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Bilateral Third and Unilateral Sixth Nerve Palsies As Early Presenting

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Bilateral Third and Unilateral Sixth Nerve Palsies As Early Presenting Eye (2002) 16, 749–753 2002 Nature Publishing Group All rights reserved 0950-222X/02 $25.00 www.nature.com/eye CE McAvoy1, S Kamalarajab1, R Best1, S Rankin1, CLINICAL STUDY Bilateral third and J Bryars1 and K Nelson2 unilateral sixth nerve palsies as early presenting signs of metastatic prostatic carcinoma Abstract Radiotherapy may be useful for the Purpose To report four cases of cranial treatment of metastatic prostatic carcinoma nerve palsy, which presented to the causing cranial nerve palsies with some ophthalmologist as the only or one of the patients experiencing either complete or earliest manifestations of prostatic carcinoma. partial resolution of their symptoms. The This is an infrequent complication of effect of newer hormonal agents or metastatic prostatic carcinoma usually only chemotherapy on this aspect of the disease is occurring late in the disease process in those not well documented in current literature. with a history of prostatic carcinoma. Eye (2002) 16, 749–753. doi:10.1038/ Methods The case records of four patients sj.eye.6700210 with a history of a cranial nerve palsy who attended the ophthalmology department and Keywords: cranial nerve palsies; base of the who had a recent or subsequent diagnosis of skull metastases; prostatic carcinoma; bilateral prostatic carcinoma were reviewed. third nerve palsies; radiotherapy; prostate Results Diplopia caused by lesions specific antigen affecting the third and sixth nerves sometimes in association with sensory symptoms may be a manifestation of Base of the skull metastases are a rare but 1 metastatic prostatic carcinoma. These documented late complication of metastatic Department of Ophthalmology findings are consistent with base of the skull prostatic carcinoma, which can give rise to Royal Victoria Hospital 1 metastases from the condition. cranial nerve palsies. We report four cases, Belfast Two patients are still alive 54 months and which were unusual in that the nerve palsy Northern Ireland, UK 12 months after the diagnosis. One of the was the presenting feature of the disease in patients died 13 months after the diagnosis two cases and a recent diagnosis of prostatic 2Department of Medicine of prostatic carcinoma was made and the carcinoma had been made in the other two. Ulster Hospital Dundonald other died 21 months after the diagnosis Northern Ireland, UK from an unrelated hypertensive brain Case reports haemorrhage. Correspondence: Conclusion Any patient presenting with CE McAvoy Case 1 diplopia must have an adequate past medical Department of history taken and in an elderly gentleman A 66-year-old male presented with facial Ophthalmology Royal Victoria Hospital this should include symptoms of prostatic tingling, which resolved and was followed by Belfast, BT12 6BA disease. If indicated urological referral and the onset of diplopia. Northern Ireland, UK measurement of prostate specific antigen may Extraocular movements revealed limitation Tel: 02890240503 ext be performed. of upgaze, adduction and depression in both 3822 In patients whose cranial nerve palsy is eyes with full abduction. Slight bilateral ptosis Fax: 02890330744 E-mail: claramcavoyȰ complicated by other sensory signs or those was noted. The right pupil was dilated and hotmail.com. in whom no sign of recovery occurs in 2 unreactive to light and accommodation but months, a contrast CT scan asking for bone the left pupil was normal. The remainder of Received: 14 September windows to be included may be helpful in the physical and neurological examinations 2001 delineating any pathology. were unremarkable. Investigations (blood accepted: 22 March 2002 Nerve palsies in metastatic prostatic carcinoma CE McAvoy et al 750 pressure, full blood picture, ESR, blood sugar, liver the sixth nerve palsy had almost completely resolved. function tests, calcium and phosphate) were normal However 2 months later he reattended with a apart from a raised alkaline phosphatase at 912 IU/l recurrence of the right sixth nerve palsy. Isotope bone (normal Ͼ120 IU/l). Iso-enzyme analysis of alkaline scan showed widespread bony metastases including phosphatase was not performed. However in retrospect tracer uptake involving the base of the skull vault. A considering the liver function tests were otherwise CT scan brain was ordered and revealed a destructive normal the raised alkaline phosphatase was most likely lesion in the upper part of the right clivus (Figure 2). bony in origin. The patient was referred to Oncology for assessment CT scans of abdomen and chest as well as for possible radiotherapy but declined any further ultrasound examination of the liver were normal. intervention and died 3 months later. Several old lacunar infarcts in both parietal lobes were noted on a non-contrast CT of brain. A MRI scan of the brain was arranged. Case 3 Three months later the patient complained of the A 68-year-old male presented with a 2-week history of insidious development of bilateral ptosis. Ophthalmological binocular horizontal diplopia and was found to have a examination now showed an almost complete 3rd right sixth nerve palsy. nerve palsy on the right as well as on the left side After 8 months of continuous review there was only (Figure 1a). Fourth and sixth nerves were intact. Both a slight improvement in the nerve palsy and in the pupils were now dilated and unreactive to light. interim it emerged that the patient had been diagnosed A contrast CT scan including bone windows as having prostate cancer. arranged to investigate the sphenoid sinus changes A CT scan was performed which revealed an noted on a recent MRI showed significant bony enhancing mass lesion in the pituitary fossa, which had overgrowth consistent with sclerotic metastases eroded into the right and left cavernous sinus (Figure 1b). This encroached into the sinus cavity (Figure 3). Pituitary function tests were normal but resulting in compression of the third and fifth nerves PSA was 619.5 ng/ml. in the lateral wall of the cavernous sinus. Prostate To confirm the possible diagnosis of metastatic specific antigen (PSA) was markedly elevated at prostatic carcinoma the lesion was biopsied and a 2768 ng/ml (normal range 0–6.5 ng/ml) and transphenoidal decompression of the pituitary subsequent prostate gland biopsy confirmed the performed. Histology showed a tumour that was diagnosis of prostatic carcinoma. Plain X-ray of the diffusely infiltrative and demonstrated glandular lumbosacral spine showed bony sclerosis in keeping differentiation. Immunohistochemical staining was with metastatic prostatic carcinoma. The patient was strongly positive for PSA. Four and a half years later commenced on cyproterone acetate and goserelin the patient is still alive having been treated with injections. The third nerve palsies improved slightly flutamide and goserelin injections as well as with better lid opening being the most beneficial factor radiotherapy to the pituitary region. noted by the patient. Twenty-one months after the start of symptoms he was admitted to hospital with right-sided weakness Case 4 and decreased consciousness. Emergency CT scan of the brain showed a hypertensive haemorrhage in the A 64-year-old male presented with a 1-day history of region of the basal ganglia and thalamus with binocular horizontal diplopia. Past medical history extension into the ventricles from which the patient included a diagnosis of prostatic carcinoma confirmed subsequently died. on biopsy the previous week. On examination he was found to have right sixth nerve palsy. Two months later he attended with Case 2 numbness down the right side of his face and was also A 76-year-old male presented with a 1-month history found to have impaired right corneal sensation. of binocular horizontal diplopia. Past medical history A CT scan of the brain revealed bony destruction included a recent prostatectomy, which histologically involving the right petrous apex. There was also a soft showed the presence of a moderately differentiated tissue mass extending anteriorly into the prostatic adenocarcinoma. Prostate specific antigen was paracavernous region explaining fifth nerve 414 ng/l. involvement (Figure 4). An isolated right sixth nerve palsy was noted on One year later he is under review by the oncologists extraocular movements. At follow-up 8 months later and is currently on hormonal treatment. Eye Nerve palsies in metastatic prostatic carcinoma CE McAvoy et al 751 Figure 1 (a) Eye movements showing an almost complete third nerve palsy on the right as well as on the left side. (b) Contrast enhanced CT scan showing extensive bony thickening and sclerosis centred in the bony margins of the sphenoid sinus with encroachment on the sinus cavity and extending laterally along the sphenoid wing into the upper part of the clivus. Discussion secondary to a destructive lesion in the clivus being the presenting features of prostatic carcinoma.3 Prostatic carcinoma is the second most common cancer Bilateral third nerve palsy is a rare occurrence. In a in men and is currently receiving much attention from series by Richards et al looking at the causes and both medical and public sources. It is infrequently prognosis of 4278 cases of paralysis of the third, fourth associated with cranial nerve palsies, which usually and sixth nerves there were only nine bilateral third occur many years after the initial diagnosis. The nerve palsies. Five were complete and four were a metastatic lesions either compress or infiltrate the mixture of partial and complete. In this series three of affected nerves.1 Our cases
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