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Evodiae Fructus on Targeted Distribution of Berberine in Rats
Int J Clin Exp Med 2018;11(8):7701-7709 www.ijcem.com /ISSN:1940-5901/IJCEM0073795 Original Article Effects of Evodiae Fructus on targeted distribution of berberine in rats Rui-Feng Liang, Wen-Jing Ge, Hui-Sen Wang, She-Feng Zhang, Xue-Xia Zhang, Geng-Sheng Li Institute of Chinese Materia Medica, Henan Provincial Academy of Traditional Chinese Medicine, Zhengzhou 450003, Henan Province, China Received September 20, 2017; Accepted May 24, 2018; Epub August 15, 2018; Published August 30, 2018 Abstract: According to Traditional Chinese Medicine (TCM) theories, Evodiae Fructus (EF) was considered as a meridian guiding drug (MGD) in Zuojin Pill and could enhance the effectiveness of prescription. However, the sci- entific evidence for this effect is still unclear. In this study, the meridian guiding mechanism of EF was investigated. Rats were randomly divided into four groups, control group (water), low dose of EF (250 mg/kg), medium dose of EF (500 mg/kg) and high dose of EF (1000 mg/kg). Water or EF was given to the rats by intragastric administra- tion for 7 days. After the last administration, berberine (80 mg/kg) was administered to rats by gavage. Then the blood and tissues of interest were collected at predetermined time points. Concentrations of berberine in different tissues were analysed by ultra-performance liquid-chromatography tandem mass spectrometry (UPLC-MS/MS) and the target parameters including relative targeting efficiency (RTE), relative uptake efficiency (RUE) and maximum relative concentration (RCmax) were calculated. Compared with control group, various doses of EF could improve the targeting efficiency of berberine in liver. -
(12) Patent Application Publication (10) Pub. No.: US 2010/0221245 A1 Kunin (43) Pub
US 2010O221245A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2010/0221245 A1 Kunin (43) Pub. Date: Sep. 2, 2010 (54) TOPICAL SKIN CARE COMPOSITION Publication Classification (51) Int. Cl. (76) Inventor: Audrey Kunin, Mission Hills, KS A 6LX 39/395 (2006.01) (US) A6II 3L/235 (2006.01) A638/16 (2006.01) Correspondence Address: (52) U.S. Cl. ......................... 424/133.1: 514/533: 514/12 HUSCH BLACKWELL SANDERS LLP (57) ABSTRACT 4801 Main Street, Suite 1000 - KANSAS CITY, MO 64112 (US) The present invention is directed to a topical skin care com position. The composition has the unique ability to treat acne without drying out the user's skin. In particular, the compo (21) Appl. No.: 12/395,251 sition includes a base, an antibacterial agent, at least one anti-inflammatory agent, and at least one antioxidant. The (22) Filed: Feb. 27, 2009 antibacterial agent may be benzoyl peroxide. US 2010/0221 245 A1 Sep. 2, 2010 TOPCAL SKIN CARE COMPOSITION stay of acne treatment since the 1950s. Skin irritation is the most common side effect of benzoyl peroxide and other anti BACKGROUND OF THE INVENTION biotic usage. Some treatments can be severe and can leave the 0001. The present invention generally relates to composi user's skin excessively dry. Excessive use of some acne prod tions and methods for producing topical skin care. Acne Vul ucts may cause redness, dryness of the face, and can actually garis, or acne, is a common skin disease that is prevalent in lead to more acne. Therefore, it would be beneficial to provide teenagers and young adults. -
Caen Ion Tech Manual 2018
TECHNICAL INFORMATION MANUAL Revision 01 – 4 July 2016 R4301P UHF Long Range Reader with GPRS/WIFI Visit the Ion R4301P web page, you will find the latest revision of data sheets, manuals, certifications, technical drawings, software and firmware. All you need to start using your reader in a few clicks! Scope of Manual The goal of this manual is to provide the basic information to work with the Ion R4301P UHF Long Range Reader with GPRS/WIFI. Change Document Record Date Revision Changes Pages 17 Mar 2016 00 Preliminary release - Added CE Compliance, CE Declaration of Conformity, FCC Grant 54, 55, 56, 57 04 Jul 2016 01 part B, FCC Grant part C Modified RoHS EU Directive 54 Reference Document [RD1] EPCglobal: EPC Radio-Frequency Identity Protocols Class-1 Generation-2 UHF RFID Protocol for Communications at 860 MHz – 960 MHz, Version 2.0.1 (April, 2015). [RD2] G.S.D. s.r.l. - Report Federal Communication Commission (FCC) – R4301P – Ion UHF Long Range Reader. Test report n. FCC-16574B Rev. 00 – 20 April 2014. [RD3] G.S.D. s.r.l. - Report Federal Communication Commission (FCC) – R4301P – Ion UHF Long Range Reader. Test report n. FCC-16547 Rev. 00 – 20 April 2014 CAEN RFID srl Via Vetraia, 11 55049 Viareggio (LU) - ITALY Tel. +39.0584.388.398 Fax +39.0584.388.959 [email protected] www.caenrfid.com © CAEN RFID srl – 2016 Disclaimer No part of this manual may be reproduced in any form or by any means, electronic, mechanical, recording, or otherwise, without the prior written permission of CAEN RFID. -
Multiplierz: an Extensible API Based Desktop Environment for Proteomics Data Analysis
multiplierz: An Extensible API Based Desktop Environment for Proteomics Data Analysis The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters Citation Parikh, Jignesh R., Manor Askenazi, Scott B. Ficarro, Tanya Cashorali, James T. Webber, Nathaniel C. Blank, Yi Zhang, and Jarrod A. Marto. 2009. multiplierz: an extensible API based desktop environment for proteomics data analysis. BMC Bioinformatics 10: 364. Published Version doi:10.1186/1471-2105-10-364 Citable link http://nrs.harvard.edu/urn-3:HUL.InstRepos:4724757 Terms of Use This article was downloaded from Harvard University’s DASH repository, and is made available under the terms and conditions applicable to Other Posted Material, as set forth at http:// nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of- use#LAA BMC Bioinformatics BioMed Central Software Open Access multiplierz: an extensible API based desktop environment for proteomics data analysis Jignesh R Parikh1, Manor Askenazi2,3,4, Scott B Ficarro2,3, Tanya Cashorali2, James T Webber2, Nathaniel C Blank2, Yi Zhang2 and Jarrod A Marto*2,3 Address: 1Bioinformatics Program, Boston University, 24 Cummington Street, Boston, MA, 02115, USA, 2Department of Cancer Biology and Blais Proteomics Center, Dana-Farber Cancer Institute, 44 Binney Street, Smith 1158A, Boston, MA, 02115-6084, USA, 3Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA, 02115, USA and 4Department of Biological Chemistry, -
Volume 128 September, 2017
Volume 128 September, 2017 Solving The Case Of The GIMP Tutorial: Awful Laptop Keyboard Exploring G'MIC Word Processing With LaTeX Tip Top Tips: Slow KDE (A Real World Example) Applications Open/Save Dialogs Workaround Playing Villagers And Repo Review: Heroes On PCLinuxOS Focus Writer PCLinuxOS Family Member Lumina Desktop Spotlight: plankton172 Customization 2017 Total Solar Eclipse PCLinuxOS Magazine Wows North America Page 1 Table Of Contents 3 From The Chief Editor's Desk ... 5 2017 Solar Eclipse Wows North America The PCLinuxOS name, logo and colors are the trademark of 9 ms_meme's Nook: PCLinuxOS Melody Texstar. 10 Solving The Case Of The The PCLinuxOS Magazine is a monthly online publication containing PCLinuxOS-related materials. It is published Awful Laptop Keyboard primarily for members of the PCLinuxOS community. The magazine staff is comprised of volunteers from the 13 Screenshot Showcase PCLinuxOS community. 14 Lumina Desktop Configuration 25 Screenshot Showcase Visit us online at http://www.pclosmag.com 26 PCLinuxOS Family Member Spotlight: This release was made possible by the following volunteers: plankton172 Chief Editor: Paul Arnote (parnote) Assistant Editor: Meemaw 27 Screenshot Showcase Artwork: Timeth, ms_meme, Meemaw Magazine Layout: Paul Arnote, Meemaw, ms_meme 28 GIMP Tutorial: Exploring G'MIC HTML Layout: YouCanToo 30 Screenshot Showcase Staff: 31 ms_meme's Nook: ms_meme phorneker Meemaw YouCanToo Everything's Gonna Be All Right Gary L. Ratliff, Sr. Pete Kelly Agent Smith Cg Boy 32 Word Processing With LaTeX daiashi Smileeb (A Real World Example) 45 Repo Review: Focus Writer Contributors: 46 Screenshot Showcase dm+ 47 Playing Villagers and Heroes in PCLinuxOS 50 PCLinuxOS Recipe Corner 51 Screenshot Showcase The PCLinuxOS Magazine is released under the Creative Commons Attribution-NonCommercial-Share-Alike 3.0 52 Tip Top Tips: Slow KDE Application Unported license. -
System: Host: Antix1 Kernel: 4.19.100-Antix.1
System: Host: antix1 Kernel: 4.19.100-antix.1-amd64-smp x86_64 bits: 64 compiler: gcc v: 6.3.0 parameters: BOOT_IMAGE=/boot/vmlinuz-4.19.100-antix.1-amd64-smp root=UUID=5d143bb5-75eb-450e-abef-5d8958ee6a67 ro quiet Desktop: IceWM 1.4.2 info: icewmtray dm: SLiM 1.3.4 Distro: antiX-17.4.1_x64-full Helen Keller 28 March 2019 base: Debian GNU/Linux 9 (stretch) Machine: Type: Laptop System: Acer product: Aspire A114-31 v: V1.09 serial: <filter> Chassis: type: 10 serial: <filter> Mobo: APL model: Bulbasaur_AP v: V1.09 serial: <filter> UEFI: Insyde v: 1.09 date: 10/17/2017 Battery: ID-1: BAT1 charge: 31.2 Wh condition: 36.7/37.0 Wh (99%) volts: 8.7/7.7 model: PANASONIC AP16M5J type: Li-ion serial: <filter> status: Charging Memory: RAM: total: 3.69 GiB used: 493.4 MiB (13.0%) RAM Report: permissions: Unable to run dmidecode. Root privileges required. PCI Slots: Permissions: Unable to run dmidecode. Root privileges required. CPU: Topology: Dual Core model: Intel Celeron N3350 bits: 64 type: MCP arch: Goldmont family: 6 model-id: 5C (92) stepping: 9 microcode: 38 L2 cache: 1024 KiB bogomips: 4377 Speed: 2244 MHz min/max: 800/2400 MHz Core speeds (MHz): 1: 1397 2: 1440 Flags: 3dnowprefetch acpi aes aperfmperf apic arat arch_capabilities arch_perfmon art bts cat_l2 clflush clflushopt cmov constant_tsc cpuid cpuid_fault cx16 cx8 de ds_cpl dtes64 dtherm dts ept ept_ad erms est flexpriority fpu fsgsbase fxsr ht ibpb ibrs ida intel_pt lahf_lm lm mca mce md_clear mmx monitor movbe mpx msr mtrr nonstop_tsc nopl nx pae pat pbe pclmulqdq pdcm pdpe1gb pebs -
MXM-6410 Ubuntu Linux 9.04 (Jaunty Jackalope) User’S Manual V1.2
MXM-6410/APC-6410 Linux User’s Manual v1.2 Computer on Module COM Ports Two USB Hosts LCD Ethernet SD MXM-6410 Ubuntu Linux 9.04 (Jaunty Jackalope) User’s Manual v1.2 1 MXM-6410/APC-6410 Linux User’s Manual v1.2 Table of Contents CHAPTER 1 MXM-6410/APC-6410 UBUNTU LINUX (JAUNTY JACKALOPE) FEATURES .. 5 1.1 BOARD SUPPORT PACKAGE (BSP) .................................................................................................. 5 1.2 DRIVERS ......................................................................................................................................... 5 1.3 DEFAULT SOFTWARE PACKAGES ..................................................................................................... 7 1.4 SPECIAL FEATURES ....................................................................................................................... 21 CHAPTER 2 SYSTEM INFORMATION .......................................................................................... 23 2.1 STARTING EVKM-MXM-6410 ..................................................................................................... 23 2.2 JUMPER SETTING .......................................................................................................................... 24 2.3 CONNECTORS ................................................................................................................................ 29 CHAPTER 3 USING UBUNTU JAUNTY JACKALOPE ................................................................ 33 3.1 BOOTING ..................................................................................................................................... -
(12) United States Patent (10) Patent No.: US 8,784.852 B2 Kunin (45) Date of Patent: Jul
US008784852B2 (12) United States Patent (10) Patent No.: US 8,784.852 B2 Kunin (45) Date of Patent: Jul. 22, 2014 (54) TOPICAL SKIN CARE COMPOSITION Katiyar SK, Ahmad N. Mukhtar H. Green Tea and Skin, Abstract from Arch Dermatol, 2000 Aug. pp. 989-994, Volume-Issue 136(8). (76) Inventor: Audrey Kunin, Mission Hills, KS (US) Hiipakka RA, Zhang HZ, Dai W. Dai Q, Liao S., Structure-activity relationships for inhibition of human 5alphareductases by (*) Notice: Subject to any disclaimer, the term of this polyphenols., Abstract from Biochem Pharmacol., Mar. 15, 2002, pp. patent is extended or adjusted under 35 1165-1176, Volume-Issue 63(6). Wenchieh Chen, Diane Thiboutot, Christos C Zouboulis, Cutaneous U.S.C. 154(b) by 437 days. Androgen Metabolism: Basic Research and Clinical Perspectives, Abstract from Journal of Investigative Dermatology, 2002, pp. 992 (21) Appl. No.: 12/395,251 1007, vol. 119. Daniel B. Yarosh, Jason W. Galvin, Stephanie L. Nay, Arely V. Pena, (22) Filed: Feb. 27, 2009 Matthew T. Canning, David A. Brown, Anti-inflammatory activity in skin by biomimetic of Evodia rutaecarpa extract from traditional (65) Prior Publication Data Chinese medicine, Journal of Dermatological Science, 2006, pp. US 2010/0221245 A1 Sep. 2, 2010 13-21, vol. 42. Gustavo Moura-Letts, León F. Villegas, Ana Marcalo, Abraham J Vaisberg, Gerald B. Hammond. In Vivo Wound-Healing Activity of (51) Int. Cl. Oleanolic Acid Derived from the Acid Hydrolysis of Anredera dif A6 IK 8/02 (2006.01) fusa, Abstract from J. Nat. Prod., 2006, pp. 978-979, Volume-Issue A 6LX3/075 (2006.01) 69(6). -
Upgrading and Performance Analysis of Thin Clients in Server Based Scientific Computing
Institutionen för Systemteknik Department of Electrical Engineering Examensarbete Upgrading and Performance Analysis of Thin Clients in Server Based Scientific Computing Master Thesis in ISY Communication System By Rizwan Azhar LiTH-ISY-EX - - 11/4388 - - SE Linköping 2011 Department of Electrical Engineering Linköpings Tekniska Högskola Linköpings universitet Linköpings universitet SE-581 83 Linköping, Sweden 581 83 Linköping, Sweden Upgrading and Performance Analysis of Thin Clients in Server Based Scientific Computing Master Thesis in ISY Communication System at Linköping Institute of Technology By Rizwan Azhar LiTH-ISY-EX - - 11/4388 - - SE Examiner: Dr. Lasse Alfredsson Advisor: Dr. Alexandr Malusek Supervisor: Dr. Peter Lundberg Presentation Date Department and Division 04-02-2011 Department of Electrical Engineering Publishing Date (Electronic version) Language Type of Publication ISBN (Licentiate thesis) X English Licentiate thesis ISRN: Other (specify below) X Degree thesis LiTH-ISY-EX - - 11/4388 - - SE Thesis C-level Thesis D-level Title of series (Licentiate thesis) 55 Report Number of Pages Other (specify below) Series number/ISSN (Licentiate thesis) URL, Electronic Version http://www.ep.liu.se Publication Title Upgrading and Performance Analysis of Thin Clients in Server Based Scientific Computing Author Rizwan Azhar Abstract Server Based Computing (SBC) technology allows applications to be deployed, managed, supported and executed on the server and not on the client; only the screen information is transmitted between the server and client. This architecture solves many fundamental problems with application deployment, technical support, data storage, hardware and software upgrades. This thesis is targeted at upgrading and evaluating performance of thin clients in scientific Server Based Computing (SBC). Performance of Linux based SBC was assessed via methods of both quantitative and qualitative research. -
Fedora 16 Release Notes Release Notes for Fedora 16
Fedora 16 Release Notes Release Notes for Fedora 16 Edited by The Fedora Docs Team Copyright © 2011 Fedora Project Contributors. The text of and illustrations in this document are licensed by Red Hat under a Creative Commons Attribution–Share Alike 3.0 Unported license ("CC-BY-SA"). An explanation of CC-BY-SA is available at http://creativecommons.org/licenses/by-sa/3.0/. The original authors of this document, and Red Hat, designate the Fedora Project as the "Attribution Party" for purposes of CC-BY-SA. In accordance with CC-BY-SA, if you distribute this document or an adaptation of it, you must provide the URL for the original version. Red Hat, as the licensor of this document, waives the right to enforce, and agrees not to assert, Section 4d of CC-BY-SA to the fullest extent permitted by applicable law. Red Hat, Red Hat Enterprise Linux, the Shadowman logo, JBoss, MetaMatrix, Fedora, the Infinity Logo, and RHCE are trademarks of Red Hat, Inc., registered in the United States and other countries. For guidelines on the permitted uses of the Fedora trademarks, refer to https:// fedoraproject.org/wiki/Legal:Trademark_guidelines. Linux® is the registered trademark of Linus Torvalds in the United States and other countries. Java® is a registered trademark of Oracle and/or its affiliates. XFS® is a trademark of Silicon Graphics International Corp. or its subsidiaries in the United States and/or other countries. MySQL® is a registered trademark of MySQL AB in the United States, the European Union and other countries. All other trademarks are the property of their respective owners. -
The Krusader Handbook the Krusader Handbook
The Krusader Handbook The Krusader Handbook 2 Contents 1 Introduction 14 1.1 Package description . 14 1.2 Welcome to Krusader! . 14 2 Features 17 3 User Interface 21 3.1 OFM User Interface . 21 3.2 Krusader Main Window . 21 3.3 Toolbars . 21 3.3.1 Main Toolbar . 21 3.3.2 Job Toolbar . 23 3.3.3 Actions Toolbar . 23 3.3.4 Location Toolbar . 23 3.3.5 Panel Toolbar . 23 3.4 Panels . 24 3.4.1 List Panel . 24 3.4.2 Sidebar . 25 3.4.3 Folder History . 26 3.5 Command Line / Terminal Emulator . 26 3.5.1 Command Line . 26 3.5.2 Terminal Emulator . 27 3.6 Function (FN) Keys Bar . 27 3.7 Folder Tabs . 28 3.8 Buttons . 28 4 Basic Functions 29 4.1 Controls . 29 4.1.1 General . 29 4.1.2 Moving Around . 29 4.1.3 Selecting . 30 4.1.4 Executing Commands . 30 4.1.5 Quick search . 31 4.1.6 Quick filter . 31 The Krusader Handbook 4.1.7 Quick select . 31 4.1.8 Context Menu . 31 4.2 Basic File Management . 32 4.2.1 Executing Files . 32 4.2.2 Copying and Moving . 32 4.2.3 Queue manager . 32 4.2.4 Deleting - move to Plasma Trash . 33 4.2.5 Shred Files . 33 4.2.6 Renaming Files, Creating Directories and Link Handling . 33 4.2.7 Viewing and Editing files . 33 4.3 Archive Handling . 34 4.3.1 Browsing Archives . 34 4.3.2 Unpack Files . -
Cyclooxygenase
COX Cyclooxygenase Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane. Pharmacological inhibition of COX can provide relief from the symptoms of inflammation and pain. Drugs, like Aspirin, that inhibit cyclooxygenase activity have been available to the public for about 100 years. Two cyclooxygenase isoforms have been identified and are referred to as COX-1 and COX-2. Under many circumstances the COX-1 enzyme is produced constitutively (i.e., gastric mucosa) whereas COX-2 is inducible (i.e., sites of inflammation). Non-steroidal anti-inflammatory drugs (NSAID), such as aspirin and ibuprofen, exert their effects through inhibition of COX. The main COX inhibitors are the non-steroidal anti-inflammatory drugs (NSAIDs). www.MedChemExpress.com 1 COX Inhibitors, Antagonists, Activators & Modulators (+)-Catechin hydrate (-)-Catechin Cat. No.: HY-N0355 ((-)-Cianidanol; (-)-Catechuic acid) Cat. No.: HY-N0898A (+)-Catechin hydrate inhibits cyclooxygenase-1 (-)-Catechin, isolated from green tea, is an (COX-1) with an IC50 of 1.4 μM. isomer of Catechin having a trans 2S,3R configuration at the chiral center. Catechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. Purity: 99.59% Purity: 98.78% Clinical Data: Phase 4 Clinical Data: No Development Reported Size: 100 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg (-)-Catechin gallate (-)-Epicatechin ((-)-Catechin 3-gallate; (-)-Catechin 3-O-gallate) Cat. No.: HY-N0356 ((-)-Epicatechol; Epicatechin; epi-Catechin) Cat. No.: HY-N0001 (-)-Catechin gallate is a minor constituent in (-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) green tea catechins.