August 2020 Asbmb Today 1 President’S Message
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THE Careers ISSUE Connect your community with a virtual scientific event Interested in hosting a virtual event? The ASBMB is here to help. The ASBMB provides a platform to share scientific research and to discuss emerging topics and technologies in an interactive, virtual setting. When you host a virtual event with the ASBMB, your event will: n accommodate up to 500 attendees n be marketed to the ASBMB’s 11,000 members n reach the ASBMB’s network of journal authors and meeting attendees Learn more about how to submit your proposal at asbmb.org/meetings-events NEWS FEATURES PERSPECTIVES 2 30 66 PRESIDENT’S MESSAGE LEADERSHIP AFTER THE LONGEST MARCH, With challenges come opportunities ON THE CUTTING EDGE SCIENCE MARCHES ON An interview with Toni Antalis, 4 the ASBMB’s new president MEMBER UPDATE 69 34 BEING BLACK 10 JOB SEEKERS FEEL THE EFFECTS IN THE IVORY TOWER IN MEMORIAM OF THE PANDEMIC AND POLITICS 12 STUDENT CHAPTERS A virtual high school science fair Careers 13 42 How a research tech can work from NEWS home in the time of COVID-19 13 ASBMB launches industry advisory group 44 Grant writing tips for beginners 14 ASBMB receives NIH grant to promote faculty diversity 47 F(i/u)nding your next hypothesis 49 Illuminating leadership during crisis 16 51 My postdoc road was rocky — LIPID NEWS then the pandemic hit Organizing fat: Mechanisms of creating and organizing cellular lipid stores 53 How can labs reopen safely? 56 A year of unrest and grace — 18 reflections on my journey to tenure JOURNAL NEWS 18 How lipid droplets stay in shape 58 Think you’d like to move away 20 Sorting and secreting insulin from the bench? by expiration date 22 Proteomics reveals hallmarks of aging 60 Supporting Ph.D. students in the time in brain stem cells of COVID-19 23 Estrogen receptor antagonist shows promise for treatment of gallstone 62 In my first real U.S. winter, I got snow; disease in my second, I got a pandemic 24 Celebrating the images scientists create 64 There and back again 25 From the journals 22 44 AUGUST 2020 ASBMB TODAY 1 PRESIDENT’S MESSAGE THE MEMBER MAGAZINE OF THE AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY With challenges OFFICERS COUNCIL MEMBERS Suzanne Barbour Toni M. Antalis Joan Broderick President Charles Craik come opportunities Gerald Hart Matt Gentry Past President Susanna Greer Audrey Lamb By Toni M. Antalis Wei Yang James M. Ntambi Secretary Takita Felder Sumter it is a a special honor to begin my particularly important in the present Joan Conaway Kelly Ten–Hagen Treasurer term as president of the American COVID-19 environment and given ISociety for Biochemistry and Mo- the novel challenges we, as scientists, EX-OFFICIO MEMBERS ASBMB TODAY EDITORIAL lecular Biology. The ASBMB is very are facing. Universities have closed, Robert S. Haltiwanger ADVISORY BOARD Carla Koehler Rajini Rao dear to me. and much research has been halted Co-chairs, 2020 Annual Chair I began my scientific career as this year. We all cautiously are work- Meeting Program Committee Ana Maria Barral Natasha Brooks an undergraduate obtaining summer ing out safe conditions for reopening Cheryl Bailey Kelly Chacón Chair, Education and research experience in a biochemistry and continuing laboratory research. A Beronda Montgomery Professional Development Bill Sullivan lab and have been hooked ever since. new paradigm is emerging at universi- Committee Melissa Vaught My doctoral thesis research at Rice ties — virus testing systems are being Daniel Raben Binks Wattenberg Chair, Meetings Committee University focused on biophysical and put in place, and there are changes Sonia Flores ASBMB TODAY kinetic analysis of electron transport to the formal academic processes, Chair, Minority Affairs Angela Hopp in cytoahrome oxidase, which led to which will undoubtedly have lasting Committee Executive Editor Nicole Woitowich [email protected] a first-author paper in the Journal of effects. Many scientific and teaching Chair, Science Outreach and Comfort Dorn Biological Chemistry. Publishing that activities are moving fully or partially Communication Committee Managing Editor first paper in JBC and receiving those online, with strict guidelines for social Terri Goss Kinzy [email protected] reprints with my name in print for the distancing and mask wearing. Chair, Public Affairs Lisa Schnabel Advisory Committee Graphic Designer first time was truly exciting! This is unchartered territory. It Ed Eisenstein [email protected] My research interests have has impacted our younger scientists Chair, Membership Committee John Arnst Susan Baserga Science Writer evolved over the years into the study significantly: graduate students aim- Chair, Women in Biochemistry [email protected] of proteases and protease-activat- ing to complete their dissertations, and Molecular Biology Laurel Oldach ed signaling pathways that affect postdoctoral fellows looking for jobs Committee Science Writter Sandra Weller [email protected] tumor metastasis, inflammation and junior faculty trying to build Chair, Publications Ed Marklin and vascular biology. My lab studies networks and collaborations. The Committee Web Editor several inflammatory mechanisms ASBMB is committed to providing Lila M. Gierasch [email protected] Editor-in-chief, JBC Allison Frick that promote blood clotting and the career-development resources for Multimedia and Social Media A. L. Burlingame Content Manager resolution of venous thrombosis as these groups, including its recently Editor, MCP [email protected] well as proteolytic signaling pathways revamped online career center, the Nicholas O. Davidson Barbara Gordon used by ovarian cancers to facilitate Art of Science Communication Editor-in-chief, JLR Executive Director Kerry-Anne Rye [email protected] tumor dissemination and spread. course and virtual presentation op- Editor-in-chief, JLR I have continued my association portunities. (See asbmb.org/career- with the society by serving on the resources for those and more.) For information on advertising, contact Pharmaceutical Media Inc. at 212-904-0374 or [email protected]. Publications Committee and the Therewill be challenges in Finance Committee and later as maintaining financial support for treasurer. This has allowed me to see discovery research with increasingly the ASBMB grow and develop into competitive funds and uncertain a robust organization that strives to economic conditions. The ASBMB www.asbmb.org/asbmbtoday meet the needs of all of its members. serves as a defender of science and PRINT ISSN 2372-0409 Thanks to the ASBMB scientific influencer of government policy on Articles published in ASBMB Today reflect solely the authors’ views and not leadership, the excellent staff and the issues of concern to ASBMB mem- the official positions of the American Society for Biochemistry and Molecular many dedicated committee volunteers, bers. The society responds rapidly Biology or the institutions with which the authors are affiliated. Mentions of products or services are not endorsements. the society is in great shape. This is to policy proposals and changes and 2 ASBMB TODAY AUGUST 2020 PRESIDENT’S MESSAGE stands firmly against attempts to po- and editorial board members, all of liticize science and science funding. whom deserve our thanks for their (See asbmb.org/advocacy for recent dedicated service to the society and policy statements and to learn how to the scientific community. participate in advocacy efforts.) With challenges come opportu- Importantly, we must ensure nities. This is an exciting time to be social justice, fairness and civility for a molecular and biological scientist. all and in all that we do. Advances in genomics, imaging, Our immediate past president, bioengineering, CRISPR technolo- Jerry Hart, did a tremendous job gies, cryogenic electron microscopy, Follow us guiding the society through some vaccine development and compu- major challenges over the past two tational learning are advancing our on Twitter years and deserves a special thanks. understanding of biological systems Importantly, he led the careful and significantly. Stay up to date on consultative effort by the society to The ASBMB is devoted to the latest science make all three ASBMB journals — advancing the science of biochem- JBC, Molecular & Cellular Proteom- istry and molecular biology and published in ics, and the Journal of Lipid Research serving the needs of the scientific ASBMB journals. — fully open access in 2021. This community. I encourage you to visit means that the final versions of the the ASBMB website (asbmb.org) to high-quality articles will be imme- learn about all of the resources and diately available to everyone around wonderful activities that the society the world, thus reducing barriers to provides and the impact on our scien- @jbiolochem scientific knowledge and accelerating tific community. scientific discoveries. A long history You too can join this effort and of sound financial stewardship by the make a difference. Let us know what society has enabled this to happen in will make us even better. We welcome an affordable way for authors — soci- your thoughts. ety members and nonmembers alike. Read ASBMB Today science writer @jlipidres We are truly indebted to Herbert Laurel Oldach’s interview with Tabor, who served at the helm of Toni Antalis on page 30. JBC for 40 years and who strongly supported and helped to mold the Toni Antalis (tantalis community of biochemists and mo- @som.umaryland.edu) is a professor of physiology at @molcellprot lecular biologists that we have today. the University of Maryland JBC Editor-in-Chief Lila Gierasch, School of Medicine, where she is also the associate MCP Editor-in-Chief Al Burlin- director for training and game and JLR co-Editors-in-Chief education and the director of the program in molecular Nicholas Davidson and Kerry-Anne medicine and the graduate Rye are doing wonderful jobs of program in life sciences. She began her term as the overseeing their publications with the ASBMB’s president on support of excellent associate editors July 1. AUGUST 2020 ASBMB TODAY 3 MEMBER UPDATE Royal Society elects for life each year on the basis of their ing and recommending actions to Clore as fellow scientific contributions.