bioRxiv preprint doi: https://doi.org/10.1101/421602; this version posted September 19, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. 1 Opposing roles of dopamine receptor D1- and D2-expressing neurons 2 in the anteromedial olfactory tubercle in acquisition of place preference 3 in mice 4 Koshi Murata1,2, Tomoki Kinoshita1, Yugo Fukazawa1,2,3, Kenta Kobayashi4, Akihiro 5 Yamanaka5, Takatoshi Hikida6, Hiroyuki Manabe7, and Masahiro Yamaguchi8 6 1. Division of Brain Structure and Function, Faculty of Medical Sciences, University of Fukui, 7 Fukui, Japan 8 2. Life Science Innovation Center, Faculty of Medical Science, University of Fukui, Fukui 910-1193, 9 Japan 10 3. Research Center for Child Mental Health Development, Faculty of Medical Sciences, University 11 of Fukui, Fukui 910-1193, Japan 12 4. Section of Viral Vector Development, National Institute for Physiological Sciences, Aichi 444- 13 8585, Japan 14 5. Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, 15 Aichi 464-8601, Japan 16 6. Laboratory for Advanced Brain Functions, Institute for Protein Research, Osaka University, Osaka 17 565-0871, Japan 18 7. Laboratory of Neural Information, Graduate School of Brain Science, Doshisha University, Kyoto 19 610-0394, Japan 20 8. Department of Physiology, Kochi Medical School, Kochi University, Kochi 783-8505, Japan 21 * Correspondence: 22 Koshi Murata, Ph.D. 23
[email protected] 24 Keywords: olfactory tubercle, attractive behavior, aversive behavior, place preference, 25 optogenetics, medium spiny neurons, dopamine receptor D1, dopamine receptor D2 26 bioRxiv preprint doi: https://doi.org/10.1101/421602; this version posted September 19, 2018.