE CROSSLINK PATTERNS 11:40 L-19 Hans Peter Bächinger, Yoshi Ishikawa, Sergei Boudko, Elena Pokidysheva Shriners Hospital for Children, Portland, OR, USA THE ROLE OF PPIASES DURING PROCOLLAGEN BIOSYNTHESIS 12:00 L-20 Wanyun Xi, Chang Li, Hao Yu, Yih-Cherng Liou National University of Singapore, Singapore PIN1AT FUNCTIONS IN PLANT DEVELOPMENT

12:20 - 14:00 Lunch break Session 3 Chair: Maria Fiammetta Romano

14:00 L-21 Nwe Nwe Soe1, Mark Sowden1, Padmamalini Baskaran2, Yeonghwan Kim1, Patrizia Nigro3, Elaine M. Smolock1, Bradford C. Berk1 1University of Rochester School of Medicine and Dentistry, Rochester, NY, USA, 2University of Wyoming, Laramie, WY, USA,3Laboratorio di Biologia Vascolare e Medicine Rigenerative, Centro Cardiologico Monzino-IRCCS, Milano, Italy ACETYLATION OF CYCLOPHILIN A IS REQUIRED FOR ITS SECRETION AND SIGNALING IN VASCULAR CELLS 14:45 L-22 Peter Seizer, Saskia von Ungern-Sternberg, David Heinzmann, Christine S. Zuern, Andreas E. May Universitätsklinikum Tübingen, Tübingen, Germany CYCLOPHILIN A AND ITS EXTRACELLULAR RECEPTOR EMMPRIN (CD147) IN ISCHEMIC AND INFLAMMATORY CARDIOMYOPATHIES

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15:15 - 17:15 Microsymposium/Poster session I and coffee break Session 3 continued Chair: Steven D. Hanes

17:15 L-23 Jiyoung Oh, Zhong Jian Shen, James S. Malter University of Texas Southwestern Medical Center, Dallas, TX, USA PIN1-FADD INTERACTIONS REGULATE FAS-MEDIATED APOPTOSIS IN ACTIVATED EOSINOPHILS 17:45 L-24 Takafumi Uchida Tohoku University, Sendai, Japan SIGNIFICANCE OF PIN1- AND GAS7-KNOCK OUT MOUSE CREATION 18:05 L-25 Ana Y. Mercedes-Camacho, Guoyan G. Xu, Ashley B. Mullins, Matthew D. Mason, Felicia A. Etzkorn Virginia Tech, Blacksburg, VA, USA PIN1: INHIBITORS AND MECHANISM 18:25 L-26 Guy Lippens1, Isabelle Landrieu1, Caroline Smet1, Amina Kamah1, Julien Giustiniani2, Béatrice Chambraud2, Etienne Emile Baulieu2 1Université de Lille, Villeneuve d'Ascq, France, 2Institut National de la Santé et de la Recherche Médicale, Le Kremlin-Bicêtre Cedex, France CONFORMATIONAL PROPERTIES OF THE IN (PHOSPHORYLATED) TAU

Saturday, September 21 Session 4 Chair: Franz. X. Schmid

8:30 L-27 Xiao Zhen Zhou, Kun Ping Lu Harvard Medical School, Boston, MA, USA THE PROLYL PIN1 AS A SIGNALING REGULATOR AND A DRUG TARGET IN CANCER AND ALZHEIMER’S DISEASE 9:15 L-28 Steven D. Hanes SUNY Upstate Medical University, Syracuse, NY, USA THE ESS1 CONTROLS TRANSCRIPTION BY RNA POLYMERASE II 9:45 L-29 Leonard Kritharides, Maaike Kockx, Wendy Jessup ANZAC Research Institute, University of Sydney, Sydney, Australia CYCLOSPORIN A IN ATHEROSCEROSIS, HYPERLIPIDEMIA, APOE SECRETION, AND REVERSE CHOLESTEROL TRANSPORT

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10:05 - 10:35 Coffee break Session 4 continued Chair: Guy Lippens

10:35 L-30 Urmi Doshi, Lauren McGowan, Safieh Tork Ladani, Donald Hamelberg Georgia State University, Atlanta, GA, USA PROBING THE INTRICATE COUPLING BETWEEN DYNAMICS AND SUBSTRATE TURNOVER IN CYCLOPHILIN A USING COMPUTER SIMULATIONS 11:05 L-31 Dorothee Kern Brandeis University, Waltham, MA, USA THE CHOREOGRAPHY OF AN ENZYME'S DANCE - DYNAMICS DURING PROLYL ISOMERASES CATALYSIS 11:35 L-32 M. Dujardin1, R. Montserret2, V. Madan3, I. Huvent1, H. Launay1, A. Leroy1, F. Penin2, R. Bartenschlager3, G. Lippens1, X. Hanoulle1 1Université Lille Nord de France, Lille, France; Université des Sciences et Technologies de Lille, Villeneuve d’Ascq, France, 2Université Lyon, Lyon, France, 3University of Heidelberg, Heidelberg, Germany THE CYCLOPHILIN A ON THE INSTRINSICALLY DISORDERED DOMAIN 2 OF HCV NS5A CONTAINS A SHORT STRUCTURAL MOTIF THAT IS ESSENTIAL FOR VIRAL REPLICATION 11:55 L-33 Valentina Bonetto Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy CYCLOPHILIN A IS A TRANSLATIONAL BIOMARKER AND A POTENTIAL THERAPEUTIC TARGET FOR AMYOTROPHIC LATERAL SCLEROSIS 12:15 L-34 Kyoungin Cho, Hemangi Patil, Jessica Wang, Haiqing Yi, Sunny Qiu, Paulo A. Ferreira Duke University Medical Center, Durham, NC, USA THE CYCLOPHILIN DOMAIN OF RANBP2 HARBORS DISCRIMINATING PHYSIOLOGICAL ACTIVITIES TOWARD DISTINCT BIOLOGICAL SUBSTRATES

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12:35 – 14:00 Lunch break Session 5 Chair: Andreas E. May

14:00 L-35 Jun O. Liu Johns Hopkins School of Medicine, Baltimore, Maryland, USA. FROM CYCLOPHILIN TO CALCINEURIN TO REGULATORS OF INTRACELLULAR CALCIUM SIGNALING PATHWAYS 14:30 L-36 Tatiana Iordanskaia1, Evan O. Nadler1, Dmitri Sviridov2, Miroslav Malesevic3, Michael Bukrinsky4 1Children’s National Medical Center, Washington, DC, USA, 2Baker IDI Heart and Diabetes Institute, Melbourne, Australia, 3Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany, 4George Washington University School of Medicine and Health Sciences, Washington, DC, USA TREATING INFLAMMATORY DISEASES WITH EXTRACELLULAR CYCLOSPORINE

15:00 - 16:50 Microsymposium/Poster session II and coffee break Session 5 continued Chair: Kun Ping Lu

16:50 L-37 Theodora Pappa1, Xianke Zeng1, Y’vonne Feeney1, Charles Clevenger2 1Northwestern University, Chicago, IL, USA, 2Virginia Commonwealth University, Richmond, VA, USA NOVEL NON-IMMUNOSUPPRESSIVE CYCLOSPORINE ANALOGUES AS BREAST CANCER THERAPEUTICS 17:20 L-38 Thomas Ratajczak Sir Charles Gairdner Hospital and The University of Western Australia, Nedlands WA, Australia STRUCTURE AND MULTIPLE FUNCTIONS OF CYCLOPHILIN 40, A TETRATRICOPEPTIDE REPEAT (TPR) CYCLOPHILIN 17:40 L-39 Eva Obermayr1,5, Dan Cacsire Castillo-Tong1, Dietmar Pils1, Paul Speiser1, Ioana Braicu2, Toon Van Gorp3,6, Sven Mahner4, Jalid Sehouli2, 3 1,5 Ignace Vergote , Robert Zeillinger 1Medical University of Vienna, Vienna, Austria, 2Charité - Universitätsmedizin Berlin, Berlin, Germany, 3Katholieke Universiteit Leuven, Leuven, Belgium, 4University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 5Ludwig Boltzmann Gesellschaft, Vienna, Austria, 6Present address: Maastricht UMC+, Maastricht, The Netherlands CYCLOPHILIN C IN CIRCULATING TUMOR CELLS

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18:00 L-40 Kimio Satoh, Yoshihiro Fukumoto, Koichiro Sugimura, Toru Shimizu, Kota Suzuki, Nobuhiro Kikuchi, Yusuke Takagi, Jun Takahashi, Hiroaki Shimokawa Tohoku University Graduate School of Medicine, Sendai, Japan CYCLOPHILIN A IS A NOVEL BIOMARKER FOR OXIDATIVE STRESS AND ATHEROSCLEROTIC DISEASES 18:20 L-41 Franz X. Schmid Universität Bayreuth, Bayreuth, Germany PROLYL ISOMERIZATION AS A RATE-DETERMING STEP IN AND PROTEIN FUNCTION

18:40 L-42 Caroline Haupt, Michael Kovermann, Rica Patzschke, Mattias Altenstein, Jochen Balbach Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany IN VITRO AND IN VIVO FUNCTION OF THE METALLOCHAPERONE SlyD

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MICROSYMPOSIA Microsymposium I on Friday, September 20 Chair: Jun O. Liu

15:15 – 15:35 Short break

15:35 P-38 Manjusha M. Kulkarni1, Anna Karafova2, Wojciech Kamysz2, Sergio Schenkman3, Roger Pelle4, Bradford S. McGwire1 1The Ohio State University Medical Center, Columbus, OH, USA, 2Medical University of Gdansk, Gdansk, Poland, 3Universidade Federal de Sao Paulo, Brazil, 4International Livestock Research Institute, Nairobi, Kenya SECRETED TRYPANOSOME CYCLOPHILIN INACTIVATES LYTIC INSECT DEFENSE PEPTIDES AND INDUCES PARASITE CALCINEURIN ACTIVATION AND INFECTIVITY 15:43 P-41 Piet Kramer, Andrea Hamann, Verena Warnsmann, Heinz D. Osiewacz J. W. Goethe University, Frankfurt, Germany ROLE OF CYCLOPHILIN D IN AGING AND LIFESPAN CONTROL OF PODOSPORA ANSERINA 15:51 P-32 Paul T. M. Lavin, Margaret M. Mc Gee Conway Institute, University College Dublin, Ireland CHARACTERISATION OF CYCLOPHILIN A LOCALISATION TO THE CENTROSOME AND MIDBODY IN TUMOUR CELLS 15:59 P-58 Iain McNae, Jacqueline Dornan, Jorge Dias Do Nascimento, Martin Wear, Malcolm Walkinshaw Centre for Translational and Chemical Biology, The University of Edinburgh, Scotland, UK CYCLOPHILIN IS A CHLORIDE ION SENSOR 16:07 P-22 Lionel Colliandre1, Abdelhakim Ahmed-Belkacem2, Muriel Gelin1, Yannick Bessin1, Jean-Michel Pawlotsly2, Jean-François Guichou1 1Centre de Biochimie Structurale, CNRS, Montpellier, France, 2IMRB, Hôpital Henri Mondor, Créteil, France RATIONAL DESIGN OF SMALL-MOLECULES INHIBITORS OF HUMAN CYCLOPHILINS AND HCV REPLICATION BY STRUCTURE BASED DRUG DESIGN 16:15 P-16 Dhruv Shah1, Mohit Gupta1, Zandrea Ambrose2, Orlando Acevedo3, 1 Patrick Flaherty 1Duquesne University, Pittsburgh, PA, USA, 2University of Pittsburgh School of Medicine, Pittsburgh, PA, USA, 3Auburn University, Auburn, AL, USA DESIGN, SYNTHESIS, AND TESTING OF TORSIONALLY RESTRICTED SMALL MOLECULE INHIBITORS OF CYCLOPHILIN A

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16:23 P-14 Maria Dimou, Aggeliki Skagia, Eleni Vezyri, Chrysoula Zografou, Anastasia Venieraki, Panagiotis Katinakis Agricultural University of Athens, Athens, Greece PEPTIDYL-PROLYL CIS/TRANS ISOMERASES ARE INVOLVED IN BACTERIAL MOTILITY AND BIOFILM FORMATION - STUDIES ON THE ROLE OF THE CYTOPLASMIC CYCLOPHILIN

Microsymposium II on Saturday, September 21 Chair: Felicia A. Etzkorn

15:00 – 15:20 Short break

15:20 P-21 Steven J. Moss1, Jose A. Garcia-Rivera2, Pieter Leyssen3, Nigel Coates1, Udayan Chatterji2, Johan Neyts3, Philippe Gallay2, Barrie Wilkinson1, Mikael Brönnegård4, Jan Nilsson4, Matthew A. Gregory1 1Isomerase Therapeutics Ltd., Cambridge, United Kingdom, 2The Scripps Research Institute, La Jolla, CA, USA, 3K.U.Leuven, Leuven, Belgium, 4Neurovive Pharmaceutical AB, Lund, Sweden BC556, A POTENT, PAN-GENOTYPIC, HIGH BARRIER TO RESISTANCE, SECOND GENERATION CYCLOPHILIN INHIBITOR FOR TREATMENT OF CHRONIC HCV INFECTION 15:28 P-62 Sreekanth Rajan, Amaravadhi Harikishore, Ho Sup Yoon Nanyang Technological University, Singapore STRUCTURAL INSIGHTS INTO SUBSTRATE AND INHIBITOR BINDINGS BY PFFKBP35 AND PVFKBP35, PEPTIDYLPROLYL CIS-TRANS ISOMERASES FROM HUMAN MALARIAL PARASITES 15:36 P-53 Kunchithapadam Swaminathan National University of Singapore, Singapore STRUCTURAL INSIGHTS OF PLANT 15:44 P-39 David Dilworth, Neda Savic, Christopher J. Nelson University of Victoria, Victoria, BC, Canada FUNCTIONS OF NUCLEAR FKBP PROTEINS 15:52 P-57 Esteban Vöhringer-Martinez Universidad de Concepción, Concepción, Chile MECHANISTIC INSIGHTS INTO THE PIN1 CATALYSIS OF CIS/TRANS PEPTIDE ISOMERIZATION 16:00 P-27 Nadja Bitomsky1, Dirk Sombroek1, Christian Moritz2, Kathrin Schultheiss1, Tilman Polonio-Vallon1, Elisa Conrad1, Carolina Glas1,

20 Cyclophilins and other Foldases

Fiamma Mantovani3, Giannino del Sal3, Francesca Peri2, Thomas G. Hofmann1 1German Cancer Research Center DKFZ-ZMBH Alliance, Heidelberg, Germany, 2European Molecular Biology Laboratory (EMBL), Heidelberg, Germany, 3Laboratorio Nazionale CIB (LNCIB), Trieste, Italy CONSERVED MECHANISM OF ACTIVATION FOR DNA DAMAGE CHECKPOINT KINASE HIPK2 BY AUTOPHOSPHORYLATION AND PIN1 BINDING 16:08 P-13 Alessandra Rustighi, Alessandro Zanini, Elena Campaner, Mattia Garutti, Giannino Del Sal National Laboratory CIB (LNCIB), Trieste, Italy ROLE OF THE PROLYL-ISOMERASE PIN1 IN BREAST CANCER AGGRESSIVENESS

21 Cyclophilins and other Foldases

POSTERS Friday, September 20 Session I - posters with odd numbers Saturday, September 21 Session II - posters with even numbers

P-01 Abdelhakim Ahmed-Belkacem, Lionel Colliandre, Nazim Ahnou, Yannick Bessin, Jean-François Guichou, Jean-Michel Pawlotsky INSERM/UPEC Hôpital Henri Mondor, Créteil, France NEW “DRUG-LIKE” CYCLOPHILIN INHIBITORS UNRELATED TO CYCLOSPORINE A POTENTLY INHIBIT HCV REPLICATION AND REVERT HCV-INDUCED MITOCHONDRIAL DYSFUNCTIONS

P-02 Caroline Haupt, Matthias Altenstein, Jochen Balbach Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany METALL-INDUCED PARAMAGNETIC RELAXATION ON PROTEINS

P-03 Tobias Aumüller, Sandra Liebscher, Miroslav Malesevic, Günther Jahreis, Frank Bordusa, Cordelia Schiene-Fischer Ulm University, Ulm, Germany DEVELOPMENT OF EFFICIENT AND VERSATILE ASSAYS TO QUANTIFY CYCLOPHILIN-INHIBITOR AFFINITY

P-04 Lukas Hoppstock1, Martin Könneke2, Peter Bayer1 1University of Duisburg-Essen, Essen, Germany, 2University of Bremen, Bremen, Germany STRUCTURE AND FUNCTION OF ARCHAEAL PARVULINS

1 2 1 P-05 Wolfgang Rudolf Christian Beyer , Gerd Hause Gunter Fischer 1Max-Planck Institute for Biophysical Chemistry Göttingen, BO Halle, Halle (Saale), Germany, 2Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany PROBING AGGREGATION KINETICS OF Aβ PEPTIDE FRAGMENTS USING A MINIMAL BACKBONE SUBSTITUTION AND PHOTOISOMERIZATION

P-06 Alessandra Bianchin1, Denis Shields1, Anthony J. Chubb1, Barrie 2 3 Wilkinson , Angus Bell 1University College Dublin, Ireland, 2Isomerase Therapeutics Ltd., UK, 3Moyne Institute, Trinity College Dublin, Ireland ANTIMALARIAL POTENTIAL OF NON-IMMUNOSUPPRESSIVE ANALOGUES OF RAPAMYCIN

P-07 Annett Boden1, Weilin Lin1, Sonja Schallenberg2, Karsten Kretschmer2, Yixin Zhang1 B CUBE, Technical University Dresden, Germany, 2CRTD/DFG-Center, Technical University Dresden, Germany LIGHT-SWITCHABLE CYCLOSPORIN A AS TOOL FOR IMMUNREGULATION

22 Cyclophilins and other Foldases

P-08 Thomas Hediger1, Boris Féaux de Lacroix1, Fabian Kruska1, Nadira Dornhof1, Cordelia Schiene-Fischer2, and Manfred Braun1 1University of Düsseldorf, Düsseldorf, Germany, 2Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany ARYL-INDANYL AND ARYL HETARYL KETONES AS NOVEL INHIBITORS OF PPIASES

P-09 A. von Brunn1, J. Carbajo-Lozoya1, M. Malešević2, D. Muth3, Y. Ma- Lauer1, B. von Brunn1, M. Su1, M. A. Müller3, G. Herrler4, C. Schwegmann-Weßels4, H.-J. Thiel5 , T. Baumert6, J. Haas7, C. Drosten3, G. Fischer2 1Ludwig-Maximilians-University (LMU) Munich, Germany 2Martin-Luther-University Halle- Wittenberg, Germany, 3University of Bonn, Germany, 4Tierärztliche Hochschule Hannover, Germany, 5Justus-Liebig Universität Gießen, Gießen, Germany, 6Université de Strasbourg, France, 7University of Edinburgh, UK FROM SARS-CORONAVIRUS (SARS-COV) ORFEOME TO CELLULAR TARGETS: INHIBITION OF CYCLOPHILINS BY CYCLOSPORINE A AND NON-IMMUNOSUPPRESSIVE DERIVATIVES RESULTS IN PAN- CORONAVIRAL REPLICATION INHIBITION, INCLUDING THE NEW MERS-COV

P-10 Y. Ma-Lauer1, J. Carbajo-Lozoya1, M. Malešević2, M. A. Müller3, G. 2 3 1 Fischer , C. Drosten , A. von Brunn 1Max-von-Pettenkofer Institute, Ludwig-Maximilians-University Munich, Germany, 2Martin- Luther-Universität Halle-Wittenberg, 3Institute of Virology, University of Bonn, Germany REPLICATION INHIBITION OF HUMAN CORONAVIRUSES SARS-COV, HCOV-NL63 AND HCOV-229E BY THE DRUG FK506

P-11 P. Bustos1, A. Perrone1, M. Cámara2, A. Fuchs1,3, M. Postan1, S. Moreno4, J. Búa1,3 1INP “Dr. M. Fatala Chaben” A.N.L.I.S.- Malbrán, Argentina, 2IDIM-CONICET, Argentina; 3CAECIHS, UAI, Argentina, 4CTEGD, University of Georgia, USA A MITOCHONDRIAL CYCLOPHILIN FROM TRYPANOSOMA CRUZI AND ITS ROLE IN PROGAMMED CELL DEATH

P-12 Steffi Stöhr1, Lisa Sandmann1, Stephanie Pfänder2, Michael P. Manns1, Eike Steinmann2, Thomas von Hahn1,3, Sandra Ciesek1 1Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, 2Division of Experimental Virology, Medical School Hannover (MHH) and Helmholtz Centre for Infection Research (HZI), Hannover, Germany, 3Institute for Molecular Biology, Hannover Medical School, Hannover, Germany HOST MTORC1 SIGNALING IS REQUIRED FOR HEPATITIS C VIRUS (HCV) RNA REPLICATION

23 Cyclophilins and other Foldases

P-13 Alessandra Rustighi1,2, Alessandro Zanini1,2, Elena Campaner1,2, Mattia 1,2 1,2,3 Garutti , Giannino Del Sal 1National Laboratory CIB (LNCIB), Trieste, Italy, 2University of Trieste, Trieste, Italy ROLE OF THE PROLYL-ISOMERASE PIN1 IN BREAST CANCER AGGRESSIVENESS

P-14 Maria Dimou, Aggeliki Skagia, Eleni Vezyri, Chrysoula Zografou, Anastasia Venieraki, Panagiotis Katinakis Agricultural University of Athens, Athens, Greece PEPTIDYL-PROLYL CIS/TRANS ISOMERASES ARE INVOLVED IN BACTERIAL MOTILITY AND BIOFILM FORMATION – STUDIES ON THE ROLE OF THE CYTOPLASMIC CYCLOPHILIN

P-15 Franziska Todt, Zeynep Cakir, Frank Reichenbach, Frank Edlich Albert-Ludwigs-Universität Freiburg, Freiburg, Germany RETROTRANSLOCATION OF BAX AND BAK FROM THE MITOCHONDRIA INTO THE CYTOSOL

P-16 Dhruv Shah1, Mohit Gupta1, Zandrea Ambrose2, Orlando Acevedo3, 1 Patrick Flaherty 1Duquesne University, Pittsburgh, USA, 2University of Pittsburgh School of Medicine, Pittsburgh, USA 3Auburn University, Auburn, USA DESIGN, SYNTHESIS, AND TESTING OF TORSIONALLY RESTRICTED SMALL MOLECULE INHIBITORS OF CYCLOPHILIN A

P-17 R. Gopalakrishnan1, S. Gaali2, X. Feng2, C. Kozany2, B. Hoogeland2, A. Bracher2, F. Hausch2 1École Polytechnique Fédérale de Lausanne, Switzerland, 2Max-Planck-Institut for Psychiatry Munich, Germany EVALUATION OF SYNTHETIC FK506 ANALOGS AS LIGANDS FOR THE FK506-BINDING PROTEINS 51 AND 52

P-18 Y. Wang1, S. Gaali2, A. Kirschner2, A. Fabian2, R. Gopalakrishnan2, C. 2 2 2 2 2 2 Kress , B. Hoogeland , U. Koch , C. Kozany , A. Bracher , F. Hausch 1EMBL, 2Max-Planck-Institut for Psychiatry Munich, Germany INCREASING LIGAND EFFICIENCY BY CONFORMATIONAL CONTROL

P-19 Himal K. Ganguly, Gautam Basu Department of Biophysics, Bose Institute, Kolkata, India CH···π INTERACTION MEDIATED STABILIZATION OF CIS-PEPTIDYL- PROLYL BOND

24 Cyclophilins and other Foldases

P-20 Julien Giustiniani1, Béatrice Chambraud1, Elodie Sardin1, Omar Dounane1, Kevin Guillemeau1, Hiroko Nakatani1, Dominik Paquet2,3, Amina Kamah4, Isabelle Landrieu4, Guy Lippens4, Etienne Emile Baulieu1, Marcel Tawk1 1Institut National de la Santé et de la Recherche Médicale, Le Kremlin-Bicêtre Cedex, France, 2,3Leopoldina Research Fellow, Tessier-Lavigne Laboratory, The Rockefeller University, New York, USA, 4Université de Lille1, Villeneuve d'Ascq, France PHYSIO-PATHOLOGICAL RELEVANCE OF FKBP52 AND TAU CONNECTION

P-21 Steven J. Moss1, Jose A. Garcia-Rivera2, Pieter Leyssen3, Nigel Coates1, Udayan Chatterji2, Johan Neyts3, Philippe Gallay2, Barrie Wilkinson1, Mikael Brönnegård4, Jan Nilsson4, Matthew A. Gregory1 1Isomerase Therapeutics Ltd., Cambridge, UK, 2The Scripps Research Institute, La Jolla, USA, 3Rega Institute for Medical Research, K.U.Leuven, Belgium, 4Neurovive Pharmaceutical AB, Lund, Sweden BC556, A POTENT, PAN-GENOTYPIC, HIGH BARRIER TO RESISTANCE, SECOND GENERATION CYCLOPHILIN INHIBITOR FOR TREATMENT OF CHRONIC HCV INFECTION

P-22 Lionel Colliandre1, Abdelhakim Ahmed-Belkacem2, Muriel Gelin1, Yannick Bessin1, Jean.-Michel Pawlotsly2, Jean.-François Guichou1 1Centre de Biochimie Structurale, Montpellier 1, France, 2IMRB, Hôpital Henri Mondor, Créteil, France RATIONAL DESIGN OF SMALL-MOLECULES INHIBITORS OF HUMAN CYCLOPHILINS AND HCV REPLICATION BY STRUCTURE BASED DRUG DESIGN

P-23 D. Heinzmann1, P. Seizer1, S. von Ungern-Sternberg1, H. Sturhan1, T. Schönberger1, K. Klingel2, G. Fischer3, Z. Kaya4, A. E. May1 1Medizinische Klinik III, Universitätsklinikum Tübingen, Germany, 2Institute of Molecular Pathology, Universitätsklinikum Tübingen, Germany, 3Max Planck Research Unit for Enzymology of Protein Folding, Halle (Saale), Germany, 4Department of Cardiology, Universitätsklinikum Heidelberg, Germany INHIBITION OF EXTRACELLULAR CYCLOPHILIN A DIMINISHES LEUKOCYTE INFILTRATION AND MYOCARDIAL REMODELLING IN A MOUSE MODEL OF AUTOIMMUNE MYOCARDITIS

P-24 Morkos A. Henena,b, Cillian Byrnec, Amina Khamaa, Isabelle Landrieua,b, a c Guy Lippens , Yves Jacquot aCNRS, Lille1 University, France, bInstitute de Recherches interdisciplinaires, VILLENEUVE D'ASCQ, France, cPierre and Marie Curie University, Paris, France NMR AND DRUG DESIGN STUDIES OF INTERACTION BETWEEN FKBP52-PPIASE DOMAIN & POTENTIAL PEPTIDE AND PSEUDOPEPTIDE SUBSTRATES

25 Cyclophilins and other Foldases

P-25 Erik Hinze1, Wolfgang Rudolf Christian Beyer2, Angelika Schierhorn3, Cordelia Schiene-Fischer3 1Max Planck Research Unit for Enzymology of Protein Folding, Halle (Saale), Germany 2Max- Planck Institute for Biophysical Chemistry Göttingen, BO Halle, Germany, 3 Martin-Luther- University Halle-Wittenberg, Halle (Saale), Germany INCORPORATING A REVERSIBLE CIS/TRANS PEPTIDE BOND PHOTOSWITCH INTO THE BACKBONE OF E.COLI PARVULIN 10

P-26 Henrik Hoffmann1, Mario Träger 2, Cordelia Schiene-Fischer1 1Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany, 2Max Planck Research Unit for Enzymology of Protein Folding, Halle (Saale), Germany CYP60 AND CYP57 - HUMAN MULTIDOMAIN CYCLOPHILINS COMPLEMENTED WITH DIFFERENT FUNCTIONAL DOMAINS

P-27 Nadja Bitomsky1, Dirk Sombroek1, Christian Moritz2, Kathrin Schultheiss1, Tilman Polonio-Vallon1, Elisa Conrad1, Carolina Glas1, Fiamma Mantovani3, Giannino del Sal3, Francesca Peri2, Thomas G. Hofmann1 1German Cancer Research Center (dkfz) DKFZ-ZMBH Alliance, Heidelberg, Germany, 2European Molecular Biology Laboratory (EMBL), Heidelberg, Germany, 3Laboratorio Nazionale CIB (LNCIB), Trieste, Italy CONSERVED MECHANISM OF ACTIVATION FOR DNA DAMAGE CHECKPOINT KINASE HIPK2 BY AUTOPHOSPHORYLATION AND PIN1 BINDING

1,2 1 1 1,3 P-28 Yun Huang , Günther Jahreis , Christian Lücke , Gunter Fischer 1Max Planck Research Unit for Enzymology of Protein Folding, Halle (Saale), Germany, 2Present address: University of Pennsylvania, Philadelphia, USA, 3Present address: Max-Planck Institute for Biophysical Chemistry, Göttingen, BO Halle, Germany SELENOXO PEPTIDE BOND: NEW TOOL TO STUDY THE STRUCTURE AND FUNCTION OF PEPTIDE BACKBONE

P-29 A. März, A. Kirschner, A. Fabian, C. Kozany, A. Bracher, F. Hausch Max-Planck-Institut for Psychiatry Munich, Germany LARGE FK506-BINDING PROTEINS CONTRIBUTE TO THE PHARMACOLOGY OF RAPAMYCIN

P-30 M. Kockx1, E. Glaros2, T. W. Ng3, P. J. Meikle3, V. Deswaerte4, W. 1 1,5 Jessup , L. Kritharides 1ANZAC Research Institute, Sydney, 2Centre for Vascular Research, UNSW, Sydney, 3Metabolomics, Baker IDI Heart and Diabetes Institute, Melbourne, 4Vascular Biology & Atherosclerosis, Baker IDI Heart and Diabetes Institute, Melbourne, 5University of Sydney, Sydney, Australia CYCLOSPORIN A CAUSES HYPERLIPIDEMIA IN THE LDLRKNOCKOUT MOUSE

26 Cyclophilins and other Foldases

P-31 Lorenz Korbinian Kollmannsberger, Nils Christian Gassen, Theo Rein Max-Planck Institute of Psychiatry, Munich, Germany DOES FKBP51 REGULATE GR TRANSCRIPTIONAL ACTIVITY BY RECRUITING KINASES AND PHOSPHATASES?

P-32 Paul T. M. Lavin, Margaret M. Mc Gee Conway Institute, University College Dublin, Ireland CHARACTERISATION OF CYCLOPHILIN A LOCALISATION TO THE CENTROSOME AND MIDBODY IN TUMOUR CELLS

1 1,2 P-33 Alfons Lawen , Tony Velkov Monash University, 1Department of Biochemistry and Molecular Biology, School of Biomedical Sciences and 2Monash Institute of Pharmaceutical Sciences, Melbourne, Australia FUNCTIONAL AND STRUCTURAL CHARACTERIZATION OF THE N- METHYLTRANSFERASE MODULES IN CYCLOSPORIN SYNTHETASE

P-34 Darren Leneghan, Angus Bell Moyne Institute of Preventive Medicine, Trinity College Dublin, Dublin 2, Ireland IMMUNOPHILIN-PROTEIN INTERACTIONS IN THE MALARIA PARASITE, PLASMODIUM FALCIPARUM

P-35 Weilin Lin, Yixin Zhang B CUBE, Center for Molecular Bioengineering, Technical University Dresden, Germany A REINVESTIGATION OF CYCLOPHILIN - CYCLOSPORIN BINDING KINETICS

P-36 Yoan Monneau1, Heddy Soufari1, Christopher Nelson2, Cameron Mackereth1 1European Institute of Chemistry and Biology, Bordeaux, France, 2University of Victoria, Canada STRUCTURE OF YEAST FPR4 CATALYTIC DOMAIN AND HISTONE H3 ISOMERIZATION

P-37 Miroslav Malešević Martin-Luther-University Halle Wittenberg, Halle (Saale), Germany SYNTHESIS OF A LIBRARY OF CYCLOSPORIN A (CSA) ANALOGUES VIA ALDEHYDE DIAMINE “CLICK” CHEMISTRY

P-38 Manjusha M. Kulkarni1, Anna Karafova2, Wojciech Kamysz2, Sergio 3 4 1 Schenkman , Roger Pelle , Bradford S. McGwire 1The Ohio State University Medical Center, Columbus, USA, 2Medical University of Gdansk, Gdansk, Poland, 3Universidade Federal de Sao Paulo, Brazil, 4International Livestock Research Institute, Nairobi, Kenya SECRETED TRYPANOSOME CYCLOPHILIN INACTIVATES LYTIC INSECT DEFENSE PEPTIDES AND INDUCES PARASITE CALCINEURIN ACTIVATION AND INFECTIVITY

27 Cyclophilins and other Foldases

P-39 David Dilworth, Neda Savic, Christopher J. Nelson University of Victoria, Victoria, BC, Canada FUNCTIONS OF NUCLEAR FKBP PROTEINS

P-40 I. H. Norville1, D. W. Begley2, D. Fox III2, D. Jenner1, F. Seufert4, C. Juli4, N. J. Harmer5, R. Stacy3, P. J. Myler3, U. Holzgrabe4, D. Lorimer2, M. Sarkar-Tyson1,6 1Dstl, Porton Down, Salisbury, UK, 2Emerald Bio, Bainbridge Island, USA, 3Seattle Biomed, Seattle, USA, 4University Würzburg, Germany, 5University of Exeter, Devon, UK, 6University of Western Australia, Nedlands, Australia EVALUATION OF NOVEL INHIBITORS AGAINST BURKHOLDERIA PSEUDOMALLEI MIP PROTEIN

P-41 Piet Kramer, Andrea Hamann, Verena Warnsmann, Heinz D. Osiewacz J. W. Goethe University, Frankfurt, Germany ROLE OF CYCLOPHILIN D IN AGING AND LIFESPAN CONTROL OF PODOSPORA ANSERINA

1 P-42 Rica Patzschke , Caroline Haupt, Michael Kovermann, Ulrich Weininger, Stefan Gröger1 Jochen Balbach1 Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany STRUCTURAL INVESTIGATIONS ON ASSISTED PROTEIN FOLDING REACTIONS IN REAL-TIME

1 2,3 1 P-43 Judith Toneatto , Mario Galigniana , Graciela Piwien-Pilipuk 1Laboratory of Nuclear Architecture and 2Laboratory of Nuclear Receptors, Instituto de Biologia y Medicina Experimental (IBYME) & 3University of Buenos Aires. Buenos Aires, Argentina PKA DEPENDENT MITOCHONDRIAL –NUCLEAR REDISTRIBUTION OF FKBP51 IS REQUIRED FOR THE CONTROL OF GENE EXPRESSION DURING THE PROCESS OF ADIPOGENESIS

P-44 Simona Romano, Anna D’Angelillo, Marika Elsa Friano, Paolo D’Arrigo, Rita Bisogni, Maria Fiammetta Romano University of Naples - Federico II - Italy FKBP51 PROMOTES ACETYLATION OF YIN YANG 1 AND REDUCES TRAIL-R EXPRESSION IN MELANOMA

P-45 G. Rühter1, M. Baumann1, K. Dinkel1, B. Klebl1, M. Malesevic3, P. Nussbaumer1, G. Fischer2 1Lead Discovery Center GmbH, Dortmund, Germany 2Max-Planck Institute for Biophysical Chemistry Göttingen, BO Halle, Germany, 3Martin-Luther-University Halle-Wittenberg, Germany SPECIFIC TARGETING OF EXTRACELLULAR CYCLOPHILINS FOR TREATMENT OF INFLAMMATORY DISEASES

28 Cyclophilins and other Foldases

P-46 Miroslav Malesevic1, Danny Gutknecht2, Erik Prell3, Claudia Klein2, Romana A. Nowak4, Jan C. Simon2, Anja Saalbach2, Cordelia Schiene- 1 Fischer 1Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany, 2 Leipzig University, Leipzig, Germany, 3Max Planck Research Unit for Enzymology of Protein Folding, Halle (Saale), Germany, 4University of Illinois, Illinois, USA ANTI-INFLAMMATORY EFFECTS OF EXTRACELLULAR CYCLOSPORINS ARE EXCLUSIVELY MEDIATED BY CD147

P-47 Philipp A. M. Schmidpeter1, Gabriel Zoldák1, Tobias Aumüller2, Günther Jahreis2, Gunter Fischer2, Franz X. Schmid1 1University of Bayreuth, Bayreuth, Germany, 2Max-Planck Research Unit for Enzymology of Protein Folding, Halle (Saale), Germany SEQUENCE SPECIFICITY OF PEPTIDYL-PROLYL ISOMERASES

P-48 Michael Schumann1, Miroslav Malešević2, Sebastian Mathea1, Wolfgang 3 2 Haehnel †, Cordelia Schiene-Fischer 1Max-Planck Research Unit for Enzymology of Protein Folding, Halle (Saale), Germany, 2Martin- Luther-University Halle-Wittenberg, Halle (Saale), Germany, 3Albert-Ludwigs-University, Freiburg, Germany REGULATION OF MCM3 CHROMATIN BINDING BY THE PROLYL ISOMERASE PIN1

P-49 Alexandra Schutkowski1, Johannes Zerweck2, Mike Schutkowski3 1Institute of Agricultural and Nutritional Sciences, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany, 2JPT Peptide Technologies GmbH, Berlin, Germany, 3Institute of Biochemistry and Biotechnology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany PEPTIDE MICROARRAYS FOR RELIABLE IDENTIFICATION OF PHOSPHORYLATION SITES IN HUMAN CYCLOPHILINS, FKBP´S AND PARVULINS

P-50 F. Seufert1, C. Juli1, M. Hein1, I. H. Norville2, D. Jenner2; M. Sarkar- Tyson2, M. Weiwad3, K. Schweimer4, P. Rösch4, R. Stacy6, P. Myler6, D. Begley5, D. Fox5, D. Lorimer5, C. A. Sotriffer1, U. Holzgrabe1 1University of Würzburg, Würzburg, Germany, 2Defence Science and Technology Laboratory, Porton Down, Salisbury, UK, 3Research Center for Enzymology of Protein Folding, Max-Planck Institute Halle, Halle, Germany, 4University of Bayreuth, Bayreuth, Germany, 5Emerald BioStructures, Bainbridge Island, USA, 6Seattle Structural Genomics Center for Infectious Disease, Seattle, USA DEVELOPMENT OF MIP-INHIBITORS

P-51 Ann Sluder, Robert Foglesong, Bernard Scorneaux, Richard Harris, Seong-Hee Park, Steve Wring, Michael Peel SCYNEXIS, Inc., Research Triangle Park, USA A NOVEL CYCLOPHILIN D INHIBITOR FOR PREVENTING MUSCLE LOSS CAUSED BY MITOCHONDRIAL STRESS

29 Cyclophilins and other Foldases

P-52 Martin Helmuth1, Werner Schmidt1, Thomas Hediger2, Manfred Braun2, 3 1 Gunter Fischer , Frank Striggow 1German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany, 2University of Düsseldorf, Düsseldorf, 2Max-Planck Institute for Biophysical Chemistry Göttingen, BO Halle, Germany EFFECTS OF PIN1 INHIBITION ON HUMAN WILD-TYPE OR P301L TAU- INDUCED HIPPOCAMPAL NEURODEGENERATION IN C57BL/6 MICE

P-53 Kunchithapadam Swaminathan National University of Singapore, Singapore STRUCTURAL INSIGHTS OF PLANT IMMUNOPHILINS

P-54 Martin Theuerkorn1, Matthias Weiwad2, Erik Prell1, Werner Schmidt3, 3 1 Frank Striggow , Gunter Fischer 1Max-Planck Institute for Biophysical Chemistry Göttingen, BO Halle (Saale), Germany, 2Martin- Luther-University Halle-Wittenberg, Halle (Saale), Germany 3German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany A STRATEGY TO INTERFERE WITH OFF-TARGET EFFECTS OF PEPTIDYL PROLYL CIS/TRANS ISOMERASE INHIBITORS: DOUBLE HEADED TARGETING IN AN AUTOIMMUNE DISEASE MODEL

P-55 S.N.I. von Ungern-Sternberg1, O. Borst1, G. Fischer2, D. Heinzmann, H. 3 1 1 1 Sturhan, E. Kremmer , M. Gawaz , A. E. May , P. Seizer 1Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls-Universität Tübingen, Germany, 2Max-Planck Institute for Biophysical Chemistry Göttingen, BO Halle (Saale), Germany, Germany, 3Helmholz Zentrum München, München, Germany CYCLOPHILIN A ACTIVATES HUMAN PLATELETS VIA EMMPRIN AND PI3-KINASE AND PROMOTES PLATELET ADHESION TO THE VASCULAR WALL

P-56 M. Villmow1, M. Baumann2, J. Balbach2, M. Fändrich1, C. Schiene- Fischer3 1Max Planck Research Unit for Enzymology of Protein Folding, Halle (Saale), Germany, 2Martin- Luther-University Halle-Wittenberg, Department of Physic, Halle (Saale), Germany, 3Martin- Luther-University Halle-Wittenberg, Institute of Biochemistry and Biotechnology, Halle (Saale), Germany THE INHIBITION OF AMYLOID Β (1-40) AGGREGATION BY CYCLOPHILINS

P-57 Esteban Vöhringer-Martinez Universidad de Concepción, Universidad de Concepción, Concepión, Chile MECHANISTIC IN SIGHTS INTO THE PIN1 CATALYSIS OF CIS TRANS PEPTIDE ISOMERIZATION

30 Cyclophilins and other Foldases

P-58 Iain McNae, Jacqueline Dornan, Jorge Dias Do Nascimento, Martin Wear, Malcolm Walkinshaw Centre for Translational and Chemical Biology, The University of Edinburgh, Scotland, UK CYCLOPHILIN IS A CHLORIDE ION SENSOR

P-59 Andreas Werner, Sahra Pilz, Blanca Iachia y Baca, Annette Flotho, Frauke Melchior Centre for Molecular Biology of the University Heidelberg (ZMBH), DKFZ - ZMBH Alliance, Heidelberg, Germany RANBP2 (CYP358) IS A MULTISUBUNIT SUMO E3 AND AN UNUSUAL CYCLOPHILIN

P-60 Bin Xia Beijing Nuclear Magnetic Resonance Center, Peking University, Beijing, China CYCLOPHILIN A INDUCES CHEMOTAXIS INDEPENDENT OF ITS PEPTIDYLPROLYL CIS-TRANS ISOMERASE ACTIVITY

P-61 Anita Yakkundi1, Rachel Bennett1, Oksana Lyubomska2, Ivette Hernandez3, Hayley McKeen1, Hayder Dyer1, Mary Hanna2, Helen McCarthy1, Roy Bicknell3, Adrien Kissenpfennig2, Tracy Robson1 1School of Pharmacy, 2School of Medicine-Queen's University, Belfast, UK, 3University of Birmingham, UK FKBPL: SECRETION AND REGULATION OF ANGIOGENESIS

P-62 Sreekanth Rajan, Amaravadhi Harikishore, Ho Sup Yoon Nanyang Technological University, Singapore STRUCTURAL INSIGHTS INTO SUBSTRATE AND INHIBITOR BINDINGS BY PFFKBP35 AND PVFKBP35, PEPTIDYLPROLYL CIS-TRANS ISOMERASES FROM HUMAN MALARIAL PARASITES

P-63 Khian Hong Pua, Gregory L. Verdine Harvard University, Department of Chemistry and Chemical Biology, Harvard Department of Stem Cell and Regenerative Biology STUDIES ON THE ANTASCOMICIN FAMILY OF NATURAL PRODUCTS

31 Cyclophilins and other Foldases

List of Participants

32 Cyclophilins and other Foldases

Abdelhakim, Ahmed-Belkacem Barth, Holger INSERM/UPEC HôpitalHenri Mondor Institute of Pharmacology and Toxicology 51 avenue du Marechal de lattre de Tassigny University of Ulm Medical Center 94010 Créteil, France Albert-Einstein-Allee 11 [email protected] D-89070 Ulm, Germany [email protected]

Altenstein, Matthias Baulieu, Etienne Emile Fachgruppe Biophysik, Institut für Physik, INSERM UMR 788 Martin-Luther-Universität Halle-Wittenberg 80, rue du General Leclerc Betty-Heimann-Straße 7 94276 Le Kremlin-Bicetre Cedex, France D-06120 Halle (Saale), Germany [email protected] [email protected]

Aumüller, Tobias Baumann, Monika Institute for Pharmaceutical Biotechnology Fachgruppe Biophysik, Institut für Physik Ulm University Martin-Luther-Universität Halle-Wittenberg Helmholtzstr. 8/1 Betty-Heimann-Straße 7 D-89081 Ulm, Germany D-06120 Halle (Saale), Germany tobias.aumü[email protected] [email protected]

Austin, Carol Bayer, Peter Selcia Ltd. Structural and Medicinal Biochemistry Fyfield Business & Research Park Centre for Medical Biotechnology Fyfield Road University of Duisburg-Essen Ongar, Essex CM5 0GS , United Kingdom Universitätsstr. 2-5 [email protected] D-45117 Essen, Germany [email protected]

Bächinger, Hans Peter Bell, Angus Shriners Hospital for Children School of Genetics & Microbiology 3101 SW Sam Jackson Park Road Moyne Institute Portland, OR 97239, USA Trinity College Dublin [email protected] Dublin 2, Ireland [email protected]

Baekelandt, Veerle Berk, Bradford C. Laboratory for Neurobiology and Gene Therapy Aab Cardiovascular Research Institute and Department of Neurosciences Department of Medicine KU Leuven University of Rochester School of Medicine and Kapucijnenvoer 33 blok i - box 7001 Dentistry 3000 Leuven, Belgium 601 Elmwood Ave, Box 706 [email protected] Rochester, NY, 14642, USA [email protected]

Balbach, Jochen Beyer, W.R. Christian Fachgruppe Biophysik, Institut für Physik, Max-Planck Institute for Biophysical Chemistry Martin-Luther-Universität Halle-Wittenberg Göttingen, BO Halle Weinbergweg 22 Betty-Heimann-Straße 7 D-06120 Halle (Saale), Germany D-06120 Halle (Saale), Germany [email protected] [email protected]

33 Cyclophilins and other Foldases

Bianchin, Alessandra Bustos, Patricia School of Medicine & Medical Sciences and Instituto Nacional de Parasitologia Dr. M. Fatala UCD-CASL (Complex and Adaptive Systems Chabén Laboratory), Paseo Colón 568 University College Dublin Ciudad de Buenos Aires, Argentina Belfield Office Park [email protected] D4 Dublin, Ireland [email protected]

Boden, Annett Chambraud, Beatrice B CUBE, Center for Molecular Bioengineering, National de la Santé et de la Recherche Technical University Dresden, Médicale Unité Mixte de Recherche 788, Arnoldstr. 18 Université Paris XI D-01307 Dresden, Germany 94276 Le Kremlin-Bicetre Cedex, France [email protected] [email protected]

Bonetto, Valentina Ciesek, Sandra Dulbecco Telethon Institute at IRCCS - Istituto di Department of Gastroenterology, Hepatology Ricerche Farmacologiche Mario Negri and Endocrinology, Via La Masa 19 Hannover Medical School 20156 Milano, Italy Carl-Neuberg-Str. 1 [email protected] D- 30625 Hannover, Germany [email protected]

Braun, Manfred Clevenger, Charles V. Institute of Organic Chemistry, Department of Pathology Heinrich-Heine-University of Düsseldorf Virginia Commonwealth University Universitätsstr. 1 Richmond, VA, USA D-40225 Düsseldorf, Germany [email protected] [email protected]

Breiman, Adina Cooreman, Michael Department of Molecular Biology and Ecology of Mitsubishi Tanaba Pharma Development Plants, America, Inc Tel Aviv University 525 Washington Boulevard, Suite 400 69978 Tel Aviv, Israel Jersey City, NJ 07310, USA [email protected] [email protected]

Brunn, Albrecht von Davis, John Max-von-Pettenkofer Institute, Selcia Ltd. Ludwig-Maximilians-University Munich Fyfield Business & Research Park, Pettenkoferstr. 9a Fyfield Road D-80336 Munich, Germany Ongar, Essex CM5 0GS, United Kingdom [email protected] [email protected]

Bukrinsky, Michael Del Sal, Giannino Department of Microbiology, Immunology and National Laboratory CIB (LNCIB), Trieste, Italy, Tropical Medicine, Department of Life Sciences, University of George Washington University Trieste School of Medicine and Health Sciences Padriciano 99 Ross Hall, Rm 734, 2300 Eye St. NW 34149 Trieste, Italy Washington, DC, 20037, USA [email protected] [email protected]

34 Cyclophilins and other Foldases

Dickey, Chad Fischer, Gunter Department of Molecular Medicine, Max-Planck Institute for Biophysical Chemistry University of South Florida Göttingen, BO Halle 4002 E Fowler Ave. Weinbergweg 22 Tampa, FL 33613, USA D-06120 Halle (Saale) [email protected] [email protected]

Dimou, Maria Flaherty, Patrick Laboratory of General and Agricultural Mylan School of Pharmacy, Department of Microbiology, Department of Agricultural Pharmacological Sciences, Division of Biotechnology Medicinal Chemistry Agricultural University of Athens Duquesne University Iera Odos 75 445 A Mellon Hall 11855, Athens, Greece Pittsburgh, PA 15282, USA [email protected] [email protected]

Dornhof, Nadira Fliri, Hans Heinrich-Heine-Universität Düsseldorf Selcia Ltd. Universitätstr.1 Fyfield Business & Research Park, D-40225 Düsseldorf, Germany Fyfield Road [email protected] Ongar, Essex CM5 0GS, United Kingdom [email protected]

Edlich, Frank Gaali, Steffen Institute for Biochemistry and Molecular Biology Max-Planck-Institut for Psychiatry Munich Albert-Ludwigs-Universität Freiburg Kraepelinstr. 2-10 Stefan-Meier-Str. 17 D-80804 Munich, Germany D-79104 Freiburg, Germany [email protected] [email protected]

Etzkorn, Felicia A. Galigniana, Mario Department of Chemistry and Department of IBYME-CONICET & Department of Biological Biochemistry Chemistry, Virginia Tech University of Buenos Aires Blacksburg, VA 24061-0212, USA Vuelta de Obligado 2490 [email protected] C1429ADN Buenos Aires, Argentina [email protected]

Fändrich, Marcus Gallay, Philippe Institute for Pharmaceutical Biotechnology Department of Immunology & Microbial Ulm University Science, Helmholtzstr. 8/1 The Scripps Research Institute D-89081 Ulm, Germany 10550 North Torrey Pines Road [email protected] La Jolla, CA 92037, USA [email protected]

Ferreira, Paulo A. Ganguly, Himal K. Duke University Bose Institute Medical Center Dep. Biophysics 2351 Erwin Road P-1/12 CIT Scheme VIIM Durham, NC 27710, USA Kolkata 700054, India [email protected] [email protected]

35 Cyclophilins and other Foldases

Garrett, Mike Hamelberg, Donald Scynexis, Inc. Department of Chemistry, and Center for Research Triangle Park Biotechnology and Drug Design Durham Georgia State University NC 27709-2878,USA Atlanta, GA 30302-3965, USA [email protected] [email protected]

Germann, Paul-Georg Hanes, Steven D. Takeda Pharmaceuticals International, Inc. Department of Biochemistry and Molecular Byk-Gulden-Str 2 Biology, D-78467 Konstanz, Germany SUNY Upstate Medical University [email protected] 750 East Adams Street Syracuse, NY 13210, USA [email protected]

Giustiniani, Julien Hanoulle, Xavier National de la Santé et de la Recherche Unité de glycobiologie Structurale et Médicale Unité Mixte de Recherche 788 Fonctionnelle, Université Paris XI Universite de Lille 1 94276 Le Kremlin-Bicetre Cedex, France UMR 8576, CNRS [email protected] Avenue Medeleiev – Bât. C9 F-59655 Villeneuve d’Ascq, France [email protected]

Göritz, Mareike Hausch, Felix Max-Planck-Innovation GmbH Max Planck Institute of Psychiatry Amalienstr. 33 Kraepelinstr. 2-10 D-80799 München,Germany D-80804 Munich, Germany [email protected] [email protected]

Gregory, Matthew A. Heinzmann, D. Isomerase Therapeutics Ltd. Universitätsklinikum Tübingen Chesterford Research Park Innere Medizin III Cambridge, CB10 1XL, United Kingdom Otfried-Müller-Str. 10 [email protected] D-72076 Tübingen, Germany

Guichou, Jean-Francois Henen, Morkos A. Centre de Biochimie Structurale UMR 8576-CNRS, Lille1 University University of Montpellier 50, Avenue Halley - BP 29, rue de Navacelles, 59655 Villeneuve d’Ascq, France 340890 Montpellier 1, France [email protected] [email protected]

Hacker, Jörg Hilgenfeld, Rolf Leopoldina Institut für Biochemie Nationale Akademie der Wissenschaften Universitat Lübeck, Jägerberg 1 Ratzeburger Allee 160 D-06108 Halle, Germany D-23562 Lübeck, Germany [email protected] [email protected]

36 Cyclophilins and other Foldases

Hinze, Erik Katinakis, Panagiotis Max Planck Research Unit for Enzymology of Agricultural University of Athens, Protein Folding Insect Mol genetics Group Weinbergweg 22 75 Iera Odos str. D-06120 Halle (Saale), Germany 118 55 Athens, Greece [email protected] [email protected]

Hoffmann, Henrik Kern, Dorothee Martin-Luther-University Halle Wittenberg Department of Biochemistry and Howard Institute for Biochemistry and Biotechnology Hughes Medical Institute, Department Enzymology, gFP5 Brandeis University Weinbergweg 22 415 South Street D-06120 Halle (Saale), Germany Waltham, MA, 02454, USA [email protected] [email protected]

Hofmann, Thomas G. Kikuchi, Nobuhiro German Cancer Research Center DKFZ-ZMBH Department of Cardiovascular medicine, Alliance Graduate School of Medicine, Im Neuenheimer Feld 280 Tohoku University D-69120 Heidelberg, Germany Seiryo1-2, 2goukan, 5F [email protected] 980-8575 Aobaku Sendai-Miyagi, Japan [email protected]

Hoppstock, Lukas Kirschner, Alexander Structural and Medicinal Biochemistry, Max Planck Institute of Psychiatry Centre for Medical Biotechnology, Kraepelinstr. 2-10 University of Duisburg-Essen D-80804 Munich, Germany Universitätsstr. 2-5 [email protected] D-45117 Essen, Germany [email protected]

Huang, Yun Kockx, Maaike Department of Chemistry, University of Sydney University of Pennsylvania ANZAC Research Institute, C22-Concord 231 South 34th Street Hospital Philadelphia, PA 19104-6323, USA Sydney, NSW 2006, Australia [email protected] [email protected]

Iachia y Baca, Blanca Ana Kollmannsberger, Lorenz-Korbinian ZMBH, Universität Heidelberg Max-Planck Institute of Psychiatry Im Neuenheimer Feld 280, Kraepelinstr. 2-10 D-069120 Heidelberg, Germany D-80804 Munich, Germany [email protected] [email protected]

Jahreis, Günther Kramer, Piet Martin-Luther-University Halle Wittenberg Institute of Molecular Biosciences, Institute of Biochemistry and Biotechnology J. W. Goethe University Weinbergweg 22 Max-von-Laue-Str. 9 D-06120 Halle (Saale), Germany D- 60438 Frankfurt, Germany [email protected] [email protected]

37 Cyclophilins and other Foldases

Kritharides, Leonard Litchfield, David University of Sydney Department of Biochemistry ANZAC Research Institute Western University London, Ontario C22-Concord Hospital Schulich School of Medicine and Dentistry Sydney, NSW 2006, Australia Medical Sciences Building 342 [email protected] N6A 5C1 London, Canada [email protected]

Lavin, Paul T.M. Liu, Jun O. University College Dublin Departments of Pharmacology and Oncology, Belfield, Dublin 4, Johns Hopkins School of Medicine Dublin, Ireland 725 N Wolfe St. [email protected] Baltimore, MD 21205, USA [email protected]

Lawen, Alfons Lu, Kun Ping Monash University Department of Medicine, Beth Israel Department of Biochemistry and Molecular Deaconess Medical Center Biology, School ofBiomedical Sciences, Harvard Medical School Melbourne, 77 Avenue, L. Pasteur Clayton, Victoria 3168, Australia Boston, MA 02210, USA [email protected] [email protected]

Leneghan, Darren Luban, Jeremy Dept. of Microbiology, School of Genetics & Molecular Medicine and Biochemistry & Microbiology, Moyne Institute of Preventive Molecular Pharmacology Medicine, University of Massachusetts Medical School Trinity College 373 Plantation Street Dublin, Dublin 2, Ireland Worcester, MA 01605, USA [email protected] [email protected]

Lin, Weilin Mackereth, Cameron B CUBE, Center for Molecular Bioengineering, European Institute of Chemistry and Biology Technical University Dresden, Inserm U869, Bordeaux Arnoldstr. 18 2 rue Robert Escarpit D-01307 Dresden, Germany 33607 Pessac Cedex, France [email protected] [email protected]

Liou, Yih-Cherng Malešević, Miroslav Department of Biological Sciences, Martin-Luther-University Halle Wittenberg Faculty of Science, Institute for Biochemistry and Biotechnology National University of Singapore Department Enzymology, gFP5 14 Science Drive 4, Singapore 117543 Weinbergweg 22 Singapore D-06120 Halle (Saale), Germany [email protected] [email protected]

Lippens, Guy Malter, James S. Unité de Glycobiologie Structurale et Southwestern Medical Center Fonctionelle, CNRS UMR 8576 Department of Pathology Université de Lille1 University of Texas 59655 Villeneuve d'Ascq, France 5323 Harry Hines Blvd. [email protected] Dallas, TX 75390-9072, USA [email protected]

38 Cyclophilins and other Foldases

Marini, Joan C. Nelson, Christopher J. Bone and Extracellular Matrix Branch University of Victoria NICHD, NIH Dep. of Biochemistry and Microbiology 9000 Rockville Pike Petch Bldg Room 207 Bethesda, MD 20892, USA 3800 Finnerty Road [email protected] Victoria, BC V8P 5C2, Canada [email protected]

Marquardt, Terry Niephagen, Angelica Scynexis, Inc. Max-Planck Institute for Biophysical Chemistry Research Triangle Park Göttingen, BO Halle Durham, NC 27709-2878, USA Weinbergweg 22 [email protected] D-06120 Halle (Saale) [email protected]

Masch, Antonia Nigro, Patrizia Martin Luther University Halle-Wittenberg Centro Cardiologico Monzino Institute for Biochemistry and Biotechnology Via Parea 4 Department of Enzymology 20138 Milano, Italy Kurt-Mothes-Str. 3 [email protected] D-06120 Halle, Germany [email protected]

May, Andreas E. Nilson, Jan Universitätsklinikum Tübingen NeuroVive Pharmaceutical AB Innere Medizin III Scheelevägen 2 Otfried-Müller-Str. 10 SE-223 81 Lund, Sweden D-72076 Tübingen, Germany [email protected] [email protected]

Mayr, Lorenz Norville, Isobel H. AstraZeneca, RD DSTL Innovative Medicines, Discovery Sciences Dstl Porton Down, Building 7 52G10, Mereside, Alderley Park, Macclesfield SP40JQ Salisbury, United Kingdom Cheshire, Sk10 4TG, United Kingdom [email protected] [email protected]

McGee, Margaret Obermayr, Eva Conway Institute Department of Obstetrics and Gynecology School of Biomolecular and Biomed Science Medical University of Vienna Belfield, Dublin 4, Ireland Waehringer Guertel 18-20 [email protected] 1090 Wien, Austria [email protected]

McGwire, Bradford S. Osiewacz, Heinz D. Division of Infectious Diseases, Center for Institute of Molecular Biosciences Microbial Interface Biology and Public Health J. W. Goethe University Preparedness for Infectious Diseases program Max-von-Laue-Str. 9 The Ohio State University Medical Center D-60438 Frankfurt, Germany 460 W. 10th Avenue [email protected] Columbus, OH 43210, USA [email protected]

39 Cyclophilins and other Foldases

Patzschke, Rica Ratajczak, Mrs. Fachgruppe Biophysik, Institut für Physik, The University of Western Australia Martin-Luther-Universität Halle-Wittenberg Centre for Medical Research Betty-Heimann-Straße 7 35 Stirling Highway D-06120 Halle (Saale), Germany Crawley, WA 6009, Australia [email protected]

Peel, Mike Ribeill, Yves Scynexis, Inc. Scynexis, Inc. Research Triangle Park Research Triangle Park Durham, NC 27709-2878, USA Durham, NC 27709-2878, USA [email protected] [email protected]

Peng, Jeffrey Robson, Tracy University of Notre Dame Queen’s University Belfast 251 Nieuwland Science Hall School of Pharmacy Notre Dame, IN 46556, USA 97 Lisburn Road, Belfast, Northern Ireland [email protected] United Kingdom [email protected]

Piwien-Pilipuk, Graciela Romano, Maria Fiammetta IBYME-CONICET University of Naples “Federico II” Vuelta de Obligado 2490 Via S. Pansini 5 Buenos Aires, C1429ADN, Argentina 80131 Napoli, Italy [email protected] [email protected]

Probst, Peter Romano, Simona Scynexis, Inc. University of Naples “Federico II” Research Triangle Park Via S. Pansini 5 Durham, NC 27709-2878, USA 80131 Napoli, Italy [email protected] [email protected]

Pua, Khian Hong Rühter, Gerd Havard University Lead Discovery Center GmbH Department of Chemistry & Chemical Biology Emil-Figge-Str. 76a 12 Oxford Street D-44227 Dortmund, Germany Cambridge, MA 02138, USA [email protected] [email protected]

Ratajczak, Thomas Rustigh, Alessandra The University of Western Australia Area Science Park Centre for Medical Research Laboratorio Nazionale CIB 35 Stirling Highway Padriciano 99, 34149 Trieste, Italy Crawley, WA 6009, Australia [email protected] [email protected]

40 Cyclophilins and other Foldases

Satoh, Kimio Schutkowski, Mike Tohoku University Martin-Luther-University Halle-Wittenberg Graduate School of Medicine Institute for Biochemistry und Biotechnology 2 1 Seiryo, Aoba-ku Department Enzymology Sendai, Miyagi 9808575, Japan Kurt-Mothes-Str. 3 [email protected] D-06120 Halle, Germany [email protected]

Schellenberger, Alfred Seufert, Florian Martin-Luther-University Halle-Wittenberg Universität Würzburg Institute for Biochemistry und Biotechnology Wilhelm-Dahl-Str. 9 Department Enzymology D-97082 Würzburg, Germany Kurt-Mothes-Str. 3 [email protected] D-06120 Halle, Germany

Schiene-Fischer, Cordelia Sluder, Ann Martin-Luther-University Halle-Wittenberg Scynexis, Inc. Institute for Biochemistry und Biotechnology Research Triangle Park Department Enzymology, gFG5 Durham, NC 27709-2878, USA Weinbergweg 22 [email protected] D-06120 Halle, Germany [email protected] halle.de

Schlott, Bernhard Steinert, Michael Fritz Lippmann Institut Age Research Technische Universität Braunschweig Beutenbergstr. 11 Institut für Mikrobiologie D-07751 Jena, Germany Spielmannstr. 7 [email protected] D-38106 Braunschweig, Germany [email protected]

Schmid, Franz X. Striggow, Frank Universität Bayreuth DZNE, Standort Magdeburg Institut für Biochemie Leipziger Str. 44, Haus 15 Universitätsstr. 30 D-39120 Magdeburg, Germany D-95440 Bayreuth, Germany [email protected] [email protected]

Schmidpeter, Philipp A.M. Sviridov, Dmitri Universität Bayreuth, Baker IDI Heart & Diabetes Institute Institut für Biochemie 75 Commercial Road Universitätsstr. 30 Melbourne 3004, Australia D-95440 Bayreuth, Germany [email protected] [email protected]

Schumann, Michael Swaminathan, Kunchithapadam Max Planck Research Unit for Enzymology of Dept. of Biological Sciences Protein Folding National University of Singapore Weinbergweg 22 Bl.S3, Room 04-06, Science Drive Singapore D-06120 Halle (Saale), Germany 4117543, Singapore [email protected] [email protected]

41 Cyclophilins and other Foldases

Theuerkorn, Martin Vöhringer-Martinez, Esteban Max-Planck Institute for Biophysical Chemistry Departamento de Físico-Química, Facultad de Göttingen, BO Halle Weinbergweg 22 Ciencias Químicas D-06120 Halle (Saale), Germany Universidad de Concepción [email protected] Edmundo Larenas 129 Concepión 12425, Región del Bio Bio, Chile [email protected]

Tropschug, Maximilian Vuagniaux, Gregoire Albert-Ludwigs-Universität Freiburg Debiopharm S. A. Institut für Biochemie und Molekularbiologie Chemin Messidor 5 Stefan-Meier-Str. 19 1006 Lausanne, Switzerland D-79104 Freiburg, Germany [email protected] [email protected]

Twak, Marcel Walkinshaw, Malcolm Unité Mixte de Recherche 788 Centre for Translational and Chemical Biology Inserm et Université Paris-Sud 11 The University of Edinburgh 94276 Kremlin Bicêtre, France Michael Swann Building, L3,King’s Buildings, [email protected] Mayfield Rd., EH9 3JR Edinburgh, Scotland, United Kingdom [email protected]

Uchida, Chyioki Weiwad, Matthias Tohoku University Martin-Luther-University Halle-Wittenberg Dept. of Molecular and Cell Biology Institute for Biochemistry und Biotechnology Lab. of Enzymology Department Enzymology, gFG5 1-1 Tsutsumidori Amamiya-machi, Aoba-ku Weinbergweg 22 Sendai, Miyagi, 981-8555, Japan D-06120 Halle, Germany [email protected] [email protected]

Uchida, Takafumi Werner, Andreas Tohoku University Centre for Molecular Biology of the University Dept. of Molecular and Cell Biology Heidelberg (ZMBH), DKFZ - ZMBH Alliance Lab. of Enzymology Im Neuenheimer Feld 280 1-1 Tsutsumidori Amamiya-machi, Aoba-ku D-069120 Heidelberg, Germany Sendai, Miyagi, 981-8555, Japan [email protected] [email protected]

Ungern-Sternberg, S. N. I. von Xia, Bin Universitätsklinikum Tübingen Peking University Innere Medizin III Beijing NMR Center Otfried-Müller-Str. 10 5 Yiheyuan Road, Haidian District D-72076 Tübingen, Germany Beijing 100871, China [email protected]

Villmow, Marten Yakkundi, Anita Max Planck Research Unit for Enzymology of Queens University Protein Folding School of Pharmacy Weinbergweg 22 University Road, Belfast, BT7 1 NN D-06120 Halle (Saale), Germany Northern Ireland, United Kingdom [email protected] [email protected]

42 Cyclophilins and other Foldases

Yong, Weidong Chinese Academy of Medical Sciences InsLab Animal Sci Pan Jia Yuan Nanli 5 100021 Beijing, China [email protected]

Yoon, Ho Sup School of Biological Sciences Nanyang Technological University 60 Nanyang Drive 637551 Singapore, Singapore [email protected]

Zhang, Yixin B CUBE, Center for Molecular Bioengineering, Technical University Dresden Arnoldstr. 18, D-01307 Dresden, Germany [email protected]

43