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(12) Patent Application Publication (10) Pub. No.: US 2006/0120980 A1 Eber (43) Pub

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(12) Patent Application Publication (10) Pub. No.: US 2006/0120980 A1 Eber (43) Pub US 2006O120980A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2006/0120980 A1 Eber (43) Pub. Date: Jun. 8, 2006 (54) NOVELDERMATOLOGICAL COMPOSITION Related U.S. Application Data USING BO-ACTIVATING ORGANOCATALYSTS (60) Provisional application No. 60/632,479, filed on Dec. 2, 2004. (76) Inventor: James J. Eberl, Hilton Head Island, SC Publication Classification (US) (51) Int. Cl. A6IR 8/49 (2006.01) Correspondence Address: (52) U.S. Cl. ................................................................ 424/62 COLEMANSUDOLSAPONE, PC. (57) ABSTRACT 714 COLORADO AVENUE BRIDGE PORT, CT 06605-1601 (US) The invention provides novel dermatological compositions and related methods useful in the activation of skin growth factors and growth receptors. Compositions of the invention (21) Appl. No.: 11/292,227 act upon follicle cells and other skin targets to induce hair growth, facilitate dermal cell repair, and enhance skin health. Compositions comprise a bio-activating organocata lyst in a pharmaceutically acceptable carrier, adapted for use (22) Filed: Dec. 1, 2005 on an animal’s skin or hair. US 2006/0120980 A1 Jun. 8, 2006 NOVELDERMATOLOGICAL COMPOSITION over rate is at least a couple of years. Thus, every living USING BO-ACTIVATING ORGANOCATALYSTS tissue is in a dynamic state of chemical change via chemical reactions. RELATED APPLICATIONS 0010. It is a novel concept that the biological reaction 0001. This application claims the benefit of provisional rates can be modified by non-enzymatic chemical catalysts application U.S. 60/632,479, filed Dec. 2, 2004, the entirety thereby drastically changing human processes. Chemical of which is incorporated by reference herein. catalysis has been applied to a myriad of inorganic and organic reactions and huge chemical complexes produce FIELD OF THE INVENTION billions of dollars of products used in about every endeavor of mankind, however its use in biological processes has been 0002 The invention relates to novel dermatological com limited. The present invention is related to applications of positions and related methods which utilize bio-activating chemical catalysis and chemical reaction rate processes to organocatalysts useful in the activation of skin growth dermal effects. It is a new approach to provide favorable factors and growth receptors. Compositions of the invention treatment for dermal conditions as described in greater detail act upon follicle cells and other skin targets to induce hair hereinbelow. growth, facilitate dermal cell repair, and enhance skin health. 0011. The need continues to exist for improved skin care compositions useful in the treatment of skin disorders, improvement in skin condition and in promotion of hair BACKGROUND OF THE INVENTION growth that utilize biologically compatible components to 0003 Free radical formation has long been associated achieve desired dermatological clinical endpoints such as with detrimental physical occurrences including tissue dam dermal cell repair or follicle stimulation through their bio age. While transition metal-containing compositions and logical reactivity. enzymes have been used in the treatment of skin disorders and in hair growth stimulation, such compositions have not OBJECTS OF THE INVENTION utilized controlled redox reactions to achieve desired der matological clinical endpoints. Our previous invention made 0012. It is an object of the invention to provide improved use of such controlled redox reactions to achieve desired skin care compositions useful in the treatment of skin, skin dermatological clinical endpoints, including hair growth and disorders and in promotion of hair growth. skin restoration. 0013. It is an additional object of the invention to provide improved compositions and methods useful in the treatment 0004 U.S. Pat. No. 5,888,522 discloses peptone digests of skin disorders and in promotion of hair growth that utilize complexed with one or more ionic transition metals, such as cosmetically compatible bio-activating organic catalysts copper, indium, tin, Zinc, or the salts thereof, that are alleged to be useful in treating a variety of skin disorders. Japanese which promote and enhance cellular mechanisms to achieve Patent No. 2002332217 to Fujii, et al. discloses hair stimu desired dermatological clinical endpoints. lating compositions containing coenzyme Q. 0014. It is a still further object of the invention to provide improved compositions and methods useful in the treatment 0005 U.S. Pat. No. 6,544,531 discloses that: (1) retinol of skin disorders and in promotion of hair growth that utilize or vitamin A alcohol is useful in the reduction of fine lines, cosmetically compatible bio-activating organic catalysts to wrinkles, and mottled hyperpigmentation in skin; (2) hydroxy acids, and particularly alpha-hydroxy acids, are achieve or enhance dermal cell repair and follicle stimula useful in increasing the clarity of the skin Surface, increasing tion. cellular turnover, and increasing skin radiance and Smooth 0015. Any one or more of these and/or other objects of ness; and (3) ascorbic acid has skin permeation and collagen the invention may be readily gleaned from a review of the synthesis activity. U.S. Pat. No. 6,544,531 discloses com description of the invention which follows. positions which include: a retinoid and preferably retinol; a dermatologically active acid; and a volatile base. Such as, for SUMMARY OF THE INVENTION example, ammonium hydroxide. 0016. In accordance with the above stated objects, the 0006 All living organisms and their processes can be instant invention provides improved skin care/hair care described by two chemical reaction rate constants as fol compositions useful in the treatment of skin, skin disorders lows: and in promotion of hair growth that utilize bio-activating organocatalysts and optional components to achieve dermal 0007) (death) k <========================== cell repair and follicle stimulation. Compositions of the >k (growth) instant invention comprise an effective amount of a bio 0008 Human biology is a dynamic cellular process all activating organocatalyst (as defined in greater detail herein) controlled by chemical reaction rates. At equilibrium, the in combination with carrier, and preferably includes com reaction rate constants are equal while in youth k is larger ponents or ingredients which are typical for skin care or hair thank, while in old age, k exceeds k. care products. In addition, compositions according to the present invention may include effective amounts of novel, 0009. Some cellular processes are very rapid, e.g., including synergistic combinations of exfoliating agents, mucous membranes turn over every 24 to 48 hours. Others peroxidant reducing agents, and trace metal catalysts. All of can be slow, e.g., prostate cells require as long as one year these compositions may be used to provide useful improve for replacement. Even bone replaces itself where the turn ments in hair growth, skin improvement (in condition, tone US 2006/0120980 A1 Jun. 8, 2006 and appearance), to treat wounds, including skin ulcers, skin reduX agent such as dihydroxymaleic acid, lipoic acid, inflammation, acne, keratoses and for insect bite relief. dihydrolipoic acid or cholesterol, undergoes an oxidation reaction with the transition metal-containing component to 0017. In alternative embodiments, compositions accord produce hydrogen peroxide which enhances dermal health ing to the instant invention may be used to treat Sore throat, and hair growth. This effect may be additive or synergistic stomach ulcers, and cancer, especially including stomach with the bio-activating organocatalysts according to the cancer and skin cancer, breast cancer, intestinal cancer, cardiovascular diseases and disease states, including athero present invention. In alternative embodiments, an effective Sclerosis, an aging heart (by enhancing contraction effi amount of a topical fever-producing agent and/or chemical ciency, for example, by providing a positive inotropic effect irritant can be used in the present compositions in place of or by enhancing a favorable heart rate by increasing the (i.e., as a replacement for) or in addition to the redox agent growth and repair of vital neurological systems operating at and/or the optional transition metal-containing component. an efficiency nature designed), to treat kidney failure and 0020 Compositions of the instant invention optionally avoid end-stage renal disease, and to treat, rebuild and repair contain a dermatologically active acid as a descquamation/ damage to tissues caused by infectious disease, including exfoliating agent that may be a cosmetically active acid or diseases caused by microbes, including viruses, bacteria and a pharmaceutically active acid, such as, for example, a fungi. In these methods, effective amounts of compositions hydroxy acid, ascorbic acid or a derivative thereof, lipoic are administered to a patient in need of therapy for an acid, dihydrolipoic acid, or a combination thereof, which aforementioned disease state or condition. also may be included as a redox agent in compositions 0018 Compositions according to the present invention according to the present invention. comprise an effective amount of bio-activating organocata 0021 Compositions of the instant invention provide a lyst in combination with a carrier as defined herein, prefer visible improvement in skin condition shortly following ably along with additional traditional components which are application of the composition to the
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