Evidence Process Documentation

Evidence Process for Hip Pain Guideline Research 9-26-17 Guideline Review using ADAPTE method and AGREE II instrument – 9/19/2017

~60 Potentially relevant guidelines identified in various resources*

16 Guidelines appraised ~44 using AGREE II analysis Guidelines Excluded

Exclusion Criteria: Non-English language Pediatrics Age of Publication Ex-U.S. focus 11 5 Limited information on advanced imaging Guidelines meeting AGREE II inclusion threshold Guidelines not meeting AGREE II inclusion of combined total score ≥ 90 threshold of combined total score ≥ 90 AND Rigor of Development Scaled Domain Score AND Rigor of Development Scaled Domain Score Percentage > 50% Percentage > 50% All were included in detailed ADAPTE recommendation analysis

*Information Resources: Ovid Medline, NCBI PubMed, National Guideline Clearinghouse, Guidelines International Network, TRIP Database, Choosing Wisely, Cochrane Database, Agency for Healthcare Research and Quality, and numerous specialty society websites Additional Internet and bibliographic searches were performed for all phases of research For use only in connection with development of AUC by the CDI Quality Institute’s Multidisciplinary Committee Evidence Process for Hip Pain Guideline Research 9/26/2017

Systematic Literature Research –Ovid Medline Database (01/01/2016 – 09/06/2017)

PICO: Suspected stress or fragility fracture with negative or indeterminate x-ray High-Level and Prospective Search Strategy: (fractur* and (hip or femoral)) AND (CT or computed tomography or computed tomography arthrogram or MRI or MRA or magnetic resonance or magnetic resonance arthrogram or bone scan or bone scintigraphy or HDP or MDP or 99mTc or PET CT or PET or SPECT or imaging) AND ((systemati* review or (randomiz* control* or RCT or randomized controlled trial*) or guidance or guideline or recommendation or (meta analysis or meta-analysis)) OR (clinical study OR clinical trial, all OR clinical trial, phase i OR clinical trial, phase ii OR clinical trial, phase iii OR clinical trial, phase iv OR clinical trial OR comparative study OR controlled clinical trial OR evaluation studies OR meta-analysis OR multicenter study OR observational study OR pragmatic clinical trial OR randomized controlled trial OR systematic review OR twin study or validation studies).pt)) NOT (case adj2 (report or study or reports or studies)) AND limit to (english language and humans and yr="2016 -Current" and "all adult (19 plus years)") 47 results in Ovid

44 Abstracts Screened Excluded 3 Observational Studies

Evidence Table References 3 Observational Studies

For use only in connection with development of AUC by the CDI Quality Institute’s Multidisciplinary Committee Evidence Process for Hip Pain Guideline Research 9/19/2017

Systematic Literature Research –Ovid Medline Database (01/01/2016 – 09/06/2017)

PICO: Suspected labral tear with or without femoral acetabular impingement, with or without previous surgery High-Level and Prospective Search Strategy: ((((labral tear or labrum tear or labral injury or labrum injury) AND (hip or acetabulum or acetabular)) OR (ischiopedic impingement or iliopsoas impingement or ischiotrochanteric impingement or subspinous impingement or subline impingement or trochanteric impingement or ischiofemoral impingement or femoropelvic impingement or femoroacetabular impingement or FAI)) AND (CT or computed tomography or computed tomography arthrogram or MRI or MRA or magnetic resonance or magnetic resonance arthrogram or bone scan or bone scintigraphy or HDP or MDP or 99mTc or PET CT or PET or SPECT or imaging) AND ((systemati* review or (randomiz* control* or RCT or randomized controlled trial*) or guidance or guideline or recommendation or (meta analysis or meta-analysis)) OR (clinical study OR clinical trial, all OR clinical trial, phase i OR clinical trial, phase ii OR clinical trial, phase iii OR clinical trial, phase iv OR clinical trial OR comparative study OR controlled clinical trial OR evaluation studies OR meta-analysis OR multicenter study OR observational study OR pragmatic clinical trial OR randomized controlled trial OR systematic review OR twin study or validation studies).pt)) NOT (case adj2 (report or study or reports or studies)) AND limit to (english language and humans and yr="2016 -Current" and "all adult (19 plus years)") 12 results in Ovid

10 Abstracts Screened 2 Observational Studies Excluded

Evidence Table References 1 Observational Study

For use only in connection with development of AUC by the CDI Quality Institute’s Multidisciplinary Committee Evidence Process for Hip Pain Research 09-26-17

Systematic Literature Research – Ovid Embase and Medline Databases (01/01/2007 – 09/20/2017)

47 Results

13 Results Diagnostic Accuracy Search Strategy: Search run on 09/20/2017

High-Level Search Strategy: Search run on 09/19/2017 (Osteoarthritis or OA or Hip,Osteoarthritis) AND (Hip) (Osteoarthritis or OA or Hip,Osteoarthritis) AND (Hip) AND AND (Radiography or x-ray) AND (CT or computed tomography or MRI or magnetic resonance) (Radiography or x-ray) AND (CT or computed tomography or MRI or magnetic resonance) AND AND ((yield or incidence or prevalence or frequency or (probability and (pre-test or pretest or post-test or posttest)) or “test probability” or “odds ratio” or ("systemati* review" or "randomiz* control*" or RCT or "randomized “hazard ratio” or “relative risk”) or (sensitivity or specificity or accuracy or controlled trial*" or guidance or guideline or recommendation or “receiver operating characteristic” or “likelihood ratio” or LR+ or LR- or "meta analysis or meta-analysis") “predictive value” or NPV or PPV ) or (management or “decision making” or therapy)) AND AND Limit to (English language and humans and yr=”2007-Current”) Limit to (English language and humans and yr="2012 -Current")

1 Abstracts Screened 12 1 Guideline 5 Abstracts Screened Excluded 5 Observational and 44 other Studies Excluded

Evidence Table References Evidence Table References 1 Guideline 2 Observational Studies 1 Research Study

*Information Resources: Ovid EmBase and Medline, NCBI PubMed, National Guideline Clearinghouse, Guidelines International Network, TRIP Database, Choosing Wisely, Cochrane Database, Agency for Healthcare Research and Quality, and numerous specialty society websites Additional Internet and bibliographic searches were performed for all phases of research For use only in connection with development of AUC by the CDI Quality Institute’s Multidisciplinary Committee Evidence Process for Hip Pain Guideline Research 09-26-17

Systematic Literature Research – Ovid Medline Databases (01/01/2015 – 09/06/2017)

33 Results

High-level and Prospective Search Strategy: Search run on 09/06/2017

((bursitis AND (intertrochanteric OR trochanter* OR ischial OR iliopectineal) OR ((hip OR glute* OR iliopsoas OR piriformis) AND (tendin* OR tear OR rupture))) AND (CT or (computed tomography) or (computed tomography arthrogram) or MRI or MRA or (magnetic resonance) or (magnetic resonance arthrogram) or (bone scan) or (bone scintigraphy) or HDP or MDP or 99mTc or (PET CT) or PET or SPECT) AND ((systemati* review or (randomiz* control* or RCT or randomized controlled trial*) or guidance or guideline or recommendation or (meta analysis or meta-analysis) OR (clinical study OR clinical trial, all OR clinical trial, phase i OR clinical trial, phase ii OR clinical trial, phase iii OR clinical trial, phase iv OR clinical trial OR comparative study OR controlled clinical trial OR evaluation studies OR meta- analysis OR multicenter study OR observational study OR pragmatic clinical trial OR randomized controlled trial OR systematic review OR twin study or validation studies)) AND Limit to (English language and humans and yr=”2015-Current”) NOT

(case AND (report or study or reports or studies))

7 Abstracts Screened 2 Meta-Analyses Studies 28 5 Observational and Excluded Other Studies

Evidence Table References 2 Meta-Analyses Studies 3 Observational and Other Studies

For use only in connection with development of AUC by the CDI Quality Institute’s Multidisciplinary Committee Evidence Process for Hip Pain Guideline Research 09-26-17

Systematic Literature Research – Ovid Medline Databases (01/01/2016 – 09/06/2017)

14 Results

High-level and Prospective Search Strategy: Search run on 09/06/2017

((septic or sepsis or osteomyelitis or (infectious arthritis) or (bacterial arthritis) or (viral arthritis)) AND (Hip or femor*)) AND (CT or (computed tomography) or (computed tomography arthrogram) or MRI or MRA or (magnetic resonance) or (magnetic resonance arthrogram) or (bone scan) or (bone scintigraphy) or HDP or MDP or 99mTc or (PET CT) or PET or SPECT) AND ((systemati* review or (randomiz* control* or RCT or randomized controlled trial*) or guidance or guideline or recommendation or (meta analysis or meta-analysis) OR (clinical study OR clinical trial, all OR clinical trial, phase i OR clinical trial, phase ii OR clinical trial, phase iii OR clinical trial, phase iv OR clinical trial OR comparative study OR controlled clinical trial OR evaluation studies OR meta- analysis OR multicenter study OR observational study OR pragmatic clinical trial OR randomized controlled trial OR systematic review OR twin study or validation studies)) AND Limit to (English language and humans and yr=”2016-Current”) NOT

(case AND (report or study or reports or studies))

2 Abstracts Screened 1 RCT 12 1 Research Study Excluded

Evidence Table References 1 RCT 1 Research Study

For use only in connection with development of AUC by the CDI Quality Institute’s Multidisciplinary Committee Evidence Process for Hip Pain Guideline Research 09-26-17

Systematic Literature Research – Ovid Medline Databases (01/01/2007 – 09/06/2017)

235 Results

High-level and Prospective Search Strategy: Search run on 09/06/2017

((Neoplasm* or metastasis or malignanc* or tumor or lytic or sclerotic or sclerosis or blastic) AND (Hip or femor*)) AND (CT or (computed tomography) or (computed tomography arthrogram) or MRI or MRA or (magnetic resonance) or (magnetic resonance arthrogram) or (bone scan) or (bone scintigraphy) or HDP or MDP or 99mTc or (PET CT) or PET or SPECT) AND ((systemati* review or (randomiz* control* or RCT or randomized controlled trial*) or guidance or guideline or recommendation or (meta analysis or meta-analysis) OR (clinical study OR clinical trial, all OR clinical trial, phase i OR clinical trial, phase ii OR clinical trial, phase iii OR clinical trial, phase iv OR clinical trial OR comparative study OR controlled clinical trial OR evaluation studies OR meta- analysis OR multicenter study OR observational study OR pragmatic clinical trial OR randomized controlled trial OR systematic review OR twin study or validation studies)) AND Limit to (English language and humans and yr=”2007-Current”) NOT

(case AND (report or study or reports or studies))

9 Abstracts Screened 231 9 Comparative and Excluded Other Studies

Evidence Table References 4 Comparative and Other Studies

For use only in connection with development of AUC by the CDI Quality Institute’s Multidisciplinary Committee