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Table of Contents: 1. Chronological list of some chart changes

Jan-Aug 2021 NEW guidelines: New CDN: Sask. SPDP some changes ACC’20 A. Fib or VTE undergoing PCI/ASCVD Aermony RespiClick for asthma -Full: Admelog, Aermony RespiClick, Gluconorm, Spiriva, Suboxone SL, Trintellix ACG’20 Management of Irritable Bowel Syndrome Corzyna for angina -EDS: Adlyxine, Avsola, Dupixent, Fasenra pen, Omnipod Cartridge, Olumiant, ACG’21 Prevent, diagnosis & treat C. difficile infection Combogesic OTC for pain Onpattro, Opsumit, Orkambi, Rituximab (via Riximyo, Ruxience & Truxima), ACG’21 Upper GI & Ulcer Bleeding Dayvigo for sleep Revestive, Soliqua, Takhzyro, Trikafta & Vyndaqel. ACR’21 Treatment of Rheumatoid Arthritis Descovy for HIV PrEP  cost: new generics: Actonel DR, Ciprodex, Cytomel, Dovobet oint, Enablex, ADA’21 American Diabetes Guideline Entyvio SC for UC/CD Enoxaparin, Esbriet, Flecainide, Flovent, Humira biosimilars, Hyoscine, AHS’21 Migraine: New Treatments into Practice Kesimpta & Zeposia for MS Infliximab, Jadenu, Kayexalate, Lamivudine, Methotrexate inj, Myforic, ASH’21 Manage VTE: Prevent & Tx pts with Cancer Nextstellis for birth control Onglyza, Pulmicort nebs, Rapaflo, Renvela, Revatio, Rituximab, Tri-Cira, CCS’21 Heart Failure Guideline Update Suboxone Film Uloric, Venofer & Visanne. CCS’21 Lipid Guidelines Trurapi is insulin aspart  new NIHB: CTS’21 Management of Very Mild & Mild Asthma New FDA: -Full: Admelog, Campral, Cyclosporine, Dex-4 liquid/gel, Emend, KDIGO’21 Management of Blood Pressure in CKD Aduhelm for Alzhiemer’s Iron polysaccharide complex (Triferexx, Polyride FE, FeraMax), NAEPP’20 American Asthma Guide: Adult/Adolescent Gemtesa for urinary incontinence Mezera 1gm foam, Minocycline, Monurol, Mycophenolate, Nabilone, Kesimpta & Ponvory for MS Shingrix (for age 65-70yrs only), Sirolimus, Tacrolimus, Trintellix, Viread Prevnar 20 for pneumococcal dx & Zyvoxam. Verquvo for heart failure -EDS: Humira 20mg syringe, Prevymis, Riximyo, Suboxone film & SL Sept-Dec 2020 NEW guidelines: New CDN: Sask. SPDP some changes ACC’20 Cardiovascular Risk Reduction in T2DM Ajovy for migraine -Full: Mya (generic Yaz), Zamine (generic Yasmin) AGA’20 GI Evaluation of Iron Deficiency Anemia Atectura & Enerzair Breezhaler for asthma -EDS: Envarsus PA, Humira 20mg, Ozempic, Velphoro, Xeljanz 10mg AHA’20 Medical Marijuana & Rec Heart Health Cabenuva IM monthly for HIV  new NIHB: AHA’20 Cardiorenal Protection with Antidiabetic Meds Lunesta for insomnia -Full: Adlyxine, Ozempic, Soliqua, Voltaren Emulgel 1.16 & 2.32 % AHA’20 Menopause Transition & Cardiovascular risk Nexplanon implant for contraception -EDS: Coaguchek, Cresemba, Linezolid, Mavenclad, Xarelto 2.5mg APA’20 Schizophrenia Guideline Osnuvo is a biosmilar of teriparatide  cost: new generics: Acarbose, Itraconazole soln, Labetalol, Leucovorin, CCS’20 Management of Atrial Fibrillation Remdesivir (Veklury) for Covid-19 Mestinon, Methimazole, Methotrexate SC, Oseltamivir, Rocaltrol, Yasmin Diabetes CDN’20 Update Pharmacologic Management Spravato for depression  Trials: diabetes DAPA-CKD, Vertis CV heart failure Emperor-Reduced, & ESC’20 Atrial Fibrillation- Diagnosis & Management Suvexx for acute migraine atrial fibrillation ELDERCARE-AF, EAST-AFNET 4 IAS-USA’20 HIV Treatment & Prevention Guidelines Tibella for vasomotor menopause sx  Fibristal discontinued due to liver toxicity Obesity Canada’20 Guidelines New FDA: Trelegy Ellipta triple therapy for asthma Winlevi for acne

June-Aug 2020 NEW guidelines: New CDN: Sask. SPDP some changes ACC’20 Manage Bleeding on Anticoagulants Avsola is a biosimilar of infliximab -Full: Mezera, Vyzulta ACCE’20 Postmenopausal Osteoporosis Betaflam steroid patch -EDS: Delstrigo, Isentress chewable tabs, Janumet XR, Mavenclad, Pifeltro, ACR’20 Gout Management Ibsrela for IBS Prevymis, Radicava, Sublocade, Triamcinolone hexacetonide, & AGA’20 Role of Probiotics in GI Disorders Mayzent for MS Vyvanse chewables. ATS’20 Treat Tobacco Dependent Adults Rybelsus oral for diabetes  new NIHB: Hypertension Canada 2020 Guidelines Xofluza for influenza -Full: Cinacalcet, Delstrigo, Dovato, Pifeltro, Vyzulta ISH’20 International Hypertension Guideline New FDA: -EDS: Cabometyx, Lenvima, Skyrizi Amzeeq foam for acne  cost: new generics: Advair Diskus, Anafranil, Brilinta, Doxazosin, Breztri for COPD Gilenya, Lotriderm, Prezista, Resotran, Renflexis, Salagen, Tactupump, Caplyta for schizophrenia Tamiflu, Tranexamic acid, Tri-Cyclen, Uloric, Visanne, Zeulide depot, Zymar Fetroja IV for UTI ↑ cost: Axid, Banzel, Concerta, Differin, Doxepin, Elmiron, Finacea, Innohep, Fintepla for seizures Protopic Kynmobi for Parkinson’s disease Discontinued products: Atasol 8, 15 & 30; Erythro-S, Etodolac, Floctafenine, Lyumjev an insulin for diabetes Jurnista, Myochrysine, Niaspan, Procyclidine & Tolbutamide Ongentys for Parkinson’s disease Rukobia for HIV Secuado topical patch- schizophrenia Xeglyze for lice Oct 2019- NEW guidelines: New CDN: Sask. SPDP some changes AAP’19 Bariatric surgery for Pediatric Patients Aklief for acne -Full: DOACs for a fib & DVT/PE during Covid-19 May 2020 ACIP’20 Adult & Child Vaccine Recommendations Amlodipine 1mg/ml solution -EDS: Chloroquine, Cresemba, Dovato, Juluca, Plaquenil, Skyrizi, Trelegy, ACP’20 Testosterone Tx in Adult Men Baqsimi nasal glucagon Xarelto 2.5mg, Xeljanz XR ADA’20 American Diabetes Guidelines Emgality for migraine  new NIHB: AGA’20 Mod-Severe Ulcerative Colitis Hydrocortisone 2.5% cream -Full: Advil 12hr, Aripiprazole, Biktarvy, Brilinta, Dex-4 tab, AMMI’19 Update for Antivirals for Influenza Ivozfo an IV antibiotic Diclofenac topical crm/gel compounded 3-10%, Differin XP, Forxiga, ASBMR’19 Secondary Fracture Prevention Lokelma for hyperkalemia Ketoprofen topical crm/gel compounded 3-10%, Hydrocortisone 2.5% crm, Izba, ATS’20 COPD Treatment Guidelines Rinvoq for RA Jardiance, Jentadueto, Komboglyze, Lidocaine 5% oint, Monoferric, IDSA/ATS’19 Dx & Tx of Adult Pneumonia-CAP Truxima for RA a biosimilar Norprolac, Onglyza, Pedialyte, Stromectol, Synjardy, USPSTF’20 Screening for Hepatitis C Velphoro for phoshate Trajenta, Xigduo New FDA: -EDS: Akynzeo, Butrans, Dabigratran generic, Duodopa, Dupixent, Erleada, Fasenra, Barhemsys for post-op N/V Fycompa, Kevzara, Kisqali, Movapo, Probuphine, Suboxone 12 & 16mg, Nexletol & Nexlizet for cholesterol Trelegy Ellipta, Velphoro, Xeljanz XR Nurtec & Reyvow for acute migraine Reblozyl for beta thalassemia anemia new levetiracetam soln & IV Stelara for mod-sev ulcerative colitis Ubrelvy & Vyepti for migraine Valtoco for seizures Vumerity & Zeposia for MS May-Sept 2019 NEW guidelines: New CDN: Sask. SPDP some changes 60mg AAN’19 Acute Migraine Tx & Prevent (Child, Adolescent) Belsomra for sleep -EDS: Biktarvy, Brilinta , Duodopa, Fasenra, Kevzara, Probuphine, Rexulti, Siliq AAP’19: ADHD Guideline Cresemba antifungal -Delist in 2019: Etidronate products, Pamidronate, Risedronate 5mg tabs ACC/AHA’19 Primary Prevention: Cardiovascular Dx Delstrigo for HIV  new NIHB: ACG’19 Management of Ulcerative Colitis in Adults Dovato for HIV -Full: Avodart, Detrol reg & LA, Epuris, Juluca, Proscar, Rexulti ACIP’19 HPV Updated Adult Recommendations Evenity for osteoporosis LAMA’s for COPD (Spiriva, Tudorza, Seebri & Incruse) AGA’19 IBS-D: Lab Evaluation of Diarrhea Onstryv for Parkinson’s LAMA + LABA combos for COPD (Duaklir, Ultibro, Inspiolto & Anoro) AGA’19 Management of Mild-Mod Ulcerative Colitis Syrizi for psoriasis -EDS: Brivlera, Cayston, Coly-Mycin, Cosentyx, Dificid, Lixiana, Maviret, Ocrevus, AGA’18 IBD in Pregnancy Clinical Care Pathway Sublocade for opioid use disorder Renflexis, Siliq AGS’19 Beers Criteria for the Older Adult Vyzulta for glaucoma  cost: Abacavir, bupropion XL, clarithromycin, Dovobet, Naltrexone, Varenicline AHA’18 Management of Atrial Fibrillation New FDA: ↑ cost: Prolopa AUA/CUA/SUFU’19 Recurrent Uncomplicated UTI  Accrufer (ferric maltol) for IDA  new generics: Duotrav, Pradaxa, Renagel, Trosec, Uloric, Viacoram Canadian CAG Management of Crohn’s (Luminal & Peds) Evenity for osteoporosis  Trials: diabetes SUSTAIN-8, DAPA-HF, Carolina, heart failure PARAGON-HF, Canadian CAG Management of IBS Mavenclad & Mayzent for MS post PCI Twilight & atrial fibrillation AFIRE, ENTRUST-AF PCI. Canadian’19 Parkinson Disease Guideline Nourianz for Parkinson’s CTS’19 COPD Pharmacotherapy Update Plenity for weight loss Endo Soc’19: Treatment of Diabetes in Older Adults Rinvoq for rheumatoid arthritis ESC’19: Diabetes, Pre-diabetes & CV Disease Rybelsus for diabetes ESC’19: Management of Dyslipidaemias Xenleta for pneumonia ESC’19: Management of Chronic Coronary Syndromes Yupelri for COPD Gold’19: Management of COPD Zulresso for depression Aug 2018- NEW guidelines: New CDN: Aspirin primary prevention: limited usefulness (elderly Aspree, diabetes Ascend; Arrive) CGRP Θ ADA’19 American Diabetes Guidelines Aimovig erenumab for migraine Sask. SPDP some changes Apr 2019 AGA’18 Management of Opioid-Induced Constipation Biktarvy for HIV -Full: Detrol LA, Kyleena, Tresiba, Vesicare AHA’18 Cholesterol Juluca for HIV -EDS: Brivlera, Dysport, Hemangiol, Lancora, Lixiana, Movapo, Ocaliva, AHA’18 Resistant Hypertension Mezera for ulcerative colitis Ocrevus, Praluent, Procysbi, Quinsair, Renflexis, Synjardy ASH’18 VTE Guidelines Monoferric- an IV iron  new NIHB: Canadian C-Change Primary Care CVD Guidelines Olumiant for arthritis -Full: Bianca, Kyleena, Mezera sup, Nicorette Quickmist, Odefsey, Oseltamivir, CCS’18 Atrial Fibrillation Orilissa for endometriosis Synjardy, Toujeo, Tresiba, Trileptal & Zomig spray Chest’18 Atrial Fibrillation Probuphine- buprenorphine implant -EDS: Androderm, Androgel, Hemangiol, Lancora, Praluent, Renvela, ESC’18 Guidelines for HTN, MI, A Fib. Soliqua, Steglujan & Xultophy: diabetes Taltz & Testim (plus 11 MS drugs)

New FDA:  new generics: Aggrenox, Atripla, fosfomycin, HP-PAC, Hydromorph Contin, Dupixent for asthma Levitra, Mavik, methimazole, Vimpat & Volibris

Inbrija for Parkinsons’s  cost: Abacavir, Accuretic, cephalexin, dapsone, inflixamide biosimilar, lacosamide,

Maviret, midodrine, MS Contin generic, Nasonex & quetiapine XR ↑ cost: amoxicillin, dicyclomine, imiquimod Jun-Jul 2018 NEW guidelines: New CDN: Clopidogrel & ASA x3mon better than ASA for TIA 5 vs 6.5%, ANN’18 Multiple Sclerosis- Disease Modifying tx Ceftobiprole a cephalosporin but ↑ major bleeding 0.9 vs 0.4% . Point AUA’18 Erectile Dysfunction Contrave for weight loss, Budesonide-formoterol combo as need vs regular dosing in mild asthma: ↓asthma CANMAT’18 Canadian Bipolar Disorder Fasenra for eosinophilic asthma, exacerbations & ICS exposure, improves lung fx, but  sx’s. SYGMA 1 & 2

CASL’18 Chronic Hepatitis C Management Movapo for Parkinson’s,  new generics: Abilify, Champix, Coversyl Plus, Inspra, Macrobid, Mavik, Siliq for psoriasis, Tamiflu, Vimovo, Zeldox Suboxone 12 /3 & 16 /4mg SL tabs  Methadone no longer needs a special prescribing license Trelegy Ellipta triple therapy for COPD  Dolutegravir may have increase neural tube defects during first trimester use Viibryd for depression Sask. SPDP some changes New FDA: -Full Formulary: Celecoxib, clopidogrel & olanzapine CGRP Θ Aimovig erenumab for migraine -EDS: Axert (for migraine ≥ 12yrs), Botox (for urinary incontinence), Andexxa Factor Xa antidote Glatech (glatiramer), Mictoryl Pediatric, Nucala, Odefsey Repatha, & Stelara EPIDIOLEX for seizures  new NIHB: Imvexxy for dyspareunia -Full: Adderall, Basaglar, Ditropan XL, Mictoryl Pediatric Lucemyra for opiate withdrawal -EDS: Adempas, Afinitor, Bosulif, Erelzi, Esbriet, Ibrance, Imbruvica, Inlyta, Olumiant for arthritis Invega Trinza, Jakavi, Nucala, Repatha, Stivarga, Tasigna, Uptravi, Vosevi & Retacrit generic epoetin biosimilar Xalkori. Feb-May 2018 NEW guidelines: New CDN: Sask. SPDP some changes ACG’18 Crohn’s disease in Adults Addyi for female sexual desire -Full: Benztropine 1mg, Ciclopirox & Methotrexate SC inj; ACIP’18 Adult & Child Vaccine Recommendations Adylxine for diabetes -EDS: Erelzi (generic Enbrel), Invega Trinza, Ravicti, Taltz, Uptravi & Vosevi. targets ACP’18 A1C for Nonpregnant adult Type 2 diabetes Akynzeo for nausea  new NIHB: AHA/ASA’18 Acute Ischemic Stroke Mavenclad for multiple sclerosis -Full: Enstilar, Entocort 3mg, magnesium oxide 835mg & methotrexate SC inj; APA’18 Alcohol Use Disorder Ozanex for impetigo -EDS: Entyvio, Rotigotine, Tantum, tenofovir & Xigduo. ASCO’17 Antiemetics Guideline Ozempic for diabetes Odyssey ACC’18: Alirocumab over 2.8yrs in ACS pts ↓all-cause death: 4.1 to 3.5% th CADDRA’18 Canadian ADHD 4 Edition Guide Symtuza for HIV Cares: Allopurinol or febuxostat in gout+CVD pts: ↑all-cause death with febuxostat Diabetes Canada Diabetes Guidelines’18 Trumenba for meningitis Impact: Trelegy in COPD had exacerbations but ↑ pneumonia, many on previous ICS vs (Breo or Anoro) Endocrine Soc’18: Testosterone tx-male Hypogonadism Xiidra for dry eyes  new generics: budesonide nebs, Coversyl Plus, hydralazine, perindopril, Hypertension Canada’18 Adult/Children & Pregnancy New FDA: Suboxone & ziprasidone. KDIGO’17 Chronic Kidney Disease-Mineral & Bone Dx Biktarvy for HIV (Lower Pan-Canadian prices: amlodipine, metformin, rabeprazole, rosuvastatin…) Jan 2018  NEW guidelines: New CDN: Sask. SPDP some changes ACC/AHA’17 Hypertension in Adults Entuzity insulin for diabetes -Full: Basaglar, Enstilar, Humalog Kwikpen 200 IU/mL, M-Ediat IR & Truvada ACC’17 Manage Bleeding on Oral Anticoagulants Foquest for ADHD ADA’18 American Diabetes Guidelines Glatect for multiple sclerosis Tardis: triple antiplatelet therapy (ASA+clopidogrel+dipyridamole) NS vs CCS’18 Antiplatelet Therapy Focused Update Tremfya for plaque psoriasis standard (clopidogrel or ASA+dipyridamole) for stroke, but had ↑ major bleeding CTS’17 COPD Pharmacotherapy New FDA: VERO: ↓ fractures with teriparatide vs risedronate in severe PMO osteoporosis SOGC ’18 Overactive Bladder Pharmacotherapy Admelog insulin for diabetes USPSTF’17 HRT Primary Prevention-Chronic Conditions Juluca for HIV  new generics: metformin ER, desvenlafaxine VA/DoD’17 American Type 2 Diabetes Ozempic for diabetes (semaglutide) Steglatro for diabetes (ertugliflozin) June-Dec 2017  NEW guidelines: New CDN: Sask. SPDP some changes AACE’17 for menopause Duavive for vasomotor HRT -Full: Cyklokapron, Monurol, Proglycem, Synthroid 137mcg & TactuPump Forte ACC’17 for Non-statin LDL lowering Erelzi is biosimilar etanercept -EDS: Brenzys, Campral, Grastofil, Fentanyl 37ug patch, Genvoya, Jadenu, Neupro, ACC’17 for Syncope Maviret & Vosevi for hepatitis C Revia, Salagen, Rilutek & Xigduo ACC’17 for Heart Failure Update Ocrevus for multiple sclerosis  new NIHB: ACG / CAG Management of Dyspepsia Shingrix for shingles vaccine -Full: Abilify Maintena, Aptivus, Arnuity, Celebrex, Celsentri, Intelence, Isentress, ACR’17 Osteoporosis-Glucocorticoid Induced Tresbia is insulin degludec Revia, Triumeq & Zeldox ACR’17 Perioperative Management of DMARDs Viberzi for IBS-D -EDS: Breo Ellipta, Daklinza, Dicetel, Entresto, Epclusa, Foxiga, Inspra, Jentadueto, Canadian Schizophrenia Guidelines 2017 Vemlidy for hepatitis b Modulon, Myrbetriq, Prevacid Fastab, Strattera, Viread, & Zepatier CCS’17 Canadian Heart Failure New FDA: Canvas: canagliflozin ↓CV events, but ↑ amputations (ie. toe or metatarsal) Drugs in Pregnancy & Lactation Eleventh Edition 2017 Bevyxxa for VTE prophylaxis RE-DUAL PCI: dabigatran & clopidogrel- ↓bleed vs triple therapy with warfarin ESC’17 Guidelines for DAPT, PAD & MI. Mavyret & Vosevi for hepatitis C Compass: Rivaroxaban 2.5mg bid + ASA ↓CV but ↑ bleeding in 20 CAD prevention Ellipta Trelegy triple therapy for COPD Exscel: Exenatide 2mg SC weekly had non-significant CV benefit vs placebo ↑ cost: Dipentum & Zaditen  new generics: Atripla, Avandia, caspofungin, clonidine, deferasirox, Diclectin,  cost: flecainide, gliclazide, Truvada Enbrel (with Brenzys), hydralazine, phenytoin, Sporanox, Truvada & Viread Apr-May 2017  NEW guidelines: New CDN: Sask. SPDP some changes ACP’17 Low Back Pain Cinqair for asthma, -EDS: Acyclovir susp, Entresto, Entyvio, Plegridy & ACP’17 Osteoporosis Guidelines Enstilar for psoriasis, for hepatitis (Daklinza, Epclusa, Sunvepra & Zepatier), ACP & AAFP’17 Hypertension for Adults ≥ 60yrs FIAST for diabetes (rapid insulin), Einstein-Choice: extended rivaroxaban better than ASA at ↓ recurrent VTE events AHA’17 Management of Valvular Heart Disease Glyxambi for diabetes, Fourier: evolocumab PCSK9 antibody ↓CV events 11.3 vs 9.8% over 2.2yr, not mortality in ACS with ticagrelor or prasugrel, & ASA CHEP’17: Canadian Hypertension Guidelines Lancora for heart failure, Topic: after 1month of DAPT , switch to clopidogrel ↓bleed CDN’17 Opioid Therapy & Chronic Noncancer Pain Mictoryl for urinary incontinence, Trinity: Triple COPD tx (beclomethasone, formoterol & glycopyrronium) > tiotropium CUA’17 Adult Overactive Bladder Odefsey for HIV, & Trust: levothyroxine no apparent benefit, older pts with subclinical hypothyroidism SOGC’17 Combined Hormonal Contraception Rexulti for schizophrenia. TT trials: testosterone improves hemoglobin & BMD, but ↑ total CV plaque  new generics: cost: amlodpine, atazanavir, atorvastatin, cholestryramine, clopidogrel, Epclusa, Cellcept, Exelon patch, Olmetec, fluoxetine liquid, gliclazide MR, indomethacin, modafinil, olmesartan, Omnaris, Reyataz & Sinemet IR. pantoprazole, ramipril, rosiglitazone, simvastatin, Sunvepra & Zepatier. New FDA: Ocrevus for MS (RRMS & PPMS) ↑ cost: cabergoline Jul 2016-  NEW guidelines: New CDN: Sask. SPDP some changes AASLD’16 American Chronic Hepatitis B Blexten & Rupall an antihistamine, -Full: Arnuity Ellipta, Backup Plan Onestep & Plan B, Tecta Mar 2017 ACG’17 H. pylori Brenzys (etanercept) for RA, -EDS: Cosentyx, Forxiga, Ofev, Simponi IV, Xolair, Zaxine ACP ’16 Gout Brivlera for epilepsy, Descovy- HIV, ACP’16 Insomnia Copaxone for 3x per week dosing,  new NIHB: ACP’17 Back Pain Epclusa & Sunvepra for hepatitis C, -Full: alendronate, ezetimibe, Fosavance, levetiracetam, risedronate, solifenacin ADA 2017: Diabetes Invega Trinza for schizophrenia, & tolterodine LA, AHA’16 Drugs that Exacerbate Heart Failure Invokamet for diabetes, -EDS: Actemra, Aptiom, Breo & Incruse Ellipta, Cosentyx, Dapagliflozin, AHA’16 Drugs that Interact with Statins Kevzara for rheumatoid arthritis, Duaklir Genuair, Inflectra, Inspiolto & Spiriva Respimat. Jardiance, Orencia, AAN’16: Restless Leg Syndrome Lixiana (edoxaban) for a fib/PE, Xeljanz. ATA’16 American Hyperthyroid Natesto for andropause, Canadian Opioid DRAFT Guideline 2017 Praluent for cholesterol, LEADER: Liraglutide vs placebo in T2DM-↓CV events & weight, but ↑ GI events CANMAT’16 Canadian Major Depression Stelara for Crohn’s disease, PEGASUS-TIMI 54: Ticagrelor vs placebo with prior MI-↓CV events but ↑ bleed CCS’16 Atrial Fibrillation Update Synjardy for diabetes, PRECISION: celecoxib was non-inferior to naproxen & ibuprofen for CV safety CCS’16 Canadian Dyslipidemia Taltz for plaque psoriasis, PIONEER AF-PCI: rivaroxaban ≤15mg OD + clopidogrel or Gold: COPD 2017 Guidelines Viberzi for IBS, riva 2.5mg bid + DAPT, had bleeding than warfarin + DAPT (triple therapy) tx H. Pylori Tortonto Consensus 2016 Zinbryta for multiple sclerosis. IAS-USA’16 Adult HIV  new generics & cost: Baraclude, NACI’16: Prevnar for ≥ 65yrs Bezalip, Fosavance, Inflectra, SOGC’16: Nausea & Vomiting in Pregnancy levetiracetam, Meltz, Micronor, Nasacort, Nasonex, Omnairs, quetiapine, rasagiline, Seasonale, Sensipar & Tamiflu.  ↑ cost: Anafranil, Aventyl. New FDA: Relistor orally, Stelara for Crohn’s Mar 2016-  NEW guidelines: New CDN: Sask. SPDP some changes Genuair Ellipta Respimat Respimat Jun 2016 American JAAD’16 Acne guideline Bydureon for diabetes, -EDS: For COPD: Duaklir , Incruse , Inspiolto & Spiriva ; American ACC’16 Role of Non-Statin tx in CVD Risk Lunesta for sleeping, Actemra SC, Fibristal, Inflectra, Jardiance, Lemtrada, Prezcobix, American ACC/AHA’16 Update: Heart Failure Praxbind for reversing dabigatran, Vyvanse 10mg & Xeljanz.

American APA’16 Antipsychotics: agitation with Dementia Trulicity & Xiguo for diabetes,  new NIHB: American AACE/ACE’16 Obesity Medical Care Zerbaxa for infection. -Full: Climara Pro, Isosrbid mononitrate, moxifloxacin & Plan B. Canadian Hypertension: CHEP’16  new generics & cost: abacavir, -EDS: Diastat, Fosrenol, Invokana & Pennsaid. Canadian CDA’16 Diabetes Update: Flozins etc. alfuzosin, Clindoxyl, duloxetine, FLAME: LAMA+LABA Ultibro less AECOPD than LABA+ICS Advair in COPD CDC’16 Prescribing Opioids for Chronic Pain efavirenz, Estrace, Kivexa & Valcyte. IRIS: Pioglitazone post TIA/stroke (↓stroke/diabetes but ↑weight/edema/fractures) Chest’16 VTE guideline-DOAC’s option New FDA: Socrates: Ticagrelor in acute ischemic stroke/TIA: not superior to ASA to ↓stroke USPSTF’16 ASA Primary Prevention CVD/Cancer Descovy & Odefsey for HIV. Summit: Fluticasone + vilanterol in high CV risk COPD pts, did not ↓mortality Nuplazid for psychosis with Parkinsons Over the Counter OTC – Advil 12hr, Flonase & Nexium Zinbryta for MS Jun 2015-  NEW guidelines: New CDN: Sask. SPDP some changes ACIP’16 USA Adult & Pediatric Vaccine Guides Arnuity Ellipta for asthma, -EDS: Abilify Maintena for Schizophrenia, Anoro Ellipta for COPD, Feb-2016 ACOG’15 Emergency Contraception Basaglar insulin for diabetes, Aptiom for seizures, ACOG’15 Nausea and Vomiting of Pregnancy Entyvio for ulcerative colitis, Diacomit for seizures, Eliquis for PE/DVT, Holkira Pak for hepatitis C, American Diabetes Association Update 2016 Daklinza for hepatitis C, Inspra for heart failure, Invokana for diabetes, Latuda for Schizophrenia, American Geriatrics Society 2015 Beers Update Duaklir & Inspiolto for COPD, Myrbetriq for overactive bladder, American ACR’15: Rheumatoid Arthritis Ella for emergency contraception, Tivicay & Triumeq for HIV & Ultibro Breezhaler for COPD. American –ASBMR’16-Bisphosphonates long term Entresto for heart failure, -Full: Androcur, Clavulin, colesevelam susp, gabapentin 600 & 800mg tabs, ATA’15 Thyroid Nodules Fetzima for depression, midodrine, minocycline, Prevacid DR, Simbrinza & zuclopenthixol. CDN’15 Acne Guidelines Genvoya for HIV,  new NIHB:

CDN’15 Guide for Primary Care Mgt of Headache Movantik for constipation, -Full: Alphagan P, Buspar, Cipro susp, Cytomel, Edarbi, Fibristal, LoLo,

CDN’15 CMHF Testosterone Deficiency Syndrome ♂ Nucala for asthma, Mona Lisa IUD, Prezcobix

CTS’15 Asthma in Preschoolers Plegridy for multiple sclerosis, -EDS: Abilify Maintena,Anoro Ellipta,Fosfomycin,Harvoni,Latuda,Toviaz,Ultibro Breezhaler IDSA: Management of Candidiasis Update 2016 Repatha for cholesterol SPRINT: Intensive BP <120 vs Standard BP <140; beneficial but ↑ adverse effects SOGC’15: Folic acid TactuoPump Forte for acne, EMPA-REG: Empagliflozin in diabetes pts ↓ CV events & mortality SOGC’15: Contraception Vibativ for pneumonia,  new generics &/or cost: alendronate, alfuzosin, Azilect, cefixime, Cellcept, Zepatier for hepatitis C. ciprofloxacin, Clindoxyl, Detrol LA, dextroamphetamine, donepezil, dronabinol,

 ↑cost: tizanidine New FDA: Duotrav, efavirnez, esomeprazole, ezetimibe, gabapentin, hydroxychloroquine,

Addyi for female sexual dysfx; moxifloxacin, olanzapine, Prometrium, quetiapine, rasagiline, solifenacin, tadalafil, Genvoya for HIV, Tecta, tolterodine ER, Trizivir, valacyclovir & zolpidem. Nucala for asthma, Praluent & Repatha for lipids. Mar-May 2015  NEW guidelines: New CDN: Dymista for rhinitis, Sask. SPDP some changes AHA/ACC/ASH’15 Hypertension Tx with CAD Exelon 15mg patch for Alzheimer’s, -EDS: Breo Ellipta for COPD, Harvoni & Sovaldi for HCV, Orencia SC for RA. SOGC’15: Vulvovaginitis Simbrinza for glaucoma.  new NIHB:  new generics & cost: Clindamycin, -Full: Aggrenox, Alendronate, BenzaClin, Benzamycin, Clindoxyl, Clopixol, donepezil, fluconazole, losartan, Combivent Respimat, Divigel, Ferrlecit, Jaydess, Tivicay, Vigamox, pregabalin, topiramate, zolmitriptan Viramune XR & Zymar. -EDS: Brillinta for ACS, Galexos, Kadian Komboglyze, Sovaldi, Turdorza & Vit E. Dec- Feb 2015  NEW guidelines: New FDA: Auryxia for  phosphate, Sask. SPDP some changes  new generics: cefixime, celecoxib, ACIP’15 USA Adult & Pediatric Vaccine Guides Gardasil 9 for HPV, -Full: carvedilol, Suboxone, valganciclovir trial ADA’15 Diabetes (Target Diastolic BP 90mm Hg) Rapivab IV for influenza, Combivent Respimat,  Paradigm-HF : valsartan + sacubitril AGA’14 Irritable Bowel Syndrome Saxenda for weight loss. escitalopram, Jaydess better than enalapril in heart failure AHA’14 Primary Stroke Prevention New CDN: Dovobet Gel –psoriasis, -EDS: Dificid, Komboglyze  Improve-IT ACS trial: ezetimibe + simva AHS’15 American Acute Adult Migraine Treatment Forxiga for diabetes, slightly better than simvastatin alone Canadian CIHR Hepatitis & HIV Coinfected Gardasil 9 –for HPV,  Updated Stopp/Start Criteria Version 2 Canadian CASL’15 Chronic Hepatitis C Holkira for hepatitis C,  Risperdone only indicated for Canadian CCS’14 Heart Failure Focus Update Kazano & Nesina for diabetes, Alzheimers’ type BPSD Canadian CTFPHC’15 Obesity in Adults Spiriva Respimat for COPD,  new lower Pan-Canadian pricing for: Drugs in Pregnancy & Lactation Tenth Edition Triumeq for HIV. -clopidogrel, gabapentin, metformin, & Endocrine Society’15 Obesity Guidelines olanzapine Gold’15 COPD Guidelines OTO-HNS’15 Allergic Rhinitis Guidelines Oct-Nov 2014  NEW guidelines: New FDA: Contrave for weight loss,  Sask. SPDP some changes  new generics: Biaxin XL, celecoxib, AHA14 NSTE-ACS, Dulaglutide for diabetes, -EDS: Aubagio, Fosrenol, Galexos, escitalopram ezetimibe, frovatriptan, AUA Overactive Bladder, Olodaterol for COPD Tudorza Genuair linezolid, Lipidil EZ, travoprost CCS 2014 Atrial Fibrillation Focused Update, dopamine receptor agonists:  new NIHB:  Diclofenac lower max of 100mg/day: SOGC Managing Menopause associated with impulse control -Full Lodalis for lipids, Nyda for lice. since  CV risk with this NSAID disorders with tx of Parkinson’s dx -EDS: Invega Sustena for schizo,  OTC soon: hydrocortisone 1% topical for schizo Paradigm-HF: sacubitril & valsartan Risperdal Consta , New CDN: Aptiom for seizures,

 mortality in heart failure Xgeva if skeletal events with prostate cancer. Fentora for pain, Harvoni: hepatitis C, DAPT: 30 vs 12 months of ASA + Wisdom: slow withdrawal of inhaled Nocdurna for urinary incontinence, clopidogrel + DES  CV event but bleed corticosteroids in COPD was safe Prezcobix for HIV, Zostavax II. Jul-Sept 2014  NEW guidelines: New CDN: Sask. SPDP some changes  new generics: adefovir, clarithromycin ACG’14 IBS & Chronic idiopathic constipation Jaydess & LoLo for birth control, Full: Apidra, Humalog, Lodalis, susp, Combivir, dutaseride, Myfortic, ADA’14 Pediatric A1C targets: <7.5% for <18yrs Nimenrix for meningitis serotype Pantoprazole Pennsaid & zoledronic acid CDN’14 Management: Anxiety, PTSD & OCD A,C,W &Y. EDS: Janumet XR, Perampanel  PD Med trial: levodopa initially best abstinence: Evins CDN Hypertensive Disorders of Pregnancy (HDP) Ultibro Breezhaler for COPD Varenicline x52wk helped  OTC soon: omeprazole & Nasocort

May-Jun 2014 New CDN:  new NIHB:  new NIHB:  new generics: almotriptan, Elocom for AF for diabetes Abilify Maintena for schizophrenia, Actemra SC & -Full: Arava, Cymbalta, Humalog Mix, -EDS: Eliquis , Janumet XR cream, efavirenz, Fosavance, Xeljanz oral for rheumatoid arthritis; Constella for IBS, Mezavant, Plavix x 1yr, Seasonale, Saphris for BPAD; mercaptopurine, Risperdal ODT, Invokana for diabetes. Seasonique, Seroquel XR, Seebri Breezhaler for COPD Sinemet CR, Wellbutrin XL, NACI update: pneumococcal vaccine in asthmatics Vyvanse, & Xalacom. & Zenhale for asthma. vancomycin, voriconazole & Yaz. Lithium: calcium level warning Topcat : spironolactone NS HF-PEF  RLS: pregabalin restless leg Sx option price: Valtrex since generic removed Poise-2: ASA & clonidine NS pre-op Feb-Apr 2014  NEW guidelines:  Lower price: metformin, pioglitazone Sask. SPDP some changes  new generics: Arthrotec, Cipro XL, ACIP’14 USA Adult & Child Vaccine Schedule New CDN: Aubagio for MS, Full: Fluconazole, Tactuo Elocom lotion, entecavir, Nasonex, AHA/ACC/HRS’14: Atrial Fibrillation Anoro Ellipta for COPD, EDS: Jentadueto, Tecfidera Risperdal M-tab, Uniphyl CIHR’13 Canadian Hepatitis C/HIV Adult Coinfection Bexsero for meningitis serotype B,  Remeron reports of QT  CitAD: citalopram  agitation in AD, Tybost & Vitekta for HIV but QT & worsened cognition Nov-Jan 2014  NEW guidelines:  Lower prices: quetiapine XR, Sask. SPDP some changes  Sammpris Collaboration: medical tx better ACOG: HRT & Heart Dx ADA’14 (Diabetes) rizatriptan, testosterone undecanoate EDS: Biphentin, Cimzia, Eliquis & than stenting for intracranial stenosis AHA’13 Lipid Guideline AHA’13 Obesity Guide New CDN: Emtrix- onychomycosis, Stribild  DI: nifedipine + clarithromycinAKI ASH/ISH BP Guide Canadian MS Guide Guanfacine Intuniv XR for ADHD,  Placide: probiotics not help AAD or  new generic: Actonel 150mg, Zaxine hepatic Canadian Society Nephrology Anemia Guideline Rifaximin -encephalopathy C. difficile in older adults atomoxetine, buproprion XL, donepezil, Galexos Sovaldi Canadian HTN: CHEP’14 JNC 8: Hypertension Simeprevir , Sofosbuvir : hep C Fosavance, Relpax, Yasmin July-Oct 2013  NEW guidelines:  Lower prices: amlodipine, Sask. SPDP some changes  new NIHB: Full: Asmanex, Cipralex, AAP’13 Pediatric Sinusitis WHO’13: HIV atorvastatin, omeprazole, pregabalin, Full: Cymbalta, Epuris, Jurnista, Magic bullet, & Ondissolve. AAP 2013: Drugs into Human Breast Milk/Lactation rabeprazole, ramipril, venlafaxine Losec 20mg, Lyrica, Pariet EDS: Banzel, Cimzia, Lyrica, Onbrez,  PAACT: new antibiotic orange book released  Higher prices: EDS: Divigel, Ezetrol, Januvia 25 & Trajenta & Vimpat.  FDA black box warnings: red shading cabergoline, natalizumab, zidovudine 50mg, Onbrez, Seebri Removed: Demerol  Calcitonin nasal discontinued due to cancer concern  Double dose Tamiflu no more effect Breezhaler, Zofran ODT.  CNT Collaboration: naproxen low CV risk  Rivaroxaban: EDS SK for acute DVT  Ketoconazole: adrenal & liver warnings New in CDN: Breo Ellipta, Emtrix,  Addition to book: Estrogel Propak  Savor-Timi 53: Saxagliptin: CV outcomes NS;  HF hosp.  Metoclopramide ok in pregnancy Jublia, Fycompa, Intuniv, Tecfidera, Tudorza  new generics: Accupril, Axert, Lescol, Reduce  NSAID lactation ratings updated COPD: 5day14day po prednisone Sustiva, Xalacom Mar-Jun 2013  NEW guidelines:  A few new additions to the book:  Sask. SPDP changes  cost/new generics: Caduet, eletriptan, ACG’13: GERD Guidelines AHA Heart Failure’13 Axiron (testosterone) underarm soln Full: Asmanex Twisthaler fluvastatin, malarone, pregabalin CCS’12 Heart Failure Guideline Update Bystolic (nebivolol) new beta-blocker EDS: Asenapine for BPAD, Toviaz  New Formulations: CCS’12 Dyslipidemia Guideline Update Myrbetriq (mirabegron) for OAB for OAB, Vyvanse for ADHD, Hydromorph Contin 4.5mg CDA’13 Diabetes Guideline: frail, ASA, pregnancy ’s Neupro (rotigotine) for Parkinson’s Zenhale for Asthma Prevista 150mg tab propionate CHEP’13: ISH elderly >80yr  SBP <150mm Hg Olux-E foam (clobetasol ) steroid  new NIHB:  Mononucleosis study: amoxicillin rash  Reflux trial: surgery or PPI’s good GERD options Silenor (doxepin) for insomnia -EDS: dabigatran, nabilone, only occurred in 30% of the pts Stribild (a quad pill daily) for HIV  Bruise Control trial: warfarin continuation better rivaroxaban, saxagliptin  FDA approved: Canagliflozin for Tecfidera (dimethyl fumarate) for MS than heparin bridging before ICD/pacemaker surgery -Removed: Ketorolac, OxyNeo diabetes,Vilanterol/fluticasone:COPD Dec-Feb 2013  NEW guidelines:  FDA approved & book additions:  Sask. SPDP  cost: rivaroxaban, sildenafil ADA 2013 Diabetes: SBP <140 mmHg rather than 130 Aubagio (teriflunomide) for MS EDS: Saphris for BPAD  New Formulations: AHA’13 Stable Ischemic Heart Disease (SIHD) Fycompa (perampanel) for seizures Toviaz for urinary incontinence Januvia 25 & 50mg tabs AHA’13 STEMI Management  CANMAT:BPAD Linzess (linaclotide) for IBS  new NIHB: Sublinox 5mg tab (lower dose in women)  Freedom: CABG superior to PCI in diabetics Potiga (ezogabine) for seizures -Full: Concerta, Evra, Levemir,  Apixaban: Health Canada AF approved Canada  Aspire & WarfASA: low dose ASA ’s recurrent VTE Seebri (glycoppyrronium) COPD Nuvaring, Twynsta  Echinacea not for <12yrs in Britian  HPS2-Thrive: niacin/laropiprant did not reach 10 outcome Tudorza (aclidinium) for COPD -EDS: Atripla, inj opiates, Intellence  Deet/icaridin: changes Public Health: Canada Xeljanz (tofacitinib) for RA  Keeps/Dops: HRT in young reassuring but under powered -Removed: Tylenol #4, Ritalin Brand only Sep-Nov 2012  NEW guidelines: Anemia CKD: KDIGO  A few new additions to the book:  new Sask. SPDP changes:  generics cost: Atacand Plus, AASM Restless Leg ACR Gout Copper IUD EDS: Xarelto for A. Fib Zidovudine AHA & ESC A. Fib AACE/ATA Hypothryroid Divigel (estradiol gel) for HRT  Miacalcin: ? long term cancer risk EU  GuidAge: ginkgo not help Alzheimer’s CDN Fibromyalgia ESC Acute MI Latuda (lurasidone) for schizophrenia  ICS: growth ~1cm long term CAMP  Milk thistle: not help hepatitis C Endocrine Society: Thyroid in Pregnancy/Postpartum Stribild (a quad pill daily) for HIV  Clopidogrel  prasugrel Trilogy ACS  SPS3: ASA + Clopidogrel combo not HIV: IAS-USA Adult NACI: Influenza 2012-13  CDC’12: not cefixime for gonorrhea  Ondansetron: max 16mg due to QT better than ASA only for lacunar strokes Jun-Aug 2012  10 NEW charts: A Fibrillation Anticholinergics  A few new additions to the book:  new Sask. SPDP changes:  generics cost: Combivir, lamivudine, Diabetes Overview Diabetes Trials: Lipids/ASA/BP Belviq (lorcaserin) for weight loss -EDS: Aclasta, Actonel DR, Banzel meropenum, rizatriptan Ederly/LTC Hepatitis B & C Hirsutism Dificid (fidaxomicin) – C.diff diarrhea Complera, Linaglitpin,  cost: entacapone, galantamine, Pain: Acute/Pall/CNCP Palliative Care Peri-Pregnancy Myrbetriq (mirabegron) – incontinence Rilpivirine, Saxagliptin 2.5mg raloxifene CKD  NEW guidelines: Omontys (peginesatide) for anemia  new NIHB:  Warfasa: aspirin (100mg od)  recurrent Canadian PSC 2012 Parksinson’s Resotran (prucalopride) – constipation -Full: Wellbutrin XL, Yaz VTE & ↔ bleeding risk vs placebo Stendra (avanafil) for erectile dysfunx Canadian Thoracic Society 2012 Asthma Toviaz (fesoterodine) – incontinence -EDS: Januvia, Janumet American-AAN/AHS Migraine Prevention Zioptan (tafluprost) for glaucoma Mar-May 2012  NEW guidelines  A few new additions to the book:  new Sask. SPDP changes:  generics cost: candesartan, finasteride, ADA 2012 Diabetes Asmanex Twisthaler (mometasone) asthma -Full: Twynsta montelukast, telmisartan, & rosuvastatin American-ACR 2012 Rheumatoid Arthritis Lodalis (colesevalam) for cholesterol -EDS: Brilinta, Gilenya, Incivek,   Prednisone dose x2yr in RA Camera II Canadian CHEP 2012 Hypertension Fampyra (dalfampridine) -walking MS OxyNeo, Victrelis  ASA ≈ warfarin in heart failure Warcef Chest 2012 Antithrombotics Onbrez Breezhaler (indacaterol) for COPD  new NIHB EDS: Abilify, Advagraft,   memantine to donepezil-no Domino NS IDSA 2012 Sinusitis Saphris (asenapine) for schizophrenia Prolia, Suboxone, Uloric   rivaroxaban in PE Einstein PE Jan-Feb 2012  NEW guidelines  A few new additions to the book:  new Sask. SPDP changes:  generic $: clopidogrel, esomeprazole, Antiepileptic & HIV Drug Interactions –AAN 2012 Gelnique (oxybutynin 10% gel) for UI -EDS: Effient, Janumet, Januvia, latanoprost, losartan, mycophenolate Vaccine –ACIP USA & NACI CDN 2012 updates HPV,HB Luxiq (betamethasone val 0.12% foam) Onglyza  DIs: Citalopram 40mg & QT meds  Altitude: Type 2 diabetes with aliskiren & ACE/ARB NYDA (dimeticone 50% soln) for lice  Gonorrhea Public Health Canada:  Cold-FX extraction process in China had  stroke & renal complications Rapaflo (silodosin) for BPH  dose for cefixime & ceftriaxone  Antiepileptics: special access meds listed Nov-Dec 2011 New Pregnancy & Lactation symbols based on color:  A few new additions to the book:  new Sask. SPDP changes:  generics cost: amlodipine &  PREGNANCY (P): Safe = P , Likely Safe = P , Aczone (dapsone 5% gel) for acne -full formulary: Lantus & Levemir atorvastatin combo, azithromycin IV, Edurant (rilpivirine) for HIV -EDS: Abilify & Invega Sustenna ceftriaxone, ramipril & HCTZ combo & Caution = P , Contraindicated = P , Unknown = P . Jalyn (tamsulosin & dutasteride) for BPH sumatriptan SC.  LACTATION (L): Safe = L , Likely Safe = L , Onsolis (fentanyl buccal film) for pain  NEW guidelines  HPS 11yr simvastatin follow up good Staxyn (vardenafil) for erectile dysfx AHA-CABG  SATURN: similar atherosclerosis Caution = L , Contraindicated = L , Unknown = L . Sublinox (zolpidem) for insomnia Hypertrophic cardiomyopathy regression with atorvastatin or (See also p. 137 of RxFiles book or Abbreviations & Symbols) Zuacta (zucapsaicin) for pain PCI rosuvastatin Sep-Oct 2011  NEW guidelines  A few new additions to the book:  Aristotle: apixaban useful for A. fib  generics cost: imipenem ADHD -AAPeds Banzel (Rufinamide) for seizures  Sammpris: med tx of symptomatic  NSAIDS’s may  abortion rate Anti-Infective Book (PAACT- orange book) Complera (emtricitabine, rilpivirine, tenofovir), intracranial arterial stenosis superior  DIs: Bactrim & ACEI/ARB/NSAIDs, Essential Tremor -AANeurology Seasonique (Estradiol & levonorgestrel), to angioplasty plus stenting Simvastatin expanded list myopathy Hypertension -NICE UK Trajenta (Linagliptin) for diabetes,  AZURE: zoledronic acid not  Saw palmetto not useful for BPH Thyroid disease during Pregnancy -ATA Twynsta (amlodipine & telmisartan) beneficial adjuvant in breast cancer  Flu vaccine: age  6month get 0.5mls Aug 2011  Acetaminophen agitation/pain in BPSD Dementia: Husebo ’11  A few new additions to the book:  new EDS criteria for Sask:  Rocket-AF: A. fib pts on warfarin  QT prolongation concerns with quetiapine & doses Renvela (Sevelamer carbonate) for CKD, Adcirca -for pulmonary hypertension or rivaroxaban: non-inferior to  40mg/day of citalopram FDA Verdeso (desonide foam) steroid topical Uloric -for select gout cases warfarin, similar bleeding but cost  Fluconazole for long term doses  400mg, pregnancy  Product changes: New Avonex pen Vimpat-for adjunctive refractory seizure  Postpartum use of birth control: rating has changed from a “C” to a “D” more concerning & Daypro discontinued. Prolia -for select osteoporosis cases Restart date based on VTE risk CDC ‘11 June-July 2011  NEW guidelines  A few new additions to the book:  new DIs: organic anion  SHARP: CKD pts on ezetimibe + ACCF/AHA Expert Consensus: Hypertension in Elderly Abstral (fentanyl SL for pain), transporting peptid (OATP) in simvastatin vs Placebo:  FDA Warnings: Actos long term ? bladder cancer, Brilinta (ticagrelor for ACS). juices oranage ,apple, grapefruit interactions atherosclerotic events, but not mortality Epoetin ESA’s Hg >110g/L MI/stroke  Varenicline concern of CV events with: aliskiren, atenolol,  generics cost: atomoxetine,  new formulations:  NIHB Addition: Diamicron MR 60mg ciprofloxacin, fexofenadine esomeprazole, nevirapine, zolmitriptan Hydromorph Contin 4.5mg & 9mg capsules Prior approval: Actemra, methadone Apr-May 2011  NEW guidelines  A few new additions to the book:  new formulations:  AIM-HIGH: trial halted, Niaspan CDN Thoracic Society: Dyspnea with COPD Byetta (exenatide SC for diabetes), Fluad: flu vaccine for elderly stroke vs simvastatin background tx CDN CHEP’11: Hypertension Seasonique (91 day birth control),  NIHB Additions: Lantus  generics cost: alendronate,cefuroxime,  VTE controversy continues with Yaz & Yasmin Tactuo (adapalene & benzoyl peroxide), Prior approval: Concerta irbesartan, levetiracetam, nevirapine, Zenhale (mometasone & formoterol) quetiapine, ramipril & repaglinide … Feb-Mar 2011  NEW guidelines  A few new additions to the book:  antipsychotics: may have EPS &  carbamazepine:  rash if HLA-B ACC/AHA NSTEMI/Unstable angina guidelines Biacna (clindamycin & tretinoin gel), withdrawl in neonates A-3101 allele present ACIP-USA Adult vaccine recommendations Daxas (roflumilast: severe COPD),  topiramate was pregnancy “C “  new generic valsartan & repaglinide ADHD-Canadian Caddra guidelines Gilenya (fingolimod oral for MS), but now downgraded to a “D”  candesartan no benefit in acute Nucynta (tapentadol CR for pain),  new Diamicron MR 60mg tab stroke (Scast trial) A. fib Canadian CCS guideline: dabigatran an option Targin (oxycodone + naloxone),  new LithMax SR lithium tablet DI: hypotension with CCB’s & eryc / clarithromycin Vimovo (naproxen + esomeprazole) Dec’10-Jan’11  new Institute of Medicine calcium & Vit D limits  ginseng lacks cognitive benefit   MS cost for interferon: Extavia  CDC updated STD tx guidelines  Zyban & Champix on formularies some 1x/yr coverage  opiate concern of fractures &    cost for generic Cosopt & Trusopt Ibuprofen & naproxen DI’s with ASA  Gardasil: FDA anorectal cancer prevention indication CV harm in the elderly  new generic repaglinide  bedtime Eltroxin dosing option Oct-Nov 2010  new CDN Osteoporosis Guidelines  Uloric for gout   cost for Cervarix  Avandia restrictions in USA & CDN   CVD risks with testosterone replacement  CCS antiplatelet therapy update  rivastigmine in delirium: mortality  calcium total intake to 1200mg/day  pantoprazole Tecta  cost  NOUGG guidelines for opiate use  VADT:  CVD events when DBP  lower Hg target with Epo in cancer in chronic pain <70mmHg pts by ASCO