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Susan Gottesman, Phd National Institutes of Health Boston Bacterial Meeting 2017 Crystal structure of Hfq in a complex with sRNA, Keynote speaker: RNA binding interfaces highlighted. Modeled using PDB: 4V2S Susan Gottesman, PhD National Institutes of Health Generously sponsored by: 2017 Boston Bacterial Meeting - Schedule and Introduction Thursday June 15 12:00 pm Registration 12:45 pm Opening Remarks I: Bacterial communities Chair: Matthew Ramsey Stephanie High-throughput analysis of targeted mutant libraries reveals new 1:00 pm Shames Legionella pneumophila effector virulence phenotypes Microbial hitchhiking promotes dispersal and colonization of new niches 1:20 pm Tahoura Samad by staphylococci Interactions between species introduce spurious associations in 1:40 pm Rajita Menon microbiome studies: evidence from inflammatory bowel disease The upper respiratory tract commensal Dolosigranulum pigrum inhibits 2:00 pm Silvio Brugger Staphylococcus aureus 2:20 pm Coffee Break II: Morphogenesis Chair: Eddie Geisinger Determining how bacteria regulate their rate of growth at the single- 2:50 pm Yingjie Sun molecule and single-cell levels by super-resolution microscopy Metabolic control of cell morphogenesis: perturbed TCA cycle halts 3:10 pm Irnov Irnov peptidoglycan biosynthesis Membrane remodeling at the division septum by the bacterial actin 3:30 pm Joseph Conti homolog FtsA 3:50 pm Kristin Little A cell envelope stress response system keeps cells in shape 4:10 pm Poster Session I - Science Center (#1-32, 60-66) III: Treatment strategies Chair: Alex Kostic Sebastien 5:30 pm BRACE for resistance: teaching phages to think ahead. Lemire 5:50 pm Jimmy Patel Novel Chemical Tools to Combat Drug-Resistant S. aureus Infection Systems Analysis Identifies Metabolic Components to Antibiotic 6:10 pm Jason Yang Susceptibility and Tolerance 6:30-8:30 PM Reception 1 2017 Boston Bacterial Meeting - Schedule and Introduction Friday June 16 8:30 am Morning Coffee IV: Gene expression Chair: Alexandra Deaconescu Kathleen A clock-phased sigma factor cascade times global circadian 9:00 am Fleming transcriptional rhythms in cyanobacteria Pervasive targeting of nascent transcripts by the RNA chaperone Hfq in 9:20 am Tracy Kambara Pseudomonas aeruginosa Transcriptome analysis of synchronously replicating Mycobacterium 9:40 am Aditya Bandekar tuberculosis yields novel insights into the interplay between cell cycle progression and physiology 10:00 am Poster Session II - Plaza Tent (#33-59, 67-123) V: Metabolism Chair: Robert Brucker Nitrate respiration provides pH dependent fitness and persistence in 11:20 am Emilio Bueno Vibrio cholerae 11:40 am David Cameron Genetic analysis of persister formation in Pseudomonas aeruginosa The Interplay Between the Regulation of Serine Metabolism and Biofilm 12:00 am Jen Greenwich Formation in Bacillus subtilis 12:20 pm Lunch (Breakout Sessions begin at 12:45) VI: Ecology and evolution Chair: Katja Taute Changes in antibiotic use drive enterococcal evolution during an extended 2:00 pm Daria Van Tyne hospital outbreak 2:20 pm Nicole Vega Ecology of bacterial community assembly in a C. elegans host model Jean-Benoit 2:40 pm Convergent protein expression stoichiometry in divergent bacteria Lalanne Leonora Convergence in the microbiomes of natural plant-associated microcosms 3:00 pm Bittleston on different continents 3:20 pm Coffee Break VII: Stress responses Chair: Jeremy Rock Meghan BB0017 is required for virulence and resistance to oxidative stress in the 3:50 pm Ramsey Lyme disease bacterium Borrelia burgdorferi Factors that modulate RecA localization to replication forks with and 4:10 pm Caroline Qin without UV radiation. Diego Vargas Regulation of mRNA stability in mycobacteria as an adaptive response to 4:30 pm Blanco stress conditions 4:50 pm Coffee Break 5:10 pm Keynote Address: Susan Gottesman 6:20 - 8:00 PM Reception Please silence your mobile devices before entering the lecture hall and breakout sessions. Recording or photography of oral or poster presentations is prohibited. Please keep your name badge on at all times during the meeting. Room 111 is available as a mothers' room. A portion of the funding for this year’s conference was made possible by grant R13AI131601 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. 2 2017 Boston Bacterial Meeting - Schedule and Introduction WELCOME! Dear Participants, On behalf of the BBM2017 Organizing Committee, we thank you for attending the 23rd Boston Bacterial Meeting! Over the past 23 years, the BBM has offered an intellectually stimulating and collegial atmosphere for bacteriologists throughout the New England area to discuss cutting-edge scientific research and to share ideas. The BBM is also proud to provide a forum that fosters collaborations between researchers from all levels, within both academia and industry. The BBM has grown significantly since its inception. The past few years have seen record-breaking participation from researchers both near and far. Given last year’s success and by popular demand we have brought back the interactive break out sessions lead by leaders in several fields within microbiology. This year we are also excited about the launching of our new website www.bostonbacterial.org. Although the BBM has undergone many changes over the last 23 years, one crucial element has remained consistent: our commitment to the highest quality research. This is particularly evident in the 24 talks and over 120 posters that will be presented at this year’s meeting. This year we are excited to feature Dr. Susan Gottesman as our Keynote Speaker. Dr. Gottesman is an NIH Distinguished Investigator, Head of the Biochemical Genetics Section at the National Cancer Institute, which is part of the National Institutes of Health (NIH). Dr. Gottesman has pioneered studies on post-transcriptional mechanisms of regulation in bacterial systems, with a focus on the role of energy-dependent proteolysis in regulation and the role of small non-coding RNAs in regulating translation and mRNA stability. Dr. Gottesman is a member of the National Academy of Sciences and the American Academy of Arts and Sciences. She received the Abbott-ASM Lifetime Achievement Award in 2011. The BBM would not be possible without the efforts of the Organizing Committee, a highly motivated and enthusiastic group of graduate students and postdocs dedicated to the success of this meeting. We are also indebted to our faculty sponsors, Tom Bernhardt and Ethan Garner, and meeting founders, Rich Losick, Roberto Kolter, John Mekalanos, and Andrew Wright, and thank them for their continuing guidance. Additionally, we thank our generous industry and NIH sponsors for their financial support! Finally, we thank all of you for your participation and support of the BBM. We hope you will find the next two days both intellectually and socially fulfilling. Thank you for joining us! Patty Rohs and Florencia Caro Co-chairs, BBM2017 3 2017 Boston Bacterial Meeting - Schedule and Introduction KEYNOTE SPEAKER SUSAN GOTTESMAN, PH.D. Susan Gottesman is an NIH Distinguished Investigator in the Biochemical Genetics Section at the National Cancer Institute (NCI), which is part of the National Institutes of Health (NIH). Dr. Gottesman has pioneered studies on post- transcriptional mechanisms of regulation in bacterial systems, with a focus on the role of energy-dependent proteolysis in regulation and the role of small non-coding RNAs in regulating translation and mRNA stability. One focus of her work has been on how these regulatory inputs affect the bacteria’s response to stress. Her laboratory has been interested in novel mechanisms for gene regulation and how these mechanisms contribute to global control circuits in Escherichia coli (E. coli). For many years, the focus of the laboratory was energy-dependent proteolysis. In the past decade, much of the lab has shifted to studying small regulatory RNAs, although they continue to investigate the mechanisms for regulating energy-dependent proteolysis. Her group first encountered small RNAs when studying the regulation of synthesis of a substrate for energy-dependent proteases. They continue to see significant overlap between mRNAs regulated by small RNAs and the products of these mRNAs that are regulated by proteolysis. Dr. Gottesman received her Ph.D. from the Department of Microbiology at Harvard University and became a postdoctoral fellow at the NIH. She then went to the Massachusetts Institute of Technology (MIT) as a research associate and returned to the NIH in 1976 as a senior investigator in the Laboratory of Molecular Biology, where she has remained. She was elected to the National Academy of Sciences in 1998 and the American Academy of Arts and Sciences in 1999. She received the Abbott-ASM Lifetime Achievement Award in 2011. This profile information was adapted from the NIH https://ccr.cancer.gov/Laboratory-of-Molecular- Biology/susan-gottesman 4 2017 Boston Bacterial Meeting – New Faculty NEW MEMBERS OF THE ACADEMIC COMMUNITY As part of the BBM’s goal to foster interactions and collaborations between various individuals and their institutions, we would like to highlight the new members of our research community who have recently begun their appointments. We encourage everyone to provide
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