RESEARCH ARTICLE Spatial characteristics and the epidemiology of human infections with avian influenza A (H7N9) virus in five waves from 2013 to 2017 in Zhejiang Province, China Haocheng Wu1,2☯, XinYi Wang1☯, Ming Xue3, Melanie Xue4, Chen Wu1, Qinbao Lu1, Zheyuan Ding1, Xiaoping Xv1, Junfen Lin1,2* a1111111111 1 Zhejiang Province Center for Disease Control and Prevention, Hangzhou, Zhejiang Province, China, 2 Key Laboratory for Vaccine, Prevention and Control of Infectious Disease of Zhejiang Province, Hangzhou, a1111111111 Zhejiang Province, China, 3 Hangzhou Centre for Disease Control and Prevention, Hangzhou, Zhejiang, a1111111111 Province, China, 4 Kingston University UK, London, United Kingdom a1111111111 a1111111111 ☯ These authors contributed equally to this work. *
[email protected] Abstract OPEN ACCESS Citation: Wu H, Wang X, Xue M, Xue M, Wu C, Lu Q, et al. (2017) Spatial characteristics and the Background epidemiology of human infections with avian The five-wave epidemic of H7N9 in China emerged in the second half of 2016. This study influenza A(H7N9) virus in five waves from 2013 to 2017 in Zhejiang Province, China. PLoS ONE 12(7): aimed to compare the epidemiological characteristics among the five waves, estimating the e0180763. https://doi.org/10.1371/journal. possible infected cases and inferring the extent of the possible epidemic in the areas that pone.0180763 have not reported cases before. Editor: Florian Krammer, Icahn School of Medicine at Mount Sinai, UNITED STATES Methods Received: February 17, 2017 The data for the H7N9 cases from Zhejiang Province between 2013 and 2017 was obtained Accepted: June 21, 2017 from the China Information Network System of Disease Prevention and Control.