DOCSLIB.ORG

An Update on the Lewis Blood Group System

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
An Update on the Lewis Blood Group System B LOOD G ROUP R EVIEW An update on the Lewis blood group system M.R. Combs This update of the Lewis blood group system (Combs MR. Lewis chills, severe back pain, hemoglobinuria, and increased levels blood group system review. Immunohematology 2009;25:112–8) of bilirubin, alanine transaminase, and serum creatinine. A describes new information on the clinical significance of Lewis monocyte monolayer assay, testing the patient’s serum with antigens regarding susceptibility of individuals to certain diseases and the possible role of bacteria in Lewis expression. This update the Le(a+) RBCs causing the reaction, was positive also describes recently reported examples of Lewis antibodies A case report in 2015 of a possible HTR due to anti-Lea causing hemolytic transfusion reactions. No new antigens have was reported in a pregnant patient with sickle cell disease with been identified in the International Society of Blood Transfusion a 10 system 7, leaving the antigen count to stand at six: Lea, Leb, LebH, a 37°C gel-reactive anti-Le . The crossmatch was compatible ALeb, BLeb, and Leab. Immunohematology 2019;35:65–66. using prewarmed plasma neutralized with Lewis substance. During transfusion, the patient experienced significant Key Words: Lewis, fucosyltransferases, antigen, antibody dyspnea, hypotension, and hemoglobinuria. Indirect bilirubin and lactate dehydrogenase tests were elevated. The direct Lewis Antigens antiglobulin test on the post-transfusion sample was negative, indicating the possibility that all incompatible RBCs were Lewis antigen fucosyltransferases are encoded by the cleared. FUT3 gene located on chromosome 19p13.3.1 The presence or A case of an HTR due to anti-Leb, also in 2015, was absence of Lewis antigens in an individual can be associated reported.11 A pretransfusion sample from a 30-year-old with the individual’s susceptibility to certain diseases and African-American woman showed a negative antibody infections. As described in a recent review,2 non-secretors detection test in solid phase. Nine days after receipt of two are more likely than secretors [Le(b+)] to be susceptible to computer crossmatch-compatible RBC units, her hemoglobin symptomatic cholera,3 bacterial meningitis,4 type 2 diabetes dropped to 7.9 g/dL. The post-transfusion sample typed as mellitus,5 and type 1 diabetes mellitus.6 In addition, increased group B, D+, although agglutination with the reagent B RBCs activity of the secretor and Lewis fucosyltransferases seems to in the reverse grouping was detected and thought to be a cold be involved in the development and control of cancers of the agglutinin. Electronic crossmatch-compatible RBC units were distal colon.2 issued. During infusion, the patient developed signs of an acute A recent review7 discusses the possible role of bacteria in HTR (chills, nausea, brown urine). An in vitro hemolytic IgM Lewis expression. The intestinal tract switches from sialylated anti-Leb was identified. A tube test–only, room temperature– glycans to fucosylated antigens with age and bacterial reactive anti-Lea was also identified. colonization.8 It is speculated that the low Leb expression on neonatal red blood cells (RBCs) reflects the immature nature References of gut flora.7 1. Combs MR. Lewis blood group system review. Immunohematology 2009;25:112–8. Lewis Antibodies 2. Ewald D, Sumner S. Blood type biochemistry and human disease. Wiley Interdiscip Rev Syst Biol Med 2016;8:517–35. Lewis antibodies are usually clinically insignificant and 3. Arifuzzaman M, Ahmed T, Rahman MA, et al. Individuals with Le(a+b–) blood group have increased susceptibility are rarely associated with hemolytic transfusion reactions to symptomatic Vibrio cholera O1 infection. PLoS NTDS (HTRs). Three recent reports of Lewis antibodies associated 2011;5:e1413. with HTRs have been reported. 4. Blackwell CC, Jonsdottir K, Weir DM, et al. Blood group, secretor status and susceptibility to bacterial meningitis. A case report from 2013 describes a severe HTR due to FEMS Microbiol Immunol 1989;1:351–6. a 9 anti-Le in a multiply transfused Le(a–b–) patient. After 5. Greenwell P. Blood group antigens: molecules seeking a receipt of a crossmatch-compatible Le(a+) RBC unit, the function? Glycoconj J 1997;14:159–73. patient developed an acute transfusion reaction with fever, IMMUNOHEMATOLOGY, Volume 35, Number 2, 2019 65 M.R. Combs 6. Smyth DJ, Cooper JD, Howson JM, et al. FUT2 nonsecretor 10. Duncan V, Pham H, Williams L III. A possible case of a status links type 1 diabetes susceptibility and resistance to haemolytic transfusion reaction caused by anti-Lea antibody. infection. Diabetes 2011;60:3081–4. Blood Transfus 2015;13:535–6. 7. Cooling L. Blood groups in infection and host susceptibility. 11. Irani MS, Figueroa D, Savage G. Acute hemolytic transfusion Clin Microbiol Rev 2015;28:801–70. reaction due to anti-Leb. Transfusion 2015;55:2486–8. 8. Nanthakumar NN, Dai D, Newburg DS, Walker WA. The role of indigenous microflora in the development of murine intestinal Martha Rae Combs, MT(ASCP)SBB, Technical Director of fucosyl- and sialyltransferases. FASEB J 2003;17:44–6. Immunohematology Reference Laboratory, Duke Hospital 9. Höglund P, Ragnhild R-L, Wikman AT. A severe haemolytic Transfusion Service, Room 1720, Box 2928, 2301 Erwin Road, transfusion reaction caused by anti-Lea active at 37°C. Blood Transfus 2013;11:456–9. Durham, NC 27710, [email protected]. 66 IMMUNOHEMATOLOGY, Volume 35, Number 2, 2019.
Load more

Recommended publications
  • Study of Blood Group (ABO and RH) Association and Secretor Status of ABH Substances in Patients with Systemic Lupus Erythematosus
    IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 18, Issue 5 Ser. 12 (May. 2019), PP 31-35 www.iosrjournals.org Study of Blood Group (ABO and RH) Association and Secretor Status of ABH Substances in Patients with Systemic Lupus Erythematosus Dr. Tashi Paleng1, Dr. A. Barindra Sharma2, Dr.Santa Naorem3, Dr. Laikangbam Dayalaxmi4, Dr. Eric Hilton Wanniang5, Dr. Eswara Moorthy G6 1Postgraduate trainee, 2Professor & Head, 3Professor, 4Senoir Resident, 5Postgraduate trainee, 6Postgraduate trainee 1,2,4,5,6Department of Transfusion Medicine, 3Department of Medicine, Regional Institute of Medical Sciences, Imphal-795004, Manipur, India Corresponding Author: Dr. Tashi Paleng Abstract: Individuals who secrete their blood group antigens in the body fluids are called secretors and individuals who do not secrete are called non-secretors. Non-secretors of blood group antigens have been found to be associated with many infectious and autoimmune diseases by many previous studies. The aims of our study were to find out any association between ABO blood group, RhD blood group and secretor status of ABH substances with the patients of Systemic Lupus Erythematosus. This Case Control study was carried out in the Department of Transfusion Medicine in collaboration with the Department of Medicine, Regional Institute of Medical Sciences, Imphal Manipur from September 2016 to August 2018. 75 confirmed SLE patients attending Rheumatology OPD, Department of Medicine and 75 healthy sex matched voluntary blood donors attending blood bank, Department of Tranfusion Medicine have been enrolled in the study. Their blood were typed for ABO and RhD groups using conventional tube technique and saliva were tested for secretor and non-secretor status using heamagglutination inhibition test.
    [Show full text]
  • Transfusion in a Rare Case of Para-Bombay Phenotype
    TRANSFUSION IN A RARE CASE OF PARA-BOMBAY PHENOTYPE Charlotte Engström1, Stefan Meyer2, Young-Lan Song1, Adriana Komarek1, Alix O’Meara3, Claudia Papet3, Kathrin Neuenschwander2, Christoph Gassner2, Beat M. Frey1 1 Immunohematology, Blood Transfusion Service Zurich, Swiss Red Cross, Switzerland. 2 Molecular Diagnostics & Research, Blood Transfusion Service Zurich, Swiss Red Cross , Switzerland. 3 Hematology/Oncology, Spital Limmattal, Schlieren, Switzerland. Background Results Individuals with Bombay phenotype are characterized by the The routine anti-A, -B and -A/B failed to detect the respective absence of ABH blood group antigens both on the surface of antigens and, most notably, no H-antigen was traceable. The red blood cells (RBCs) and in secretions resulting from RBCs showed only weak agglutination with the potent anti-A/B silenced mutations in FUT1 (h/h) and FUT2 (se/se) genes, serum (Grifols). Only anti-H, but no anti-A or anti-B, was respectively. In contrast, para-Bombay phenotype retains identified in the serum. Initial ABO genotyping by sequence- some H antigen on RBCs either induced from a weakly active specific priming (PCR-SSP) resulted in AB genotype. In order (H+weak/H+weak) or completely silenced FUT1 gene (h/h). to confirm serological H-deficient phenotype a more detailed The latter is mandatory linked with an active FUT2 gene analysis was performed including sequencing of FUT1 and (Se/Se or Se/se) enabling synthesis of ABH-antigens in FUT2 which revealed an active secretor status (Se/Se) but secretions which may be adsorbed from the plasma onto homozygosity for the FUT1*01W.09 allele (c.658C>T, RBCs surface (1, 2).
    [Show full text]
  • The Incidence of Spontaneous Abortion in Mothers with Blood Group O Compared with Other Blood Types
    IJMCM Meta analysis Spring 2012, Vol 1, No 2 The incidence of spontaneous abortion in mothers with blood group O compared with other blood types ∗ Mohammad Hassanzadeh-Nazarabadi 1∗∗, Sahar Shekouhi 1, Najmeh Seif 1 Faculty of Medicince, Department of Medical Genetics, Mashhad University of Medical Sciences, Mashhad, Iran Although ABO incompatibility between mother and fetus has long been suspected as cause of spontaneous abortion in man, its precise contribution has not been completely resolved. In spite of reports in which the incompatible mating was recognized to be a cause of habitual abortion, and which eventually results in infertility or a reduction in the number of living children compared with the number in compatible matings, such effects were not observed in other studies. The aim of this review article was to show some evidence of relationship between ABO incompatibility and spontaneous abortion. Key words: spontaneous abortion, ABO blood group, incompatibility In 1900 Karl Landsteiner reported a series of discovered, attention was directed toward the tests, which identified the ABO blood group system. possibility of harmful effects when mother and This is the only blood group in which antibodies are fetus have different blood groups. As early as 1905 constantly, predictably, and naturally present in the A. Dienst suggested that toxemia of pregnancy serum of people who lack the antigen. ABO might be due to the transfusion of ABO- compatibility between mother and fetus is crucial (1). incompatible fetal blood into the mother. This was not substantiated, and the problem of ABO Downloaded from ijmcmed.org at 17:08 +0330 on Saturday September 25th 2021 Abortion interaction between mother and fetus was largely Spontaneous abortion also known as overshadowed by the more dramatic effects of Rh miscarriage, refers to a pregnancy that ends incompatibility leading to Rh hemolytic disease.
    [Show full text]
  • Secretor Status, Fucosyltransferase 2 (Fut2) Gene Polymorphisms and Susceptibility to Hiv Infections Among Female Sex Workers in Nairobi, Kenya
    SECRETOR STATUS, FUCOSYLTRANSFERASE 2 (FUT2) GENE POLYMORPHISMS AND SUSCEPTIBILITY TO HIV INFECTIONS AMONG FEMALE SEX WORKERS IN NAIROBI, KENYA Nadia Musimbi Chanzu W80/83581/2012 A Thesis Submitted in Fulfillment for the Degree of Doctor of Philosophy (Ph.D) in the University of Nairobi Institute of Tropical and Infectious Diseases University of Nairobi 2014 DECLARATION This Thesis is my original work and has not been presented for a degree in any other University. Nadia Musimbi Chanzu Signed: ………………………………………………… This Thesis has been presented with our approval as University Supervisors: Prof. Walter Mwanda, MBChB., MD. Signed: …………………………………………… Date: ……………………………………………… Prof. Omu Anzala, MBChB, PhD. Signed: …………………………………………… Date: ……………………………………………… Dr. Julius Oyugi, MSc. Ph.D Signed: …………………………………………… Date: ……………………………………………… ii DEDICATION This Thesis is dedicated to my parents, Yusuf Chanzu and Jamila Chanzu, my siblings, Abdalla, Issa, and Zahra. Thank you for the confidence you have always had in me. Thank you for your tremendous encouragement, support and prayers. I also dedicate this book to my late grandfather Abdalla Baraka Chanzu and my late great grandfather Baraka Lwoya Chanzu for their foresightedness which encouraged our family acquire high level quality education. iii ACKNOWLEDGEMENTS This work has had the support and goodwill of so many people that it is difficult to acknowledge each one of them individually, I would like to thank my entire family for their continued support. A special mention to my mother Jamila Chanzu, for always encouraging me to pursue my dreams, and teaching me that education was truly the key to success, her patience and kind heart. My father, Yusuf Chanzu for his continued support, mentorship and for teaching me that there is nothing impossible.
    [Show full text]
  • (FUT2) Non-Secretor Status and Blood Group B Are Associated With
    Downloaded from gut.bmj.com on September 29, 2014 - Published by group.bmj.com Gut Online First, published on July 15, 2014 as 10.1136/gutjnl-2014-306930 Pancreas ORIGINAL ARTICLE Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study Frank Ulrich Weiss,1 Claudia Schurmann,2,3 Annett Guenther,1 Florian Ernst,2 Alexander Teumer,2 Julia Mayerle,1 Peter Simon,1 Henry Völzke,4 Dörte Radke,4 Andreas Greinacher,5 Jens-Peter Kuehn,6 Martin Zenker,7 Uwe Völker,2 Georg Homuth,2 Markus M Lerch1 ▸ Additional material is ABSTRACT published online only. To view Objective Serum lipase activities above the threefold Significance of this study please visit the journal online (http://dx.doi.org/10.1136/ upper reference limit indicate acute pancreatitis. We gutjnl-2014-306930). investigated whether high lipase activity—within the reference range and in the absence of pancreatitis—are What is already known on this subject? For numbered affiliations see ▸ The definition of acute pancreatitis includes end of article. associated with genetic single nucleotide polymorphisms (SNP), and whether these identified SNPs are also characteristic clinical symptoms in combination Correspondence to associated with clinical pancreatitis. with elevated serum enzyme activities (amylase Professor Markus M Lerch, or lipase) above three times the upper Methods Genome-wide association studies (GWAS) on 1 Department of Medicine A, ‘ ’ ‘ reference limit. Elevated lipase levels below University Medicine Greifswald, phenotypes serum lipase activity and high serum lipase activity’ were conducted including 3966 German this cut-off are not considered diagnostic for Fleischmannstrasse 41, pancreatitis, and can be observed in a number 17475 Greifswald, Germany; volunteers from the population-based Study-of-Health-in- [email protected] of non-pancreatic conditions.
    [Show full text]
  • Impact of Recipient ABH Secretor Status on Outcome in Minor ABO-Incompatible Hematopoietic Stem Cell Transplantation
    TRANSPLANTATION AND CELLULAR ENGINEERING Impact of recipient ABH secretor status on outcome in minor ABO-incompatible hematopoietic stem cell transplantation Andreas Holbro,1,2 Martin Stern,1 Laura Infanti,1,2 Alix O’Meara,1 Beatrice Drexler,1 Beat M. Frey,3 Jean-Marie Tiercy,4 Jakob R. Passweg,1 Christoph Gassner,3 Andreas Buser,1,2 and Joerg-Peter Sigle2,5 llogeneic hematopoietic stem cell transplanta- BACKGROUND: The impact of ABO incompatibility on tion (HSCT) is a potentially curative treatment hematopoietic stem cell transplantation (HSCT) approach for different malignant and nonma- outcome is controversial. As ABH substances are lignant diseases.1 Several given factors such expressed on tissues and secreted in body fluids, they Aas patient age, comorbidities, donor type, and donor- could drive an immune response in minor ABO- recipient sex combinations have been shown to affect sur- incompatible HSCT. The aim of the study was to inves- vival and major outcomes after HSCT.2 Scoring systems tigate the prognostic role of the recipients’ ABH secretor integrate these pretransplant determinants into a global status. transplant risk assessment.3 STUDY DESIGN AND METHODS: Patients who under- ABO incompatibility is not considered an obstacle for went minor ABO-incompatible HSCT were included. HSCT and occurs in approximately 30% to 50% of trans- Secretor status was determined either serologically or plants.4 Different types of donor-recipient ABO incompat- by molecular genetics. ibilities exist and are classified as either major, minor, or RESULTS: Between March 1996 and June 2012, a bidirectional.5 In major ABO-incompatible HSCT the total of 176 patients received minor ABO-incompatible patient has preformed antibodies (i.e.
    [Show full text]
  • Questionable ABO Blood Grouping in the Setting of Solid Organ Transplantation-A Case Report and Possible Resolution Techniques
    Hematology & Transfusion International Journal Case Report Open Access Questionable ABO blood grouping in the setting of solid organ transplantation-a case report and possible resolution techniques Abstract Volume 4 Issue 1 - 2017 A 52 year-old male who was admitted to our hospital for a penetrating chest trauma, Hanan Gerges, Susan Nahirniak as per our policy, a massive hemorrhage protocol (MHP) was activated to expedite Department of Laboratory Medicine and Pathology, University laboratory testing results and provision of blood products. On arrival, no identity or of Alberta and Alberta Health Services, Canada age were known, so 2units of unmatched group O, Rh positive red cells were issued while preparing an unmatched MHP pack which usually contains 6units of group O, Correspondence: Hanan Gerges, Department of Laboratory Rh positive red cells, 2units of AB plasma +/- one unit of platelets. No specimen was Medicine and Pathology, 4B1.23 WMC University of Alberta submitted for type and screen as the patient was bleeding profusely from the chest Hospital, 8440-12 St. Edmonton, AB, T6G 2B7, Canada, Fax wound. Despite multiple requests, we continued to provide blood products and a sample 1(780)407-8599, Tel 1 (780)297-8420, was received only after transfusing 24packed red cells, 2units of plasma and 1unit of Email [email protected] pooled platelets. As expected, both forward and reverse grouping showed mixed field reactions and accordingly interpreted by policy as questionable ABO. Rh typing was Received: October 14, 2016 | Published: February 15, 2017 clearly positive. The patient continued to be supported during surgery with group O red cells and AB plasma.
    [Show full text]
  • Immunohematology Vol 21, #4
    D DDD D DDD D D D DDD D DDD D D ImmunohematologyD D D D JOURNALDD OF BLOOD GROUP SEROLOGYDD AND EDUCATION D D DDD D DDD D DDD D DDD D D D DDD D DDD D DDD D DDD D D D DDD D DDD D DDD D DDD D D D DDV OLUMED 21, NUMBER 4,D 2005 D D D Immunohematology JOURNAL OF BLOOD GROUP SEROLOGY AND EDUCATION VOLUME 21, NUMBER 4, 2005 CONTENTS 141 Review: the Rh blood group system: an historical calendar P. D . I SSITT 146 Reactivity of FDA-approved anti-D reagents with partial D red blood cells W. J. J UDD,M.MOULDS,AND G. SCHLANSER 149 Case report: immune anti-D stimulated by transfusion of fresh frozen plasma M. CONNOLLY,W.N.ERBER,AND D.E. GREY 152 Incidence of weak D in blood donors typed as D positive by the Olympus PK 7200 C.M. JENKINS, S.T. JOHNSON, D.B. BELLISSIMO,AND J.L. GOTTSCHALL 155 Review: the Rh blood group D antigen . dominant, diverse, and difficult C.M.WESTHOFF 164 COMMUNICATIONS Letters from the editors Ortho-Clinical Diagnostics sponsorship Thank you to contributors to the 2005 issues 166 168 Letters from the outgoing editor-in-chief Letter from the incoming editorial staff Thank you with special thanks to Delores Changing of the guard 169 IN MEMORIAM John Maxwell Bowman, MD; Professor Sir John V.Davies, MD;Tibor J.Greenwalt, MD; and Professor J.J.Van Loghem 174 176 177 ANNOUNCEMENTS UPCOMING MEETINGS ADVERTISEMENTS 180 INSTRUCTIONS FOR AUTHORS 181 INDEX — V OLUME 21, NOS.
    [Show full text]
  • Para-Bombay B Phenotype: a Rare ABH Blood Group Variant at Tertiary
    J Res Clin Med, 2021, 9: 21 doi: 10.34172/jrcm.2021.021 TUOMS https://jrcm.tbzmed.ac.ir P R E S S Case Report Para-Bombay B phenotype: a rare ABH blood group variant at tertiary care hospital, Gwalior India Dharmesh Chandra Sharma1* ID , Sunita Rai2, Sachin Singhal3, Prakriti Gupta4, Shailendra Sharma5 1Associate Blood Transfusion Officer (ABTO), Incharge, BCSU & Aphaeresis, Blood Bank Department of Pathology, G. R. Medical College, Gwalior, India 2Assistant Professor, Pathology G. R. Medical College, Gwalior, India 3Medical Officer G. R. Medical College, Gwalior, India 4Demonstrator, Department of Pathology G. R. Medical College, Gwalior, India 5Post Graduate Student, Department of Pathology G. R. Medical College, Gwalior, India Article info Abstract Article History: The H antigen is the precursor substance for A and B antigens formation on red blood cells of Received: 14 Feb. 2021 an individual, and its absence is termed as H deficient phenotype. The lack of H antigen on Accepted: 12 Apr. 2021 both red blood cell (RBCs) and secretions results in a classical Bombay phenotype with anti-H e-Published: 14 May 2021 antibodies in serum. If the H antigen is absent on RBCs and present in secretions and plasma, the resulting blood group is the Para-Bombay phenotype. Although, the H gene is genetically Keywords: absent in Para-Bombay (hh genotype), at least one Se (Secretor) gene is present. Para-Bombay or • H-antigen red blood cell (RBC) H negative secretor individuals may or may not have anti-H in their serum. • Para-Bombay In both cases, routine blood grouping is O.
    [Show full text]
  • Vel Blood Group System: a Review J.R
    Journal of Blood Group Serology and Molecular Genetics VOLUME 33, N UMBER 2, 2017 This issue of Immunohematology is supported by a contribution from Grifols Diagnostics Solutions, Inc. Dedicated to advancement and education in molecular and serologic immunohematology Immunohematology Journal of Blood Group Serology and Molecular Genetics Volume 33, Number 2, 2017 CONTENTS C ASE R EPO R T 51 Hematologic complications in a patient with Glycine soja polyagglutination following fresh frozen plasma transfusion R.P. Jajosky, L.O. Cook, E. Manaloor, J.F. Shikle, and R.J. Bollag R EVIEW 56 The Vel blood group system: a review J.R. Storry and T. Peyrard C ASE R EPO R T 60 Two cases of the variant RHD*DAU5 allele associated with maternal alloanti-D J.A. Duncan, S. Nahiriniak, R. Onell, and G. Clarke R EVIEW 64 The FORS awakens: review of a blood group system reborn A.K. Hult and M.L. Olsson C ASE R EPO R T 73 A suspected delayed hemolytic transfusion reaction mediated by anti-Joa R.P. Jajosky, W.C. Lumm, S.C. Wise, R.J. Bollag, and J.F. Shikle R EVIEW 76 Recognizing and resolving ABO discrepancies G.M. Meny B OOK R EVIEW 82 Bloody Brilliant: A History of Blood Groups and Blood Groupers S. Gerald Sandler 84 90 94 96 A NNOUN C EMENTS A DVE R TISEMENTS I NST R U C TIONS S U B S cr IPTION FO R A UTHO R S I NFO R M AT I O N E DITO R - IN -C HIEF E DITO R IAL B OA R D Sandra Nance, MS, MT(ASCP)SBB Philadelphia, Pennsylvania Patricia Arndt, MT(ASCP)SBB Geralyn M.
    [Show full text]
  • ISBT Science Series
    Science Series INTRODUCTION TO BLOOD TRANSFUSION: FROM DONOR TO RECIPIENT rstar @pikisupe Join the conversation on social media with the hashtag #IntrotoBloodTransfusion ISBT Science Series Volume 15 Supplement 1 December 2020 Special issue: Introduction to Blood Transfusion: From Donor to Recipient CONTENTS Volume 15, Number S1, December 2020 Special issue: Introduction to Blood Transfusion: From Donor to Recipient List of contributors………………………………………………………………………….. ............................................................................................. 1 First Edition • Introduction .......................................................................................................................................................................................... 3 Second Edition • Introduction .......................................................................................................................................................................................... 4 • Preface ................................................................................................................................................................................................... 5 Abbreviations ........................................................................................................................................................................................... 6 Glossary ......................................................................................................................................................................................
    [Show full text]
  • Para-Bombay Phenotype Yashovardhan Et Al Case Report: Para-Bombay Phenotype: Report of a Rare Blood Group A
    Para-Bombay phenotype Yashovardhan et al Case Report: Para-Bombay phenotype: report of a rare blood group A. Yashovardhan,1 I.S. Chaitanya Kumar,1 K.V. Sreedhar Babu,1 B. Suresh Babu,1 Anju Verma,1 B. Siddhartha Kumar,2 D.S. Jothi Bai1 Departments of 1Immunohaematology and Blood Transfusion, 2Medicine, Sri Venkateswara Institute of Medical Sciences, Tirupati ABSTRACT The blood sample of a 54-year-old male patient who presented with signs and symptoms suggestive of anaemia was submitted to the Blood Bank for blood grouping and cross-matching. In forward grouping, no agglutination was ob- served with A, B and AB antisera, but agglutination was noticed with D antiserum (Group O). In reverse grouping, there was agglutination in tube labelled A and no agglutination in tubes B and O (Group B) resulting in discrepancy between forward and reverse grouping. Further testing confirmed that the individual's blood group was Para-Bombay B (Para-BH), which is a rare entity. The Para-Bombay phenotype is very rare. Only a few cases of Para-Bombay were reported in India till now and none from Andhra Pradesh. This entity is characterized by the absence of H, A and B antigens on the red cells but their presence in saliva and secretions of gastrointestinal and genitourinary tracts. Proper identification of this phenotype is very important; otherwise this particular blood group may be mislabelled as group O. Key Words: Para-Bombay, H-antigen, Secretor status Yashovardhan A, Chaitanya Kumar IS, Sreedhar Babu KV, Suresh Babu B, Verma A, Siddhartha Kumar B, Jothi Bai DS.
    [Show full text]