HIV PREVENTION Among Young Injecting Drug Users
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
HIV and Substance Use October 2016
HIV and Substance Use October 2016 Fast Facts • Alcohol and other drugs can affect a person’s judgment and increase risk of getting or transmitting HIV. • In people living with HIV, substance use can worsen the overall consequences of HIV. • Social and structural factors make it difficult to prevent HIV among people who use substances. Substance use disorders, which are problematic patterns of using alcohol or another substance, such as crack cocaine, methamphetamine (“meth”), amyl nitrite (“poppers”), prescription opioids, and heroin, are closely associated with HIV and other sexually transmitted diseases. Injection drug use (IDU) can be a direct route of HIV transmission if people share needles, syringes, or other injection materials that are contaminated with HIV. However, drinking alcohol and ingesting, smoking, or inhaling drugs are also associated with increased risk for HIV. These substances alter judgment, which can lead to risky sexual behaviors (e.g., having sex without a condom, having multiple partners) that can make people more likely to get and transmit HIV. In people living with HIV, substance use can hasten disease progression, affect adherence to antiretroviral therapy (HIV medicine), and worsen the overall consequences of HIV. Commonly Used Substances and HIV Risk • Alcohol. Excessive alcohol consumption, notably binge drinking, can be an important risk factor for HIV because it is linked to risky sexual behaviors and, among people living with HIV, can hurt treatment outcomes. • Opioids. Opioids, a class of drugs that reduce pain, include both prescription drugs and heroin. They are associated with HIV risk behaviors such as needle sharing when injected and risky sex, and have been linked to a recent HIV outbreak. -
Advisory Council on the Misuse of Drugs
ACMD Advisory Council on the Misuse of Drugs Chair: Dr Owen Bowden-Jones Secretary: Zahi Sulaiman 1st Floor (NE), Peel Building 2 Marsham Street London SW1P 4DF Tel: 020 7035 1121 [email protected] Sarah Newton MP Minister for Vulnerability, Safeguarding and Countering Extremism Home Office 2 Marsham Street London SW1P 4DF 10 March 2017 Dear Minister, RE: Further advice on methylphenidate-related NPS In February 2016, my predecessor Professor Les Iversen wrote to the then minister for Preventing Abuse, Exploitation and Crime, requesting that the Temporary Class Drug Order (TCDO) on seven methylphenidate-related Novel Psychoactive Substances be re-laid for a further 12 months. This TCDO was re-laid until June 2017, to allow the Advisory Council on the Misuse of Drugs (ACMD) more time to collect the evidence required to provide further advice for full control under the Misuse of Drugs Act 1971. The ACMD believes that the TCDO has been effective in reducing the prevalence of these substances and that the TCDO level of control was proportionate in the interim. I am now pleased to present to you the ACMD’s further advice on this matter in the enclosed report. The ACMD’s recommendation for full control applies to the seven substances currently controlled under the TCDO and extends to an additional five closely-related substances. These five similar substances have subsequently appeared on markets following the TCDO and are included in this advice due to their potential for similar harms. Recommendation The ACMD recommends that the -
Needle Sharing Among Intravenous Drug Abusers: National and International Perspectives
Needle Sharing Among Intravenous Drug Abusers: National and International Perspectives U. S. DEPARTMENT OF HEALTH AND HUMAN SERVICES • Public Health Service • Alcohol, Drug Abuse, and Mental Health Administration Needle Sharing Among Intravenous Drug Abusers: National and International Perspectives Editors: Robert J. Battjes, D.S.W. Roy W. Pickens, Ph.D. Division of Clinical Research National Institute on Drug Abuse NIDA Research Monograph 80 1988 U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service Alcohol, Drug Abuse, and Mental Health Administration National Institute on Drug Abuse 5600 Fishers Lane Rockville, MD 20857 For sale by the Superintendent of Documents, U.S. Government Printing Office Washington, DC 20402 NIDA Research Monographs are prepared by the research divisions of the National Institute on Drug Abuse and published by its Office of Science. The primary objective of the series is to provide critical reviews of research problem areas and techniques, the content of state-of-the-art conferences, and integrative research reviews. Its dual publication emphasis is rapid and targeted dissemination to the scientific and professional community. Editorial Advisors MARTIN W. ADLER, Ph.D. MARY L. JACOBSON Temple University School of Medrcrne National Federation of Parents for Philadelphia. Pennsylvania Drug-Free Youth Omaha, Nebraska SYDNEY ARCHER, Ph.D. Rensselaer Polytechnic Institute Troy, New York REESE T. JONES, M.D. Langley Porter Neuropsychiatric lnstitute RICHARD E. BELLEVILLE. Ph.D. San Francisco, California NB Associates, Health Sciences RockviIle, Maryland DENISE KANDEL, Ph.D. KARST J. BESTEMAN College of Physicians and Surgeons of Alcohol and Drug Problems Association Columbia University of North America New York, New York Washington, D. -
Treatment of Alzheimer's Disease and Blood–Brain Barrier Drug Delivery
pharmaceuticals Review Treatment of Alzheimer’s Disease and Blood–Brain Barrier Drug Delivery William M. Pardridge Department of Medicine, University of California, Los Angeles, CA 90024, USA; [email protected] Received: 24 October 2020; Accepted: 13 November 2020; Published: 16 November 2020 Abstract: Despite the enormity of the societal and health burdens caused by Alzheimer’s disease (AD), there have been no FDA approvals for new therapeutics for AD since 2003. This profound lack of progress in treatment of AD is due to dual problems, both related to the blood–brain barrier (BBB). First, 98% of small molecule drugs do not cross the BBB, and ~100% of biologic drugs do not cross the BBB, so BBB drug delivery technology is needed in AD drug development. Second, the pharmaceutical industry has not developed BBB drug delivery technology, which would enable industry to invent new therapeutics for AD that actually penetrate into brain parenchyma from blood. In 2020, less than 1% of all AD drug development projects use a BBB drug delivery technology. The pathogenesis of AD involves chronic neuro-inflammation, the progressive deposition of insoluble amyloid-beta or tau aggregates, and neural degeneration. New drugs that both attack these multiple sites in AD, and that have been coupled with BBB drug delivery technology, can lead to new and effective treatments of this serious disorder. Keywords: blood–brain barrier; brain drug delivery; drug targeting; endothelium; Alzheimer’s disease; therapeutic antibodies; neurotrophins; TNF inhibitors 1. Introduction Alzheimer’s Disease (AD) afflicts over 50 million people world-wide, and this health burden costs over 1% of global GDP [1]. -
Epidemics of HIV, HCV and Syphilis Infection Among Synthetic Drugs
www.nature.com/scientificreports OPEN Epidemics of HIV, HCV and syphilis infection among synthetic drugs only users, heroin-only users and Received: 7 November 2017 Accepted: 28 March 2018 poly-drug users in Southwest China Published: xx xx xxxx Shu Su1, Limin Mao 2, Jinxian Zhao3, Liang Chen3, Jun Jing4, Feng Cheng4 & Lei Zhang 1,4,5 The number of poly-drug users who mix use heroin and synthetic drugs (SD) is increasing worldwide. The objective of this study is to measure the risk factors for being infected with hepatitis C (HCV), human immunodefciency virus (HIV) and syphilis among SD-only users, heroin-only users and poly- drug users. A cross-sectional study was conducted in 2015 from a national HIV surveillance site in Southwest China, 447 poly-drug, 526 SD-only and 318 heroin-only users were recruited. Poly-drug users have higher drug-use frequency, higher rates of drug-sharing and unsafe sexual acts than other users (p < 0.05). About a third (36.7%) of poly-drug users experienced sexual arousal due to drug efects, which is higher than the rate among other drug users. Poly-drug users had the highest prevalence of HIV (10.5%) and syphilis (3.6%), but heroin-only users had the highest prevalence of HCV (66.0%) (all p < 0.05) among three groups. Logistic regression shows among poly-drug users, having sex following drug consumption and using drugs ≥1/day were the major risk factors for both HIV (Adjusted odds ratio (AOR) = 2.4, 95% CI [1.8–3.4]; 2.3, [1.6–3.1]) and syphilis infection (AOR = 4.1, [2.1–6.9]; 3.9, [1.8–5.4]). -
Methylphenidate-Based
ACMD Advisory Council on the Misuse of Drugs Chair: Professor Les Iversen Secretary: Zahi Sulaiman 1st Floor (NE), Peel Building 2 Marsham Street London SW1P 4DF Tel: 020 7035 1121 [email protected] Minister of State for Crime Prevention Home Office 2 Marsham Street London SW1P 4DF 31 March 2015 Dear Minister, I am writing to recommend that you lay a temporary class drug order (TCDO) pursuant to section 2A of the Misuse of Drugs Act 1971 on a number of methylphenidate-based NPS: ethylphenidate, 3,4-dichloromethylphenidate (‘3,4- DCMP’), methylnaphthidate (‘HDMP-28’), isopropylphenidate (‘IPP’ or ‘IPPD’) and propylphenidate. Methylphenidate-based NPS Methylphenidate is a licensed stimulant pharmaceutical and is controlled in the UK as a Class B controlled drug. The methylphenidate-related materials being marketed as NPS have psychoactive effects so similar to the parent compound that they can be expected to present similar risks to users. Although ethylphenidate is by far the most widely available of this group, other variants are already in the market place. In the short term, to address the widespread availability of methylphenidate-based NPS and the associated problems which are being reported, the ACMD has considered the evidence on methylphenidate-based NPS and recommends control of these NPS by means of a TCDO. The attached report contains the ACMD’s consideration of the evidence concerning methylphenidate-based NPS. 1 In providing this advice, I would like to convey my thanks to Police Scotland, the National Programme on -
Analysis of Anthrax Immune Globulin Intravenous with Antimicrobial Treatment in Injection Drug Users, Scotland, 2009–2010 Xizhong Cui,1 Leisha D
RESEARCH Analysis of Anthrax Immune Globulin Intravenous with Antimicrobial Treatment in Injection Drug Users, Scotland, 2009–2010 Xizhong Cui,1 Leisha D. Nolen,1 Junfeng Sun, Malcolm Booth, Lindsay Donaldson, Conrad P. Quinn, Anne E. Boyer, Katherine Hendricks, Sean Shadomy, Pieter Bothma, Owen Judd, Paul McConnell, William A. Bower, Peter Q. Eichacker This activity has been planned and implemented through the joint providership of Medscape, LLC and Emerging Infectious Diseases. Medscape, LLC is accredited by the American Nurses Credentialing Center (ANCC), the Accreditation Council for Pharmacy Education (ACPE), and the Accreditation Council for Continuing Medical Education (ACCME), to provide continuing education for the healthcare team. Medscape, LLC designates this Journal-based CME activity for a maximum of 1.00 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. All other clinicians completing this activity will be issued a certificate of participation. To participate in this journal CME activity: (1) review the learning objectives and author disclosures; (2) study the education content; (3) take the post-test with a 75% minimum passing score and complete the evaluation at http://www.medscape.org/journal/eid; and (4) view/print certificate. For CME questions, see page 175. Release date: December 15, 2016; Expiration date: December 15, 2017 Learning Objectives Upon completion of this activity, participants will be able to: 1. Assess recommendations for the management of systemic anthrax and the use of anthrax immune globulin intravenous (AIG-IV) 2. Distinguish variables associated with the application of AIG-IV in the current study 3. -
The Context of HIV Risk Among Drug Users and Their Sexual Partners
National Institute on Drug Abuse RESEARCH MONOGRAPH SERIES The Context of HIV Risk Among Drug Users and Their Sexual Partners 143 U.S. Department of Health and Human Services • Public Health Service • National Institutes of Health The Context of HIV Risk Among Drug Users and Their Sexual Partners Editors: Robert J. Battjes, D.S.W. Zili Sloboda, Sc.D. William C. Grace, Ph.D. NIDA Research Monograph 143 1994 U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service National Institutes of Health National Institute on Drug Abuse 5600 Fishers Lane Rockville, MD 20857 ACKNOWLEDGMENT This monograph is based on the papers from a technical review on “The Context of HIV Risk Among Drug Users and Their Sexual Partners” held on April 22-23, 1993. The review meeting was sponsored by the National Institute on Drug Abuse. COPYRIGHT STATUS The National Institute on Drug Abuse has obtained permission from the copyright holders to reproduce certain previously published material as noted in the text. Further reproduction of this copyrighted material is permitted only as part of a reprinting of the entire publication or chapter. For any other use, the copyright holder’s permission is required. All other material in this volume except quoted passages from copyrighted sources is in the public domain and may be used or reproduced without permission from the Institute or the authors. Citation of the source is appreciated. Opinions expressed in this volume are those of the authors and do not necessarily reflect the opinions or official policy of the National Institute on Drug Abuse or any other part of the U.S. -
Supervised Injection Services: What Has Been Demonstrated?
Drug and Alcohol Dependence 145 (2014) 48–68 Contents lists available at ScienceDirect Drug and Alcohol Dependence j ournal homepage: www.elsevier.com/locate/drugalcdep Review Supervised injection services: What has been demonstrated? ଝ A systematic literature review a,b,∗ c,d e a,b Chloé Potier , Vincent Laprévote , Franc¸ oise Dubois-Arber , Olivier Cottencin , a,b Benjamin Rolland a Department of Addiction Medicine, CHRU de Lille, Univ Lille Nord de France, F-59037 Lille, France b University of Lille 2, Faculty of Medicine, F-59045 Lille, France c CHU Nancy, Maison des Addictions, Nancy F-54000, France d CHU Nancy, Centre d’Investigation Clinique CIC-INSERM 9501, Nancy F-54000, France e Institute of Social and Preventive Medicine, University Hospital Center and University of Lausanne, Chemin de la Corniche 10, 1010 Lausanne, Switzerland a r t i c l e i n f o a b s t r a c t Article history: Background: Supervised injection services (SISs) have been developed to promote safer drug injection Received 18 May 2014 practices, enhance health-related behaviors among people who inject drugs (PWID), and connect PWID Received in revised form 14 October 2014 with external health and social services. Nevertheless, SISs have also been accused of fostering drug use Accepted 14 October 2014 and drug trafficking. Available online 23 October 2014 Aims: To systematically collect and synthesize the currently available evidence regarding SIS-induced benefits and harm. Keywords: Methods: A systematic review was performed via the PubMed, Web of Science, and ScienceDirect Supervised injection service databases using the keyword algorithm [(“SUPERVISED” OR “SAFER”) AND (“INJECTION” OR “INJECT- Safer injection facility ING” OR “SHOOTING” OR “CONSUMPTION”) AND (“FACILITY” OR “FACILITIES” OR “ROOM” OR “GALLERY” Supervised injecting center Drug consumption room OR “CENTRE” OR “SITE”)]. -
Prescription Stimulants
Prescription Stimulants What are prescription stimulants? Prescription stimulants are medicines generally used to treat attention-deficit hyperactivity disorder (ADHD) and narcolepsy— uncontrollable episodes of deep sleep. They increase alertness, attention, and energy. What are common prescription stimulants? • dextroamphetamine (Dexedrine®) • dextroamphetamine/amphetamine combination product (Adderall®) • methylphenidate (Ritalin®, Concerta®). Photo by ©iStock.com/ognianm Popular slang terms for prescription stimulants include Speed, Uppers, and Vitamin R. How do people use and misuse prescription stimulants? Most prescription stimulants come in tablet, capsule, or liquid form, which a person takes by mouth. Misuse of a prescription stimulant means: Do Prescription Stimulants Make You • taking medicine in a way or dose Smarter? other than prescribed Some people take prescription stimulants to • taking someone else’s medicine try to improve mental performance. Teens • taking medicine only for the effect it and college students sometimes misuse causes—to get high them to try to get better grades, and older adults misuse them to try to improve their When misusing a prescription stimulant, memory. Taking prescription stimulants for people can swallow the medicine in its reasons other than treating ADHD or normal form. Alternatively, they can crush narcolepsy could lead to harmful health tablets or open the capsules, dissolve the powder in water, and inject the liquid into a effects, such as addiction, heart problems, vein. Some can also snort or smoke the or psychosis. powder. Prescription Stimulants • June 2018 • Page 1 How do prescription stimulants affect the brain and body? Prescription stimulants increase the activity of the brain chemicals dopamine and norepinephrine. Dopamine is involved in the reinforcement of rewarding behaviors. -
Hallucinogens: an Update
National Institute on Drug Abuse RESEARCH MONOGRAPH SERIES Hallucinogens: An Update 146 U.S. Department of Health and Human Services • Public Health Service • National Institutes of Health Hallucinogens: An Update Editors: Geraline C. Lin, Ph.D. National Institute on Drug Abuse Richard A. Glennon, Ph.D. Virginia Commonwealth University NIDA Research Monograph 146 1994 U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service National Institutes of Health National Institute on Drug Abuse 5600 Fishers Lane Rockville, MD 20857 ACKNOWLEDGEMENT This monograph is based on the papers from a technical review on “Hallucinogens: An Update” held on July 13-14, 1992. The review meeting was sponsored by the National Institute on Drug Abuse. COPYRIGHT STATUS The National Institute on Drug Abuse has obtained permission from the copyright holders to reproduce certain previously published material as noted in the text. Further reproduction of this copyrighted material is permitted only as part of a reprinting of the entire publication or chapter. For any other use, the copyright holder’s permission is required. All other material in this volume except quoted passages from copyrighted sources is in the public domain and may be used or reproduced without permission from the Institute or the authors. Citation of the source is appreciated. Opinions expressed in this volume are those of the authors and do not necessarily reflect the opinions or official policy of the National Institute on Drug Abuse or any other part of the U.S. Department of Health and Human Services. The U.S. Government does not endorse or favor any specific commercial product or company. -
Guidelines and Best Practices for BC's Harm Reduction Supply
Best Practices for British Columbia’s Harm Reduction Supply Distribution Program A provincial best practices document published by the BC Harm Reduction Strategies and Services (BCHRSS) Committee to provide guidance to BC’s harm reduction services, supply distribution, and collection programs. SEPTEMBER 2008 The BC Harm Reduction Strategies and Services (BCHRSS) Committee is comprised of representatives from BC’s Regional Health Authorities, BC Centre for Disease Control and Provincial Health Services Authority, the BC Ministry of Healthy Living and Sport, and First Nations and Inuit Health. The BCHRSS is dedicated to reducing drug-related harms such as death, disease, and injury, including transmission of blood-borne pathogens through the sharing of drug paraphernalia. This document was prepared by River Chandler. 1 Table of Contents Introduction 3 Program Delivery Models 3 Fixed Site Mobile Services Outreach Pharmacy Vending Machines Peer Distribution Policies and Procedures 5 Assessment, Monitoring and Evaluation 5 Staffing 6 Safer Injecting Supplies 6 Safer Crack Cocaine Smoking Supplies 7 Additional Services 7 Education and Health Promotion 8 Needle Recovery and Disposal 8 Population Specific Considerations 9 Women Aboriginal People Involvement of People who use Ilegal Drugs 9 Community Engagement 10 Law Enforcement and Public Order 10 Responsibilities 11 BC Health Authorities Provincial Health Services Authority/British Columbia Centre for Disease Control BC Ministries of Healthy Living and Sport and Health Services Provincial Government