MINAX contains the active ingredient tartrate CONSUMER MEDICINE INFORMATION

What is in this leaflet blood vessels in the body, as well as lung problems, or have had helping the heart to beat more them in the past This leaflet answers some common regularly. • You have a history of allergic questions about MINAX. It does not Your doctor will have explained why problems, including hayfever contain all of the available you are being treated with MINAX • You have low blood pressure information. and told you what dose to take. MINAX may be used either alone or • You have a very slow heartbeat It does not take the place of talking to (less than 45-50 beats/minute) your doctor or pharmacist. in combination with other medicines to treat your condition. • You have certain other heart All medicines have benefits and conditions risks. Your doctor has weighed the Ask your doctor if you have any risks of you taking MINAX against questions about why MINAX has • You have phaeochromocytoma the benefits they expect it will have been prescribed for you. (a rare tumour of the adrenal for you. Your doctor may have prescribed gland) which is not being MINAX for another reason. treated already with other If you have any concerns about medicines taking this medicine, talk to your Follow all directions given to you • You have a severe blood vessel doctor or pharmacist. by your doctor carefully. disorder causing poor Keep this leaflet with your They may differ from the circulation in the arms and legs medicine. information contained in this leaflet. • You are receiving/having You may need to read it again. MINAX is not addictive. emergency treatment for shock or severely low blood pressure. If you are not sure whether you should start taking this medicine, What MINAX is used Before you take talk to your doctor. for MINAX Do not take this medicine after the expiry date printed on the pack or MINAX belongs to a group of When you must not take it medicines called beta-blockers. if the packaging is torn or shows MINAX is used to: Do not take MINAX if: signs of tampering. · lower high blood pressure, also • You have any allergies to If it has expired or is damaged, return called hypertension metoprolol tartrate, the active it to your pharmacist for disposal. ingredient in MINAX, or any of · prevent angina (chest pain) Do not give MINAX to children. the ingredients listed at the end The safety and effectiveness of · treat or prevent heart attacks, or of this leaflet, or any other beta- MINAX in children has not been reduce your risk of heart blocker medicine. complications following a heart established. Some of the symptoms of an allergic attack reaction may include shortness of If you are not sure whether you · prevent migraine headaches. breath, wheezing or difficulty should start taking this medicine, talk to your doctor. It works by changing the body©s breathing; swelling of the face, lips, response to some nerve impulses, tongue or other parts of the body; Before you start to take it especially in the heart. rash, itching or hives on the skin or you may feel faint. As a result, it decreases the heart©s You must tell you doctor if you need for blood and oxygen and • You have asthma, wheezing, have any allergies to: therefore reduces the amount of work difficulty breathing or other the heart has to do. It also widens the

MINAX 1 · Metoprolol tartrate or any of the · calcium channel blockers or They may differ from the ingredients listed at the end of calcium antagonists, medicines information contained in this leaflet. this leaflet. used to treat blood pressure and If you do not understand the · Any other medicine, including angina, for example verapamil instructions on the pack ask your other beta-blocker medicines and diltiazem doctor or pharmacist for help. · Any other substances, such as · medicines used to treat high foods, preservatives or dyes. blood pressure, for example How much to take clonidine, , and For high blood pressure: Tell your doctor if you have, or prazosin have had, any medical conditions, The usual starting dose is one 50 mg · medicines used to treat abnormal especially the following: or 100 mg tablet once a day for one or irregular heartbeat, for week. · Asthma, wheezing, difficulty example amiodarone, breathing or other lung problems disopyramide and quinidine The dose is then usually increased to 50 mg or 100 mg once or twice daily. · · medicines used to treat arthritis, · An overactive thyroid gland pain, or inflammation, for Your doctor may tell you to take a different amount of MINAX. · Liver problems example and ibuprofen Follow your doctor's instructions · Kidney problems · warfarin, a medicine used to carefully. · Certain types of angina prevent blood clots If you are taking other prescription · Any other heart problems · digoxin, a medicine used to treat medicines which lower blood · Phaeochromocytoma, a rare pressure, your doctor may need to tumour of the adrenal gland change the dose of them to obtain the · medicines used to treat diabetes best results for you. · Any blood vessel disorder · cimetidine, a medicine used to causing poor circulation in the For angina pectoris: treat stomach ulcers arms and legs. The usual dose is 50 mg or 100 mg · medicines used to treat bacterial Tell your doctor if you are taken two or three times a day. infections, for example rifampicin pregnant or plan to become After (heart · medicines used to treat pregnant. attack): depression. Like most beta-blocker medicines, The usual dose is 100 mg taken twice · Monoamine-oxidase inhibitors MINAX is not recommended for use a day, often starting with a lower (MAOIs). during pregnancy. dose for 2 days. These medicines may be affected by Tell your doctor if you are For migraine prevention: breastfeeding or wish to MINAX or may affect how well it The usual dose is 50 mg to 75 mg breastfeed. works. You may need different amounts of your medicine, or you taken twice a day (100 to 150 mg a MINAX passes into breast milk, may need to take different medicines. day), taken in divided doses morning hence there is a possibility that the Your doctor will advise you. and evening. breastfed baby may be affected. Your doctor and pharmacist have Ask your doctor or pharmacist if If you have not told your doctor more information on medicines to be you are unsure of the correct dose about any of the above, tell them careful with or avoid while taking for you. before you start taking MINAX. MINAX. They will tell you exactly how much to take. Taking other medicines If you have not told your doctor about any of these things, tell them Tell your doctor or pharmacist if before you take any MINAX. How to take it you are taking any other Swallow the tablets with a glass of medicines, including any that you water. buy without a prescription from a MINAX tablets can be divided in pharmacy, supermarket or health How to take MINAX food shop. half along the breakline, if your doctor has prescribed half a tablet. Some medicines and MINAX may Follow all directions given to you interfere with each other. These by your doctor or pharmacist include: carefully. · other beta-blocker medicines, including beta-blocker eye drops

MINAX 2 When to take it You may need urgent medical dropping too much. If you continue attention. to feel unwell, tell your doctor. Take your medicine at about the same time each day before or after If you take too much MINAX your If you are being treated for food. blood pressure may drop too far. You diabetes, make sure you check will feel faint or faint, and your heart your blood sugar level regularly Taking it at the same time each day rate will also slow down. You may and report any changes to your will have the best effect. It will also also have nausea, vomiting and doctor. help you remember when to take it. convulsions. In extreme cases, MINAX may affect how well your serious heart and lung problems may How long to take it diabetes is controlled. It may also occur. cover up some of the symptoms of Continue taking your medicine for low blood sugar (also called as long as your doctor tells you. hypoglycaemia) such as a fast This medicine helps to control your heartbeat. MINAX may increase the condition, but does not cure it. It is While you are taking time your body takes to recover from important to keep taking your MINAX low blood sugar. Your doctor may medicine even if you feel well. need to change your dose of diabetic DO NOT STOP TAKING MINAX Things you must do medicines, including insulin. TABLETS SUDDENLY. Visit your doctor regularly so they Before starting any new medicine, The dose needs to be reduced slowly can check on your progress. tell your doctor or pharmacist that you are taking MINAX. over 7 to 14 days to make sure that Elderly patients especially need to be your condition does not get worse. monitored to stop their blood Tell all the doctors, dentists and Your doctor will tell you how to pressure falling too far. pharmacists who are treating you gradually reduce the dose before that you are taking MINAX. stopping completely. If you become pregnant while taking MINAX, tell your doctor. Tell your surgeon, anaesthetist or dentist that you are taking MINAX If you have a severe allergic If you forget to take it if you plan to have surgery, reaction to foods, medicines or If it is almost time for your next including dental surgery, that insect stings, tell your doctor dose (within 6 hours), skip the dose needs a general anaesthetic. immediately. you missed and take your next dose MINAX interacts with certain If you have a history of allergies, when you are meant to. general anaesthetics and may cause a there is a chance that MINAX may Otherwise, take the missed dose as sudden drop in blood pressure. worsen the allergic reactions and soon as you remember, and then go cause it to be harder to treat. Tell your doctor if you have to take back to taking your tablets as you any medical tests while you are If you feel light-headed, dizzy or would normally. being treated with MINAX. faint when getting out of bed or Do not take a double dose to make standing up, get up slowly. up for the dose you missed. Things you must not do You may feel light-headed or dizzy If you are not sure what to do, ask Do not stop taking MINAX, or when you begin to take MINAX. your doctor or pharmacist. lower the dose, without checking This is because your blood pressure with your doctor. If you have trouble remembering has fallen suddenly. when to take your medicine, ask your Stopping MINAX suddenly may Standing up slowly, especially when pharmacist for some hints. worsen your angina or cause other you get up from bed or chairs, will heart complications to occur. Your help your body get used to the If you take too much doctor may want you to gradually change in position and blood reduce the amount of MINAX you (overdose) pressure. If this problem gets worse are taking before stopping Immediately telephone your doctor or continues, talk to your doctor. completely. or the Poisons Information Centre Make sure you drink enough water Do not use MINAX to treat any (telephone 13 11 26) for advice, or during exercise and hot weather other conditions unless your doctor go to Accident and Emergency at when you are taking MINAX, tells you to. the nearest hospital, if you think especially if you sweat a lot. you or anyone else may have taken Do not give MINAX to anyone else, If you do not drink enough water too much MINAX. Do this even if even if they have the same while taking MINAX, you may feel there are no signs of discomfort or condition as you. faint or light-headed or sick. This is poisoning. because your blood pressure is

MINAX 3 Things to be careful of · feeling sick (nausea), vomiting · chest tightness, difficulty breathing, wheezing, noisy Be careful driving or operating · stomach upset, diarrhoea or breathing machinery until you know how constipation, weight gain MINAX affects you. · dry mouth, changes in taste · chest pain, changes in heart rate or palpitations MINAX may cause drowsiness, sensation tiredness, dizziness or · sleeping problems, nightmares · swelling of the face, lips, tongue or throat which may cause lightheadedness in some people. If · mood changes or depression any of these occur, do not drive, difficulty swallowing or breathing operate machinery or do anything · short-term memory loss, inability · yellowing of the eyes or skin else that could be dangerous. to concentrate or confusion (jaundice), generally unwell Be careful drinking alcohol while · hair loss These are very serious yet rare side taking MINAX. · increased sweating, runny or effects. You may require immediate Combining MINAX and alcohol can blocked nose. medical attention or hospitalisation. make you more drowsy, dizzy or These side effects are usually mild. Tell your doctor if you notice lightheaded. Tell your doctor as soon as possible anything that is making you feel Dress warmly during cold weather, if you notice any of the following: unwell. especially if you will be outside for · dizziness, lightheadedness or Other side effects not listed above a long time. fainting especially on getting up may also occur in some patients. Beta-blocker medicines tend to quickly decrease blood circulation in the · tingling or "pins and needles" in skin, fingers and toes. This may the hands or feet make you more sensitive to cold After taking MINAX temperatures. · coldness, burning, numbness or pain in the arms and/or legs Storage · skin rash or worsening of psoriasis Keep MINAX where children cannot reach it. Side effects · symptoms of sunburn such as redness, itching and blistering, A locked cupboard at least one-and- Tell your doctor or pharmacist as that occur more quickly than a-half metres above the ground is a soon as possible if you do not feel usual good place to store medicines. well while you are taking MINAX. · abnormal thinking or Keep your tablets in a cool dry Like all other medicines, MINAX hallucination. place where the temperature stays may have unwanted side effects in below 30°C. · buzzing or ringing in the ears, some people. Sometimes they are deafness Do not store MINAX or any other serious, most of the time they are not. medicine in the bathroom or near a · dry or irritated eyes, blurred You may need medical treatment if sink. Do not leave MINAX in the vision you get some of the side effects. car or on window sills. If you are over 65 years of age, you · problems with sexual function Heat and dampness can destroy some may have an increased chance of · constant "flu-like" symptoms medicines. getting side effects. with tiredness or lack of energy Do not be alarmed by this list of · unusual bleeding or bruising Disposal possible side effects. These are serious side effects. You If your doctor tells you to stop You may not experience any of them. may need urgent medical attention. taking MINAX, or your tablets Ask your doctor or pharmacist to Serious side effects are rare. have passed their expiry date, ask your pharmacist what to do with answer any questions you may Tell your doctor immediately or go any that are left over. have. to Accident and Emergency at the Tell your doctor or pharmacist if nearest hospital if you notice any of you notice any of the following and the following: they worry you: · shortness of breath, being less · headache, tiredness, drowsiness, able to exercise weakness or lack of energy · swelling of the ankles, feet or legs · aches and pains, painful joints

MINAX 4 Product description MINAX 50 - AUST R 34408 MINAX 100 - AUST R 34410 What it looks like MINAX comes in 2 strengths of This leaflet was prepared in May tablets: 2020. · MINAX 50 mg - round, white, scored tablet marked ML/50 on one side and a Greek alpha symbol on the reverse. Each bottle contains 100 tablets. · MINAX 100 mg - round, white, scored tablet marked ML/100 on one side and Greek alpha symbol on the reverse. Each bottle contains 60 tablets.

Ingredients The active ingredient in MINAX is metoprolol tartrate: · each MINAX 50 mg tablet contains 50 mg of metoprolol tartrate · each MINAX 100 mg tablet contains 100 mg of metoprolol tartrate. The tablets also contain: · lactose monohydrate · microcrystalline cellulose · povidone · colloidal anhydrous silica · sodium starch glycollate · magnesium stearate. MINAX 100 also contains: · purified talc · carmellose sodium. MINAX contains sugars (as lactose), traces of galactose and sulfites. The tablets are gluten free.

Manufacturer MINAX is made in Australia by: Alphapharm Pty Ltd Level 1, 30 The Bond 30-34 Hickson Road Millers Point NSW 2000 www.mylan.com.au

Australian registration numbers:

MINAX 5