ORIGINAL ARTICLES Tianjin University of Traditional Chinese Medicine1, Tian Jin; Institute of Medicinal Plant Development2, Chinese Academy of Medical Sciences and Peking Union Medical College, Bei Jing, China Antidepressant-like effect and phytochemical profile of supercritical CO2 extract from Citri reticulatae pericarpium FENGXIA LI1, KANGLI ZHANG1,2, MENG YU2, TONGTONG CHEN1,2, LIYAN MA2, HONGWU ZHANG2, HONGMEI JIA2,*, ZHONGMEI ZOU2,* Received February 18, 2021, accepted March 26. 2021 *Corresponding authors: Zhong Mei Zou, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College. No. 151 Malianwa North Road, Haidian District, Beijing 100193 P. R. China
[email protected] HongMei Jia, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College. No. 151 Malianwa North Road, Haidian District, Beijing 100193 P. R. China
[email protected] Pharmazie 76: 249-255 (2021) doi: 10.1691/ph.2021.1408 Citri reticulatae pericarpium is a condiment, adding much flavor in Chinese food. Also it can be used to treat depression as a Traditional Chinese Medicine (TCM). The study here aimed to evaluate the antidepressant effect between the supercritical CO2 extract (SC-E) from Citri reticulatae pericarpium and the essential oil extracted by steam distillation (SD-E). And chemical compositions of SC-E were qualitatively analyzed by ultra-perfor- mance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) and gas chro- matography-mass spectrometry (GC-MS). Compared with SD-E, SC-E showed a stronger antidepressant-like effect in FST and TST mice. And it also decreased the content of monoamine oxidase (MAO) in the cerebral cortex of stressed mice.