DOCSLIB.ORG

Designing Ionic-Complementary

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Designing Ionic-Complementary DESIGNING IONIC-COMPLEMENTARY HYDROGELS FOR BONE TISSUE REPAIR A thesis submitted to the University of Manchester for the degree of Doctor of Philosophy (PhD) in the Faculty of Chemical Engineering and Analytical Science 2014 MSc. LUIS ALBERTO CASTILLO DIAZ School of Chemical Engineering and Analytical Science CONTENTS List of figures……………………………………………………………….................4 List of abbreviations…………………………………………………………….……..5 Declaration…………………………………………………………………………….8 Copyright………………………………………………………………………………9 Acknowledgements…………………………………………………………………..10 Thesis Structure……………………………………………………………….…..….11 Abstract………………………………………………………………………………12 Objectives of the thesis………………………………………………………………13 1 Chapter 1 - Introduction. Versatile peptide hydrogels for bone and dental tissue regeneration………………….…………………….………………………..…….….14 2 Chapter 2- Human osteoblasts within soft peptide hydrogels promote mineralisation in vitro…………………………………………………………………….….70 3 Chapter 3 - Functional peptide hydrogels for bone formation applications………..71 4 Chapter 4 - Osteogenic differentiation of human mesenchymal stem cells promotes mineralisation within an octa-peptide hydrogel……………………...…....99 5 Chapter 5- Materials and methods……………………….………………………129 5.1 Materials…………………………………………………………………….…..129 2 5.2 Methods…………………………………………………………………………130 5.3 References………………………………………………………………………139 6 Chapter 6 – Conclusions, outlook and recommendations for future work………..140 6.1 Conclusions……………..……………………………………………………....140 6.2 Outlook………………………………………………………………………….141 6.3 Recommendations for future work……………………………………………...141 Appendix……………………………………………………………………………143 3 LIST OF FIGURES Figure 1. Representative of a peptide hydrogel containing cell culture media. Gel has been plated into a 12 well insert of 15 mm of inner diameter and 3 µm of pore diameter……………………………………………………………………………..132 Figure 2. Representative of the flow of media in between the cell culture insert and the well plate to aid the gelation of the FEFEFKFK gel. The media flows from the bottom to the top of the gel………………………………………………………....132 Figure 3. Oscillatory rheometer……………………………………………………135 4 LIST OF ABBREVIATIONS 2-D two-dimensional 3-D three-dimensional AB alveolar bone ALP or alkphos alkaline phosphatase AP-1 activator protein-1 ATR-FTIR attenuated total reflectance-Fourier transform infrared spectroscopy BGs bioactive glasses bFGF basic fibroblast growth factor BMP’s bone morphogenetic proteins BMUs basic multicellular units BSA bovine serum albumin BSP bone sialoprotein CD circular dichroism CDs clusters of differentiation COL-I1 type I collagen or collagen I COX-2 cyclooxygenase-2 CPC cetylpyridinium chloride DCs dendritic cells ddH2O double distilled water DMEM Dulbecco’s modified Eagle’s medium DPBS Dulbecco’s phosphate-buffered saline DPSCs dental pulp stem cells ECM extracellular matrix EDTA ethylenediaminetetraacetic acid EGF epidermal growth factor EthD-1 ethidium homodimer FBS fetal bovine serum FN fibronectin FSH follicle-stimulating hormone GAGs glycosaminoglycans GCs glucocorticoids GMSCs gingival mesenchymal stem cells GPa gigapascal HA hyaluronic acid HA hydroxyapatite HCA hydroxycarbonate apatite hMSCs human mesenchymal stem cells HOBs or hOBs human osteoblasts HPLC high-performance liquid chromatography HSCs hematopoietic stem cells ICC immunocytochemistry IEC ion-exchange chromatography IGF-1 insulin growth factor-1 IFN-γ interferon gamma IFR infrared spectroscopy 5 IL interleukin MCGS mesenchymal cell growth supplement MCP-1 monocyte chemoattractant protein-1 M-CSF macrophage colony-stimulator factor MIP-1α macrophage inflammatory protein-1 alpha MMPs metalloproteinases of matrix MPa megapascal MSCs mesenchymal stem cells NF-κB nuclear factor-κB NKs natural killer cells NMR nuclear magnetic resonance NOD nucleotide-binding oligomerisation domain OBs osteoblasts OCN osteocalcin OCs osteoclasts ODP osteopontin-derived peptide OPF oligo poly (ethylene glycol) fumarate OPG osteoprotegerin OPN osteopontin ONN osteonectin pAb primary antibody PBS phosphatase-buffered saline PCL poly (ε-caprolactone) PDFG platelet-derived growth factor PDL periodontal ligament PDLSCs periodontal ligament stem cells PEG polyethylene glycol PEG-2 prostaglandin-2 PEGDMA polyethylene glycol dimethacrylate PEO poly (ethylene oxide) PFA paraformaldehyde PGA polyglicolic acid PLA polylactic acid PLLA poly-L-lactide acid PLGA poly (lactic-coglycolide) PMNs polymorphonuclear cells PNIPAAm poly (N-iso-propylacrylamide) pNPP p-Nitrophenyl phosphate PPF poly (propylene fumarate) PTH parathormone PVA poly (vinyl alcohol) RANK receptor activator of NF-κB RANKL receptor activator of NF-κB ligand ROS reactive oxygen species 6 RT room temperature sAb secondary antibody SAXS small angle X-ray scattering SEC size exclusion chromatography SPPS solid phase peptide synthesis TCP tissue culture plastic TEOS tetraethylorthosilicate TEM transmission electron microscopy TFA trifluoroacetic acid TGF-β transforming factor-beta Ths helper T lymphocytes TIMPS tissue inhibitors of metalloproteinase TLRs toll-like receptors TNF-α tumor necrosis factor-alpha TRAP tartrate-resistant acid phosphatase Tregs regulator T cells VCAM-1 vascular cell adhesion molecule-1 VEGF vascular endothelial growth factor 7 DECLARATION The University of Manchester PhD by published work candidate declaration Candidate name: Luis Alberto Castillo Díaz Faculty: Chemical Engineering and Analytical Science Thesis title: Designing ionic-complementary hydrogels for bone tissue repair Declaration to be completed by the candidate: I declare that no portion of this work referred to this thesis has been submitted in support of an application for another degree or qualification of this or any other university or other institute of learning. Signed: Date: 8 COPYRIGHT The author of this thesis (including any appendices and/or schedules to this thesis) owns and copyright in it (“the Copyright”)1 and he has given The University of Manchester the right to use such Copyright for any administrative, promotional, educational and /or teaching purposes. Copies of this thesis, either in full or in extracts, may be made only in accordance with the regulations of the John Rylands University Library of Manchester. Details of these regulations may be obtained from the librarian. This page must form part of any copies made. The ownership of any patents, designs, trademarks and any all other intellectual property rights except for the Copyright (the “Intellectual Property Rights”), and any reproductions of copyright works, for example graphs and tables (“Reproductions”), which may be described in this thesis, may not be owned by the author and may be owned by third parties. Such intellectual Property Rights and Reproductions cannot and must not be made available for use without the prior written permission of the owner (s) of the relevant intellectual Property Rights and/or Reproductions. Further information on the conditions under which disclosure, publication and exploitation of this thesis, the Copyright and any Intellectual Property Rights and/or Reproductions described in it may take place is available from the Head School of Chemistry (or the Vice-President) and the Dean of the Faculty of Engineering and Physical Sciences, for Faculty of Engineering and Physical Sciences candidates. 1This excludes material already printed in academic journals, for which the copyright belongs to said journal and publisher. Pages for which the author does not own the copyright are numbered differently from the rest of the thesis. 9 ACKNOWLEDGEMENTS First and foremost I would like to thank my supervisor Prof. Aline Fiona Miller, for giving me the opportunity to work on this fascinating project, and for her generous and unconditional support. Another thanks goes to my co-supervisor, Prof. Julie Elizabeth Gough and to Dr Alberto Saiani for their support and the opportunity to work in an extraordinary interdisciplinary network. I am also proud and grateful to have been part of the Polymers and Peptides, and the Tissue Engineering research groups, where I had the opportunity to work in a great atmosphere meeting extraordinary people. I would like to thank my colleagues, Dr Ayeesha Mujeeb, Dr Claire Tang, Dr Jean Baptiste-Guilbaud, Dr Jonathan Gibbons, Dr Louise Carney, Dr Mohamed Elsawy, Dr Mi Zhou, Dr Kate Alexandra Meade, Dr Richard Balint, Dr Stephen Boothroyd, Dr Natasha Bhuiyan, Simon Wan, Shirley Bentley, Dr Nabilah Russlan, Dr Laura Szkolar, Dr Israa Sabree, Dr Deepak Kumar, Chistopher Hickling, and Dr Dave Roberts for their comradeship and kindly support. A special thanks to CONACyT-Mexico, for the generous fellowship support. Last but not least, another thanks goes to my wife Dr Juana Elizabeth Reyes Martinez, my parents and sisters, María Priscila del Castillo Frías, Dr Benjamín Raziel Jaramillo Ávila and Dr Elsa Aurora Calleja Quevedo, because of without their support, the culmination of this work would not have been possible. 10 THESIS STRUCTURE This thesis describes the design of peptide hydrogels for bone tissue engineering applications. The body of this thesis includes an article that has been already published, and three manuscripts, which will be submitted for publication. The format of both the published paper and the three manuscripts has been modified to fit in the template of this thesis, however the main text was not modified. The references either for the article or manuscripts are at the end of each chapter, as in the submitted version. In this thesis, a review manuscript
Load more

Recommended publications
  • Mothers in Science
    The aim of this book is to illustrate, graphically, that it is perfectly possible to combine a successful and fulfilling career in research science with motherhood, and that there are no rules about how to do this. On each page you will find a timeline showing on one side, the career path of a research group leader in academic science, and on the other side, important events in her family life. Each contributor has also provided a brief text about their research and about how they have combined their career and family commitments. This project was funded by a Rosalind Franklin Award from the Royal Society 1 Foreword It is well known that women are under-represented in careers in These rules are part of a much wider mythology among scientists of science. In academia, considerable attention has been focused on the both genders at the PhD and post-doctoral stages in their careers. paucity of women at lecturer level, and the even more lamentable The myths bubble up from the combination of two aspects of the state of affairs at more senior levels. The academic career path has academic science environment. First, a quick look at the numbers a long apprenticeship. Typically there is an undergraduate degree, immediately shows that there are far fewer lectureship positions followed by a PhD, then some post-doctoral research contracts and than qualified candidates to fill them. Second, the mentors of early research fellowships, and then finally a more stable lectureship or career researchers are academic scientists who have successfully permanent research leader position, with promotion on up the made the transition to lectureships and beyond.
    [Show full text]
  • Start-Up Company Networking Event 31St March 2021 (Wednesday) 1800 – 2000 Online (MS Teams)
    Start-up company networking event 31st March 2021 (Wednesday) 1800 – 2000 Online (MS Teams) IChemE start-up company networking event Aims: Event details: • Build a community of chem-eng- • Anticipated participants: related start-ups for sharing • 13 start-ups information and experience • 1 government grant expert • ~20 IChemE members (spectators) • Inspire students/researchers about the application of chem eng knowledge and possible career paths Schedule • 1800 – 1830: Introduction by start-up representatives • 3 min each (10 start-ups: CMCL Innovations / Manchester Biogel / Octeract / Carbon Sink LLC / Accelerated Materials / Dye Recycle / Olwg / Nanomox / Solveteq / Greenr) • 1830 – 1910: Talks by Professor Nigel Brandon, Mr Phil Caldwell & Dr David Hodgson • 10 min each --- > start-up journey + key learning points • 10 min Q & A for all three speakers • 1910 – 1930: Talk by Dr Mat Westergreen-Thorne • 10 min --- > application of government grants • 10 min Q & A • 1930 – 2000: Panel discussions • Topics: • Personal development for start-up founders with technical background • Early-stage development: common mistakes, major milestones, resources available • Website: https://www.rfcpower.com/ Prof. Nigel Brandon (Director & co-founder) • Founded: 2017 • Product: Novel hydrogen-manganese reversible fuel • https://www.imperial.ac.uk/people/n.brandon cell for grid scale energy storage. • Email: [email protected] • RFC Power specializes in developing novel flow • Dean of the Faculty of Engineering and Chair in battery chemistries for energy storage systems. The Sustainable Development in Energy, Imperial College company was spun out from Imperial College’s London. Departments of Earth Science & Engineering and Chemistry in 2017, underpinned by a number of • BSc(Eng) in Minerals Technology and PhD in scientific breakthroughs and patents from the labs of electrochemical engineering from Imperial College Nigel Brandon, Anthony Kucernak, Javier Rubio Garcia London, followed by a 14 year research career in and Vladimir Yufit over the prior 8 years.
    [Show full text]
  • The Jon Weaver Phd Prize 2014
    Macro Group UK & Polymer Physics Group Bulletin No 82 July 2014 Number Page 82 1 July 2014 MACRO GROUP UK POLYMER PHYSICS GROUP BULLETIN INSIDE THIS ISSUE: Editorial Views from the Top 2 Welcome to the July edition of the Macro Group and PPG bulletin. This edition sees a change to the PPG bulletin officer. Steve Eichhorn is 3 stepping down from this role and is replaced by Anthony Higgins. The Committee members MacroGroup and PPG committees would like to thank Steve for all his editorial work over the last two years. Awards 4 As usual, this issue of the bulletin contains several reports on recent conferences, and we would like to remind students that bursaries are News 7 available to MacroGroup and PPG student members to help fund conference expenses (see p10 for details of MacroGroup bursaries and Competitions announcements 10 p11 for details of bursaries available to PPG student members). Of special note, is the availability of the DH Richards bursaries to postdoctoral researchers who are members of the MacroGroup. Bursaries & Conference Reports 10-14 We also have many notices of forthcoming meetings and we would like to highlight in particular the one day Careers in Polymer Science: Beyond Forthcoming Meetings 15-18 Academia event in October, aimed specifically at postgraduate students and post-docs considering non-academic career paths. This issue also sees the call for nominations for the PPG Founders’ PrizePrizePrize and the PPG/DPOLY exchange lectureship with deadlines in early September. Contributions for inclusion in the BUL- LETIN should be emailed (preferably) Thank you to everyone who has contributed an item to this newsletter.
    [Show full text]
  • Macro Group Uk Polymer Physics Group Bulletin
    Macro Group UK & Polymer Physics Group Bulletin No 83 January 2015 Number Page 83 1 January 2015 MACRO GROUP UK POLYMER PHYSICS GROUP BULLETIN INSIDE THIS ISSUE: Editorial Happy New Year and welcome to the January 2015 edition of Views from the Top 2 the Macro Group and PPG bulletin. Firstly we congratulate our distinguished award winners. Professor Richard Jones (University of Sheffield) is the recipient Committee Members 3 of the 2015 PPG Founders’ Prize. He will be presented with the award and give the Founders’ lecture at the PPG biennial in Manchester in September of this year. Dr Paola Carbone (University Awards 4-9 of Manchester) has been selected as the DPOLY Exchange Lecturer. She will present her lecture at the March 2015 meeting of the News 10 American Physical Society in San Antonio, Texas. Further details regarding both awards and the meeting in Manchester are given inside this issue of the bulletin. We also congratulate Professor Competitions Announcements 11-12 Cameron Alexander (The University of Nottingham) and Dr Paul D. Topham (Aston University) winners of the 2014 Macro Group Bursaries & Meeting Reports 12-19 UK Medal and Macro Group UK Young Researchers Medal, respectively. We would like to remind PhD students and postdoctoral Forthcoming Meetings 20-29 researchers who are members of the Macro Group that D. H. Richards bursaries are available to help fund conference expenses. We would like to encourage current polymer physics PhD students, and also those who have recently completed their studies, to apply for the Ian Macmillan Ward Prize. Contributions for inclusion in the BUL- As well as the prize announcement, this issue includes an LETIN should be emailed (preferably) article describing Professor Ward’s contributions to polymer physics or sent to either: and the decision by the PPG committee to name the PhD student prize in his honour.
    [Show full text]
  • 2011-06-15-Mothers-In-Science.Pdf
    The aim of this book is to illustrate, graphically, that it is perfectly possible to combine a successful and fulfilling career in research science with motherhood, and that there are no rules about how to do this. On each page you will find a timeline showing on one side, the career path of a research group leader in academic science, and on the other side, important events in her family life. Each contributor has also provided a brief text about their research and about how they have combined their career and family commitments. This project was funded by a Rosalind Franklin Award from the Royal Society 1 Foreword It is well known that women are under-represented in careers in These rules are part of a much wider mythology among scientists of science. In academia, considerable attention has been focused on the both genders at the PhD and post-doctoral stages in their careers. paucity of women at lecturer level, and the even more lamentable The myths bubble up from the combination of two aspects of the state of affairs at more senior levels. The academic career path has academic science environment. First, a quick look at the numbers a long apprenticeship. Typically there is an undergraduate degree, immediately shows that there are far fewer lectureship positions followed by a PhD, then some post-doctoral research contracts and than qualified candidates to fill them. Second, the mentors of early research fellowships, and then finally a more stable lectureship or career researchers are academic scientists who have successfully permanent research leader position, with promotion on up the made the transition to lectureships and beyond.
    [Show full text]
  • Human Osteoblasts Within Soft Peptide Hydrogels Promote Mineralisation In
    TEJ0010.1177/2041731414539344Journal of Tissue EngineeringCastillo et al. 539344research-article2014 Original Article Journal of Tissue Engineering Volume 5: 1–12 Human osteoblasts within soft peptide © The Author(s) 2014 DOI: 10.1177/2041731414539344 hydrogels promote mineralisation in vitro tej.sagepub.com Luis A Castillo Diaz1,2, Alberto Saiani2,3, Julie E Gough3 and Aline F Miller1,2 Abstract Biomaterials that provide three-dimensional support networks for the culture of cells are being developed for a wide range of tissue engineering applications including the regeneration of bone. This study explores the potential of the versatile ionic-complementary peptide, FEFEFKFK, for such a purpose as this peptide spontaneously self-assembles into β-sheet-rich fibres that subsequently self-associate to form self-supporting hydrogels. Via simple live/dead cell assays, we demonstrated that 3 wt% hydrogels were optimal for the support of osteoblast cells. We went on to show that these cells are not only viable within the three-dimensional hydrogel but they also proliferate and produce osteogenic key proteins, that is, they behave like in vivo bone cells, over the 14-day period explored here. The gel elasticity increased over time when cells were present – in comparison to a decrease in control samples – indicating the deposition of matrix throughout the peptide scaffold. Moreover, significant quantities of calcium phosphate were deposited. Collectively, these data demonstrate that ionic-complementary octapeptides offer a suitable three-dimensional environment for osteoblastic cell function. Keywords Scaffold, peptide hydrogel, osteoblast cells, bone formation, mechanical properties Received: 25 February 2014; accepted: 2 May 2014 Introduction The majority of work within cell biology over the past These peptide-based hydrogels are typically fabricated few decades has been carried out in vitro on two-dimen- from short amino acid sequences that spontaneously self- sional (2D) systems, such as tissue culture plastic (TCP).1 assemble into β-sheet- or α-helix-rich fibres.
    [Show full text]
  • Journal of Tissue Engineering
    Journal of Tissue Engineering http://tej.sagepub.com/ Human osteoblasts within soft peptide hydrogels promote mineralisation in vitro Luis A Castillo Diaz, Alberto Saiani, Julie E Gough and Aline F Miller J Tissue Eng 2014 5: DOI: 10.1177/2041731414539344 The online version of this article can be found at: http://tej.sagepub.com/content/5/2041731414539344 Published by: http://www.sagepublications.com On behalf of: Institute of Tissue Regeneration Engineering Additional services and information for Journal of Tissue Engineering can be found at: Email Alerts: http://tej.sagepub.com/cgi/alerts Subscriptions: http://tej.sagepub.com/subscriptions Reprints: http://www.sagepub.com/journalsReprints.nav Permissions: http://www.sagepub.com/journalsPermissions.nav Downloaded from tej.sagepub.com by guest on December 1, 2014 TEJ0010.1177/2041731414539344Journal of Tissue EngineeringCastillo et al. 539344research-article2014 Original Article Journal of Tissue Engineering Volume 5: 1–12 Human osteoblasts within soft peptide © The Author(s) 2014 DOI: 10.1177/2041731414539344 hydrogels promote mineralisation in vitro tej.sagepub.com Luis A Castillo Diaz1,2, Alberto Saiani2,3, Julie E Gough3 and Aline F Miller1,2 Abstract Biomaterials that provide three-dimensional support networks for the culture of cells are being developed for a wide range of tissue engineering applications including the regeneration of bone. This study explores the potential of the versatile ionic-complementary peptide, FEFEFKFK, for such a purpose as this peptide spontaneously self-assembles into -sheet-rich fibres that subsequently self-associate to form self-supporting hydrogels. Via simple live/dead cell assays, we demonstrated that 3 wt% hydrogels were optimal for the support of osteoblast cells.
    [Show full text]
  • School of Chemical Engineering and Analytical Sciences Catalytic Research Prof
    Faculty of Sciences and Engineering Faculty of Engineering and Physical Sciences School of Chemical Engineering and Analytical Sciences Catalytic Research Prof. Chris Hardacre School of Chemical Engineering and Analytical Science [email protected] Chris Hardacre is Head of the School of Chemical Engineering and Analytical Science and Professor of Chemical Engineering, with research interests in heterogeneous catalysis, in-situ method development and ionic liquids. He has 350+ publications with an H-index of 65 and over 15,000 citations. He is a Member of the Royal Irish Academy, Fellow of the Institute of Chemical Engineering and Fellow of Royal Society of Chemistry. He has a number of awards including the inaugural Andrew Medal for catalysis and has won ~£28M research grant over the past 20 years. We are a world-leading research group working on heterogeneous catalysis and ionic liquids. We have developed a number of state-of-the-art techniques for in- situ monitoring of the systems studied and have strong links with industry. We target applications in energy, bulk, fine and pharmaceutical chemical synthesis as well as environmental protection: •Non-thermal plasma catalysis. ACS Catal., 2015, 5 956; 2014, 4, 666; •Neutron and X-ray scattering studies of catalysts and ionic liquids, Chem. Sci., 2013, 4, 3484; 2013, 4, 1270; 2011, 2, 1594; •Activating gold catalysts. ACS Catal., 2012, 2, 552; Angew. Chem. Int. Ed., 2011, 50, 8912; JACS, 2009, 131, 6973; •Electrochemical reduction of CO2. Angew. Chem. Int. Ed., 2015, 54, 14164.(Hot
    [Show full text]
  • Nanopeptide 2012: Peptides As Nanomaterials & Biomaterials An
    Nanopeptide 2012: Peptides as Nanomaterials & Biomaterials An international symposium under the Date auspices of several learned societies November 12 - 14, 2012 Venue Auspices of the Protein & Peptide Science Group The Manchester Institute of Supported by the Biotechnology, European Peptide Society University of Manchester, UK First announcement & call for papers A multidisciplinary meeting covering all aspects of the subject from materials science, soft matter physics, biophysics, chemis- try through to biomedical applications. Programme Committee • Aline Miller, University of Manchester • Louise Serpell, University of Sussex • Rein Ulijn, University of Strathclyde Programme Topics • Peptide Design, Collagens & Coiled Coils • Peptide Biomaterials & Tissue Regeneration • Peptide Interactions with Materials & Nanomaterials • Peptide Nanostructures for Opto/Electronic Application • Dynamic Peptide Systems & Self-assembly • Peptide Hydrogels • Peptide / Polymer Interactions Keynote Speaker • Peptide and protein scaffolds, nanoparticles • Peptide-based drug delivery systems David Kaplan, Tufts University Keynote Speaker • David Kaplan, Tufts University, USA Other Confirmed Speakers • Dave Adams, University of Liverpool • Gonen Ashkenasy, Ben Gurion University, Israel • Hans Börner, Humboldt-Universität zu Berlin, Germany • Joel Collier, University of Chicago, USA • Ian Hamley, University of Reading • Jeff Hartgerink, Rice University, USA More information • Hiroshi Matsui, CUNY, USA [email protected] • Joel Schneider, National Cancer Institute, USA • Thomas Scheibel, University of Bayreuth, Germany • Anthony Weiss, University of Sydney, Australia Poster Prize • Dek Woolfson, University of Bristol There will be a Poster Prize for young • Bing Xu, Brandeis University, USA researchers kindly sponsored by the Oral Communications & Poster Session Protein & Peptide Science Group of Abstracts are solicited for oral and/or poster presentation. the RSC. For more information, visit Deadline: October 1, 2012 (late posters November 1, 2012) the website.
    [Show full text]
  • RSC Biomaterials Programme
    Dear Delegates, Welcome to Liverpool! It is with great pleasure that I welcome you to the Annual Conference of the RSC Biomaterials Chemistry Special Interest Group here at the University of Liverpool. The RSC Biomaterials Chemistry Special Interest Group was set up in 2005 to provide a focus for groups in universities and industry working on the synthesis and characterisation of biomaterials. The annual meeting brings together researchers from across the UK and internationally, working to advance knowledge and focus on biomaterial chemistry research and development. The event aims to enhance the understanding of the chemistries underlying the use of biomaterials in applications including antimicrobial surfaces, drug delivery and regenerative medicine. The focus of this year’s meeting is Anti-Infective Materials and Device Related Infections, Biomaterials for Therapeutic Delivery, Biomaterials for Tissue Induction and Regenerative Medicine and Bioresponsive Surfaces. Our plenary speakers are world leaders in their respective fields: Professor Robert Hancock (University of British Columbia, Canada), Professor John Fisher (University of Leeds), Professor Graham Leggett (University of Sheffield) and Professor Rasmita Raval (University of Liverpool). The response from the biomaterials research community has been excellent for this year’s meeting with 34 different institutions and companies, including 7 from beyond the UK including The Netherlands, Ireland, Iraq, Pakistan, Brazil, Saudi Arabia and Nigeria. The breadth of work to be presented
    [Show full text]
  • Emerging Investigators 2016: Novel Design Strategies for New Functional Materials Cite This: J
    Journal of Materials Chemistry A View Article Online PROFILE View Journal | View Issue Profile: Emerging Investigators 2016: novel design strategies for new functional materials Cite this: J. Mater. Chem. A,2016,4, 6670 DOI: 10.1039/c6ta90084d www.rsc.org/MaterialsA Candace Chan is an Assistant Professor in the materials science and engineering program in the School for Engineering of Matter, Transport and Energy at Arizona State University (ASU). Prior to joining ASU in 2011, she was a Miller Postdoctoral Fellow at the University of California, Ber- keley in the Department of Chemistry. She received her Ph.D. in chemistry from Stan- ford University in 2009. As a graduate student, she was an NSF Graduate Fellow, Stanford Graduate Fellow, and winner of Published on 26 April 2016. Downloaded 04/05/2016 06:37:12. the MRS Graduate Student Award (Silver) Andriy Zakutayev is a scientist at the ETH Zurich (Switzerland) for Ph.D. study. and TMS Ross N. Tucker Award in Elec- National Renewable Energy Laboratory Prior to his appointment at ICIQ, he was tronic Materials. She received a B.S. in (USA) working on materials research and an Oberassistent (Senior Scientist/ chemistry from Rice University in 2005. Her device development for novel solar energy Lecturer) at the ETH Zurich. His research research group is designing and studying conversion and other technologies, using interests are centered on the develop- the unique properties of nanostructured high-throughput combinatorial experi- ment of heterogeneous catalysts and materials for applications in electro- mental methods. Dr Zakutayev has a Ph.D. processes based on rational under- chemical energy storage, photocatalysis, in Physics from Oregon State University, standing aided by in situ and in operando and water treatment.
    [Show full text]
  • Polymer-Solvent Complexes and Intercalates
    Conference Call ICCT-2010 provided an open, collaborative environ- Supramolecular Systems” ment for researchers from a wide range of fields of sci- Gaetano Guerra, Universita di Salerno, Italy ence and engineering. ICCT-2012 will be held in August “Polymer Co-crystalline Phase” 2012 in Búzios, Brazil. Akira Harada, Osaka University, Japan “From Supramolecular Chemistry to Polymer Science” Kazuya Saito <[email protected]>, a professor at the University of Wim E. Hennink, Utrecht University, The Tsukuba, Japan, was executive secretary of the conference. Mary Anne White, a Netherlands “Self-Assembling Hydrogels for professor at Dalhousie University, Canada, was a member of the international advi- Proteins Release” sory board, a presenter of a public lecture, and co-chair of a workshop at ICCT-2010. Erdogan Kiran, Virginia Tech, Blacksburg, USA “Polymorphic Transformations and Morphological Modifications of Polymers in Polymer-Solvent Complexes Dense Fluids” Jean-François Luz, Fraunhofer Institute, and Intercalates Potsdam, Germany “Design of Synthetic by Jean-Michel Guenet Hydrogels with a Sol-Gel or a Gel-Sol Thermoreversible Transition in Aqueous The 8th International Conference on Polymer-Solvent Medium” Complexes and Intercalates, held in Strasbourg, Yasushi Maeda, Fukui University, Japan France, from 5 to 8 July 2010, was the first of the series “Hydration of Temperature-Responsive to be granted IUPAC sponsorship. Polymers Observed by IR Spectroscopy” The topic of this series of international confer- Ulrich Maschke, Université de Lille, France ences was originally centered on polymer systems “Dispersions of Liquid Crystals in Polymers: that are obtained through the co-crystallization, or in Investigation of Thermo-Physical, Morph- a broader sense through the co-organization, of poly- ological, and Electro-Optical Properties” mer chains or macromolecules with solvent molecules.
    [Show full text]