Aalborg Universitet

Mogens Schou (1918-2005) a scientist, a doctor and a champion Rybakowski, Janusz K; Vinberg, Maj; Kessing, Lars V; Malhi, Gin S; Selo, Marylou; Licht, Rasmus W Published in: Bipolar Disorders

DOI (link to publication from Publisher): 10.1111/bdi.12739

Publication date: 2018

Document Version Accepted author manuscript, peer reviewed version

Link to publication from Aalborg University

Citation for published version (APA): Rybakowski, J. K., Vinberg, M., Kessing, L. V., Malhi, G. S., Selo, M., & Licht, R. W. (2018). Mogens Schou (1918-2005): a scientist, a doctor and a lithium champion. Bipolar Disorders, 20(8), 680-682. https://doi.org/10.1111/bdi.12739

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Downloaded from vbn.aau.dk on: September 23, 2021 This article isprotected rights by All copyright. reserved. 10.1111/bdi.12739 doi: lead todifferences version between this andthe ofPleasecite article Version Record. this as been and throughtypesetting, proofreadingwhich may thecopyediting, process, pagination This article un has for and accepted been publication actual birthday.During the symposium, Janusz Rybakowski highlightedscientific the achievements of Schou. Mogens time life the and lithium to dedicated Copenhagen in organized was symposium forgotten. been have well may lithium assiduousness and research lithium of Schou Mogens giant true a and scientist basic and clinical Danish great the 6 5 4 Psychiatry, University of Sydney, 3 Copenhagen University Hospital, 2 1 Articletype : Editorial JANUSZDR. RYBAKOWSKI (Orcid ID : 0000 Department of Aalborg University Hospital, Psychiatry, Aalborg, Denmark International Advocacy Liaison, NewYork, USA Clinic CADE and Aca Department Adultof Psychiatry, Poznan University of Medical Sciences, Poznan, Poland Accepted ArticleCopenhagen Affective DisorderResearch Centre(CADIC), Psychiatric CentreCopenhagen, In November this year, we marked the 100th anniversary of the birthday of Mogens Schou, Mogens of birthday the of anniversary 100th the marked we year, this November In Janusz Rybakowski K. Mogens Schou (1918 didthan more The celebration took place on November 23, 2018, the day before Mogens Schou’s Mogens before day the 2018, 23, November on place took celebration The Clinical Medicine,Aalborg University, Aalborg, Denmark demic Departmentof Psychiatry

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This article isprotected rights by All copyright. reserved. toxic and effectiveness clinical symptoms its and serum in lithium of concentration the between relations was which mmol/l, 2 to 0.5 within remained serum six in all. During improvement spectacular “c had 30 whom among state manic lithium,w of effect real the as unusual patients I action. antimanic potential lithium’s reported had Cade John psychiatrist Australian the after years devoted to the therapy. lithium on observations and pioneering many Mogens Schou lithium Research Unit Risskov in Hospital Psychiatric University a Although undertook then and onwards. Mogens Schou's brother had manic psychiatry Danish a reputwas KessingLars discussed the clinical use lithium:of why, and when for whom. positionedandacutestabilizers.the managementmoodinmania Lichtof Rasmus king lithiumof the he what focusedSelo Schou, on MarylouMogens Accepted 1954, n Article

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mani his riig n lncl scity eprmna booy ad neurochemistry. and biology, experimental psychiatry, clinical in training concentration the of graduated pivo - Schou gave lithium for the first time to a manic patient a manic to firsttimethe forlithium Schou gave 1988. patients while fifteen showed some improvement and three showed no effect at effect no showed three and improvement some showed fifteen while

a hich was not well known at that time. The time. that atknownwell not was hich used a neutral preparation (placebo) for comparative purposes to show to purposes comparative for (placebo) preparation neutral a used . When it was performed over half a century ago, century a half overperformed was it When . a studies tal rom 1951 until the end of his life he was associated with the Aarhus the with associated was he life his of end the until 1951 rom

Primus Inter Pares” serv who is with a degree a with thevast majority whomof r ept hs aso fr research for passion his Despite published ed oes co sme up summed Schou Mogens er afcie ypos Tev o tee ains showed patients these of Twelve symptoms. affective lear” enhagen in 1918. 1918. in enhagen as regarded by ht nomd lncl rcie with practice clinical informed that the u sre a the as served but drug serum inblood systematicallywas established, and - depressive illness. the first controlled study controlled first the

director of director

in medicine in meant for patients. Gin Malhipatients.Gin meant for . With his co an important element for further for element important an many various psychiatric institutions from 19 from institutions psychiatric various (1887 Schou Jacob Hans father, His as the organizational founder of modern f n eerh xmnn al set of aspects all examining research in lf

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This article isprotected rights by All copyright. reserved. years w occurredmania or recurrencesof anti requiring deterioration a as define (discontinuationwas receivelithiumillness Recurrenceof design). to continued whichgroup lith which in group a in illness of course the the between in performed were initiative significant a exercised such eight Subsequently, issue. this on trials questioned article the in published T Shepherd. Michael and Blackwell Barry psychiatrists British the of characterization a , clinical picture, outcomes as well as suggested management. with cases, eight on based published, was poisoning lithium of description as a provided discovery lithium receiving subjects in This outcome fatal sometimes with reabsorption. toxicity lithium of explanation sodium plausible to relationship its and tubule) proximal the in renal handlingstudy on lithium of elucid described, was (goiter) t first the For studies. and observations clinical lithiumon it shortenedwas to the average twoof weeks. b year a within depression) or ( the that found They disorder. affective bipolar and unipolar mirror a performed colleague, this, Following Baastrup). Christian (Paul Denmark and Hartigan) (Geoffrey England from came They recurrences. depressive and manic on therapy lithium an concerni knowledge contemporary

Accepted Article ext a manic treatment. Analysis of all of Analysis treatment. manic two (on average(on 30%) thanreceiving while placebo (on avera ensive articlepublished in at usiue which substitute salt How by marked was ago, century of half a exactly 1968, year The of effect prophylactic possible a on pointing appeared reports first the 1960s, early the In

years preceding lithium treatment. Most of these studies these of Most treatment. lithium preceding years 1970 ever, in the same year, same the in ever, – 1973. The patients The 1973. Lancet

the validity of of validity the based on findings in a large a in findings on based

n ws ild titled was and

sciti hsiaiain r omnig eua atdpesv or antidepressive regular commencing or hospitalization psychiatric occurred - mg suy f ihu pohlxs n eighty on prophylaxis lithium of study image " the findings on on findings the Pharmacological Reviews" ng pharmacology, biochemistry a biochemistry pharmacology, ng were required to required were a strong backlash again backlash strong a this efore lithium efore

ated rud the around research showed that the percentage of patients in whom in patients of percentage the that showed research “ rpyatc ihu. nte Teaetc yh” The Myth?”. Therapeutic Another Lithium. Prophylactic ium was discontinued and replaced with placebo with a with placebo with replaced and discontinued was ium

the mechanism renal of lithium reabsorption (occurr ime, the adverse effect of lithium on thyroid functionthyroid on lithium of effect adverse the ime, ere placebo lithium

significantly lower while receivinglithiumsignificantlylower while administration group of 330 lithium 330 of group

Europe (in Denmark and Denmark (in Europe have at least two least at have 1940/1950 ’s effectiveness and requesting and effectiveness ’s

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ge 70%) lithium prophylaxis took place lead place took prophylaxis lithium

average duration of of duration average heir criticism heir ' . lo te is comprehensive first the Also, s. Schou was 13 weeks while during a year a during while weeks 13 was

employed a method comparing method a employed trials nd clinical effects of lithium in lithium of effects clinical nd [3]

recurrences of the illness in illness the of recurrences - tgte with together ,

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This article isprotected rights by All copyright. reserved. R Medical with (shared Award rec recurrences)in disordersmood it regard even researchers become and lithium on was It journal. the treatment in article scientific first the of author the became and board Lithium is extracted from stone and brineon location. A conference IGSLI group the conception, its Since and mortality of decrease the on lithium of influence favorable Lithium of found Study (IGSLI), the Patients for Group International the of Fathers Founding the were Ottawa " Th 1993. and 1988 1986, 1983, in appeared editions revised successive The is This published. were 1980, drug, show preg in lithium using forty Babies Lithium of Register an reported 12 disorder, bipolar to increase in their artistic productivity, due lithium with treated artists 24 From creativity. artistic h and artists, among of aspects various the influences therapy Lithium Treatment of Mood Disorders" ta

AcceptedInternationalAmongprestigiousFoundationnumerousthe awards.Scientific them,Kitty ipient of Article cama ucsie sus f oes Schou Mogens of issues successive oes co authored Schou Mogens Between Müller Bruno with together Schou, Mogens Schou Mogens ther lithium As lithium of promulgation his In

h bs eiecd hraooia srtg i trea in strategy pharmacological evidenced best the D - sac Aad 18) Itrainl oit o Ltim Research Lithium of Society International (1987), Award esearch eitn dpeso. fe mn yas ltim au lithium years, many After depression. resistant s a esert where a significant part of of part significant a where esert favo

, 1990

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apy can be administered in pregnancy, Mogens Schou was an initiator of the of initiator an was Schou Mogens pregnancy, in administered be can apy 1994 the extremelywasdedicatedto d n 98 I te 90 te ru pbihd semin published group the 1990s the In 1988. in ed

a practical guide to lithium therapy for doctors, for therapy lithium to guide practical a risk/benefitratio infavor lithium.of

women with women ae (94, on ae eoil wr (92, let akr Clinical Lasker Albert (1982), Award Memorial Cade John (1974), Cade) s h scn mi idcto fr ihu ue atr rvnig mood preventing (after use lithium for indication main second the as ) . journalpublished.was "Lithium" - has been has

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Since the rs. as . .

This article isprotected rights by All copyright. reserved. AcceptedReferences: personal commitment to scienceand patient careare irreplaceable lasti and permanent a leave will field the to contribution Editor first the Gershon, Samuel of end the to come would psychiatricof hospitalization study observational an of basis showe the on Finland from report a recently, and depression unipolar in effectiveness prophylactic has lithium that confirming published, been ahave studies controlled of suspected he where depression unipolar of significan prophylaxis for Article lithium of issue the concerned participate Despite Poznañ. in place took Marylou Selo. G Paul to conferred conference international activity media and rese of field the in achievements exceptional for given Scho Achievement Award (2004). C.I.N.PAchievement(1995), 3. 2. 1. ws oiae a is honorary its as nominated was u

d that lithium that d There was no sign then that several days after the Poznan IGSLI conf IGSLI Poznan the after days several that then sign no was There From (ISBD),Disorders BipolarInternational Societyof the of 1999in foundation the With Johnson FN, ed. Lithium Research and Therapy. Academic Press, London, 1976 Schou M, Thompsen K. Lithium prophylaxis recurrentof endogenous affectivedisorders. In: treatment. Schou administration lithiumof salts. J Schou M t efficacy, especially among so among especially efficacy, t ; it was during this conference that conference this during was it ;

23

M – , . , Juel 25 September 2005, September 25 Amdisen A Br J.Med 1968; 3: 710 rof, Martin Alda and Janus and Alda Martin rof, and advocacy in the field of of field the in advocacy and monotherapy is the pharmacological treatment associated with the lowest risk lowest the with associated treatmentpharmacological the is monotherapy - Nielsen N s Aog h ISI ebr, h Mgn Shu cetfc wrs were awards scientific Schou Mogens the members, IGSLI the Among .

’ his busy lithium busy his Hewas twicenominated to Nobel prizein medicine s , s Pioneers in Psycho Pioneersin s

EskjaerJe in patients with severeunipolar depression. age . - , Strömgren E in - - related Chief of "Bipolar Disorders" noticed: Although Mogens Schou's Mogens Although noticed: Disorders" "Bipolar of Chief Mogens

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- presid Neurol cal - 713. led "hidden bipolars". "hidden led limitations - oriented life. Amon life. oriented , Olsen Occurrence T. goitreof during n. ic 2001, Since ent.

, Voldby H z Rybakowski, and the advocacy the and Rybakowski, z Schou participated in the 19th IGSLI conference that conference IGSLI 19th the in participated Schou Neurosurg he presented one of his new research proposals. It proposals. research new his of one presented he - pharmacologyandLifetime(2000),NARSADAward ioa afcie disorder affective bipolar , he was quite pleased quite was he , arch, educational activity and organizational and activity educational arch, . Thetreatment of manic psychoses by the

Psychiatry. 1954; 17: g eay te os f i hmnt and humanity his of loss the legacy, ng

oes Schou Mogens g a plethora of praising obitu praising of plethora a g Over the years a growing number growing a years the Over .

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Mogens

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u This article isprotected rights by All copyright. reserved. Accepted Article 5. 4.

Schou M. Schou M. Lithium Treatment of Mood Disorders. A Practical Guide. Karger, Basel, 2004. Psychiatry 1979; 135: 97 Schou ArtisticM. productivity and lithium prophylaxis inm - 103.

anic - depressiveillness. BrJ