Modeling a Transdisciplinary Approach to Current Research
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NATIONAL HISPANIC SCIENCE NETWORK ON DRUG ABUSE Tenth Annual International Conference Modeling a Transdisciplinary Approach to Current Research Agendas September 30-October 2, 200 The Westin Canal Place New Orleans, Louisiana Mission Statement The National Hispanic Science Network on Drug Abuse is dedicated to improving the health of Hispanics by increasing the amount and quality of interdisciplinary translational research on drug abuse, and fostering the development of Hispanic scientists in drug abuse research. National Steering Committee Patricia E. Molina, M.D., Ph.D. William A. Vega, Ph.D. Chair, NHSN Vice-Chair, NHSN Richard Ashman Professor & Head Provost Professor & Director, Roybal Institute Department of Physiology University of Southern California Director, Alcohol & Drug Abuse Center Louisiana State University Health Sciences Center María Elena Icaza Medina-Mora, Ph.D. Chief Director, Department of Epidemiology Sergio Aguilar-Gaxiola, M.D., Ph.D. & Psychosocial Research, Instituto Nacional Professor of Clinical Internal Medicine & Director de Psiquiatría, Ramón de la Fuente, Mexico Center for Reducing Health Disparities (CRHD) University of California, Davis Laura O’Dell, Ph.D. Chair, Early Career Leadership Subcommittee Margarita Alegría, Ph.D. Assistant Professor Professor, Center for Multicultural Mental Health Department of Psychology Research University of Texas at El Paso Cambridge Health Alliance Steffanie A. Strathdee, Ph.D. Hortensia Amaro, Ph.D. Associate Dean of Global Health Sciences Associate Dean, Bouvé College of Health Sciences Harold Simon Professor & Chief Distinguished Professor of Health Sciences & Division of Global Public Health, Department Counseling Psychology of Medicine, University of California, San Diego Director, Institute on Urban Health Research Bouvé College of Health Sciences José Szapocznik, Ph.D. Northeastern University Professor & Chair Department of Epidemiology & Public Health C. Hendricks Brown, Ph.D. Associate Dean for Translational Research Professor, Department of Epidemiology & Public Health & Community Development University of Miami University of Miami Leonard M. Miller School of Medicine Leonard M. Miller School of Medicine Ana Mari Cauce, Ph.D. Yonette F. Thomas, Ph.D. Dean, College of Arts & Sciences Associate Vice President, Research & Compliance University of Washington Howard University, Washington, DC Voluntary Associate Professor of Epidemiology and Diana Martínez, M.D. Public Health University of Miami, Leonard M. Miller Associate Professor School of Medicine Department of Psychiatry Columbia University Avelardo Valdez, Ph.D. Professor & Director, Center for Drug & Social Policy Research Graduate College of Social Work, University of Houston Modeling a Transdisciplinary Approach to Current Research Agendas Scientific Program for Thursday 30 September 200 0 7:30 AM–5:00 PM REGISTRATION 8:00 AM–8:30 AM CONTINENTAL BREAKFAST AND NETWORKING 8:30 AM–8:45 AM WELCOMING REMARKS (Ballroom) Patricia E. Molina, M.D., Ph.D., Chair, NHSN Richard Ashman Professor & Head, Department of Physiology, Director, Alcohol & Drug Abuse Centerr of Excellence, Louisiana State University Health Sciences Center Diana Martinez, M.D., 2010 NHSN Scientific Conference Chair Associate Professor, Department of Psychiatry, Columbia University Segio Aguilar-Gaxiola, M.D., Ph.D., 2010 NHSN Scientific Conference Co-Chair Professor of Clinical Internal Medicine & Director, Center for Reducing Health Disparities, University of California, Davis Jean Lud Cadet, M.D., 2010 NHSN Scientific Conference Chair Chief, Molecular Neuropsychiatry Research Branch, National Institutes of Health National Institute on Drug Abuse, Intramural Research Program Thursday – September 30, 20 8:45 AM–9:45 AM PLENARY OPENING SESSION (Ballroom) PRESENTER Antonello Bonci, M.D., Scientific Director, NIH/NIDA, Intramural Research Program (IRP) “Synaptic Plasticity in the Dopamine System: Therapeutic Implications for Substance Use Disorders” DESCRIPTION Experience-dependent plasticity at excitatory synapses of the mesocorticolimbic system is a fundamental brain mechanism that enables adaptation to an ever-changing environment. These synaptic responses are critical for the planning and execution of adaptive behaviors that maximize survival. The mesocorticolimbic system mediates procurement of positive reinforcers such as food and sex; however, drugs of abuse re-sculpt this crucial circuitry to promote compulsive drug-seeking behavior. My presentation will discuss the long-term changes in glutamatergic neurotransmission that occur within the mesolimbic system following drug exposure. In addition, we will discuss the possibility of AMPARs as promising targets against cocaine abuse. 9:45 AM–0:5 AM QUESTIONS AND ANSWERS FOR THIS SESSION 0:5 AM–0:45 AM COFFEE BREAK & NETWORKING 0:45 AM–2:5 PM EPIGENETICS IN DRUG ABUSE RESEARCH: WHAT WE KNOW (Ballroom) DESCRIPTION This panel will provide a view of epigenetics and its significance in understanding the link between biology and environment. Most of the genetic variants that have been identified have only small effects on the risk of developing the common diseases with which they have been associated (i.e. asthma, heart disease, diabetes, addictions, etc). A large challenge remains in accounting for the rest of the heritability of the risk. At the forefront of these challenges is the environment, which may be the fulcrum balancing the effects of genetic variation with gene expression. As eloquently described by LaPlant and Nestler (200), “epigenetics is a molecular translator that interprets diverse environmental stimuli into changes in gene expression via the regulation of chromatin structure”. Panelists will provide the audience with a brief overview of epigenetics, a discussion of how animal models can potentially inform an understanding of the role of epigenetics in addiction, and the challenges of linking genome- wide epigenetic studies to population health. CO-CHAIRS Yonette Thomas, Ph.D, Associate Vice President for Research and Compliance, Howard University, Washington, D.C., Voluntary Associate Professor of Epidemiology and Public Health University of Miami, Leonard M. Miller School of Medicine. Guillermo Prado, Ph.D., Associate Professor of Epidemiology and Public Health, Director of the Doctorate in Epidemiology Program, University of Miami, Leonard M. Miller School of Medicine PRESENTERS Joni Rutter, Ph.D., Associate Director for Population and Applied Genetics, Division of Basic Neuroscience and Behavioral Research, NIDA/NIH “On Top of Genetics: An Overview of Epigenetics” Jerry Stitzel, Ph.D., Associate Professor, Institute for Behavioral Genetics, University of Colorado at Boulder “Epigenetics in Animal Models of Addiction: Opportunities and Challenges” 2 National Hispanic Science Network On Drug Abuse Tenth Annual Conference Thursday – September 30, 20 Matt McQueen, Ph.D., Assistant Professor, Institute for Behavioral Genetics, University of Colorado at Boulder “Integrating Epigenetics into Population-Based Studies of Complex Disease” 2:5 PM–2:45 PM QUESTIONS AND ANSWERS FOR THIS SESSION 12:45 PM–2:00 PM MENTORING LUNCHEON (Crescent Ballroom) “From Public Housing to Distinguished Professor: The Story of how Nena Became Dr. Amaro” PRESENTER Hortensia Amaro, Ph.D., Associate Dean, Distinguished Professor of Health Sciences & Counseling Psychology, Director, Institute on Urban Health Research, Bouvé College of Health Sciences, Northeastern University, Boston, MA DESCRIPTION In this presentation I hope to share my own experiences of how my personal history and social context informed the choices I made, how I managed adversity, and who I became professionally. This is a very personal and individual story, with an n of . Nevertheless, my hope in sharing it with you is to hopefully inspire you to reflect on your own life journey, what your basic principles are, and how these have shaped your professional choices and work. Why is this important? Integrating who we are in various spheres of our lives, that is having an integrated sense of self, requires reflection and self understanding. I believe that such understanding serves as the basis for how we respond to challenging situations and difficult decisions that most of us face at some point in our professional lives 0 as academics and researchers. For example, we often face decisions regarding opportunities that come along, disappointments/discouragements and questions about whether to persevere in our areas of interest, whether to stay or leave a certain position or whether to accept a job offer. Without a clear internal compass of who you are, your values and passion, such decisions will be difficult to make. 2:00 PM–3:00 PM PLENARY SESSION (Ballroom) PRESENTER Nora D. Volkow, M.D., Director, National Institute on Drug Abuse/National Institutes of Health “The Promise of Transdisciplinary Approaches to Accelerating Addiction Research” DESCRIPTION The inherent complexity of drug abuse and addiction, with levels of influence ranging from genetic/ epigenetic, developmental and bio-behavioral to social and environmental necessitates their study from across a wide array of scientific disciplines. Transdisciplinary approaches where teams of researchers pool their expertise to accelerate new knowledge about the interplay of individual, social and environmental factors in initiating and sustaining these disorders and their many harmful consequences are critical to progress in developing effective strategies for their prevention