Thyroid Gland, Adrenal Glands, and Gonads Anterior Pituitary Negative Feedback Mechanism Finishes the Gonadotropin Releasing Hormone (Gnrh)
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The Endocrine System Disease of the Pituitary Gland Endocrine System Diseases of the Thyroid Maria Alonso, CDE, PA-C Disease of the Adrenal Glands Diabetes Mellitus Lipid Disorders UMDNJ PANCE/PANRE Review Course (becoming Rutgers July 1, 2013) UMDNJ PANCE/PANRE Review Course UMDNJ PANCE/PANRE Review Course (becoming Rutgers July 1, 2013) http://commons.wikimedia.org/wiki/File:Illu_endocrine_system.jpg (becoming Rutgers July 1, 2013) UMDNJ PACE/PANRE Review Course becoming Rutgers July 1, 2013 PITUITARY ANATOMY Pituitary Anatomy •Small pea-sized gland at the base of brain •Located in the “Sella Turcica” •Functions as "The Master Gland" •Attached below hypothalamus by stalk •Large anterior lobe (adenohypophysis) PituitaryPituitary GlandGland •Smaller posterior lobe (neurohypophysis) •The optic chiasm lies directly above •Supplied by internal carotid artery UMDNJ PANCE/PANRE Review Course UMDNJ PANCE/PANRE Review Course (becoming Rutgers July 1, 2013) UMDNJ PANCE/PANRE Review Course Public domain available at: (becoming Rutgers July 1, 2013) (becoming Rutgers July 1, 2013) http://commons.wikimedia.org/wiki/File:Grays_pituitary.png UMDNJ PACE/PANRE Review Course becoming Rutgers July 1, 2013 Quick Review Quick Review: Hypothalamic Quick Review Pituitary Axis Hypothalamus Neurosecretory cells send messages from Hypothalamus brain to hypothalamus GnRH GHRH SS TRH DA CRH ++ Hypothalamus sends chemical hormones + ++__+ to the pituitary gland OxytocinPosterior Pituitary ADH Pituitary gland secretes hormones to the FSH/LH GH GH/TSH TSH Prolactin ACTH thyroid gland, adrenal glands, and gonads Anterior Pituitary Negative feedback mechanism finishes the Gonadotropin releasing hormone (GnRH). Growth hormone releasing hormone (GHRH) loop Somatostatin (SS), Thyrotropin releasing hormone (TRH), Dopamine (DA) UMDNJ PANCE/PANRE Review Course UMDNJ PANCE/PANRE Review Course Corticotropin releasing hormone (CRH) UMDNJ PANCE/PANRE Review Course (becoming Rutgers July 1, 2013) (becoming Rutgers July 1, 2013) (becoming Rutgers July 1, 2013) UMDNJ PACE/PANRE Review Course becoming Rutgers July 1, 2013 HYPOPITUITARISM Pituitary Disorders Hypopituitarism- Congenital Causes ACQUIRED CAUSES Hypopituitarism – Congenital causes Hypothalamic gene defects Tumors are the most common cause in adults Pituitary gene defects Irradiation for other cranial tumors Hormone receptor gene defects Vascular: bleed, infarct, Sheehan’s Hypopituitarism- Acquired causes Hormone receptor gene defects Anencephaly, neural tube defect Inflammatory: sarcoidosis, TB Pituitary aplasia, usually fatal at birth Metabolic: Fe deposits/hemochromatosis, Pituitary tumors (adenomas) amyloidosis, illness, malnutrition Kallmann syndrome: x-recessive GnRH defect with hypogonadism, delayed **Empty Sella Syndrome: puberty, osteoporosis, anosmia unable to see gland on imaging due to any of above. May have shrunk or flattened UMDNJ PANCE/PANRE Review Course UMDNJ PANCE/PANRE Review Course UMDNJ PANCE/PANRE Review Course (becoming Rutgers July 1, 2013) (becoming Rutgers July 1, 2013) (becoming Rutgers July 1, 2013) UMDNJ PACE/PANRE Review Course becoming Rutgers July 1, 2013 Pituitary Tumors Types of Adenomas Clinical Manifestations Mass effect Microadenomas (<10 mm) Prolactinoma prolactin/hypogonadism and galactorrhea (25-40%) (Lactotroph) headaches Macroadenomas (>10mm) Null cell no active hormone (10-25%) bitemporal hemianopsia Rarely malignant Somatotroph GH/acromegaly and gigantism (10-15%) Diplopia Locally invasive Corticotroph ACTH/ Cushing’s (10-15%) destroy hormone producing cells Gonadotroph FSH/LH (15-20%) compresses gland or hypothalamus Symptoms based on hormone involved Thyrotroph TSH/ hyperthyroidism (1%) UMDNJ PANCE/PANRE Review Course UMDNJ PANCE/PANRE Review Course (becoming Rutgers July 1, 2013) UMDNJ PANCE/PANRE Review Course (becoming Rutgers July 1, 2013) (becoming Rutgers July 1, 2013) UMDNJ PACE/PANRE Review Course becoming Rutgers July 1, 2013 Prolactinoma 25-40% Treatments Prolactin Treatments Occurs M/C 20-50 yo Medical therapy- Hyperprolactinemia Dopamine inhibits prolactin secretion decreases hormone and tumor Hypogonadism dopamine agonist- Bromocriptine negative effect on GnRH Estrogen, TRH, and GHRH positively effect replace hormones (thyroid/adrenal) reduction in LH and FSH prolactin secretion Surgical excision Females - galactorrhea, oligomenorrhea, amenorrhea Transsphenoidal Excess can be caused by lactation, Males- headache, visual disturbance, Gamma Knife/ Stereotactic Non-invasive tumors, drugs, hypothyroidism, impotence Radio Surgery impotence hypothalamic dysfunction UMDNJ PANCE/PANRE Review Course UMDNJ PANCE/PANRE Review Course UMDNJ PANCE/PANRE Review Course (becoming Rutgers July 1, 2013) (becoming Rutgers July 1, 2013) (becoming Rutgers July 1, 2013) UMDNJ PACE/PANRE Review Course becoming Rutgers July 1, 2013 Prolactinoma Excessive Growth Hormone Excessive Growth Hormone Work up: Secretion Excessive Growth Hormone BHCG, prolactin level, TSH CT/MRI of the Brain Acromegaly – adults 98% cases adenomas is the cause DDx: excessive exercise After epiphyseal closure Hx chest wall surgery Usually mixed cell tumors chest trauma Gigantism – children renal failure cirrhosis Before epiphyseal closure (excessive height) Increase risk- DM, HTN, CAD TX : dopamine agonist- Bromocriptine Surgical excision UMDNJ PANCE/PANRE Review Course UMDNJ PANCE/PANRE Review Course UMDNJ PANCE/PANRE Review Course (becoming Rutgers July 1, 2013) (becoming Rutgers July 1, 2013) (becoming Rutgers July 1, 2013) UMDNJ PACE/PANRE Review Course becoming Rutgers July 1, 2013 Prominent jaw/ Brow Physical Manifestations Prominent jaw/ Brow Hands doughy / Large hands Enlargement of extremities hands doughy / large hands Coarse facial features prominent mandible, brow, nose, lips, tongue Coarse, oily, thick skin Organomegaly Public domain available at: UMDNJ PANCE/PANRE Review Course http://commons.wikimedia.org/wiki/File:Acromegaly_hands.JPEG (becoming Rutgers July 1, 2013) Public domain available at: UMDNJ PANCE/PANRE Review Course UMDNJ PANCE/PANRE Review Course http://commons.wikimedia.org/wiki/File:Acromegaly_facial_features.JPEG (becoming Rutgers July 1, 2013) (becoming Rutgers July 1, 2013) UMDNJ PACE/PANRE Review Course becoming Rutgers July 1, 2013 Related Conditions Related Conditions Related Conditions Musculoskeletal Cardiac Hypertrophy of joint cartilage and Musclosketal Left ventricular hypertrophy synovial tissue Diastolic dysfunction Cardiac carpal tunnel syndrome Dysrhythmias arthritis Metabolic Hypertension arthralgia Metabolic Sleep apnea Insulin resistance, glucose intolerance, DM UMDNJ PANCE/PANRE Review Course UMDNJ PANCE/PANRE Review Course UMDNJ PANCE/PANRE Review Course (becoming Rutgers July 1, 2013) (becoming Rutgers July 1, 2013) (becoming Rutgers July 1, 2013) UMDNJ PACE/PANRE Review Course becoming Rutgers July 1, 2013 Dwarfism Labs/ Diagnostic Tests Treatment Less than 4’10” is height Labs Surgical (50% success w/macroadenomas) GH and IGF-1: 5x normal in acromegaly Disproportionate- skeletal Prolactin, glucose Radiotherapy dysplasia Liver enzymes, Blood urea nitrogen(BUN) Achondroplasia Calcium Short-trunk dwarf Serum FT4 and TSH Medical Therapy Proportionate- medical or Glucose Suppression test = Diagnose Dopamine Agonist- (brocriptine) genetic conditions Glucose should suppress GH, in acromegaly it GH Receptor Antagnoist- (Pegvisomant) Growth hormone does not deficiency Imaging: MRI UMDNJ PANCE/PANRE Review Course UMDNJ PANCE/PANRE Review Course (becoming Rutgers July 1, 2013) (becoming Rutgers July 1, 2013) Public domain available at: UMDNJ PANCE/PANRE Review Course http://commons.wikimedia.org/wiki/File:Paul_Steven_Miller_EEOC.jpg (becoming Rutgers July 1, 2013) UMDNJ PACE/PANRE Review Course becoming Rutgers July 1, 2013 Growth Hormone Deficiency Achondroplasia Stimulation Test Mutations in the FGFR3 gene Insufficient GHRH from hypothalamus Autosomal dominant Insufficient production of GH by pituitary Gold Standard Insulin Tolerance Test (ITT), then another agent clonidine, L-Dopa, glucagon, Short stature < 4’10” Genetic Mutation- GHRHR, GH1 arginine or GhRH should cause an increase in Overweight Acquired- tumors/irradiation GH levels Short limbs Idiopathic- M/C Stimulation test measures the level of growth hormone (GH) in the blood after stimulation Prominent brow Genetic disorders- Turner, Noonan, PWS The test measures the ability of the pituitary Midfacial hypoplasia SGA gland to release GH under stimulation Public domain available at: http://commons.wikimedia.org/wiki/File:Jason_Acu%C3%B1a_-_Wee-Man_-_ Waterfront_Marriott,_Portland,_Oregon_-_August_15,_2009_-_Full_Body.jpg UMDNJ PANCE/PANRE Review Course UMDNJ PANCE/PANRE Review Course UMDNJ PANCE/PANRE Review Course (becoming Rutgers July 1, 2013) (becoming Rutgers July 1, 2013) (becoming Rutgers July 1, 2013) UMDNJ PACE/PANRE Review Course becoming Rutgers July 1, 2013 GROWTH HORMONE Diabetes Insipidus Central Diabetes Insipidus = REPLACEMENT LOW ADH Vasopressin (ADH): Anti-Diuretic Hormone Somatotropin given as daily SQ injection Disruption of the normal production, until bone fusion (Bone Age) storage and release of ADH Synthesized in hypothalamus: stored and May not need further treatment as adults, released from posterior pituitary consider repeating stimulation test Two Main forms: Primary: No organic lesion, autoimmune Central (neurogenic): deficiency of ADH, low Side effects