S. Chavez-Álvarez, et al.: Cutaneous manifestations in inflammatory bowel disease Contents available at PubMed www.anmm.org.mx PERMANYER Gac Med Mex. 2016;152:557-64 www.permanyer.com GACETA MÉDICA DE MÉXICO ORIGINAL ARTICLE Cutaneous manifestations in inflammatory bowel disease Sonia Chavez-Álvarez1, Minerva Gómez-Flores1* and Jorge Ocampo-Candiani2 1Dermatology Department; 2Dermatologic Surgery, Hospital Universitario Dr. José Eleuterio González. Monterrey, N.L., Mexico Abstract Inflammatory bowel disease (IBD), mainly chronic unspecific ulcerative colitis and Crohn’s disease have increased in inci- dence in the last decades. These have multiple extraintestinal manifestations, with those of the skin appearing after the in- testinal clinical presentation. These are classified as: granulomatous dermatosis, reactive dermatosis, and those secondary to treatment of IBD, and other dermatosis. This article presents the pathogenesis, clinical approach, treatment and expected evolution of these manifestations. (Gac Med Mex. 2016;152:557-64) Corresponding author: Minerva Gómez-Flores,
[email protected] KEY WORDS: Inflammatory bowel disease. Ulcerative colitis. Crohn’s disease. Oral ulcers. Erythema nodosum. Pyoderma gangrenosum. Sweet´s syndrome. Malnutrition. Fissures. Fistules. (CD), which has an important hereditary component1. ntroduction I Skin manifestations actual prevalence is hard to es- timate due to diagnostic difficulty, but a prevalence Inflammatory bowel disease (IBD) has multiple ex- of up to 40% is estimated in 20 to 40-year old pa- traintestinal manifestations, including skin manifesta- tients2-6. tions that most times appear after the intestinal clinical The presence of human tropomyosin isoform 5 and presentation, which makes it essential identifying them a colonic epithelial protein in the skin, eyes, biliary for an adequate diagnostic and therapeutic approach.