NORTHEAST OHIO

MEDICAL UNIVERSITY

DEPARTMENT OF ANATOMY & NEUROBIOLOGY

Presents

Synapses, muscular dystrophy and schizophrenia

By

Lin Mei, Ph.D. Chairman & Professor Department of Neurosciences School of Medicine Case Western Reserve University Director Cleveland Brain Health Initiative

Thursday, January 10, 2019 4:00 p.m. F-118

For further information, please call (330) 325-6293 or (330) 325-6636

Page 1 of 37 Lin Mei Curriculum Vitae

Department of Neurosciences School of Medicine Case Western Reserve University 10900 Euclid Ave. Cleveland, OH 44106-4975

Office Phone: 216-368-4928 Email: [email protected]

Education: Diploma of Medicine, 1982, Jiangxi Medical College, Nanchang, China M.S. (Neuropharmacology), 1985, Institute of Pharmacology & Toxicology, Beijing, China. Advisor: Professor Jin-Chu Yan PhD (Pharmacology and Toxicology), 1989, University of Arizona, Tucson, Arizona. Advisors: Professors Henry I. Yamamura and William Roeske

Appointments: 1981-1982, Intern, First Affiliated Hospital, Jiangxi Medical College, Nanchang, China 1989-1994, Postdoctoral Fellow/Research Associate, HHMI, Department of Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, Maryland. Advisor: Professor Richard Huganir 1994-1999, Assistant Professor, Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia 1999-2002, Assistant Professor, Neurobiology, Pathology, and Physical Medicine and Rehabilitation, University of Alabama at Birmingham, Birmingham, Alabama 2002-2004, Associate Professor, Neurobiology, Pathology, and Physical Medicine and Rehabilitation, University of Alabama at Birmingham, Birmingham, Alabama 2004-2017, Professor, Department of Neurology, School of Medicine, Augusta University (formerly Medical College of Georgia, Georgia Health Sciences University, and Georgia Regents University), Augusta, Georgia 2004-2017, Georgia Research Alliance Eminent Scholar in Neuroscience 2004-2009, Chief, Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Augusta University, Augusta, Georgia 2009-3/2014, Director, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta University, Augusta, Georgia 4/2014-10/2017, Professor and Chair (Inaugural), Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, Georgia 11/2017-Present, Professor and Chair, Department of Neuroscience, Case Western Reserve University School of Medicine, Cleveland, Ohio 11/2017-Present, Allen C. Holmes Professor of Neurological Diseases, Case Western Reserve University, Cleveland, Ohio 11/2017-Present, Director, Cleveland Brain Health Initiative

Professional Experience: 1996 – 2010, Guest Investigator, the Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China - 1 - 1999 – 2008, Member, Council of the Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China 2003, Monitor, Neural Plasticity, Gordon Research Conference 2006 – 2015, Visiting Professor, Southern Medical University, Guangzhou, China 2008 – 2015, Member, Eminent Scholar Advisory Group, Georgia Research Alliance 2009, 2013, Ad Hoc Member, Board of Scientific Councilors, NIMH, NIH 2011, Member, Chancellor Search Committee, Board of Regents, University System of Georgia 2011 – 2012, Member, Scientific Advisory Board, Mind-NRG, Switzerland 2013, Member, Board of Trustees, Georgia Research Alliance 2013 – Present, Member, International Advisory Board, International Symposium on Cholinergic Mechanisms (ISCM) 2013 – Present, Visiting Professor, Nanchang University, Nanchang, Jiangxi, China

Professional Societies: Alpha Psi Chapter of Rho Chi Honor Society, since 1987 Society for Neuroscience, since 1994; Membership and Chapters Committee, 2007-2010; Achievement Awards Selection Committee, 2010 – 2012 Chinese Biological Investigators Society (CBIS), since 1998, Treasurer, 2006 – 2010 Society of Chinese Bioscientists in America (SCBA), since 1994; Council member, 2015- 2017 American Association for the Advancement of Science (AAAS), since 2000; Fellow, since 2013 American College of Neuropsychopharmacology (ACNP), since 2012; Program Committee (2015 - present) 2018 - 2022 Member, Committee on Committee, Society for Neuroscience

Grant Review Service: Chartered Members of NIH Study Sections: 2003 – 2005, Chartered Member, NIH Syn (Synapses, Cytoskeleton and Trafficking) Study Section 2007 – 2011, Chartered Member and Ad Hoc Chair, NIH CHHD-C (2) (Child Health and Human Development) Study Section 2011 – 2013, Chartered Member, NIH PMDA (Pathophysiological Basis of Mental Disorders and Additions) Study Section 2018 – 2023, Chartered Member, NIH NDPR (Neurodifferentiation, Plasticity, and Regeneration) Study Section Ad Hoc Members of NIH Study Sections: 2000 – 2003, NIH MCDN-1 Study Section 2004, Reviewer of Cutting Edge Basic Research Award Program (CEBRA, NIDA), NIH 2005, NIH MDCN-F (04) Study Section 2006, NIH ZRG1 NDBG-A Study Section & CHHD-C Study Section 2007, NIH CEBRA ZDA1 MXS-M (01) Study Section 2007, 2008, 2010, 2011, Ad Hoc Reviewer, NIH NDPR Study Section 2010, NIH ZRG1 MDCN-G (91) S Study Section 2011, NIH ZRG1 MDCN-F (04) Study Section 2011, NIH ZHD1 DSR-Y (50) Study Section 2011, NIH Special Emphasis Panel ZRG1 MDCN-P (57) 2012 NIH Special Emphasis Panel ZRG1 MDCN-P (57) 2013, NIH ZRG1 BDCN-C (02) Study Section - 2 - Page 3 of 37 2013, NIH ZRG1 F03B-G (20) L Study Section 2014, NIH PMDA Study Section 2014, NIH Clinical Neuroplasticity and Neurotransmitters (CNNT) Study Section 2014, NIH ZRG1 BDCN-C (02) M (Developmental Brain Disorder and Psychiatric Disorders) 2014, NIH ZMH1 ERB-L (01) P (Conte Centers for Basic or Translational Mental Health Research, P50) 2015, Chair, NIH ZRG1 BDCN-L (03) M (Brain Disorders & Clinical Neuroscience) 2015, NIH PMDA Study Section 2015, 2016, NIH MDCN-R (86) R15 AREA Study Section 2016, NIH New Innovator Award Review 2016, VA RRD Career Development Award Program 2016, NIH ZRG1 MDCN-A (02) 2016, NIH Molecular and Cellular Substrates of Complex Brain Disorders Special Emphasis Panel ZRG1 MDCN-P (57) 2016, NIH ZRG1 MDCN-R (86) Academic Research Enhancement Award (AREA) 2017, NIH ZRG1 MDCN-R (86) Academic Research Enhancement Award (AREA) 2017, NDPR (Neurodifferentiation, Plasticity, and Regeneration Study Section) 2017, NIH Neurodevelopment, Synaptic Plasticity, and Neurodegeneration panel (F03A) 2018, Co-Chair, ZRG1 BDCN-W(05) (Brain Disorders and Clinical Neuroscience), NIH. 2018, Simons Foundation Autism Research Initiative (SFARI), SIMONS FOUNDATION

Reviewer for other funding agencies: 2003 – 2005, Member, Oversea Review Board, National Natural Science Foundation, China Ad Hoc Grant Review Activities for Department of Veterans Affairs (since 1996), Natural Sciences and Engineering Research Council of Canada (1998), National Science Foundation (since 1998), Jewish Hospital Foundation (1999), Bank of America (2000), Raine Medical Research Foundation, Australia (2000), Philip Morris External Research Program (2001-2005), Muscular Dystrophy Association (since 2003), Italian Telethon Review (since 2003), Czech Science Foundation (2004), Alzheimer’s Disease Association (since 2004), Austrian Science Fund (2004), North Carolina Biotechnology Center (2004), Research Grant Council, Hong Kong (since 2005), Oak Ridge Associated Universities (since 2005), Swiss Science Foundation (2007), Welcome Trust (since 2008), Association Française contre les Myopathies (since 2010), Fund for Scientific Research (Belgium) (since 2011), Council for the Earth and Life Sciences (the Netherlands), French National Research Agency (2015), Medical Research Council (MRC), UK.

Editorial Service: 2000 – Present, Member, Editorial Board, NeuroSignals 2005 – Present, Member, Editorial Board, Neuroscience Bulletin 2007 – Present, Academic Editor, PLoS ONE 2007 – 2010, Member, Editorial Board, Brain Research Bulletin 2008 – 2010, Editor-in-Chief, 2010 – present, Section Editor, Molecular Brain 2010 – 2016, Associate Editor, Journal of Neuroscience 2014 – Present, Associate Editor, Cell & Bioscience 2014 – Present, Member, Editorial Board, Neurology: Neuroimmunology and Neuroinflammation 2015 – Present, Member, Editorial Board, Scientific Reports 2017-present, Member, Editorial Board, Brain Research

- 3 - Ad Hoc Reviewer for more than 50 journals including American Journal of Physiology, American Journal of Psychiatry, Biological Psychiatry, Brain Research, Cell Reports, Current Biology, Developmental Biology, Development, Developmental Cell, Developmental Neurobiology, eLife, EMBO Journal, European Journal of Neuroscience, EMBO Journal, FASEB Journal, Human Molecular Genetics, Journal of Biological Chemistry, Journal of Cell Biology, Journal of Clinical Investigation, Journal of Cell Science, Journal of Comparative Neurology, Journal of Neuroscience, Journal of Physiology, Molecular Biology of Cell, Molecular Cell, Molecular Cellular Biology, Molecular Cellular Neuroscience, Molecular Psychiatry, Nature, Nature Communications, Nature Methods, Nature Neuroscience, Nature Review Neuroscience, Neuron, Neuropsychopharmacology, Neuroscience, Oncogene, Physiological Review, PLoS Biology, Proceedings of National Academy of Sciences, Science, Translational Psychiatry, and Trends in Neuroscience.

Meeting Organization Service: 2004, Co-Chair, Symposium for Chinese Neuroscientists Worldwide 2004, Guangzhou, China 2009, Co-Chair, Program Committee of 2009 International Symposium, Society of Chinese Bioscientists in America (SCBA), Taipei 2010, Vice Chair, Gordon Research Conference on Molecular and Cellular Neurobiology, Hong Kong 2011, Session Chair, Synapses: From Molecules to Circuits and Behavior, Cold Spring Harbor Laboratory 2011, Session Chair, 13th SCBA International Symposium, Guangzhou, China 2011, Organizer, Symposium on Mental Disorders, 9th Chinese Society for Neuroscience Annual Meeting, Zhengzhou, China 2012, Session Chair, Symposium for Chinese Neuroscientists Worldwide 2012, Xi’an, China 2012, Chair, Gordon Research Conference on Molecular and Cellular Neurobiology, Hong Kong 2013, Session Chair, XIV International Symposium on Cholinergic Mechanisms in Hangzhou, China 2015, Chair, Symposium on Synapse Formation and Neurodevelopmental Disorders, SfN 2015 Annual Meeting in Chicago. 2017, Chair, Program Committee, 15th SCBA International Symposium, Hangzhou, China

University and Departmental Committee Service: 2002, 2003, Faculty Search Committee, Department of Neurobiology, UAB 2002, Course Committee for direct admit Ph.D. students, UAB 2004 – 2014, Steering Committee of the Institute of Neuroscience, MCG 2004 – 2014, Steering Committee of the Center of Excellence in Neuroscience, MCG 2004 – Present, Steering Committee of the Neuroscience Graduate Program, MCG 2004 – 2009, IMMAG’s Institute Faculty Executive Committee, MCG 2004, 2005, Search Committee, Synapses and Cognitive Neuroscience Center, MCG 2005, 2006, Chair, Space Committee, IMMAG, MCG 2006 – 2012, Faculty Promotion and Tenure Committee, MCG School of Medicine 2008 – 2011, Intramural Grants Program Review Committee, MCG 2010 – Present, Internal Advisory Committee, Vice President of Research, Augusta University 2011 – 2013, Member, Long Term Strategy Planning Committee, Augusta University 2011, Member, Search Committee for Psychiatry Department Chair, Augusta University - 4 - Page 5 of 37 2012, Co-Chair, Task Force Reviewing Basic Neuroscience Department, Augusta University 2012, Member, Search Committee for Director of Lab Animal Service, Augusta University 2013, Co-Chair, Search Committee for Chair, Department of Pharmacology, Medical College of Georgia, Augusta University 2013, Faculty Promotion and Tenure Committee, MCG, Augusta University 2015, Animal Care and Use Task Force Committee, Augusta University 2016, Co-Chair, Search Committee for Georgia Eminent Scholar Professors, Augusta University 2016 – 10/2017, Augusta University Strategic Planning Project Committee, Augusta University, Augusta, Georgia 2016 – 8/2017, MCG Faculty Appointment, Development, Promotion and Tenure Review Committee, Augusta University, Augusta, Georgia 2015 – 2017, Chair, Ethnic Committee, Research and Development, Charlie Norwood VAMC, Augusta, Georgia

Honors: 1987, Honorary Citizen of Tucson, the City of Tucson, Arizona 1987, First Place Winner, 8th Annual Arizona Health Science Center Student Research Forum, University of Arizona 1989, Superior Performance Award, Department of Pharmacology, College of Medicine, University of Arizona 1994, Research Development Award, School of Medicine, University of Virginia 1994, FIRST Award, NIH 1995, Research Starter Award, Pharmaceutical Research & Manufacturers of American Foundation 1999, Faculty Development Award, Howard Hughes Medical Institute and University of Alabama at Birmingham 2004, Georgia Research Alliance Eminent Scholar in Neuroscience 2006, Distinguished Service Award, School of Graduate Studies, Medical College of Georgia 2008, Distinguished Faculty Award for Basic Science Research, Medical College of Georgia 2008, Mathilde Solowey Lecture Award in Neurosciences, sponsored by the National Institutes of Health and administered by the Foundation for Advanced Education in Sciences 2008, Distinguished Investigator, National Alliance for Research on Schizophrenia and Depression (NARSAD) 2012, Chair, Gordon Research Conference on Molecular and Cellular Neurobiology, Hong Kong 2013, Fellow, American Association for the Advancement of Science (AAAS) 2015, GRU Research Institute Mahesh Distinguished Research Award 2017, Fellow, American College of Neuropsychopharmacology (ACNP)

Special Lectureship 2009, Alberta Heritage Foundation for Medical Research Visiting Lecturer 2014, Keynote Speaker, Southeastern Neuroscience Symposium, Augusta, Georgia 2014, Professor Cai Qiao Memorial Lecture, 24th Congress of Chinese Association for Physiological Sciences (CAPS), Shanghai, China 2015, Keynote Speaker, Neuroscience Day, University of Miami, Miami, Florida 2015, Bei Shizhang Lecture, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China 2016, Plenary Seminar Speaker, Rutgers Brain Health Institute, Rutgers, New Jersey - 5 - 2017, Distinguished Seminar, NSF STC Emergent Behavior of Integrated Cellular Systems (EBICS), MIT, Georgia Institute of Technology, and University of Illinois. 2017, Keynote Speaker, Symposium on Hippo Signaling and Neuro-Muscular Biology, Medical College of Wisconsin Milwaukee, Wisconsin 2018, Keynote Speaker, Biomedical Graduate Student Symposium, Case Western Reserve University

Grant Supports:

Active:

1. NIH R01 NS082007-07 (07/1/2013 - 06/30/2023) Title: Mechanisms of neuromuscular junction formation Direct Cost: $389,641 Major goal: This will investigate molecular mechanisms of neuromuscular junction formation. PI: Lin Mei Co-I: Wen-Cheng Xiong, Jeffrey Savas

2. 1/01IBX001020A (10/1/2013 – 9/30/2023) Veteran Administration Office and Development Title: Mechanisms of neuromuscular regeneration Direct Cost: $250,000 Major Goal: This proposal to investigate effects of nerve injury on the neuromuscular junction. We will determine whether restoring agrin-Lrp4-MuSK signaling promotes the regeneration of this peripheral synapse.

3. NIH 2R01MH083317-06, April 1, 2014 – March 31, 2019 Title: NRG1-ErbB4 regulation of synaptic plasticity and behavior Direct Cost: $358,943 per year Major Goal: This proposal is to study neuregulin 1 and its receptor ErbB4, both susceptibility genes of schizophrenia, to better understand their physiological functions and pathophysiological mechanisms. PI: Lin Mei Co-I: Wen-Cheng Xiong

4. NIH 1 R01 NS090083-01A1, July 1, 2015 – June 30, 2020 Title: Characterization of Agrin/LRP4 antibody-positive myasthenia gravis Direct Cost: $394,612 per year Major Goal: The project collaborates with more than 20 centers in the U.S. to study agrin/LRP4 antibodies as novel biomarkers in myasthenia gravis (MG) patients and to investigate pathogenic mechanisms. PI: Lin Mei Co-I: Michael Rivner

5. NIH 1 R01 AG051510-01, October 1, 2015 – September 30, 2020 Title: Agrin signaling in maintaining neuromuscular junction in aging Direct Cost: $250,000 per year Major Goal: The proposal will study the role of agrin/LRP4 signaling in maintaining the neuromuscular junction during ageing. PI: Lin Mei - 6 - Page 7 of 37 Co-I: Wen-Cheng Xiong

Previous:

1. MDA #240849, 8/1/2012 – 7/31/2015, Muscular Dystrophy Association Title: Mechanisms of LRP4 autoantibodies in myasthenia gravis Direct Cost: $130,000 per year Major Goals: This proposal is to study pathogenic mechanisms of LRP4 autoantibodies in myasthenia gravis. PI: Lin Mei

2. Dongmin Yin, Critical period for abnormal neuregulin 1 signaling to cause schizophrenia-related behaviors. Young Investigator Award, NARSAD, 1/1/2013 – 12/31/2014.

3. Yongjun Chen, Neuroprotection by ErbB4 in parvalbumin-positive interneurons. Postdoctoral Fellowship, American Heart Association, 9/1/2012 – 8/31/2014. Role: Mentor

4. NIH R21 NS078774, 8/1/2012 – 7/31/2014 Title: Mechanisms of neuregulin 1 protection of excitatory neurons in stroke models Direct Cost: $120,625 per year Major Goals: To study if neuregulin 1 protects excitatory neurons in stroke indirectly by regulating GABAergic neurons. PI: Lin Mei Co-Investigator: Darrell Brann

5. NIH R01 MH083317, 5/6/2008 – 3/31/2013 (no cost extension to 3/31/2014) Title: Neuregulin-1 regulation of neurotransmission Direct Cost: $250,718 per year Major Goals: This proposal is to investigate how neuregulin 1 enhances GABA release in the brain, whether neuregulin 1 alters pyramidal neuron firing and whether mice are behavioral abnormal when ErbB4 is mutated from parvalbumin-positive neurons. PI: Lin Mei Co-PI: Almira Vazdarjanova

6. NIH RO1 NS040480, 1/1/2010 – 1/31/2014 Title: Regulation and activation of MuSK Direct Cost: $206,872 per year Major Goals: This proposal is to study the role of LRP4 and Wnts in regulating MuSK activation, AChR clustering and neuromuscular junction formation. PI: Lin Mei

7. Yisheng Lu, ErbB4 in amygdala is critical for cued fear conditioning. Young Investigator Award, NARSAD, 9/1/2012 – 8/31/2013. Role: Mentor

8. NIH R01 NS060648, 2/1/2008 – 1/31/2013 Title: Molecular Mechanisms Underlying Axon Pathfinding Major Goals: This project is to study molecular mechanisms of axon guidance. PI: Wen-Cheng Xiong - 7 - Co-Investigator: Lin Mei

9. R01NS056415, 4/1/2008 – 1/31/2012 (no cost extension to 1/31/2013) Title: Neuromuscular Junction Formation Major Goals: This proposal is to investigate the role of beta-catenin in neuromuscular junction formation. In particular, how beta-catenin controls a retrograde signal will be studied. PI: Lin Mei

10. 1R13NS078948-01, NIH, 3/1/2012 – 2/28/2013 Title: 2012 Molecular and Cellular Neurobiology Gordon Research Conference Major Goals: Meeting support. PI: Lin Mei

11. MDA135637, 7/1/2010 – 6/31/2012, Muscular Dystrophy Association Title: Neuromuscular Junction Formation Major Goals: This proposal is to study how LRP4 interacts with MuSK and thus regulates AChR clustering. PI: Lin Mei

12. 3R01MH083317-03S1, 4/1/2010 – 3/31/2013 Title: Neuregulin-1 regulation of neurotransmission. Major Goals: This supplement provides stipend for a minority graduate student. PI: Lin Mei. Co-PI: Almira Vazdarjanova

13. R01NS056415-02S1, 9/30/2009 – 9/29/2011, Title: Neuromuscular Junction Formation, PI: Lin Mei, Major Goals: This ARRA supplemental support is aimed at identification of target genes of beta-catenin.

14. R21/R33 MH083563, 5/1/2008 – 4/30/2011, PI: Lin Mei, Title: Generation and Characterization of GAD67-ErbB4 Transgenic Mice. Major Goals: This grant is to generate mice that overexpress ErbB4 in GAD67-positive neurons.

15. NARSAD Distinguished Investigator Award, 5/1/2008-4/31/2009

16. Bin Zhang, Postdoctoral Fellowship, American Heart Association, 7/1/2007-6/30/2009

17. Muscular Dystrophy Association, 1/1/06 – 12/31/08, PI: Lin Mei

18. National Institutes of Health RO1 NS44521, 8/1/03 – 7/31/07, PI: Lin Mei

19. National Institutes of Health RO1 NS45710, 4/15/03-2/28/08, PI: Lin Mei, Co-I: Wen C. Xiong

20. Philip Morris External Research Program, 3/1/03 – 2/28/06

21. Muscular Dystrophy Association, 7/1/03 – 6/30/06

22. Qiang Wang, Predoctoral Fellowship from American Heart Association, Southeastern Affiliation, 7/1/2002 – 6/30/2004

- 8 - Page 9 of 37 23. G. Clem Dobbin, Predoctoral Fellowship, Neuroscience Training Grant from NIH, University of Alabama at Birmingham, 7/1/2003 – 6/30/2004

24. Muscular Dystrophy Association, 7/1/1997 – 6/30/2000

25. March of Dimes, 6/1/1998 – 11/30/2000

26. National Institutes of Health, R29 NS34062, 5/1/1995 – 4/31/2001

27. Michael Tanowitz, Predoctoral Fellowship for Advanced Predoctoral Training in Pharmacology/Toxicology, Pharmaceutical Research & Manufacturers of America Foundation, 7/1/1998 – 6/30/2000

28. American Cancer Society, IRG-72256, 10/1/1994 – 6/30/1995

29. Pharmaceutical Research and Manufacturers of America Foundation, 1/1/1995 – 12/31/1995

Primary Research Interests:

My lab focuses on two main lines of research. One is on mechanisms of synapse formation, using the neuromuscular junction as model whereas the other is on pathophysiological mechanisms of brain disorders including schizophrenia and autism.

The neuromuscular junction is a peripheral synapse formed between motoneurons and muscle fibers, critical for accurate and rapid control of muscle contraction. This classic chemical synapse has served as an informative model of synapse function and synaptogenesis. Although many synaptic components are known, how they are assembled to form a functional synapse remains unclear. We have identified LRP4 as a receptor for agrin, revealing a mechanism how signals are transduced from agrin to the tyrosine kinase MuSK. We have discovered antibodies against LRP4 and agrin in patients with myasthenia gravis and demonstrated that they are causal to myasthenia gravis. Recently, we have found that rapsyn, a classic scaffold protein, may serves as an enzyme for AChR clustering. We have also revealed novel pathways that are critical for the development and function of the neuromuscular junction. Currently, we are studying pathophysiological mechanisms of muscular dystrophies including congenital myasthenia syndrome, myasthenia gravis and ALS.

Schizophrenia is a disabling mental disorder that affects ~ 1 % of the population worldwide and the seventh most costly illness in USA. However, schizophrenia lacks pathological hallmarks and thus remains one of the least understood brain disorders. Recent identification of schizophrenia susceptibility genes has begun to shed light on its pathophysiology. Both NRG1 and ErbB4 are schizophrenia risk genes in diverse populations based on association studies. This notion is supported by recent meta-analysis, genome- wide association study (GWAS), and genome-wide copy number analysis. Moreover, NRG1 SNPs (single nucleotide polymorphism) relate to reduced prepulse inhibition (PPI), a measure of sensorimotor gating, altered activity of frontal and temporal lobes, and/or higher risk for development of psychotic symptoms in schizophrenia patients. However, the physiological function of NRG1 and ErbB4 and pathophysiological mechanisms of neuregulin 1-ErbB4 malfunction remain largely unknown. In the past decade, research from my lab has contributed to a better understanding of both. - 9 -

H. Wu, Wen C. Xiong, L. Mei, To build a synapse: Signaling pathways in neuromuscular junction assembly. Development 137:1017-1033, 2010

L. Mei and W.C. Xiong, Neuregulin-1 signaling in neural development, synaptic plasticity and schizophrenia. Nature Rev. Neurosci. 9:437-452, 2008

L. Mei and K.-A. Nave, Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases. Neuron 83:27-49, 2014

L. Li, W.C. Xiong, L. Mei, Neuromuscular junction formation, ageing, and disorders. Ann. Rev. Physiol. 2018

Full publications can be found at the NCBI website: https://www.ncbi.nlm.nih.gov/sites/myncbi/1bAiDfyCak2ki/bibliography/46375173/public/?sort=date&di rection=descending

Bibliography:

Research Articles:

1. Lin Mei, and J.C. Yan: Effects of exogenous acetylcholine on tension of smooth muscle in isolated guinea pig trachea. Acta Pharmacol. Sin. 8:105-109, 1987. PMID:2958993 2. Lin Mei, J.X. Wang, W.R. Roeske, and H.I. Yamamura: Thermodynamic analyses of pirenzepine binding to membrane-bound and solubilized muscarinic receptors from rat forebrain and heart. J. Pharmacol. Exp. Ther. 242:991-1000, 1987. PMID:3656121 3. J.X. Wang, Lin Mei, H.I. Yamamura, and W.R. Roeske: Solubilization with digitonin alters the kinetics of pirenzepine binding to muscarinic receptors from rat forebrain and heart. J. Pharmacol. Exp. Ther. 242:981-990, 1987. PMID:3116203 4. M. Serra, Lin Mei, W.R. Roeske, G.K. Lui, M. Watson, and H.I. Yamamura: The intact human neuroblastoma cell (SH-SY5Y) exhibits high affinity pirenzepine binding associated with hydrolysis of phosphatidylinositols. J. Neurochem. 50:1513-1521, 1988. PMID:3361307 5. Lin Mei, H.I. Yamamura, and W.R. Roeske: Muscarinic receptor mediated hydrolysis of phosphatidylinositols in human neuroblastoma SH-SY5Y cells is sensitive to pertussis toxin. Brain Res. 447:360-363, 1988. PMID:3390705 6. J. Lai, Lin Mei, W.R. Roeske, F.Z. Chung. H.I. Yamamura, and J.C. Venter: The cloned murine M1 muscarinic receptor is associated with the hydrolysis of phosphatidylinositols in transfected murine B82 cells. Life Sci. 42:2489-2502, 1988. PMID:3374268 7. Lin Mei, J. Lai, W.R. Roeske, J.C. Venter, and H.I. Yamamura: Pharmacological characterization of the muscarinic receptor and its coupling in the transfected B82 cells. J. Pharmacol. Exp. Ther. 248:661-670, 1989. PMID:2537406 8. Lin Mei, W.R. Roeske, and H.I. Yamamura: The coupling of muscarinic receptors to hydrolysis of phosphatidylinositols in human neuroblastoma SH-SY5Y cells. Brain Res. 504:7-14, 1989. PMID:2557126 9. Lin Mei, J. Lai, H.I. Yamamura, and W.R. Roeske: The relationship between agonist states of M1 muscarinic receptor and the hydrolysis of inositol lipids in transfected murine fibroblast cells (B82) expressing difference receptor densities. J. Pharmacol. Exp. Ther. 251:90-97, 1989. PMID:2795474

- 10 - Page 11 of 37 10. R.C. Speth, Lin Mei, and H.I. Yamamura: Angiotensin II receptor binding and actions in NG108-15 cells. Peptide Res. 2:232-239, 1989. PMID:2562484 11. Lin Mei, W.R. Roeske, K.T. Izutsu, and H.I. Yamamura: Characterization of muscarinic receptors in human libial glands. Eur. J. Pharmacol. 176:367-370, 1990. PMID2328757 12. W.R. Roeske, J. Lai, Lin Mei, J.W. Bloom and H.I. Yamamura. Pharmacologic comparison of the cloned M1 and M2 muscarinic receptors of the rat expressed in murine fibroblast cells. Eur. J. Pharmacol., 183, 1618, 1990. 13. S.J. Moss, A. Ravindran, Lin Mei, J.-B. Wang, P. Kofuji, R.L. Huganir and D.R. Burt: Functional expression of murine GABAA receptor alpha-1, beta-1 and gamma-2 subunits in transfected cells. Neurosci. Lett. 123:265-268, 1991. PMID:1851269 14. Lin Mei, J. Lai, H.I. Yamamura, and W.R. Roeske: Pharmacological comparison of selected agonists for the M1 muscarinic receptors in transfected murine fibroblast cells (B82). J. Pharmacol. Exp. Ther. 256:689-694, 1991. PMID:1704434 15. Lin Mei, R.L. Huganir: Purification and characterization of a phosphotyrosine protein phosphatase which dephosphorylates the nicotinic acetylcholine receptor. J. Biol. Chem. 266:16063-16072, 1991. PMID:1651933 16. Lin Mei, C.A. Doherty, and R.L. Huganir: RNA splicing regulates the phosphatase activity of a rat protein tyrosine phosphatase containing two SH2 domains (PTP1D). J. Biol. Chem. 269:12254-12262, 1994. PMID:7512964 17. Lin Mei, K. Liao, and R.L. Huganir: Characterization of substrate specificity of the protein tyrosine phosphatase purified from electric organ of Torpedo californica. Neurosci. Lett. 182:21-24, 1994. PMID:7891879 18. M.B. Tanowitz, H. Sun, and Lin Mei: Surgical denervation increases the protein tyrosine phosphatase activity in skeletal muscles. Brain Res. 712:299-306, 1996. PMID:8814906 19. Lin Mei, A.M. Kachinsky, J. Seidan, R. Kuncl, J.B. Miller, and R.L. Huganir: Differential expression of PTP1D, a protein tyrosine phosphatase, in skeletal muscle fibers. Exp. Cell Res. 224:379-390, 1996. PMID:8612715 20. J. Si, Z. Luo, and Lin Mei: Induction of acetylcholine receptor gene by ARIA requires activation of MAP kinase. J. Biol. Chem. 271:19752-19759, 1996. PMID:8702681 21. J. Si, D.S. Miller and L. Mei. Identification of an element required for acetylcholine receptor-inducing activity (ARIA)-induced expression of the acetylcholine receptor ε subunit gene. J. Biol. Chem. 272:10367-10371, 1997. PMID:9099674 22. C.Y. Wang, J. Ni, H. Jiang, T.A. Hsu, M. Dugich-Djordjevic, L. Feng, M. Zhang, Lin Mei#, R. Gentz#, and B. Lu#: Cloning and characterization of GDNF receptor beta: a novel receptor for members of GDNF family of neurotrophic factors. Neurosci. 83:7-14, 1998. #share senior authorship. PMID:9466395 23. J.M. Cunnick, J.F. Doresey, Lin Mei, and J. Wu: Reversible regulation of SHP-1 tyrosine phosphatase activity by oxidation. Biochem. Mol. Biol. Internat. 45:887-894, 1998. PMID:9739453 24. J. Si and Lin Mei: ERK MAP kinase activation is required for ARIA-induced increase in all five AChR subunit mRNAs as well as synapse-specific expression of the AChR ε- transgene. Mol. Brain Res. 67:18-27, 1999. PMID:10101228 25. L. Feng, C.-Y. Wang, H. Jiang, C. Oho, Lin Mei, and B. Lu: Differential signaling of GDNF and BDNF in cultured ventral mesencephalic neurons. Neuroscience 93:265-273, 1999. PMID:10430490 26. J. Si, Q. Wang, and Lin Mei: Essential roles of c-JUN and c-JUN NH2-terminal kinase (JNK) in neuregulin increased expression of acetylcholine receptor epsilon-subunit. J. Neurosci. 19:8498-8508, 1999. PMID:10493750 - 11 - 27. S. Won, J. Si, M. Colledge, K.S. Ravichandran, S.C. Froehner, Lin Mei: Neuregulin- increased expression of AChR epsilon-subunit gene requires ErbB3 interaction with Shc. J. Neurochem. 73:2358-2368, 1999. PMID:10582594 28. M. Tanowitz, J. Si, G.S. 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Agrin and low‐ density lipoprotein–related receptor protein 4 antibodies in amyotrophic lateral sclerosis patients. Muscle Nerve 55:430-432, 2017 145. H.F. Jiao*, X.D. Sun*, R. Bates*, L. Xiong, F. Liu, L. Li, H.S. Zhang, S.Q. Wang, M.T. Xiong, M. Patel, A.M. Stranahan, W.C. Xiong, B.M. Li#, L. Mei#. Tmem108 is required for glutamatergic transmission in dentate gyrus. Proc. Nat. Acad. Sci. USA. 114: 1177- 1182, 2017 (*, equal contributing; #, equal corresponding) 146. Z. Tan Z, Y. Liu, W. Xi, H.F. Lou, L. Zhu, Z. Guo, L. Mei, S. Duan. Glia-derived ATP inversely regulates excitability of pyramidal and CCK-positive neurons. Nat Commun. 8:13772, 2017 147. L. Xiong, J.U. Jung, H.H. Guo, J.X. Pan, X.D. Sun, L. Mei, W.C. Xiong. WC. Osteoblastic Lrp4 promotes osteoclastogenesis by regulating ATP release and adenosine-A2AR signaling. J. Cell Biol. 216:761-778, 20 148. K. Zhao, C. Shen, Y. Lu, Z. Huang, L. Li, C.D. Rand, J. Pan, X.D. Sun, Z. Tan, H. Wang, G. Xing, Y. Cao, W.C. Xiong, and L. Mei. Muscle Yap is a regulator of neuromuscular junction formation and regeneration. J. Neuroscience 37:3465-3477, 2017 (Cover) (Highlighted by Faculty 1000, DOI: 10.3410/f.727317699.793531488) 149. H. Wu, S. Yao, S. Zhang, J.R. Wang, P.D. Guo, X.M. Li, W.J. Gan, L. Mei, T.M. Gao, J.M. Li. Elevated expression of Erbin destabilizes ERα protein and promotes tumorigenesis in hepatocellular carcinoma. J. Hepatol. 66:1193-1204, 2017 150. I. Cordts, N. Bodart, K. Hartmann, K. Karagiorgou, J. Tzartos, L. Mei, J. Reimann, P. Van Damme, M. Rivner, A. Vigneron, J. Weis, J. Schulz, S. Tzartos, and K.G. Claeys. - 20 - Page 21 of 37 Screening for lipoprotein receptor-related protein 4-, agrin-, and titin-antibodies and exploring the autoimmune spectrum in myasthenia gravis. Journal of Neurology 264:1193-1203, 2017. 151. W. Liu, F.L. Tang, S. Lin, K. Zhao, L. Mei, J. Ye, and W.C. Xiong. Vps35-deficiency impairs SLC4A11 trafficking and promotes corneal dystrophy. PLoS One. 12:e0184906, 2017 152. Frank Hanisch, Michael Rivner, Chenyong Shen, Lin Mei, Malte Kornhuber. Antibodies to agrin in immunosuppressed" quadruple-seronegative" myasthenia gravis. Neurology, 2017 153. X.-C. Ye, J.-X. Hu, L. Li, Q. Li, F.-L. Tang, S. Lin, D. Sun, X.-D. Sun, G.-Y. Cui, L. Mei, W.C. Xiong. Astrocytic Lrp4 (Low-Density Lipoprotein Receptor–Related Protein 4) Contributes to Ischemia-Induced Brain Injury by Regulating ATP Release and Adenosine-A2AR (Adenosine A2A Receptor) Signaling. Stroke, 49: 165-174, 2018 154. D. Sun, X.-D. Sun, L. Zhao, D.-H. Lee, J.-X. Hu, F.-L. Tang, J.-X. Pan, L. Mei, X.-J. Zhu, W.-C. Xiong. Neogenin, a regulator of adult hippocampal neurogenesis, prevents depressive-like behavior. Cell Death & Disease, 9:8 doi:10.1038/s41419-017-0019-2, 2018 155. Y.-N. Wang, D. Figueiredo, X.-D. Sun, Z.-Q. Dong, W.-B. Chen, W.-P. Cui, F. Liu, H.-S. Wang, H.-W. Li, H. Robinson, E.-K. Fei, B.-X. Pan, B-M Li, W-C Xiong and L. Mei. Controlling of glutamate release by neuregulin3 via inhibiting the assembly of SNARE- complex. Proc. Nat. Acad. Sci. 115:2508-2513, 2018 156. T.W. Lin, Z. Tan, A. Barik, D. Yin, E. Brudvik, H. Wang, W.C. Xiong, L. Mei. In vivo genetic evidence for GABA activity regulation of circuit assembly. J. Neurosci. 38:2533- 2550, 2018. 157. M. Yan, Z. Liu, E. Fei, W. Chen, X. Lai, B. Luo, P. Chen, H. Jing, J. Pan, M. Rinver, W.C. Xiong, and L. Mei. Induction of anti-agrin antibodies causes myasthenia gravis in mice. Neuroscience, 373:113-121, 2018. 158. Z. Tan, H. Robinson, D. Yin, Y. Liu, F. Liu, H. Wang, T.W. Lin, G. Xing, W.C. Xiong, L. Mei. Hippocampal ErbB4-dependent GABA activity for top-down attention. Neuron 98:380-393, 2018 159. J.-X. Pan, L. Xiong, K. Zhao, P. Zeng, B. Wang, F.-L. Tang, D. Sun, H.-h. Guo, X. Yang, S. Cui, W.-F. Xia, L. Mei, and W.-C. Xiong. YAP promotes osteogenesis and suppresses adipogenic differentiation by regulating β-catenin signaling. Bone Res. 6:18, 2018. 160. J.R. Appel, S. Ye, F. Tang, D. Sun, H. Zhang, L. Mei and W.-C. Xiong. Increased Microglial Activity, Impaired Adult Hippocampal Neurogenesis, and Depressive-like Behavior in Microglial VPS35-Depleted Mice. J. Neuroscience 38:5949-5968, 2018 161. C. Shen*,**, L. Li**, K. Zhao**, L. Bai, A. Wang, X. Shu, Y. Xiao, J. Zhang, K. Zhang, T. Hui, W. Chen, B. Zhang, W. Hsu, W.-C. Xiong, L. Mei*. Motoneuron Wnts regulate neuromuscular junction development. eLife. 7, 2018 pii: e34625. doi: 10.7554/eLife.34625 (*, co-corresponding; **, co-first) 162. K. Zhao*, C. Shen,*,** L. Li, H. Wu, G. Xing, Z. Dong, W. Chen, H. Zhang, J. Pan, H. Wang, W. Cui, X.D. Sun, S. Li, X. Li, X. Huang, W.C. Xiong, and L. Mei**. Sarcoglycan Alpha Mitigation of Neuromuscular Junction Decline in Aged Mice by Stabilizing Lrp4. J. Neurosci. 38:8860-8873, 2018. (Cover) *, equal contributing; **, co-corresponding. 163. X.-D. Sun*,**, W.-B. Chen**, D. Sun**, J. Huang, Y.-Q. Li, J.-X. Pan, Y.-N. Wang, K. Zhao, Z.-Q. Dong, H.-S. Wang, L. Xiong, A. Xuan, S.-T. Zhao, A. Pillai, W.-C. Xiong* and L. Mei Neogenin in amygdala for neuronal activity and fear memory. J. Neurosci. (in press) (*, co-corresponding; **, co-first)

- 21 - 164. H. Wang,* F. Liu,* W. Chen,* X. Sun, W. Cui, Z. Dong, K. Zhao, H. Zhang, H. Li, G. Xing, E. Fei, B.-X. Pan, B.-M. Li, W.-C. Xiong, Lin Mei. Genetic recovery of ErbB4 in adulthood partially restores brain functions in null mice. PNAS (in press)

Reviews and Chapters:

1. Lin Mei, and J.C. Yan: Advances in subclassifications of muscarinic acetylcholine receptors. Progress Physiol. Sci. 16:215-219, 1985. 2. J.X. Wang, K. Gulya, T.W. Vickroy, M. Watson, Lin Mei, W.R. Roeske, E.K. Perry, R.H. Perry, H.C. Fibiger, and H.I. Yamamura: Alterations of cholinergic and somatostatin systems in Alzheimer’s disease and its animal models. In: Liver and Aging-1986, Liver and Brain, K. Kitani ed., Elsevier Science Publishers, 1986. 3. W.R. Roeske, J.X. Wang, K. Gulya, M. Korc, M. Serra, M. Ackerman, Lin Mei, T. Vickroy, M. Watson, and H.I. Yamamura: Biochemical, functional and anatomic evidence for putative muscarinic receptor subtypes using selective antagonists [3H]AF-DX 116 and [3H]pirenzepine. In: Cellular and Molecular Basis of Cholinergic Function, M.J. Dowdall and J.N. Hawthorne ed., Ellis Horwood, 1987. 4. J.X. Wang, W.R. Roeske, Lin Mei, E. Malatynske, W. Wang, E.K. Perry, and H.I. Yamamura: Nicotinic and muscarinic M2 receptor alterations in the cerebral cortex of patients with senile dementia for the Alzheimer’s type (SDAT). In: Pharmacology, M.J. Rand and C. Raper, ed., Elsevier Science Publishers, 1987. 5. Lin Mei, S. Waite, J. Lai, D.R. Gehlert, M. Tyler, P. Buzby, W.R. Roeske, and H.I. Yamamura: Muscarinic receptor mRNAs localized in rat brain by in situ hybridization. Biotech Update 4:20, 1989. 6. Lin Mei, W.R. Roeske, and H.I. Yamamura: Molecular pharmacology of muscarinic receptor heterogeneity. Life Sci. 45:1831-1851, 1989. 7. K.R. Wagner, Lin Mei, R.L. Huganir: Protein tyrosine kinases and phosphatases in the nervous system. Current Opinion of Neurobiology 1:65-73, 1991. 8. J. Lai, T.L. Smith, Lin Mei, M. Ikeda, Y. Fujiwara, J. Gomez, M. Halonen, W.R. Roeske, and H.I. Yamamura: The molecular properties of the M1 muscarinic receptor and its regulation of cytosolic calcium in a eukaryotic gene expression system. Advances in Experimental Medicine & Biology. 287:313-330, 1991. 9. Lin Mei, W.R. Roeske, H.I. Yamamura: Muscarinic receptors: pharmacological subtypes, structures, functions and regulations. In: Pharmacodynamics and Drug Development: Perspectives in Clinical Pharmacology, N.R. Cutler, J.J. Sramek, and P.K. Narang, ed., John Wiley & Sons, 1994. 10. Lin Mei and J. Si: Tyrosine phosphorylation and synapse formation at the neuromuscular junction. Life Sci. 57:1459-1466, 1995. 11. J. Si, M. Tanowitz, S. Won and Lin Mei: Regulation by ARIA/Neuregulin of acetylcholine receptor gene transcription at the neuromuscular junction. Life Sci. 62:1497-1502, 1998. 12. Y.Z. Huang and Lin Mei: Neuregulin/Erbin signal transduction pathway in the development of nervous system. Progress Physiol. Sci. 32:197-203, 2001 13. Y. Z. Huang, Q. Wang, S. Won, Z.G. Luo; W.C. Xiong, Lin Mei: Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function. Int. J. Dev. Neurosci. 726:1-13, 2002 14. L. Mei and W.C. Xiong: Two birds with one stone: a novel motif for AChR assembly quality control. Trends Neurosci. 26:178-81, 2003 15. Z. Luo, Q. Wang, G. C. Dobbins, S. Levy, W.C. Xiong, Lin Mei. Signaling complexes for postsynaptic differentiation. J. Neurocytol. 32:697-708, 2003

- 22 - Page 23 of 37 16. X.L. Yang, W.C. Xiong, L. Mei. Lipid rafts in neuregulin signaling at synapses. Life Sci. 75:2495-2504, 2004 17. W.C. Xiong and Lin Mei: An Unconventional Role of Neurotransmission in Synapse Formation. Neuron 46:521-523, 2005. 18. G. Clement Dobbins, Bin Zhang, Wen C. Xiong, and Lin Mei. The role of the cytoskeleton in neuromuscular junction formation. J. Mol. Neurosci. 30:115-118, 2006. 19. Q. Wang, B. Zhang, W.C. Xiong, and L. Mei. MuSK signalings at the neuromuscular junction. J. Mol. Neurosci. 30:223-226, 2006 20. Lin Mei and Wen C. Xiong. Signal integration by focal adhesion kinase at point contacts in growth cones. Cell Science Reviews 3:47-53, 2007 21. W.C. Xiong and Lin Mei. Neuregulin-1 in schizophrenia. Future Neurology 2:477-480, 2007. 22. L. Mei and W.C. Xiong. Neuregulin-1 signaling in neural development, synaptic plasticity and schizophrenia. Nature Rev. Neurosci. 9:437-452, 2008 23. B. Zhang, W.C. Xiong, L. Mei. Get ready to Wnt: prepatterning in neuromuscular junction formation. Dev. Cell 16:325-327, 2009 24. W.C. Xiong and L. Mei. FAK interaction with MBD2: a link from cell adhesion to nuclear chromatin remodeling. Cell Adhesion & Migration. 4:77-80, 2009 25. H. Wu, Wen C. Xiong, L. Mei. To build a synapse: Signaling pathways in neuromuscular junction assembly. Development 137:1017-1033, 2010 26. C.B. Chan*, Y. Chen*, X. Liu, L. Papale, A. Escayg, L. Mei, K. Ye. Essential role of PIKE GTPases in neuronal protection against excitotoxic insults. Adv. Biol. Regul. 52:66-76, 2012 (*, equal contribution). PMID:21925531 27. Y. Lu1, D.M. Yin1, W.-C. Xiong, and L. Mei. Modeling schizophrenia in neuregulin 1 and ErbB4 mutant mice. In: Animal Models of Schizophrenia. Ed: P. O’Donnell, Humana Press, 2011. 28. D.M. Yin, Y. Chen, A. Sathyamurthy, W.C. Xiong, and L. Mei. Synaptic dysfunction in schizophrenia. Adv. Exp. Med. Biol. 970: 493-516, 2012. PMID: 22351070. 29. A. Barik, W.C. Xiong, L. Mei. MuSK: A kinase critical for the formation and maintenance of the neuromuscular junction. In: Protein Kinase Technologies, Ed: Hideyuki Mukai, Springer, 2012. 30. Y. Peng, W.C. Xiong, and L. Mei. Culture of dissociated hippocampal neurons. Methods Mol. Biol. 1018: 39-47, 2013. PMID: 23681615. 31. C. Wang and L. Mei. In utero electroporation in mice. Methods Mol. Biol. 1018: 151-163, 2013. PMID: 23681626. 32. H. Wu and L. Mei. Morphological analysis of neuromuscular junctions by immunofluorescent staining of whole-mount mouse diaphragms. Methods Mol. Biol. 1018: 277-285, 2013. PMID: 23681637. 33. D.M. Yin, W.C. Xiong, L. Mei. Adolescent dopamine slows spine maturation. Nature Neuroscience, 16:1514-1516, 2013. PMID: 24165676 34. Y. Tao, W.C. Xiong, L. Mei. Erbin in cortical inhibition. Future Neurology, 8:369-372, 2013. 35. C. Shen, W.C. Xiong, L. Mei. Caspase-3, shears for synapse pruning. Dev. Cell 28:604- 606, 2014. 36. L. Mei and K.-A. Nave, Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases. Neuron, 83:27-49, 2014. 37. R.P. Lisak, B. Zhang, C. Shen, L. Mei. Neuromuscular junction as Achilles' heel: Yet another autoantibody? Neurology. 84:214-215, 2015.

- 23 - 38. N. Muthusamy, Y.J. Chen, D.M. Yin, L. Mei, C. Bergson. C. Complementary roles of the neuron-enriched endosomal proteins NEEP21 and calcyon in neuronal vesicle trafficking. J. Neurochem. 132:20-31, 2015. 39. C.Y. Shen, W.C. Xiong, and L. Mei. LRP4 in neuromuscular junction and bone development and diseases. Bone, 80:101-108, 2015. 40. L. Mei and J.P. Borg. ERBB2 oncogenicity: ERBIN helps to perform the job. Mol. Cell Oncology. 2:e995033, 2015. 41. E. Fei, W.C. Xiong, and L. Mei. Ephrin-B3 recruits PSD -95 to synapses. Nature Neuroscience 18:1535-1537, 2015 42. L. Mei, W.C. Xiong. Agrin to YAP in cancer and neuromuscular junction. Trends in Cancer. 3:247-248, 2017 43. C. Legay, L. Mei: Moving forward with the neuromuscular junction. J. Neurochem. 142 (Suppl 2): 59-63, 2017. 43. L. Li, W.C. Xiong, and L. Mei. Neuromuscular junction formation, ageing, and disorders. Annual Review of Physiology, 80:159-188, 2018 44. M.H. Rivner, M. Pasnoor, M. Dimachkie, R. Barohn, L. Mei. Muscle-Specific Tyrosine Kinase and Myasthenia Gravis Owing to Other Antibodies. Neurologic Clinics, 36:293- 310, 2018. 45. M Yan, GL Xing, WC Xiong, L Mei. Agrin and LRP4 antibodies as new biomarkers of myasthenia gravis. Ann. New York Acad. Sci. 1413: 126-135, 2018

Books:

Neural Development: Methods and Protocols, Editors: Renping Zhou and Lin Mei. Humana Press, New York. 2013

III. Patent applications

1. L. Mei, W.C. Xiong, R.S. Woo, and X.M. Li. Compositions and methods for treating neurological disorders. US Patent Application #: 20100136004; Publication Date: 06/03/2010.

This patent describes the invention of neuregulin 1/ErbB4's role in neurotransmission and synaptic plasticity.

2. W.C. Xiong, J.H. Lee, L. Mei. Netrin-1 compositions and methods of use thereof. US Patent Application #: 20100260774; Publication Date: 10/14/2010.

The patent describes the invention of netrin-1's role in sperm motility.

3. L. Mei, Y. Tao, W.C. Xiong. Methods and compositions for modulating ErbB2 activity. US Patent Application #: 20100291077; Publication Date: 11/18/2010.

This patent describes the invention of modulation of ErbB2 activity by adapter proteins.

4. L. Mei, W.C. Xiong, B. Zhang and Chengyong Shen. Detection and treatment of LRP4- associated neurotransmission disorders. US Patent 9,897,614. Published 2/20/2018. (International Patent Application #: PCT/US2010/053483; Filing Date: 10/21/2010. International Publication Number: WO 2011/050134 A2; Publication Date: 04/28, 2011.)

- 24 - Page 25 of 37 This patent describes the invention of detection and treatment of LRP4-associated neurotransmission disorders.

5. L. Mei, W.C. Xiong, Y. Tao, C.Y. Shen, S.W. Luo. Erbin peptides. U.S.S.N. 61/768,333.

This patent describes the invention of a peptide to inhibit breast tumor growth by disrupting the ErbB2-ErbB2 interaction.

Teaching Service:

Graduate Committees 5/1998 – 8/1999, Pharmacological Sciences Training Program, University of Virginia (UVA) 9/1996 – 8/1999, Cell and Molecular Biology, UVA 5/1995 – 8/1999, Cancer Training Program, UVA 2002 – 2004, Molecular and Cellular Biology Admission Committee, University of Alabama at Birmingham (UAB)

Thesis Committees 1996 Wendy Liu, Ph.D., UVA Robert Fern, Ph.D., UVA 1998 Xuemei Luo, Ph.D., UVA Amy Brownawell, Ph.D., UVA Eric H. Middlekauff, M.S., UVA 1999 Geoff Alms, Ph.D., UVA Mary Rose Burnham, Ph.D., UVA Eileen Michelle Resnick, Ph.D., UVA Mary Rose Burnham, Ph.D., UVA Amy Ma, Ph.D., UVA 2000 Hongju Wu, Ph.D., UAB 2002 Zhenjie Lu, Ph.D., UAB 2003 Jon Cowan, Ph.D., UAB 2003 Xiao Li, Ph.D., UAB 2002 Qiang Wang, Ph.D., UAB 2003 Yong Hu, Ph.D., UAB 2007 Clem Dobbins, Ph.D., UAB Yamei Tang, Ph.D., MCG Nagendran Muthusamy, Ph.D., MCG Annie Ting, Ph.D., MCG Xihui Liu, Ph.D., Huazhong University of Science and Technology Yu Liu, Ph.D., Wuhan University 2015 Jason Lee, Grace Fox, Tong Luo, Ph.D., MCG

High School Students 2002 Jana Kay Wright, UAB (Bennett Scholars Program) 2010 Michael Luo, Dougherty Valley High School, San Ramon, CA 2013 Yinglin Li, Evans High School, Evans, Georgia Kevin Attiyeh, Oakland College Preparatory School, Oakland, California Eugene Heimann, Oakland College Preparatory School, Oakland, California 2015 Yitao Tu, Lakeside High School

- 25 - Workstudy Students 2003 Shoshanah Levy, UVA

Independent Undergraduate Research Program: 1995/1996 Eric B. Billig, UVA 1995/1996 Christopher Wladika, UVA 1996/1997 Daniel Miller, UVA 2018 Jonathan Liu, David Chang, Ethan Kinstler, CWRU

Ph.D. Rotation Students 1995 Jennifer McPherson, UVA 1997 Jennifer Gruenke, Timothy A. Schulz, UVA 1998 Lin Gao, UVA 2002 G. Clem Dobbins, Eddy Y. Wen, UAB 2003 Xinrui Li, Luqin Deng, Youngnam Jin, Willie Hudson, Senthil Nathan, UAB 2004 William C. Risher and Navjot Singh Pabla MCG 2005 Lijuan Zhou, Jinling Yang, MCG 2006 Annie Ting, MCG 2008 R. David Fessler and Ning Zhao, MCG 2009 Arnab Barik, C. Ryan Bates, and Jonathan Bean, MCG 2010 Anupama Sathyamurthy, MCG 2010 Dwight Figueiredo, MCG 2012 Thiri Lin, Georgia Regents University Christopher Rice, MD/PhD student, Georgia Regents University Amanda Crider, Georgia Regents University 2013 Kartik Angara, Grace Fox, Sean Naughton, Kai Zhao, Georgia Regents University 2014 Hongsheng Wang, Georgia Regents University 2015 Najeah Okashah (MD/PhD), Wonjo Jang (MD/PhD), Sam Spellicy (MD/PhD), Lacey Williams (MD/PhD), Helen Morris, Stephanie Christianson, Heath Robinson, Chandler Goldman 2016 Khadijah Alexander, Augusta University 2018 Ivan Santiago, Chen Shen, Vachan Vadmal, CWRU

Summer Research Internship Programs 1995 Primrose Musingarimi, undergraduate, UVA 1997 Emaka Ofobike, Jr., undergraduate, UVA 1999 Rajesh Swaminathan, undergraduate, UVA 2003 Harleen Khanijoun, undergraduate, Summer Program in Neurobiology, UAB 2004 Elaine Wang, undergraduate, UAB, Summer Program in Neurobiology, UAB 2007 William “Benji” White, STAR student (Georgia Tech) 2008 Voravut “Dan” Tangpisuthipongsa, STAR student (Georgia Tech) 2008 Yiming Yin, undergraduate, Peking University 2009 Ke Zhou, undergraduate, Peking University 2010 Anish Joseph, MCG STAR student (Georgia Tech) Albert Kim, medical student, MCG, GRU 2011 Xiang Zhang, undergraduate, Peking University 2013 Mihir Patel, MCG STAR student (University of Georgia, Athens, Georgia) Andrew Bowman, medical student, MCG, GRU 2014 Heath Robinson, MCG STAR student (University of Georgia, Athens, Georgia) 2015 Margret J. Fang and Austin Wallace, medical students, MCG, GRU - 26 - Page 27 of 37 Joseph Balbona, STAR student (Vanderbilt University) 2016 Egil Brudvik, MCG STAR student (Union College in Barbourville, Kentucky) 2017 Johnathon James Rast, MCG/AU STAR student (Georgia Southern) 2018 Sarisha Mahajan, high school student (Revere High School, Richfield, Ohio) 2018 Megan Opatrny, medical student (CWRU SOM)

Teaching/Lecturing

Medical education 1995-1999 Medical Pharmacology, UVA 2001-2004, Medical Neuroscience, Discussion Leader (6 contact hours), UAB 2002-2004, Lecture for Neurology Residents (1 lecture hour), UAB 2005, Grand Round Lecture, Neurology, MCG, Augusta University 2008, Grand Round Lecture, Psychiatry, MCG, Augusta University 2009, Grand Round Lecture, Neurology, Wayne State University

Graduate education 1998, Pharmacology: Molecules to System, UVA 1996-1997, Biological Chemistry (504), UVA 1996-1999, Molecular Endocrinology (co-director), UVA 1997, Cell and Molecular Biology (CMB) Student Seminar (director), UVA 2000-2004, CMB IV B: Principles of Development (2 lecture hours), UAB 2000-2002, Cell. & Mol. Neurobiology (2 lecture hours), UAB 2001 – 2006, Developmental Neurobiology (12 lecture hours), Hong Kong University of Science and Technology, Hong Kong 2000-2004, Topics in Neurobiology, Course One, Director (9 lecture hours; 36 contact hours), UAB 2000-2004, Developmental Neuroscience (Neur 720/CMB705C, 4 lecture hours), UAB 2001-2004, CMB 6/7, Stem Cells in Developing and Aging Brain, Director (5 lecture hours; 25 contact hours), UAB 2002-2004, CMB Methods Course (2 lecture hours), UAB 2004-2005, Neuroscience I (2 lecture hours, 1 lab hour), MCG, Augusta University 2004-2005, UGA BIOL honors (1 lecture hour), SGS/MCG with UGA. 2006-2008, Neuroscience I (4 lecture hours, 1 lab hour), MCG, Augusta University 2009 - 2011, Director, Molecular and Cellular Neuroscience and teaching faculty (4 lecture hours), Peking University, Beijing, China 2009 - 2017, Neuroscience I (6 lecture hours, 1 lab hour), MCG, Augusta University

Trainees:

Current

PhD Students Kai Zhao, Bachelor of Pharmacy/pharmacology (2009), China Pharmaceutical University, Nanjing, Jiangsu, China (8/2014 – present) Hongsheng Wang, Bachelor of Pharmacy (2009), Yantai University; MS in Pharmacology (2013), Yantai University, Shandong, China (8/2015 – present) Heath Robinson, Bechelor of Science (2015), University of Georgia, Athens, Georgia (7/2016 – present)

- 27 - Zhaoqi Dong, Bachelor of Science (2013), Jiangnan University, School of Pharmacy, Jiangsu, China (8/2016-present) Peng Zeng, Bachelor of Clinic Medicine (2011), Medical School, Tibet University for Nationalities, Tibet, China (9/2017 – present)

Visiting Students Wenbing Chen, Bachelor in Bioengineering, Nanchang University (2013); PhD student, Institute of Life Science, Nanchang University, China (6/2017 - present) Min Yan, Bachelor in Clinic Medicine, Jiangxi Medical College (2002), MS in Biochemistry and Molecular Biology, Jilin University (2006), PhD student, Institute of Life Science, Nanchang University, (07/2017 – present) Zheng Yu, Master in clinical medicine, Nanchang University (2011); PhD student, Institute of Life Science, Nanchang University, China (03/2018 - present) Hongyang Jing, Bachelor in biology science, Nanchang University (2014); PhD student, Institute of Life Science, Nanchang University, China (03/2018 - present)

Research Fellows Zhibing Tan, PhD in Neuroscience (2014), Institute of Neuroscience, Chinese Academy of Sciences, Shanghai (8/2014 – present) Hongsheng Zhang, PhD in Cell Biology (2014), Institute of Genetics and Developmental Biology, Chinese Academy of Science, Beijing, China (1/2015 – present) Guanglin Xing, PhD in Genetics, Institute of Life Science, Southeast University, Nanjing, China (11/2015 – present). Lei Zhang, PhD in Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Beijing, China (2/2016-present) Wanpeng Cui, PhD in Molecular Neuroscience (2015), Tokyo Medical and Dental University (9/2016 – present) Haiwen Li, PhD in Biochemistry and Molecular Biology (2016), Beijing Institute of Radiation Medicine, Beijing, China (4/2017 – present) Kongyan Wu, PhD in Neuroscience (2012), Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China (9/2017 – present) Nannan Gao, PhD in Biochemistry and Cell Biology (2017), Chinese Academy of Sciences, Shanghai, China (11/2017 – present) Rangjuan Cao, PhD in Cell Biology (6/2014), Institute of Cytology and Genetics, Northeast Normal University, Changchun, China (12/2017-present)

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Ph.D. Graduate Students: Michael Tanowitz, PhD in Pharmacology 2000, University of Virginia. Thesis: Synaptic roles of tyrosine phosphatases. Present position: Postdoctoral fellow in Mark Von Zastrow’s lab, UCSF. Sandra Won, PhD in Neuroscience, University of Virginia (2000). Thesis: Neuregulin signaling at synapses. Present position: Postdoctoral fellow in Craig Garner’s lab, Stanford University. Yang-Zhong Huang, PhD in Molecular Neurobiology 2000, Center of Life Sciences, Chinese Academy of Sciences, Shanghai, China. Thesis: Regulation of neuregulin signaling by PDZ domain-containing proteins interacting with ErbB receptor tyrosine kinases. Present position: Postdoctoral fellow in James O. McNamara’s lab, Duke University.

- 28 - Page 29 of 37 Li Ma, PhD in Molecular Neurobiology 2001, Center of Life Sciences, Chinese Academy of Sciences, Shanghai, China. Thesis: ErbB proteins and lipid rafts – ligand-regulated translocation of neuregulin signaling complexes into lipid rafts. Present position: Postdoctoral fellow in James Morgan’s lab, St. Jude Research Hospital, Memphis, Tennessee. Qiang Wang, PhD in Neurobiology 2004. University of Alabama at Birmingham, Birmingham, Alabama. Thesis: Mechanisms of AChR clustering at the neuromuscular junction. Present position: Postdoctoral fellow in Alex Kolodikin’s lab, Johns Hopkins University School of Medicine, Baltimore, Maryland. Clem Dobbins, PhD in Neurobiology 2007, University of Alabama at Birmingham, Birmingham, Alabama. Thesis: The rapsyn-α-actinin interaction. Present position: Postdoctoral fellow at University of Alabama at Birmingham. Yu Liu, PhD in Neurobiology 2008, Medical School of Wuhan University, Wuhan, China. Current position: Assistant Professor, Medical School of Wuhan University, Wuhan, China. Annie Ting, PhD in Neuroscience (2010), Medical College of Geogia, Augusta, Geogia. Present position: Postdoctoral Fellow, Hong Kong Univerisity of Science and Technology, Hong Kong, China. Xihui Liu, MD (2004) and PhD in Medicine (2009), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Present position: Postdoctoral Fellow, UT Southwestern, Dallas, Texas. Chuan Liang, MD (2006) and PhD in Meidcine (2012), Medical School of Wuhan University, Wuhan, China (9/2008 – 12/2011). Present position: Attending Physician, Wuhan Hospital, Wuhan, China. Arnab Barik, Bachelor of Technology in Biotechnology (2008) Chennai, SRM University, Chennai, Tamil Nadu, India (9/2009 – 5/2014 for PhD and 5/204-3/2015 for postdoc). Present position: Postdoctoral Fellow, NIH. Xiangdong Sun, Bachelor from Southern Medical University, Guangzhou, China (8/2011 – 6/2014). Present position: Postdoctoral Fellow, MCG. Ryan Bates, BS in Biology (2007), Georgia Southern University (7/2009 – 7/2014). Present Position: Medical Student, Mercer University School of Medicine, Savanah, Georgia. Jonathan Bean, BS in Experimental Psychology (2007), University of South Carolina, Columbia, South Carolina (7/2009 – 7/2015). Present Position: Postdoctoral Fellow, University of Washington, Seattle, Washington. Arupama Sathyamurthy, Bachelor of Technology (2008) Chennai, SRM University, Chennai, Tamil Nadu, India (1/2010 – 5/2015). Present Position: Postdoctoral Fellow, NIH. Weike Deng, PhD in Animal Neural Science, Nanchang University (9/2014 – 8/2015). Present Position: Associate Professor, Nanchang University. Dwight Figueiredo, Bachelor of Life Sciences, St. Xavier’s College, University of Mumbai, India (7/2011 – 5/2016). Present Position: Postdoctoral Fellow, Tata Institute of Fundamental Research, Mumbai Huifeng Jiao, Bachelor in Zoology, Nanchang University. PhD in Neuroscience, Institute of Life Science, Nanchang University, China (9/2013 – 1/2017). Current Position: Assistant Professor, Nanchang University. Thiri Lin, Bachelor of Science in Biology (2010), Queens University of Charlotte, Charlotte, North Carolina (9/2012 – 9/2017). Current Position: Medical School Shu Shu, Bachelor in Biology Information Technology, Huazhong University of Science and Technology, Wuhan, China (5/2017 – 3/2017)

Postdoctoral Fellows or Visiting Scholars - 29 - Jutong Si (12/1995-12/1999), Ph.D. in Virology, Wuhan University, China. Current position: Research Associate at the University of Washington, Seattle, Washington Hongwei Sun (1994-1995), Ph.D. in Agriculture, Virginia Tech. Current position: Research Associate at Baylor Medical College, Houston, Texas Quansheng Du (1998-1999), Ph.D. in Virology, Wuhan University, China. Current position: Associate Professor at the Medical College of Georgia, Augusta, Georgia Zhenge Luo (1/2000-5/2003), Ph.D. in Microbiology, Institute of Microbiology, Beijing. Current position: Investigator, Institute of Neuroscience, Chinese Academy of Sciences Zhi-Hua Yang (9/2000-9/2002), Ph.D. in Molecular Biology, Institute of Basic Medical Sciences, Beijing. Current position: Associate Professor, Institute of Environmental Medicine, Chinese Academy of Military Medical Sciences, Tianjin, China. Ren Lai (2002-2003), Ph.D. in Animal Sciences. Current position: Investigator, Institute of Animal Sciences, Chinese Academy of Sciences, Kunming, China. Xiao-li Yang (12/2002-7/2004), Ph.D. in Molecular Biology. Current position: research associate at Department of Medicine, University of Alabama at Birmingham Xiao-qun Wang (5/2006-1/2007), Ph.D. in Plant Biology. Current position: Investigator, Institute of Biophysics, Chinese Academy of Sciences, Beijing Ran-sook Woo (6/2004 – 1/2007), Ph.D. in Pharmacology. Current position: Assistant Professor, Department of Anatomy and Neuroscience, School of Medicine, Eulji University, 143-5, Yongdu-dong, Jung-gu, Daejeon, 301-832, Korea Penggao Dai (5/2004 – 1/2007), PhD in Bioengineering, Chinese Academy of Sciences, Beijing, China. Current position: Associate Professor, Northwest University, Xi’an, China Xian-ping Dong (6/2003 – 1/2007), Ph.D. in Neurobiology. Current position: Assistant Professor, Department of Physiology and Biophysics, Dalhousie University, Halifax, Canada Chang-hoon Kim (3/2002 – 10/2006), Ph.D. in Plant Biology. Current position: Assistant Professor, CHA Medical University, Seoul, Republic of Korea Dan Zhu (9/2003 – 5/3007), PhD. in Neurobiology. Current position: Research Associate, Emory University. Tian-ming Gao (5/2005 – 4/2006), PhD in Neurobiology, Sun Yat-Sen University of Medical Sciences, Guangzhou. Current position: Vice President, Southern Medical University, Guangzhou, China. Xiao-ming Li (5/2005 – 6/2008), PhD in Neurobiology (2003), First Millitary Medical University. Current position: Professor, Zhejiang University, Hanzhou, China. Ezekiel Carpenter-Hyland (5/2006-1/2008). Ph.D. in Neuroscience, Medical University of South Carolina. Current position: Research Associate at Morehouse School of Medicine. Shiwen Luo (8/2005 – 5/2009), PhD in Molecular Biology. Current position: Professor, Nanchang Univeristy, Nanchang, Jiangxi, China Lei Wen (4/2008 – 7/2009), PhD in Neuropharmacology (2005), Beijing Institute of Pharmacology and Toxicology, Beijing, China. Current position: Professor, Amoy University, Amoy, China Huayi Bai (10/2009 – 5/2010), PhD in Neurobiology (2008), Zhejiang University School of Medicine, Hangzhou, China. Current position: Professor, Yunnan Agriculture University. Xinhong Zhu (2/2009 – 8/2010), MD (1991) Henan Traditional Chinese Medicine Academy; PhD in Neurobiology (2005), The First Military Medical University, Guangzhou, China. Current position: Professor and Vice Chair, Department of Neurobiology, Southern Medical University, Guangzhou, China. Xiaoyu Hou (10/2009 – 7/2010), PhD in Neuropharmacology (2003), Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. Current position:

- 30 - Page 31 of 37 Professor and Chair, Department of Neurobiology, Xuzhou Medical University, Xuzhou, China. Yanmei Tao (8/2005 – 1/2012, postdoctoral fellow), PhD in Neuroscience (2005), Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China. Current position: Professor, Hangzhou Normal University, Hangzhou, Zhejiang, China. Chunlei Wang (5/2010 – 7/2012) PhD in Neuroscience (2008), Institute of Neuroscience, Shanghai, China. Current position: Research Associate at Salk Institute, La Jolla, California. Haitao Wu (10/2008 – 9/2012) PhD in Cell Biology (2007), Institute of Basic Medical Sciences, Beijing, China. Current position: Associate Professor, Institute of Basic Medical Sciences, Beijing, China. Yisheng Lu (9/2008 – 8/2013) PhD in Neurobiology, Tsinghua University, Beijing, China. Current position: Research Associate, Brain Behavioral Discovery Institute, Georgia Regents University. Bin Zhang (11/2003 – 10/2013) PhD in Biochemistry and Molecular Biology (2002), Peking Union Medical College, Beijing, China. Current position: Professor, Department of Physiology, Tonji Medical College, Huazhong University of Science and Technology. Seon-Myung Kim (9/2012-12/2013), PhD in Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju, Korea. Current position: Deputy General Manager in R&D center in AnyGen Co. Ltd., South Korea. Dongmin Yin (9/2008 – 7/2014), PhD in Molecular and Cellular Neuroscience (2008), Peking University, Beijing, China. Current position: Professor, Institute of Brain Research, East China Normal University, Shanghai, China. Yongjun Chen (10/2008-12/2014), PhD in Neurobiology (2008), Southern Medical University, Guangzhou, China. Current position: Professor and Deputy Director, South China Research Center of Acupuncture and Moxibustion, Guangzhou University of Chinese Medicine, Guangzhou, China. Xinchun Ye, PhD in Neurology (2011), School of Medicine, Nanjing University, Nanjing, China (12/2013 – 3/2015). Current position: Professor and Chair, Department of Neurology, Affiliated Hospital, Xuzhou Medical University, Xuzhou, Jiangsu, China. Chengyong Shen, PhD in Biochemistry and Cell Biology (2008), Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China (12/2008 – 6/2015). Current position: Professor, Department of Neurology, Affiliated Hospital, Zhejiang University, Hangzhou, China. Yu Cao, PhD in Biochemistry and Molecular Biology (2014), Chinese Academy of Military Medical Sciences, Beijing (9/2014 – 6/2016). Current Position: Postdoctoral Fellow, Georgia Cancer Center, Augusta University. Yao Tian, PhD in Genetics, Institute of Life Science, Southeast University, Nanjing, China (11/2015 – 11/2016). Current Position: Assocaite Professor, Southeastern University, Nanchang, China Zhihui Zhu, PhD in Neuroscience (2014), Otto-von-Guericke University of Magdeburg, Germany. (8/2015 – 11/2016). Current Position: Postdoctoral Fellow, Augusta Univeristy. Xiangdong Sun, PhD in Neurobiology (2014), Southern Medical University, Guangzhou, China (7/2014 – 5/2017). Current Position: Professor, Guangzhou Medical University, Guangzhou, China Fang Liu, PhD in Neurobiology (2008), Institute of Neurobiology, Fudan University, Shanghai, China. (4/2014 – 9/2017) Yanan Wang, PhD in Neurobiology (2015), Zhejiang University, Hangzhou, China (9/2015 – 9/2017) Yu Liu, PhD in Neuroscience, Zhenjiang University, Hangzhou, China (06/2016-10/2017). - 31 - Lei Li, PhD in Cell Biology (2013), Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China. (9/2013 – 12/2017) Ran Wang, PhD in Brain Research, Niigata University Graduate School of Medical and Dental Sciences (5/2017 – 2/2018)

Invited Talks:

1992 Neuroscience Division, Abbott Laboratories, Abbott Park, Illinois. Department of Pharmacol. & Ther., Louisiana State Univ. Med. Center, Shreveport, LA. Glaxo Institute for Molecular Biology, Geneva, Switzerland. Department of Pharmacology, Univ. of Pennsylvania School of Med. Philadelphia, PA. Merck, Sharp & Dohme Research Laboratories, West Point, Pennsylvania. Department of Pharmacology, Brown University School of Medicine, Providence, RI. Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.

1993 Twenty-sixth Winter Conference on Brain Research, Whistler, British Columbia Worcester Foundation of Experimental Biology, Shrewsbury, Massachusetts. Department of Neuroscience, University of California at Riverside, Riverside, CA. Institute of Metabolic Disorders, Miles Inc., West Haven, Connecticut. Department of Neuroscience, Albert Einstein Coll. of Med., Bronx, New York. ImmunoGen Inc., Cambridge, Massachusetts. Department of Pharmacol. & Exp. Ther., Boston Univ., Sch. of Med., Boston, MA Department of Mol. And Med. Pharmacol., UCLA Sch. of Med., Los Angeles, CA.

1995 Department of Biochemistry, Univ. of Virginia Sch. of Med., Charlottesville, VA. First International Symposium on Neuroreceptor Mechanisms, Niigata, Japan. Department of Neuroscience, Univ. of Virginia Sch. of Med., Charlottesville, VA.

1996 Shanghai Research Center of Life Sciences, Chinese Academy of Science, Shanghai. Xianshan Conference Special Symposium, Beijing, China. National Institute of Aging, National Institutes of Health, Baltimore, MD.

1997 National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD. Second International Symposium on Neuroreceptor Mechanisms, Sapporo, Japan Department of Physiology, University of North Carolina, Chapel Hill, NC.

1998 The 3rd Int. Symp. Biotechnol., Med., and Pharm. For Young Scientist, Beijing, China Gordon Conference on Molecular Neurobiology, Beijing, China

1999 Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL. Third International Symposium of Life Sciences, SRCLS, CAS, Shanghai, China Department of Biochemistry, University of Kentucky, Lexington, KY. Department of Neurobiology, University of Kentucky, Lexington, KY. - 32 - Page 33 of 37 8th Intl. Sym. of Soc of Chinese Bioscientists in America (SCBA), Hong Kong, China

2000 Department of Physical Medicine and Rehabilitation, UAB, Birmingham, AL. Gordon Conference on Molecular Neurobiology, Hong Kong, June 4th Life Spring Symposium, Beijing, China Department of Neurosurgery, UAB, Birmingham, AL Opening Remarks, March of Dimes Walk America 2000. Team Captain Kick-Off.

2001 National Institute of Mental Health, National Institutes of Health, Bethesda, MD. Cancer Center, Georgetown University, Washington, D.C. Department of Biochemistry, Hong Kong Univ. of Science and Technology, Hong Kong Department of Physiology and Biophysics, University of Alabama at Birmingham, AL Department of Pathology, University of Alabama at Birmingham, AL Department of Cellular & Molecular Medicine, University of Ottawa, Ontario, Canada

2002 Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh. Discussion Leader, Gordon Research Conference, Mol. & Cell. Neurobiol., Hong Kong The Third Symposium of Neuroscience, Chengdu, China Department of Dept. of Pathol. & Anatomy, Eastern Virginia Med. Sch.

2003 Homel Institute, University of Minnesota Department of Environmental Health Sciences, Univ. of Alabama at Birmingham, AL Department of Hematology/Oncology, University of Alabama at Birmingham, AL Mini-Symposium on Molecular Neuroscience: Technology Applications, Hong Kong University of Science and Technology Alzheimer’s Disease Research Center, University of Alabama at Birmingham, AL St. Louis University, Department of Biology, St. Louis, MO Department of Anatomy and Neurobiology, Washington University, St. Louis, MO Starks Neuroscience Research Institute, Indiana University, Indiana, IN

2004 Department of Neuroscience, University of Pennsylvania, Philadelphia, PA Medical College of Georgia, Augusta, GA NIMH, NIH, Bethesda, MD Department of Cell Biology, University of Alabama at Birmingham, AL Department of Pharmacology, University of Alabama at Birmingham, AL Gordon Research Conference, Mol. & Cell. Neurobiol., Hong Kong Department of Biological Chemistry, University of Michigan, An Arbor, MI

2005 Department of Neurobiology, Duke University, Durham, NC Department of Biochemistry, Medical College of Georiga, Augusta, GA Department of Biochemistry, Hong Kong Univ. of Science and Technology, Hong Kong Dept. of Cell and Dev. Biol., Univ. of North Carolina at Chapel Hill, Chapel Hill, NC Institute of Biophysics, Chinese Academy of Sciences, Beijing, China XIIth International Symposium on Cholinergic Mechanisms, Alicante, Spain - 33 -

2006 Grand Round, Department of Neurology, Medical College of Georgia 11th SCBA Int. Symp., Society of Chinese Bioscientists in America, San Francisco, CA 1st Int. Conference on Synapses, Memory, Drug Addiction, and Pain, Toronto, Canada Sils Symposium, Sils-Maria, Switzerland Neuroscience Program, University of Virginia, Charlottesville, VA

2007 Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences (GIBH) Barrow Neurological Institute, Phoenix, Arizona International Conference for Neurons and Brain Diseases, Toronto, Canada Georgia/South Caroline Neuroscience Consortium Meeting Department of Neurology, Northwestern University Department of Biology, Georgia State University Department of Neurobiology, Drexel University Department of Cellular Biology, University of Georgia, Athens, GA Miami University, Miami, Florida Myelin Satellite Symposium, International/American Society for Neurochemistry (ISN/ASN), Chichen Itza, Mexico National Institute of Biological Sciences, Beijing, China Institute of Biophysics, Chinese Academy of Sciences, Beijing, China Peking University School of Life Sciences, Beijing, China

2008 Dept. Pharmacol., Emory University School of Medicine, Atlanta, Georgia Dept. Neurosci., Lerner Research Institute, Cleveland Clinic Foundation, Ohio XIII International Symposium on Cholinergic Mechanisms, Foz do Iguaçu, Brazil Depart. Neurosci. & Cell Biol., UMDNJ-Robert Wood Johnson Medical School Mathilde Solowey Lecture in Neurosciences, NIH International Conference for Neurons and Brain Disease, Seoul, Korea Guarda Symposium, Guarda, Switzerland Program of Neuroscience, Medical College of Georgia Healthy Minds Across America, NARSAD Eli Lilly Company, Indianapolis, Indiana Society for Neuroscience, Minisymposium on Neuregulin 1, Washington, DC

2009 Neurology Grand Round, Wayne State University, Detroit, Michigan Dept Physiology, Northwestern University, Chicago, Illinois Dept Physiology, Emory University, Atlanta, Georgia Dept. Mol, Cell & Dev Biology, Yale University, New Haven, Connecticut College of Medicine, Zhejiang University, Hanzhou, Zhejiang, China Institute of Life Sciences, East China Normal University, Shanghai, China Charlie Norwood VA Medical Center, Augusta, Georgia School of Medicine, Peking University, Beijing, China Institute of Pharmacology, National Cheng Kung University, Tainan, Taiwan Nagoya University Graduate School of Medicine, Nagoya, Japan Saitama Medical University, Tokyo, Japan Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China - 34 - Page 35 of 37 Alberta Heritage Foundation for Medical Research Visiting Lecturer, Hotchkiss Brain Inst, Univ of Calgary, Canada 2009 International Conference on Brain Diseases: Basic and Clinical Aspects, Xuzhou, China International Society of Neurochemistry, Pushan, Korea Keynote Speaker to Young Investigators, Neurobiology of Disease in Children, Louisville, KY Department of Biology, Pennsylvania State University, University Park, PA Department of Psychiatry, Columbia University, New York, New York

2010 Shanghai Jiaotong University, School of Medicine, Shanghai, China Nanjing Medical University, Nanjing, China Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas Winter Conference on Neural Plasticity, Aruba Department of Medicine, Medical College of Georgia, Augusta, Georgia Departments of Behavioral Medicine, West Virginia University, Morgantown, West Virginia Muscle Institute, University of Pennsylvania, Philadelphia, Pennsylvania Centre for Research in Neuroscience, McGill University, Montreal, Quebec, Canada Department of Cell Biol. & Anatomy, Louisiana State University, New Orleans, Louisiana Gordon Research Conference, Mol. & Cell. Neurobiol., Hong Kong Higher Cognition Function of Brain Forum, Chinese Soc. Neuroscience, Nanchang, China Guarda Symposium, Guarda, Switzerland Université Paris Descartes, Sorbonne Paris Cité, France Neuroscience Seminar, University of Texas Southwestern Medical Center, Dallas, Texas Department of Mol. Biophys. & Physiol., Rush University Medical Center, Chicago Department of Physiology, University of Maryland at Baltimore, Baltimore, Maryland

2011 Department of Neuroscience, Johns Hopkins Univ. School of Medicine, Baltimore, Maryland Department of Biology, Texas A & M, College Station, Texas Synapses: From Molecules to Circuits and Behavior, Cold Spring Harbor Laboratory Tongji Medical School, Huazhong University of Science and Technology, Wuhan, China Institute of Basic Medical Sciences, Beijing, China GlaxoSmithKline R & D, Shanghai, China Johnson & Johnson, PRD, San Diego, California 13th SCBA International Symposium, Guangzhou, China 9th Chinese Society for Neuroscience Annual Meeting, Zhengzhou, China Department of Neurobiology, China University of Science and Technology, Hefei, China Int. Symposium on Skeletal Muscle Maintenance, Wasting and Repair, Ascona, Switzerland Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania Department of Pharmacology, University of Virginia, Charlottesville, Virginia

2012 Department of Neuroscience, Tufts University, Boston, Massachusetts Departments of Pharmacology and Psychiatry, University of Texas HSC at San Antonio Symposium for Chinese Neuroscientists Worldwide 2012, Xi’an, China Institute of Animal Sciences, Chinese Academy of Sciences, Kunming, China. Guarda Symposium, Guarda, Switzerland Department of Biomedizin, Universitat Basel, Basel, Switzerland Institute of Neural Development and Regeneration, Hangzhou Normal University, China Keynote Speaker, 9th Annual Sym., Chinese Assoc. Basic & Clinic Psych., Hangzhou, China - 35 - Department of Neurobiology, Second Military Medical University, Shanghai, China Shanghai Jiaotong University, Shanghai, China Department of Neuroscience, Scripps Florida, Jupiter, Florida ACNP 51st Annual Meeting, Hollywood, Florida

2013 Carolinas Health Care, Charlotte, NC Department of Cell Biology, Emory University, Atlanta, GA Dept. Pharmaceutical & Biomed. Sci., College of Pharmacy, University of Georgia XIV International Symposium on Cholinergic Mechanisms in Hangzhou, China US-Japan Workshop on Synaptic Plasticity, Seattle, Washington EMBO Workshop: Mol. Mechanisms of Muscle Growth and Wasting, Centro Stefano Franscini, Ascona, Switzerland Symposium of Depression, Chinese Neuroscience Society, Beijing, China Inst. Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China Department of Molecular, Cellular, & Developmental Biology, University of Michigan Dept. Physiol. & Biophys., Faculty of Med., Dalhousie Univ., Halifax, Nova Scotia, Canada Dept. Pharmacol. & Tox., Medical College of Wisconsin, Milwaukee, Wisconsin

2014 Department of Pharmacology, University of Tennessee, Memphis, Tennessee 2014 Symposium of Chinese Neuroscientists Worldwide, Suzhou, China 2014 Int. Symposium on Synaptic Transmission, Plasticity and Disease, Wuhan, China Gordon Research Conference, Mol. & Cell. Neurobiol., Hong Kong East China Normal University, Shanghai, China Virginia Tech Carilion Research Institute, Roanoke, Virginia Guarda Symposium on Neuromuscular Junction, Guarda, Switzerland Professor Qiao Cai Memorial Lecture, 24th Congress of Chinese Association for Physiological Sciences (CAPS), Shanghai, China Keynote Speaker, the Fourth Forum on Advances in Psychiatry & Clinical Psychology and 100th Anniversary Ceremony of the An-Ding Psychiatric Hospital, Beijing 2nd Annual Molecular Psychiatry Meeting, San Francisco

2015 Center for Organogenesis, University of Michigan, Ann Arbor, Michigan MRC Centre for Developmental Neurobiology, King's College, London Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK Zilkha Neurogenetic Institute, Keck School of Medicine, Univ. South California, Los Angeles SCBA the 15th International Symposium, Taipei, Taiwan Center for Brain Research, Medical University of Vienna 44th European Muscle Conference, Warsaw, Poland Symposium on synapse formation and neurodevelopment disorders, SfN 2015 Annual Meeting in Chicago (Chair) Schulich School of Medicine & Dentistry, Western University, London, Canada. Department of Physiology, State University of New York at Buffalo. Keynote Lecture, Neuroscience Day, University of Miami, Miami, Florida Guangzhou University of Chinese Medicine, Guangzhou, China Center of Life Sciences, Peking University, Beijing, China

2016 - 36 - Page 37 of 37 Dept. of Physiol. & Pharmacol., Coll. of Veterinary Medicine, Univ. of Georgia, Athens, GA Dept. of Pharmacol. & Toxicol., Morehouse School of Medicine, Atlanta, GA 4th International Symposium on Neurotransmission and Synaptic Plasticity, Nanchang, China Case Western Reserve University, School of Medicine, Cleveland, Ohio Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania College of Life Sciences, Northeastern Normal University, Jilin, China Guarda Symposium on Neuromuscular Junction, Guarda, Switzerland XVth International Symposium on Cholinergic Mechanisms, Marseille, France Plenary Seminar Series, Rutgers Brain Health Inst., Rutgers Univ., Piscataway, New Jersey Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California Invited Speaker, American College of Neuropsychopharmacology Annual Meeting, Hollywood, Florida

2017 Distinguished Seminar Series, Dept. of Genetics, Perelman Sch. Med., Univ. Pennsylvania Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia Department of Physiology, Northwestern University, Chicago, Illinois. 13th Int. Conf. on Myasthenia Gravis and Related Disorders, New York Academy of Sciences University of Arizona, College of Medicine-Phoenix, Phoenix, Arizona Distinguished Seminar, NSF STC Emergent Behavior of Integrated Cellular Systems (EBICS), MIT, Georgia Institute of Technology, and University of Illinois Symposium on Synaptic Development, Signaling and Neuro-disorders, Hong Kong University of Science and Technology, Hong Kong

2018 NIH Neuroscience Seminar, National Institutes of Health, Bethesda, Maryland Department of Neuroscience, Cleveland Clinic, Cleveland, Ohio Jiangsu Key Laboratory of Brain Disease Bioinformation, Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, Jiangsu, China Department of Biological Sciences, University of Toledo, Toledo, Ohio Kent State University, Youngstown, Ohio 5th International Symposium on Synaptic Transmission and Plasticity (2018ISSTP), Guangzhou, China Maxwell Mozell Seminar, State University of New York, Upstate Medical University, Syracuse, New York Big Data Neuroscience Workshop 2018, the Advanced Computational Neuroscience Network (ACNN) Guarda Symposium on Neuromuscular Junction, Guarda, Switzerland Molecular mechanisms of muscle wasting during aging and disease, Congressi Stefano Franscini, Monte Verità, Ascona, Switzerland Department of Biology, Case Western Reserve University, Cleveland, Ohio Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio

2019 Northeast Ohio Medical University (NEOMED), Rootstown, Ohio Department of Neuroscience, Thomas Jefferson University, Philadelphia, Pennsylvania The 16th international Symposium on Cholinergic Mechanisms (ISCM-XVI), Weizmann Institute of Science campus in Rehovot, Israel

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