KCNQ3 Antibody Cat. No.: 57-914
KCNQ3 Antibody
Specifications
HOST SPECIES: Rabbit
SPECIES REACTIVITY: Mouse
This KCNQ3 antibody is generated from rabbits immunized with a KLH conjugated IMMUNOGEN: synthetic peptide between 651-679 amino acids from the C-terminal region of human KCNQ3.
TESTED APPLICATIONS: WB
APPLICATIONS: For WB starting dilution is: 1:1000
PREDICTED MOLECULAR 97 kDa WEIGHT:
Properties
This antibody is purified through a protein A column, followed by peptide affinity PURIFICATION: purification.
CLONALITY: Polyclonal
ISOTYPE: Rabbit Ig
CONJUGATE: Unconjugated
October 1, 2021 1 https://www.prosci-inc.com/kcnq3-antibody-57-914.html PHYSICAL STATE: Liquid
BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
CONCENTRATION: batch dependent
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
OFFICIAL SYMBOL: KCNQ3
Potassium voltage-gated channel subfamily KQT member 3, KQT-like 3, Potassium ALTERNATE NAMES: channel subunit alpha KvLQT3, Voltage-gated potassium channel subunit Kv73, KCNQ3
ACCESSION NO.: O43525
GENE ID: 3786
USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background and References
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and one of two related proteins encoded BACKGROUND: by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2).
REFERENCES: 1) Bailey, S.D., et al. Diabetes Care (2010) In press :
2) Gomez-Posada, J.C., et al. J. Neurosci. 30(27):9316-9323(2010)
3) Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
4) Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
ANTIBODIES FOR RESEARCH USE ONLY.
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