KCNQ3 Antibody Cat. No.: 57-914 KCNQ3 Antibody Specifications HOST SPECIES: Rabbit SPECIES REACTIVITY: Mouse This KCNQ3 antibody is generated from rabbits immunized with a KLH conjugated IMMUNOGEN: synthetic peptide between 651-679 amino acids from the C-terminal region of human KCNQ3. TESTED APPLICATIONS: WB APPLICATIONS: For WB starting dilution is: 1:1000 PREDICTED MOLECULAR 97 kDa WEIGHT: Properties This antibody is purified through a protein A column, followed by peptide affinity PURIFICATION: purification. CLONALITY: Polyclonal ISOTYPE: Rabbit Ig CONJUGATE: Unconjugated October 1, 2021 1 https://www.prosci-inc.com/kcnq3-antibody-57-914.html PHYSICAL STATE: Liquid BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide. CONCENTRATION: batch dependent Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. Additional Info OFFICIAL SYMBOL: KCNQ3 Potassium voltage-gated channel subfamily KQT member 3, KQT-like 3, Potassium ALTERNATE NAMES: channel subunit alpha KvLQT3, Voltage-gated potassium channel subunit Kv73, KCNQ3 ACCESSION NO.: O43525 GENE ID: 3786 USER NOTE: Optimal dilutions for each application to be determined by the researcher. Background and References The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and one of two related proteins encoded BACKGROUND: by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2). REFERENCES: 1) Bailey, S.D., et al. Diabetes Care (2010) In press : 2) Gomez-Posada, J.C., et al. J. Neurosci. 30(27):9316-9323(2010) 3) Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) : 4) Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009) ANTIBODIES FOR RESEARCH USE ONLY. For additional information, visit ProSci's Terms & Conditions Page. October 1, 2021 2 https://www.prosci-inc.com/kcnq3-antibody-57-914.html.