Proposed Spin-Off of Alcon
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Verily Forms Strategic Alliances with Novartis, Otsuka, Pfizer and Sanofi
Verily Forms Strategic Alliances with Novartis, Otsuka, Pfizer and Sanofi to Transform Clinical Research Leading biopharmaceutical organizations join Project Baseline initiative to engage more patients and clinicians in research and speed evidence generation South San Francisco, CA -- May 21, 2019 -- Verily, an Alphabet company, today announced strategic alliances with Novartis (NYSE: NVS), Otsuka (NYSE: OTSKY), Pfizer Inc. (NYSE: PFE) and Sanofi (EURONEXT: SAN, NASDAQ: SNY) to develop digitally innovative, patient-centered clinical research programs using Project Baseline’s evidence generation platform and tools. The Baseline Platform is designed to engage more patients and clinicians in research, increase the speed and ease of conducting studies and collect more comprehensive, higher quality data, including outside the four walls of a clinic. Across the United States, the number of people participating in clinical research -- including clinical trials and observational studies -- is less than 10% of the population.1 In addition to low participation, challenges in research include data fragmentation, inefficient operations and limited value for patients. Alongside academic research institutions, patient-advocacy groups and health systems, Verily and its industry partners aim to implement a more patient-centric, technology-enabled approach to research, and increase the number and diversity of clinical research participants. They will also explore novel approaches to generating real-world evidence using the Baseline Platform to collect, organize and activate health information from electronic health records, sensors and other digital sources. Over the coming years, Novartis, Otsuka, Pfizer and Sanofi each plan to launch clinical studies leveraging the platform across diverse therapeutic areas, such as cardiovascular disease, oncology, mental health, dermatology and diabetes. -
DWS (CH) II Small and Mid Caps Switzerland
Marketing Material DWS (CH) II Small and Mid Caps Switzerland Equity Funds - Europe - Regions/Countries August 2021 As at 31/08/2021 Fund Data Performance Investment Policy Performance - Share Class FD (in %) The goal of the sub-fund is primarily to achieve long-term growth in Swiss Francs through investment in a portfolio of stocks from Swiss issuers that are listed in a representative Swiss equities index of small and medium enterprises or the small and mid- cap subindex of a Swiss equities index (“the benchmark”). The investment strategy is based on a transparent and comprehensible investment process, focuses on stock selection. Fund Benchmark (since 09/08/2006): SPI EXTRA Total Return (RI) Past performance is no indication of current or future performance, and the performance data do not take account of the commissions and costs Fund Management's Comment incurred on the issue and redemption of units. For detailed comments on the fund and its corresponding markets please see the annual report. Cumulative performance (in %) - share class FD 1 m 1 y 3 y 5 y s. Inception YTD 3 y avg 5 y avg 2017 2018 2019 2020 CHF 3.0 42.7 36.1 77.7 421.8 29.6 10.8 12.2 29.9 -21.6 29.3 1.8 EUR 2.7 42.0 42.2 80.2 650.5 30.2 12.5 12.5 19.4 -18.6 33.7 2.2 BM IN CHF 2.5 34.9 39.1 90.5 284.2 23.7 11.6 13.8 29.7 -17.2 30.4 8.1 Further Characteristics (3 years) / VAR (1 year) - share class FD Volatility 18.36% Maximum Drawdown -21.26% VAR (99%/10 days) 7.23% Sharpe Ratio -- Information Ratio -0.16 Correlation Coefficient 0.97 Alpha -1.26% Beta 1.05 Tracking Error -
312.1.Full.Pdf
Ann Rheum Dis: first published as 10.1136/annrheumdis-2021-eular.1066 on 19 May 2021. Downloaded from 312 Scientific Abstracts Acknowledgements: This study was funded by Novartis Pharma AG. The found many DEGs from baseline with GUS treatment and none with PBO. These authors thank Richard Karpowicz, PhD, of Health Interactions, Inc, for providing included genes related to B-, T-, NK-, and plasma cells (increased by GUS) and medical writing support/editorial support, which was funded by Novartis Pharma- neutrophils, monocytes, eosinophils, and macrophages (decreased by GUS), ceuticals Corporation, East Hanover, NJ, in accordance with Good Publication suggestive of a partial normalization of immune cell composition in whole blood. Practice (GPP3) guidelines (http://www.ismpp.org/gpp3). Conclusion: Using whole transcriptome profiling, we detected DEGs in blood Disclosure of Interests: Gurjit S. Kaeley Consultant of: Novartis Pharmaceuti- samples obtained from PsA pts vs. healthy controls, suggesting a dysregulation cals Corporation, Georg Schett Speakers bureau: AbbVie, Bristol Myers Squibb, of immune cell profiles in PsA. The majority of these disease-associated genes Celgene, Janssen, Eli Lilly, Novartis, and Pfizer, Consultant of: AbbVie, Bristol were modulated by GUS, with directionality toward a normalization of whole Myers Squibb, Celgene, Janssen, Eli Lilly, Novartis, and UCB, Grant/research blood transcriptomic signatures. support from: Bristol Myers Squibb, Celgene, GSK, Eli Lilly, and Novartis, Philip REFERENCES: G Conaghan Consultant of: or Speakers bureau: AbbVie, AstraZeneca, Bristol [1] Deodhar A et al. Lancet. 2020;395:1115. Myers Squibb, Eli Lilly, EMD Serono, Flexion Therapeutics, Galapagos, Gilead, [2] Mease P et al. Lancet. 2020;395:1126. Novartis, and Pfizer, Grant/research support from: UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Dennis McGona- Table 1. -
Corporate Governance
Business report Corporate governance Transparency is one of the key elements of good corporate governance, to which Sonova is committed. Good corporate governance is essential for Sonova and we strive for high standards in this field. What “good corporate governance” means is an evolving matter and we constantly monitor the latest changes to the requirements. Compliance is an integral element of our corporate culture and embedded in our core values. We therefore continued to strengthen the Sonova Group compliance program during the 2017/18 financial year, putting particular emphasis on integrating our acquired businesses into our compliance culture, designing new global compliance training, and updating our antibribery policy. Our continuing compliance efforts help us to live our values of ethical behavior and unquestionable integrity. At Sonova, corporate governance is based upon, and structured to conform with, relevant standards and practices. The company fulfils its legal duties under the Swiss Code of Obligations, the SIX Swiss Exchange Directive on Information relating to Corporate Governance, and the standards defined in the Swiss Code of Best Practice for Corporate Governance. This report describes the principles of corporate governance for the Sonova Group and provides background information on the Group’s executive officers and bodies as of March 31, 2018. All relevant documents can be accessed at the corporate governance section of the Sonova website: www.sonova.com/en/commitments/corporategovernance. For clarity and transparency, the compensation report is presented as a separate chapter of the annual report. Sonova Annual Report 2017/18 37 CORPORATE GOVERNANCE Group structure Operational group structure The Sonova Group is headquartered in Stäfa, Switzerland, and is active in over 100 countries. -
CA Signed Novartis 315 Settlement Agreement Signed California
STATE SETTLEMENT AGREEMENT I. PARTIES This Settlement Agreement (the "Agreement") is entered into between the State of California ("the State") and Novartis Pharmaceuticals Corporation ("Novartis"), collectively, "the Parties." II. PREAMBLE As a preamble to this Agreement, the Parties agree to the following: A. At all relevant times, Novartis, (a subsidiary of Novartis International AG, which is headquartered in Basel, Switzerland) was a corporation with its principal place of business in East Hanover, New Jersey, distributed, marketed and/or sold pharmaceutical products in the United States, including drugs sold under the trade names of Lotrel, Valturna, Starlix, Tekamlo, Diovan, Diovan HCT, Tekturna, Tekturna HCT, Exforge, and Exforge HCT (the "Covered Drugs"). B. On January 5, 2011 , Oswald Bilotta, (the "Relater") filed a sealed qui tam action, which was subsequently amended on October 19, 2012, as of right on April 3, 2013 (pursuant to an unopposed motion dated March 21 , 2013), and on July 10, 2013 (pursuant to a stipulation dated July 8, 2013) (the "Civil Action") in the United States District Court for the Southern District of New York captioned United States of America et al. , ex rel. Oswald Bilotta et al. v. Novartis Pharmaceuticals Corporation Civil Action No. 1 l-cv-00071 , alleging, inter alia, that Novartis violated the False Claims Act ("FCA") and the Anti-Kickback Statute, 42 U.S.C. §I320a-7b(b) (the "AKS"), by paying doctors remuneration to prescribe the drugs Lotrel, Valturna, Starlix, Tekturna, Tekturna HCT, Diovan, Diovan HCT, Exforge, and Exforge HCT through the mechanism ofspeaker program honoraria and related misconduct. Novartis-315 Page 1 of 19 On April 26, 2013, the United States intervened in the Civil Action against Novartis by filing a Notice of Election to Intervene and Complaint-in-Intervention, in which it is asserted that claims against Novartis under the FCA and common law. -
Annual Report 2018 19 Table of Content
FINANCIAL REPORT Annual Report 2018 19 Table of content Letter to shareholders 2 Our product and service offering 6 Strategy and businesses 10 Corporate governance 36 Compensation report 60 Financial review 96 5 year key figures 104 Consolidated financial statements 105 Financial statements of Sonova Holding AG 175 Investor information 188 Corporate Responsibility Report 190 Letter to shareholders Dear shareholders, 2018/19 marked another year of solid financial performance, posting further record levels of sales and profits to which all three businesses contributed. Moreover – and as expected – growth accelerated from the first half-year to the second, driven by the launch of a number of innovative products and solutions. Sonova affirmed its leading position in audiological performance with the release of the Marvel™ technology platform. Marvel takes full advantage of the unique connectivity enabled by our SWORD™ (Sonova Wireless One Radio Digital) chip and combines it with the proven convenience of our rechargeable solutions. We also made significant progress in our retail business, which we have renamed “audiological care” for one simple reason: care is what we deliver. The expert service We have made significant provided by our hearing care professionals adds key value for the consumer. progress in implementing our strategy. Our cochlear implants business launched a series of innovative new products to strengthen its leading position in this expanding market. Robert Spoerry You will find details of these and other strategic initiatives in the “strategy and businesses” section of this report. The global market in which we operate is poised for further growth, as developed countries see increasing demand from the “baby boomer” generation and developing countries begin to bridge the gap in hearing care provision. -
Lafargeholcim CDP Climate Change 2020
LafargeHolcim Ltd - Climate Change 2020 C0. Introduction C0.1 (C0.1) Give a general description and introduction to your organization. Company Profile LafargeHolcim is the global leader in building materials and solutions. It is active in four business segments: Cement, Aggregates, Ready-Mix Concrete, and Solutions and Products. It was founded in mid-2015 following the merger of Lafarge S.A and Holcim Ltd. The Group has a presence in around 80 countries and has over 70 000 employees. In 2019 it recorded CHF 26.7 bn in net sales and has 286 mt of annual cement production capacity worldwide. The Group has over 2,300 plants (including over 1,400 in ready mix concrete, 649 in aggregates and 264 in cement and grinding plants). The Group has solutions and services in cement, concrete, and aggregates for the following businesses: buildings, infrastructure, distribution, oil and gas, affordable housing, and construction systems. Cement is manufactured through a large-scale, capital-and-energy-intensive process. At the core of the production process is a rotary kiln, in which limestone and clay are heated to approximately 1,450 degrees Celsius. The semi-finished product, clinker, is created by sintering. In the cement mill, gypsum is added to the clinker and the mixture is ground to a fine powder – traditional Portland cement. Other high-grade materials such as granulated blast furnace slag, fly ash, pozzolan, and limestone can be added in order to modify the properties of the cement for special uses or specific application. Aggregates include crushed stone, gravel, and sand. They can also be recycled from concrete wastes. -
Event Calendar
Published on Novartis (https://www.novartis.com) Home > Printer-friendly PDF > Event Calendar Event Calendar View recent presentations and learn more about upcoming events. Disclaimer: Disclaimer: The information in the presentations on these pages was factually accurate on the date of publication. These presentations remain on the Novartis website for historical purposes only. Novartis assumes no responsibility to update the information to reflect subsequent developments. Readers should not rely upon the information in these pages as current or accurate after their publication dates. Tab: Upcoming Events Third quarter results 2021 Oct 26, 2021 Basel, Switzerland Recent Events [1] ESG Investor Day Sep 30, 2021 Watch the webcast [2] Download the podcast (MP3 66 MB) [3] Access our interactive slide deck (PDF 9.6 MB) [4] Read the media release [5] Novartis ESG Investor Day 2021 6 key takeaways [6] Bernstein Strategic Decisions Conference Sep 23, 2021 Baader Investment Conference Sep 21, 2021 Bank of America Merrill Lynch Global Healthcare Virtual Conference Sep 15, 2021 Morgan Stanley Global Healthcare Conference Sep 13, 2021 Citi's GEMS Virtual Conference 2021 Sep 8, 2021 Second quarter results 2021 Jul 21, 2021 Basel, Switzerland Media release English (PDF 0.4 MB) [7] Deutsch (PDF 0.4 MB) [8] Français (PDF 0.4 MB) [9] Interim financial report (PDF 0.5 MB) [10] Watch the webcast [11] Read the presentation transcript [12] Download the podcast (MP3 45 MB) [13] Download the interactive presentation (PDF 4.5 MB) [14] Novartis ESG Update - July -
FACTSHEET - AS of 29-Sep-2021 Solactive Switzerland 40 Equal Weight Index TR
FACTSHEET - AS OF 29-Sep-2021 Solactive Switzerland 40 Equal Weight Index TR HISTORICAL PERFORMANCE 6,000 5,000 4,000 3,000 2,000 1,000 Jan-2000 Jan-2005 Jan-2010 Jan-2015 Jan-2020 Solactive Switzerland 40 Equal Weight Index TR CHARACTERISTICS ISIN / WKN DE000SLA98V4 / SLA98V Base Value / Base Date 1000 Points / 03.03.1999 Bloomberg / Reuters SOCH40ET Index / .SOCH40ET Last Price 5520.10 Index Calculator Solactive AG Dividends Included Index Type Total Return Calculation 09:00am to 10:30pm (CET), every 60 seconds Index Currency CHF History Available daily back to 03.03.1999 Index Members 40 FACTSHEET - AS OF 29-Sep-2021 Solactive Switzerland 40 Equal Weight Index TR STATISTICS 30D 90D 180D 360D YTD Since Inception Performance -6.87% -1.29% 6.88% 26.84% 16.30% 452.01% Performance (p.a.) - - - - - 7.86% Volatility (p.a.) 14.33% 11.91% 11.14% 12.42% 11.49% 18.86% High 5927.07 5927.07 5927.07 5927.07 5927.07 5927.07 Low 5498.67 5498.67 5111.72 4101.40 4734.43 549.01 Sharpe Ratio -4.04 -0.43 1.30 2.20 1.96 0.42 Max. Drawdown -7.23% -7.23% -7.23% -8.17% -7.23% -68.82% VaR 95 \ 99 -22.5% \ -33.9% -29.8% \ -57.3% CVaR 95 \ 99 -29.9% \ -44.8% -47.2% \ -78.4% COMPOSITION BY CURRENCIES COMPOSITION BY COUNTRIES CH 97.6% CHF 100.0% AT 2.4% TOP COMPONENTS AS OF 29-Sep-2021 Company Ticker Country Currency Index Weight (%) DUFRY AG DUFN SE Equity CH CHF 2.80% SWISSCOM AG SCMN SE Equity CH CHF 2.69% ALCON INC ALC SE Equity CH CHF 2.67% SONOVA HOLDING AG SOON SE Equity CH CHF 2.64% UBS GROUP AG UBSG SE Equity CH CHF 2.63% JULIUS BAER GRUPPE AG BAER SE Equity CH CHF 2.61% KUEHNE & NAGEL INTERNATIONAL AG KNIN SE Equity CH CHF 2.60% NESTLE SA NESN SE Equity CH CHF 2.60% SWISS LIFE HOLDING AG SLHN SE Equity CH CHF 2.60% CHOCOLADEFABRIKEN LINDT & SPRUENGLI AG LISP SE Equity CH CHF 2.60% FACTSHEET - AS OF 29-Sep-2021 Solactive Switzerland 40 Equal Weight Index TR DISCLAIMER © Solactive AG, 2021. -
Investor Presentation
Participants Company overview Pharmaceuticals Oncology Financial review Conclusion Appendix References Q1 2021 Results Investor presentation 1 Investor Relations │ Q1 2021 Results Participants Company overview Pharmaceuticals Oncology Financial review Conclusion Appendix References Disclaimer This presentation contains forward-looking statements within the meaning of the United States Private Securities Litigation Reform Act of 1995, that can generally be identified by words such as “potential,” “expected,” “will,” “planned,” “pipeline,” “outlook,” or similar expressions, or by express or implied discussions regarding potential new products, potential new indications for existing products, potential product launches, or regarding potential future revenues from any such products; or regarding the impact of the COVID-19 pandemic on certain therapeutic areas including dermatology, ophthalmology, our breast cancer portfolio, some newly launched brands and the Sandoz retail and anti-infectives business, and on drug development operations; or regarding potential future, pending or announced transactions; regarding potential future sales or earnings of the Group or any of its divisions; or by discussions of strategy, plans, expectations or intentions; or regarding the Group’s liquidity or cash flow positions and its ability to meet its ongoing financial obligations and operational needs; or regarding our collaboration with Molecular Partners to develop, manufacture and commercialize potential medicines for the prevention and treatment of COVID- 19 and our joining of the industry-wide efforts to meet global demand for COVID-19 vaccines and therapeutics by leveraging our manufacturing capacity and capabilities to support the production of the Pfizer-BioNTech vaccine and to manufacture the mRNA and bulk drug product for the vaccine candidate CVnCoV from CureVac. -
Amc Lapis Glob Top 20 Gen Revol
Data as of 31.08.2021 August 2021 AMC LAPIS GLOB TOP 20 GEN REVOL PRODUCT STRATEGY FACTS AND FIGURES ISIN CH1103333931 The AMC on "LAPIS GLOBAL TOP 20 GENOMIC Currency USD REVOLUTION" is an actively managed portfolio of equities, which is based on investment Maturity Date Open End advice and recommendation by Lapis Asset NAV Date 30.08.2021 Management AG. The Lapis Global Top 20 Genomic Revolution is composed of the worldwide best-known Valor 110333393 and leading top 20 companies (gene therapy, Dividend Reinvested bioinformatics, bio-inspired computing, molecular medicine, pharmaceutical innovation) based on the FX Overlay Disabled research approach of an internationally recognized Issue Date 19.05.2021 company. All stocks are equally weighted and the NAV 110.20 certificate is rebalanced on a quarterly basis (end of January, April, July and October). Mgmt Fee (total) 1.35% Rebalancing Quarterly AuM USD 6’790’721 Components 21 Certificates 61’790 Issuer Bank Julius Baer Last Rebalancing 02.07.2021 PERFORMANCE 1 month -0.81% 52 week high 123.40 3 months 2.04% 52 week low 100.00 1 year N/A All-time high 123.40 Since inception 10.20% All-time low 100.00 YTD N/A Max draw down -14.67% Data as of 31.08.2021 August 2021 PRICE CHART MONTHLY RETURNS 2015 120 2016 115 2017 110 2018 105 2019 2020 100 8.00 13.61 -9.45 -0.81 2021 19 May 8 Jun 29 Jun 19 Jul 9 Aug 30 Aug Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec UNDERWATER EQUITY CURVE PERFORMANCE ANNUAL 0% 10% -5% 8% 2017 - 2018 - 6% 2019 - -10% 2020 - 4% 2021 10.20% 2% -15% 0% 19 May 8 Jun 29 -
Fund Risk Management
FUND RISK MANAGEMENT Monthly Report Umbrella Cosmos Lux International Net Asset Value 11,496,391.95 Sub-fund CHF Currency CHF August 2019 Portfolio date 26/08/2019 FUND ID Fund name Cosmos Lux International TNA end of period 11,496,391.95 NAV end of period 117.48 Sub-fund name CHF TNA start of period 11,830,504.83 NAV start of period 120.89 ISIN LU0989373237 TNA Variation -2.82% NAV Variation -2.82% Currency CHF Benchmark SWISS MARKET INDEX Subscriptions 0.00 FUND RISK PROFILE Low Redemptions 0.00 RISK MANAGEMENT COMMENTS Stale price overview No stale price. Operational risk No material NAV error occurred during the period. No massive redemption occurred during the period. Risk Metrics: Scorecard reporting 4Cs (based on NAV date) Leverage Counterparty risk Concentration risk Liquidity risk . <100% NAV <5% or 10% <10% >90% liquid day Investment Compliance dashboard Type of breach Description Origin Start date Close Date Active/Passive Impact Regulator reporting UCITS 50 (2) (a) Persistent overdraft Start of warning period 14/01/2019 21/01/2019 WARNING N/A N/A Investment Compliance specific NA Total Expense Ratio - Internal limit 3% As of 28/06/2019 (Quarterly): Without transaction fees B CAP: 2.78% Portfolio Turnover As of 28/06/2019 (Quarterly): 26.02% Please note that PTR displayed is calculated on an annual basis as specified in the CSSF circular 03/122. VaR - Leverage NA Liquidity Risk No issue to report. Investment Manager comments 1 FUND RISK MANAGEMENT Monthly Report Umbrella Cosmos Lux International Net Asset Value 11,496,391.95 Sub-fund CHF Currency CHF August 2019 Portfolio date 26/08/2019 Regulatory main limit checks Check result Indicator Check result Indicator Issuer Exposure < 10% NAV 5.48% Cash Counterparty Exposure < 20% NAV 1.55% OECD Govt Bond Exposure < 35% NAV NA OTC Counterparty Exposure NA 5/40 Rule 10.55% Aggregated Group Exposure 5.48% Borrowing limit < 10% NAV NA Cover Rule (liquid assets vs.