University of Groningen Brain Death and Organ Donation Hoeksma, Dane
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University of Groningen Brain death and organ donation Hoeksma, Dane IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2017 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Hoeksma, D. (2017). Brain death and organ donation: Observations and interventions. Rijksuniversiteit Groningen. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. 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Download date: 28-09-2021 CHAPTER 9 LIST OF ABBREVIATIONS EDTA Ethylenediaminetetraacetic acid DCIP 2,6-dichloroindophenol ECD Expanded critera donors AKI Acute kidney injury FAO Fatty acid oxidation Paw Airway pressure FOV Field of view ALT Alanine transaminase FiO2 Fraction of inspired oxygen ADH Antidiuretic hormone FeNa Fractional sodium excretion ASL Arterial spin labelling GPx Glutathione peroxidase AST Aspartate transaminase GR Glutathione reductase AST Aspartate transaminase GAPDH Glyceraldehyde 3-phosphate dehydrogenase BOLD Blood oxygen level dependent HO-1 Heme oxygenase 1 BW Body weight H2O2 Hydrogen Peroxide BSA Bovine serum albumin HAES Hydroxethyl starch BD Brain death IL-6 Interleukin 6 9 FCCP Carbonyl cyanide-4-(trifuoromethoxy) phenylhydrazone IL-10 Interleukin-10 9 CAT Catalase IL-6 Interleukin-6 CPP Cerebral perfusion pressure ICP Intracranial pressure Cxcl1 Chemokine ligand 1 I-R Ischemia-reperfusion Ccl2 Chemokine ligand 2 IPK Isolated perfused kidney CK-MB Creatine kinase (myocardium) LDH Lactate dehydrogenase CrC Creatinine clearance LDHA Lactate dehydrogenase A Cinc1 Cytokine induced neutrophil chemoattractant1 LD Living donor DBD Deceased brain-dead MRI Magnetic resonance imaging DCD Deceased circulatory death MDA Malondialdehyde DGF Delayed graft function MnTMPyP: Manganese(III) tetrakis(1-methyl-4-pyridyl)porphyrin DGF Delayed graft function MAP Mean arterial pressure DPBS Dulbecco’s phosphate-buffered saline MCP-1 Monocyte chemotactic protein 1 TE Echo time NAG N-acetyl- -D-glucosaminidase ETC Electron transport chain NADPH nicotinamide adenine dinucleotide phosphate ETCO2 End-tidal CO2 NA Noradrenaline 146 147 CHAPTER 9 GSSG Oxidized glutathione SaO2 Oxygen saturation PAS Periodic-Acid Schiff PMSF Phenylmethylsulfonyl fuoride PBS Phosphate buffered saline Pfk-1 Phosphofructokinase-1 PMN Polymorphonuclear PEEP Positive end expiratory pressure PNF Primary non-function P-P Probability-probabilty Pc Pyruvate carboxylase Pk Pyruvate kinase ROS Reactive oxygen species 9 GSH Reduced glutathione 9 TR Repetition time RCR Respiratory control ratio Crs Serum creatinine SD Standard deviation SOD: Superoxide dismutase SVR Systemic vascular resistance TLDA TaqMan low density array TBA Thiobarbituric acid TGF- Transforming growth factor-beta TCA Tricarboxylic acid TNF- α Tumor necrosis factor alpha TNF- α Tumor necrosis factor α UCr Urinary creatinine Vcam1 Vascular adhesion molecule 1 H2O Water W/D Wet-dry 148 149 CHAPTER 9 AUTHOR AFFILIATIONS YS Bodar1 NR Jespersen2 HE Bøtker2 C Laustsen11 A Breedijk3 HGD Leuvenink1 J Bubberman1 NJ Majenberg1 JGM Burgerhof4 R Nørregaard9 J Ciapaite5,6 PJ Ottens1 M Erasmus7 M Pedersen11 AC van Erp1 RA Rebolledo1,12,13 H van Goor8 ZS Veldhuis1 D Hoeksma1 J Wiersema-Buist1 CMV Hottenrott1 JC Wolters5,14 B Jespersen9,10 B Yard3 1 - Department of Surgery, Groningen Transplant Center, University Medical Center Groningen, the Netherlands 2 - Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark 3 - Department of Medicine, Nephrology, Endocrinology, Diabetology, Rheumatology, 9 Heidelberg University, Mannheim, Germany 9 4 - Faculty of Medical Sciences, Department of Epidemiology, University Medical Center Groningen, Groningen, The Netherlands 5 - Systems Biology Centre for Energy Metabolism and Ageing, University of Groningen, Groningen, the Netherlands. 6 - Department of Pediatrics, University Medical Center Groningen, Groningen, the Netherlands. 7 - Deparment of cardiothoracical surgery, University Medical Center Groningen, Groningen, the Netherlands 8 - Department of Pathology and Medical Biology, University Medical Center Groningen, Groningen, the Netherlands 9 - Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. 10 - Department of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark 11 - MR Research Center, Clinical Institute, Aarhus University, Aarhus, Denmark. 12 - Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile. 13 - Department of Digestive Surgery, Faculty of Medicine. Pontifcia Universidad Católica de Chile, Santiago, Chile. 14 - Department of Analytical Biochemistry, Research Institute of Pharmacy, University of Groningen, Groningen, The Netherlands. 150 151 CHAPTER 9 ACKNOWLEDGMENTS I would like to thank Jan Niesing for providing data and fgures at the eleventh hour! I would like to start off by mentioning the frst three guys I met when I just arrived in Norbert Majenberg en Sonja Buisman. My beloved students! I know I learned a lot from Groningen: Martijn Posthumus, Diederik van Korven, and Wouter aan de Stegge. supervising you and I hope you guys learned a thing or two from me! I enjoyed working Experiencing my frst year in Groningen just would not have been the same without the together with the both of you! three of you. You guys know what I mean! After having to have moved from Utrecht, the days spent with you guys made this transition to Groningen feel seamless. We became Atta Rehman, in was in dire need of another oxidative stress outcome measurement and friends and made that year a true once in a life-time experience! Thinking about it and as a matter of chance there you were! Thanks for helping me with the lab work and the realizing those days are gone makes me sad! I love you guys! Indian food we enjoined on numerous occasions! I hope you and your family are doing well in Pakistan! Henri, or as they say these days: professor Leuvenink! The moment I stepped into your offce I immediately knew I was in the right place! You have the ability to appeal to a wide Danial, you are the kind of person that radiates warmth and openness, even in the middle variety of people which is something I really admire. Thanks for believing in me from the of the night when we met in the lab! I knew I had a friend in you the frst time we met! We time I set foot in your offce! should make that trip to Iran soon! Pragmatic, charismatic, and sympathetic is how I would describe you professor van Goor. Anne Koning and Leon van Dullemen, I don’t know anyone who even closely resembles It’s these characteristics which drew me to you and I think the same holds true for many either of you! You are unique in both your own ways and I am glad I started (and fnished!) others! I really admire your work ethic and learned a great deal from you even though we my PhD project alongside you guys! only started working extensively together in the last year of my PhD! Offce mates Dirk Bosch and Maarten Niebling, sitting in the offce with you guys was a Jacco Zwaagstra, as the head of the lab I really had to watch out for you! Not adhering total experience! Getting pencil cases fown at my neck at a hundred miles an hour whilst to protocols and not wearing a lab-coat got me into trouble with you on a regular basis! listening to the worst music outweighed the fact that no work got done! However, this never stood in the way of a good friendship and I really enjoyed our talks, 9 especially about travelling abroad! Thanks to everyone else from surgical research lab, Welmoet, Geert, Bo, Jeffrey, 9 Michael, Douwe, Jelle, Ton, Valerie, Jan-binne, Peter, Dafna, Leonie and from other Petra, to put it simple, you were indispensable throughout my PhD time! My frst days in labs Vicenzo Terlizzi and Marc Seelen. the lab were under your supervision as were some of my last! I never stopped learning from you. Your organizational and of course technical skills were essential for me and my All other fellow medical students who made my medical and PhD career an unforgettable experiments! one: Catherine de Sonnaville, Ignas Houben, Ashling Stel, Moniek Wouters, Guy Metting van Rijn, Erik Heeg, Michiel van Basten-Batenburg, Thank you! Suzanne, thanks for putting a smile on my face every time you were in the lab! Your soft- natured personality is something truly amazing! Thanks for helping me around the lab and All members of the Masterraad, Manon Crull, Broes Vervliet, Bernard Vonck, Jorien van with experiments every now and then! Dooren, thanks for the times we spent together! Janneke, I think you have the most experience out of anyone in the lab! The passion and My paranymphs Rik Mencke en Marc Kirschbaum. Rik, we got to know each other at the determination you bring to the job is admirable! Thanks for always helping me so swiftly start of both our PhD’s. Even though you were working on a completely different topic, with any histology work! I hope you have a great time in your new house! you knew all the details of mine due to the endless amount of questions I would ask you! If there was anyone I could ask for help any place, anywhere, anytime, it was you! You Maxi & Rolando. Older than me, both of you were like mentors to me considering the really saved me at moments! You are a person who is truly yourself and not afraid to show amount of experience and “know how” you brought to the table.