Complementary and Alternative Treatments for Alopecia: a Comprehensive Review
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WO 2014/167554 A2 16 October 2014 (16.10.2014) P O P C T
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2014/167554 A2 16 October 2014 (16.10.2014) P O P C T (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 47/10 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (21) International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, PCT/IB20 14/060675 DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, 12 April 2014 (12.04.2014) KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (25) Filing Language: English OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (26) Publication Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (30) Priority Data: zw. 1103/DEL/2013 12 April 2013 (12.04.2013) IN (84) Designated States (unless otherwise indicated, for every (71) Applicant: VYOME BIOSCIENCES PVT. LTD. kind of regional protection available): ARIPO (BW, GH, [IN/IN]; 459 F.I.E, First Floor, Patparganj Industrial Area, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, New Delhi 110092 (IN). -
(In)Determinable: Race in Brazil and the United States
Michigan Journal of Race and Law Volume 14 2009 Determining the (In)Determinable: Race in Brazil and the United States D. Wendy Greene Cumberland School fo Law at Samford University Follow this and additional works at: https://repository.law.umich.edu/mjrl Part of the Comparative and Foreign Law Commons, Education Law Commons, Law and Race Commons, and the Law and Society Commons Recommended Citation D. W. Greene, Determining the (In)Determinable: Race in Brazil and the United States, 14 MICH. J. RACE & L. 143 (2009). Available at: https://repository.law.umich.edu/mjrl/vol14/iss2/1 This Article is brought to you for free and open access by the Journals at University of Michigan Law School Scholarship Repository. It has been accepted for inclusion in Michigan Journal of Race and Law by an authorized editor of University of Michigan Law School Scholarship Repository. For more information, please contact [email protected]. DETERMINING THE (IN)DETERMINABLE: RACE IN BRAZIL AND THE UNITED STATES D. Wendy Greene* In recent years, the Brazilian states of Rio de Janeiro, So Paulo, and Mato Grasso du Sol have implemented race-conscious affirmative action programs in higher education. These states established admissions quotas in public universities '' for Afro-Brazilians or afrodescendentes. As a result, determining who is "Black has become a complex yet important undertaking in Brazil. Scholars and the general public alike have claimed that the determination of Blackness in Brazil is different than in the United States; determining Blackness in the United States is allegedly a simpler task than in Brazil. In Brazil it is widely acknowledged that most Brazilians are descendants of Aficans in light of the pervasive miscegenation that occurred during and after the Portuguese and Brazilian enslavement of * Assistant Professor of Law, Cumberland School of Law at Samford University. -
H2O2-Mediated Oxidative Stress Affects Human Hair Color by Blunting Methionine Sulfoxide Repair
The FASEB Journal • Research Communication Senile hair graying: H2O2-mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair J. M. Wood,*,†,1 H. Decker,‡ H. Hartmann,‡ B. Chavan,* H. Rokos,*,† ʈ J. D. Spencer,*,† S. Hasse,*,† M. J. Thornton,* M. Shalbaf,* R. Paus,§, and K. U. Schallreuter*,2 *Department of Biomedical Sciences, Clinical and Experimental Dermatology, and †Institute for Pigmentary Disorders, University of Bradford, Bradford, UK; ‡Institute of Molecular Biophysics, University of Mainz, Mainz, Germany; §Department of Dermatology, University of Lu¨beck, Lu¨beck, ʈ Germany; and University of Manchester, Manchester, UK ABSTRACT Senile graying of human hair has been decline—especially in today’s world, where humans are the subject of intense research since ancient times. confronted with increasing pressure to stay “forever Reactive oxygen species have been implicated in hair young and vital.” Hence, senile and premature graying follicle melanocyte apoptosis and DNA damage. Here has long attracted researchers and industry alike with we show for the first time by FT-Raman spectroscopy in scientific as well as commercial targets. Yet, apart from vivo that human gray/white scalp hair shafts accumu- various hair dyes of varying efficacy and duration, fully late hydrogen peroxide (H2O2) in millimolar concen- satisfactory solutions for the graying problem remain to trations. Moreover, we demonstrate almost absent cat- be brought to market. A key reason still not addressed alase and methionine sulfoxide reductase A and B is that the underlying molecular and cellular mecha- protein expression via immunofluorescence and West- nisms of graying remain under debate (1–3). ern blot in association with a functional loss of methi- So far, the biological process of hair graying has been -O) repair in the entire gray attributed to the loss of the pigment-forming melano؍onine sulfoxide (Met-S O formation of Met cytes from the aging hair follicle, including the bulb؍hair follicle. -
What's the Best Treatment for Cradle Cap?
From the CLINIcAL InQUiRiES Family Physicians Inquiries Network Ryan C. Sheffield, MD, Paul Crawford, MD What’s the best treatment Eglin Air Force Base Family Medicine Residency, Eglin Air for cradle cap? Force Base, Fla Sarah Towner Wright, MLS University of North Carolina at Chapel Hill Evidence-based answer Ketoconazole (Nizoral) shampoo appears corticosteroids to severe cases because to be a safe and efficacious treatment of possible systemic absorption (SOR: C). for infants with cradle cap (strength of Overnight application of emollients followed recommendation [SOR]: C, consensus, by gentle brushing and washing with usual practice, opinion, disease-oriented baby shampoo helps to remove the scale evidence, and case series). Limit topical associated with cradle cap (SOR: C). ® Dowden Health Media Clinical commentary ICopyrightf parents can’t leave it be, recommend brush to loosen the scale. Although mineral oil andFor a brush personal to loosen scale use noonly evidence supports this, it seems safe Cradle cap is distressing to parents. They and is somewhat effective. want everyone else to see how gorgeous This review makes me feel more FAST TRACK their new baby is, and cradle cap can make comfortable with recommending ketocon- their beautiful little one look scruffy. My azole shampoo when mineral oil proves If parents need standard therapy has been to stress to the insufficient. For resistant cases, a cute hat to do something, parents that it isn’t a problem for the baby. can work wonders. If the parents still want to do something -
Black Music of All Colors
SÉRIE ANTROPOLOGIA 145 BLACK MUSIC OF ALL COLORS. THE CONSTRUCTION OF BLACK ETHNICITY IN RITUAL AND POPULAR GENRES OF AFRO-BRAZILIAN MUSIC José Jorge de Carvalho Brasília 1993 Black Music of all colors. The construction of Black ethnicity in ritual and popular genres of Afro-Brazilian Music. José Jorge de Carvalho University of Brasília The aim of this essay is to present an overview of the charter of Afro-Brazilian identities, emphasizing their correlations with the main Afro-derived musical styles practised today in the country. Given the general scope of the work, I have chosen to sum up this complex mass of data in a few historical models. I am interested, above all, in establishing a contrast between the traditional models of identity of the Brazilian Black population and their musics with recent attempts, carried out by the various Black Movements, and expressed by popular, commercial musicians who formulate protests against that historical condition of poverty and unjustice, forging a new image of Afro- Brazilians, more explicit, both in political and in ideological terms. To focus such a vast ethnographic issue, I shall analyse the way these competing models of identity are shaped by the different song genres and singing styles used by Afro-Brazilians running through four centuries of social and cultural experience. In this connection, this study is also an attempt to explore theoretically the more abstract problems of understanding the efficacy of songs; in other words, how in mythopoetics, meaning and content are revealed in aesthetic symbolic structures which are able to mingle so powerfully verbal with non-verbal modes of communication. -
Model-Based Prediction of Human Hair Color Using DNA Variants
Hum Genet (2011) 129:443–454 DOI 10.1007/s00439-010-0939-8 ORIGINAL INVESTIGATION Model-based prediction of human hair color using DNA variants Wojciech Branicki • Fan Liu • Kate van Duijn • Jolanta Draus-Barini • Ewelina Pos´piech • Susan Walsh • Tomasz Kupiec • Anna Wojas-Pelc • Manfred Kayser Received: 23 August 2010 / Accepted: 7 November 2010 / Published online: 4 January 2011 Ó The Author(s) 2010. This article is published with open access at Springerlink.com Abstract Predicting complex human phenotypes from well as blond, and brown hair color with over 0.8 preva- genotypes is the central concept of widely advocated per- lence-adjusted accuracy expressed by the area under the sonalized medicine, but so far has rarely led to high receiver characteristic operating curves (AUC). The iden- accuracies limiting practical applications. One notable tified genetic predictors also differentiate reasonably well exception, although less relevant for medical but important between similar hair colors, such as between red and blond- for forensic purposes, is human eye color, for which it has red, as well as between blond and dark-blond, highlighting been recently demonstrated that highly accurate prediction the value of the identified DNA variants for accurate hair is feasible from a small number of DNA variants. Here, we color prediction. demonstrate that human hair color is predictable from DNA variants with similarly high accuracies. We analyzed in Polish Europeans with single-observer hair color grading Introduction 45 single nucleotide polymorphisms (SNPs) from 12 genes previously associated with human hair color variation. We The concept of personalized medicine assumes that pre- found that a model based on a subset of 13 single or diction of phenotypes based on genome information can compound genetic markers from 11 genes predicted red enable better prognosis, prevention and medical care which hair color with over 0.9, black hair color with almost 0.9, as can be tailored individually (Brand et al. -
Table 1B 2005 Community Prescription Numbers, Together with Government
TABLE 1B 2005 COMMUNITY PRESCRIPTION NUMBERS, TOGETHER WITH GOVERNMENT AND PATIENT COSTS FOR PBS-LISTED DRUGS Table 1B includes an estimate of community (non-public hospital) prescription numbers for the 2005 calendar year, costs (government and patient contribution) for the items with a four digit PBS/RPBS code, together with the defined daily dose (DDD) where assigned. There is no cost information available for items with a five digit Amfac drug code. Table 1 exclude the presentation of information on any item with an estimated community use of less than 110 prescriptions in 2005. The prescription items are arranged by ATC code on generic name, and by form and strength using either the PBS drug code (4 digit) or, for non-PBS items, the Amfac drug code (5 digit). Consult the index (page 255) by generic drug name to obtain the appropriate ATC code. An index by 2nd level of the ATC classification follows: ALIMENTARY TRACT AND METABOLISM PAGE NO A01 STOMATOLOGICAL PREPARATIONS 181 A02 DRUGS FOR ACID RELATED DISORDERS 182 A03 DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS 185 A04 ANTIEMETICS AND ANTINAUSEANTS 187 A05 BILE AND LIVER THERAPY 188 A06 LAXATIVES 189 A07 ANTIDIARRHOEALS, INTESTINAL 191 ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS A08 ANTIOBESITY PREPARATIONS, EXCLUDING DIET PRODUCTS 193 A09 DIGESTIVES, INCLUDING ENZYMES 194 A10 DRUGS USED IN DIABETES 195 A11 VITAMINS 197 A12 MINERAL SUPPLEMENTS 199 A14 ANABOLIC AGENTS FOR SYSTEMIC USE 200 177 BLOOD AND BLOOD FORMING ORGANS B01 ANTITHROMBOTIC AGENTS 201 B02 ANTIHAEMORRHAGICS 203 B03 -
FORENSIC DNA PHENOTYPING and MASSIVE PARALLEL SEQUENCING by Krystal Breslin
FORENSIC DNA PHENOTYPING AND MASSIVE PARALLEL SEQUENCING by Krystal Breslin A Thesis Submitted to the Faculty of Purdue University In Partial Fulfillment of the Requirements for the degree of Master of Science Department of Biological Sciences Indianapolis, Indiana December 2017 ii THE PURDUE UNIVERSITY GRADUATE SCHOOL STATEMENT OF COMMITTEE APPROVAL Dr. Susan Walsh, Chair Department of Biology Dr. Kathleen Marrs Department of Biology Dr. Benjamin Perrin Department of Biology Approved by: Dr. Stephen Randall Head of the Graduate Program iii Dedicated to my husband and two sons. Thank you for always giving me the courage to follow my dreams, no matter where they take us. iv ACKNOWLEDGMENTS I would like to acknowledge and thank everyone who has helped me to become the person I am today. I would like to begin by thanking Dr. Susan Walsh, my PI and mentor. Your passion for science is contagious and has been instrumental in helping to inspire me to pursue my goals. Without your trust and guidance, I would not have been able to grow into the scientist I am today. You are a true role model and I am eternally grateful to have worked with you for the last three years. I cannot wait to see where the future takes you and your research. Secondly, I would like to thank Dr. Ben Perrin and Dr. Kathy Marrs for being a valuable part of my advisory committee. You are both very impressive scientists, and I truly value the input you have provided to my thesis. I would also like to acknowledge and thank each and every member of the Walsh laboratory: Charanya, Ryan, Noah, Morgan, Mirna, Bailey, Stephanie, Lydia, Emma, Clare, Sarah, Megan, Annie, Wesli, Kirsten, Katherine, and Gina. -
Zinc Therapy in Dermatology: a Review
Hindawi Publishing Corporation Dermatology Research and Practice Volume 2014, Article ID 709152, 11 pages http://dx.doi.org/10.1155/2014/709152 Review Article Zinc Therapy in Dermatology: A Review Mrinal Gupta, Vikram K. Mahajan, Karaninder S. Mehta, and Pushpinder S. Chauhan DepartmentofDermatology,Venereology&Leprosy,Dr.R.P.Govt.MedicalCollege,Kangra(Tanda),HimachalPradesh176001,India Correspondence should be addressed to Vikram K. Mahajan; [email protected] Received 1 May 2014; Accepted 23 June 2014; Published 10 July 2014 Academic Editor: Craig G. Burkhart Copyright © 2014 Mrinal Gupta et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Zinc, both in elemental or in its salt forms, has been used as a therapeutic modality for centuries. Topical preparations like zinc oxide, calamine, or zinc pyrithione have been in use as photoprotecting, soothing agents or as active ingredient of antidandruff shampoos. Its use has expanded manifold over the years for a number of dermatological conditions including infections (leishmaniasis, warts), inflammatory dermatoses (acne vulgaris, rosacea), pigmentary disorders (melasma), and neoplasias (basal cell carcinoma). Although the role of oral zinc is well-established in human zinc deficiency syndromes including acrodermatitis enteropathica, it is only in recent years that importance of zinc as a micronutrient essential for infant -
Australian Statistics on Medicines 1997 Commonwealth Department of Health and Family Services
Australian Statistics on Medicines 1997 Commonwealth Department of Health and Family Services Australian Statistics on Medicines 1997 i © Commonwealth of Australia 1998 ISBN 0 642 36772 8 This work is copyright. Apart from any use as permitted under the Copyright Act 1968, no part may be repoduced by any process without written permission from AusInfo. Requests and enquiries concerning reproduction and rights should be directed to the Manager, Legislative Services, AusInfo, GPO Box 1920, Canberra, ACT 2601. Publication approval number 2446 ii FOREWORD The Australian Statistics on Medicines (ASM) is an annual publication produced by the Drug Utilisation Sub-Committee (DUSC) of the Pharmaceutical Benefits Advisory Committee. Comprehensive drug utilisation data are required for a number of purposes including pharmacosurveillance and the targeting and evaluation of quality use of medicines initiatives. It is also needed by regulatory and financing authorities and by the Pharmaceutical Industry. A major aim of the ASM has been to put comprehensive and valid statistics on the Australian use of medicines in the public domain to allow access by all interested parties. Publication of the Australian data facilitates international comparisons of drug utilisation profiles, and encourages international collaboration on drug utilisation research particularly in relation to enhancing the quality use of medicines and health outcomes. The data available in the ASM represent estimates of the aggregate community use (non public hospital) of prescription medicines in Australia. In 1997 the estimated number of prescriptions dispensed through community pharmacies was 179 million prescriptions, a level of increase over 1996 of only 0.4% which was less than the increase in population (1.2%). -
Quantitative Mapping of Human Hair Greying and Reversal in Relation to Life Stress
RESEARCH ARTICLE Quantitative mapping of human hair greying and reversal in relation to life stress Ayelet M Rosenberg1, Shannon Rausser1, Junting Ren2, Eugene V Mosharov3,4, Gabriel Sturm1, R Todd Ogden2, Purvi Patel5, Rajesh Kumar Soni5, Clay Lacefield4, Desmond J Tobin6, Ralf Paus7,8,9, Martin Picard1,4,10* 1Department of Psychiatry, Division of Behavioral Medicine, Columbia University Irving Medical Center, New York, United States; 2Department of Biostatistics, Mailman School of Public Health, Columbia University Irving Medical Center, New York, United States; 3Department of Psychiatry, Division of Molecular Therapeutics, Columbia University Irving Medical Center, New York, United States; 4New York State Psychiatric Institute, New York, United States; 5Proteomics and Macromolecular Crystallography Shared Resource, Columbia University Irving Medical Center, New York, United States; 6UCD Charles Institute of Dermatology & UCD Conway Institute, School of Medicine, University College Dublin, Dublin, Ireland; 7Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, United States; 8Centre for Dermatology Research, University of Manchester, Manchester, United Kingdom; 9Monasterium Laboratory, Mu¨ nster, Germany; 10Department of Neurology, H. Houston Merritt Center, Columbia Translational Neuroscience Initiative, Columbia University Irving Medical Center, New York, United States Abstract Background: Hair greying is a hallmark of aging generally believed to be irreversible and linked to *For correspondence: [email protected] psychological stress. Methods: Here, we develop an approach to profile hair pigmentation patterns (HPPs) along Competing interests: The individual human hair shafts, producing quantifiable physical timescales of rapid greying transitions. authors declare that no Results: Using this method, we show white/grey hairs that naturally regain pigmentation across competing interests exist. -
Genetic Determinants of Skin Color, Aging, and Cancer Genetische Determinanten Van Huidskleur, Huidveroudering En Huidkanker
Genetic Determinants of Skin Color, Aging, and Cancer Genetische determinanten van huidskleur, huidveroudering en huidkanker Leonie Cornelieke Jacobs Layout and printing: Optima Grafische Communicatie, Rotterdam, The Netherlands Cover design: Annette van Driel - Kluit © Leonie Jacobs, 2015 All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system or transmitted in any form or by any means, without prior written permission of the author or, when appropriate, of the publishers of the publications. ISBN: 978-94-6169-708-0 Genetic Determinants of Skin Color, Aging, and Cancer Genetische determinanten van huidskleur, huidveroudering en huidkanker Proefschrift Ter verkrijging van de graad van doctor aan de Erasmus Universiteit Rotterdam op gezag van rector magnificus Prof. dr. H.A.P. Pols en volgens besluit van het College voor Promoties. De openbare verdediging zal plaatsvinden op vrijdag 11 september 2015 om 11:30 uur door Leonie Cornelieke Jacobs geboren te Rotterdam PROMOTIECOMMISSIE Promotoren: Prof. dr. T.E.C. Nijsten Prof. dr. M. Kayser Overige leden: Prof. dr. H.A.M. Neumann Prof. dr. A.G. Uitterlinden Prof. dr. C.M. van Duijn Copromotor: dr. F. Liu COntents Chapter 1 General introduction 7 PART I SKIn COLOR Chapter 2 Perceived skin colour seems a swift, valid and reliable measurement. 29 Br J Dermatol. 2015 May 4; [Epub ahead of print]. Chapter 3 Comprehensive candidate gene study highlights UGT1A and BNC2 37 as new genes determining continuous skin color variation in Europeans. Hum Genet. 2013 Feb; 132(2): 147-58. Chapter 4 Genetics of skin color variation in Europeans: genome-wide association 59 studies with functional follow-up.