Spider Bites
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
RESEARCH ARTICLE Anti-Glioma Effect of Pseudosynanceia
DOI:10.31557/APJCP.2021.22.7.2295 Effect of Pseudosynanceia Melanostigma Venom on Glioblastoma Cells RESEARCH ARTICLE Editorial Process: Submission:02/14/2021 Acceptance:07/15/2021 Anti-Glioma Effect of Pseudosynanceia Melanostigma Venom on Isolated Mitochondria from Glioblastoma Cells Maral Ramezani, Fatemeh Samiei, Jalal Pourahmad* Abstract Background: Glioblastoma is the most common primary malignant tumor of the central nervous system that occurs in the spinal cord or brain. Pseudosynanceia Melanostigma is a venomous stonefish in the Persian Gulf, which our knowledge about is little. This study’s goal is to investigate the toxicity of stonefish crude venom on mitochondria isolated from U87 cells. Methods: In the first stage, we extracted venom stonefish and then isolated mitochondria have exposed to different concentrations of venom. Finally, mitochondrial toxicity parameters (Succinate dehydrogenase (SDH) activity, Reactive oxygen species (ROS), cytochrome c release, Mitochondrial Membrane Potential (MMP), and mitochondrial swelling) have evaluated. Results: To determine mitochondrial parameters, we used 115, 230, and 460 µg/ml concentrations. The results of our study show that the venom of stonefish selectively increases upstream parameters of apoptosis such as mitochondrial swelling, cytochrome c release, MMP collapse and ROS. Conclusion: This study suggests that Pseudosynanceia Melanostigma crude venom has selectively caused toxicity by increasing active mitochondrial oxygen radicals. This venom could potentially be a candidate for the treatment of glioblastoma. Keywords: Mitochondria- glioblastoma- fish venoms- cell line- tumor- toxicity-Persian Gulf Asian Pac J Cancer Prev, 22 (7), 2295-2302 Introduction freshwater or saltwater. Marine animals most commonly used for animals live in saltwater, i.e. in oceans, seas, Glioblastoma multiform is the most common group of etc. -
Family Practice
THE JOURNAL OF FAMILY ONLINE EXCLUSIVE PRACTICE Paul K. Carlton, Jr, MD, Brown recluse spider bite? FACS The Texas A&M University Consider this uniquely Health Science Center College Station, Tex conservative treatment [email protected] An antihistamine and observation work as well— and often better—than more intensive therapies. Practice recommendations oped it in 4 phases, which I describe in • Be concerned about brown recluse this article. Not only does this conser- envenomation when a patient vative approach consistently heal con- reports intensifying localized firmed brown recluse bite wounds, but pain disproportionate to physical should a bite be mistakenly attributed findings after a “bite” (C). to the brown recluse (or one of its rela- tives in the Loxosceles genus of spider), • Prescribe an oral antihistamine there is no harm to the patient, nor any alone to control symptoms, even big expense. with a necrotic wound, and mark the IN THIS ARTICLE patient’s progress over 24 hours (C). z Spider bite z Is a brown recluse • If the patient improves dramatically, to blame? or MRSA? continue the antihistamine; with little Due to limited experience among the Page E6 or no improvement, consider giving an wider medical community in identifying antibiotic with the antihistamine (C). spider envenomation,1-4 bite recognition and selection of appropriate therapy can Strength of recommendation (SOR) be difficult. A Good-quality patient-oriented evidence Early findings can be confusing. B Inconsistent or limited-quality patient-oriented evidence C Consensus, usual practice, opinion, disease-oriented Brown recluse bites typically feel like a evidence, case series pin prick. -
Western Black Widow Spider
Arachnida Western Black Widow Spider Class Order Family Species Arachnida Araneae Theridiidae Latrodectus hesperus Range Reproduction Special Adaptations The genus is worldwide. Growth: gradual, molts several times. Venom: Although never Western Texas, Okla- Egg: produced in bunches of 40 or more, wrapped in silk and sus- aggressive, the females homa and Kansas north pended from the web, can hatch within a week of being laid. occasionally bite hu- to Canada and west to the Immature: pure white after hatching and slowly gaining color with each mans but only in self defense (males do not Pacific Coaststates molt. Adult: may live for several years. The female can store sperm for many bite humans). They months. It is a fallacy that the female always eats the male after can cause a serious but Habitat mating. rarely fatal result. The venom is neurotoxic and Found in tropical, temper- Physical Characteristics is reported to be 15 times ate and arid zones in a as poisonous as that of the rattlesnake. Symptoms multitude of habitats. Mouthparts: chelicerate, fangs are perpendicular to body line. Duct from a include a painful tight- poison gland opens from the base of each fang. The mouth and ening of the abdomenal jaws are on the underside of the head. Niche wall muscles, increased Legs: 8 long, narow legs. blood pressure and body Eyes: 8 eyes. Usually found in temperature, nausea, lo- Egg: their eggs are layed in clusters and covered with silk to undisturbed places like calized edema, asphyxia form an egg sac. wood piles, outhouses, and convulsions. Medical Immature: white at first , gaining color with each molt. -
Anatomy and Physiology
ASSIGNMENT 22 Book Assignment: “Poisoning and Drug Abuse,” pages 22-1 to 22-34 22-1. Poisoning is defined as contact with or 22-6. Which of the following is the method of exposure to a toxic substance. choice for the HM to use to induce vomiting? 1. True 2. False 1. 15-30 cc of syrup of Ipecac 2. 2 teaspoonfuls of dry mustard in water 22-2. Toxicology is defined as the science of 3. 2 teaspoonfuls of an active charcoal poisons. slurry 4. To tickle the back of the victim’s 1. True throat 2. False 22-7. When a patient ingests an acid or base 22-3. A patient presents with dilated pupils, treatment is to give a neutralizing agent fever, dry skin, urinary retention, decreased orally. bowel sounds, and increased heart rate. What toxidrome does this set of symptoms 1. True suggest? 2. False 1. Narcotic 2. Anticholinergic 22-8. If the HM is unable to reach the poison 3. Withdrawal control center or a physician for specific 4. Non-syndrome syndrome instructions, how should the HM treat a victim who has ingested turpentine? 22-4. A patient presents with salivation, 1. Induce vomiting and observe lacrimation, urination, and muscle 2. Give 1 to 2 ounces of vegetable oil weakness. What toxic syndrome does this orally set of symptoms suggest? 3. Neutralize the poison with vinegar and water 1. Anticholinergic 4. Give 1 to 2 tablespoonfuls of milk 2. Cholinergic of magnesia 3. Narcotics 4. Sympathominetic 22-9. Of the following, which is considered the most common agent in inhalation 22-5. -
Development of the Cursorial Spider, Cheiracanthium Inclusum (Araneae: Miturgidae), on Eggs of Helicoverpa Zea (Lepidoptera: Noctuidae)1
Development of the Cursorial Spider, Cheiracanthium inclusum (Araneae: Miturgidae), on Eggs of Helicoverpa zea (Lepidoptera: Noctuidae)1 R. S. Pfannenstiel2 Beneficial Insects Research Unit, USDA-ARS, Weslaco, Texas 78596 USA J. Entomol. Sci. 43(4): 418422 (October 2008) Abstract Development of the cursorial spider, Cheiracanthium inclusum (Hentz) (Araneae: Miturgidae), from emergence to maturity on a diet of eggs of the lepidopteran pest Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) was characterized. Cheiracanthium inclusum developed to adulthood with no mortality while feeding on a diet solely of H. zea eggs and water. The number of instars to adulthood varied from 4-5 for males and from 4-6 for females, although most males (84.6%) and females (66.7%) required 5 instars. Males and females took a similar time to become adults (54.2 ± 4.0 and 53.9 ± 2.0 days, respectively). Egg consumption was similar between males and females for the first 4 instars, but differed for the 51 instar and for the total number of eggs consumed to reach adulthood (651.0 ± 40.3 and 866.5 ± 51.4 eggs for males and females, respectively). Individual consumption rates suggest the potential for high impact of C. inclusum individuals on pest populations. Development was faster and survival greater than in previous studies of C. inc/usum development. Key Words spider development, egg predation Spiders have been observed feeding on lepidopteran eggs in several crops (re- viewed by Nyffeler et al. 1990), but only recently has the frequency of these obser- vations (Pfannenstiel and Yeargan 2002, Pfartnenstiel 2005, 2008) suggested that lepidopteran eggs may be a common prey item for some families of cursorial spiders. -
Introduction to Arthropod Groups What Is Entomology?
Entomology 340 Introduction to Arthropod Groups What is Entomology? The study of insects (and their near relatives). Species Diversity PLANTS INSECTS OTHER ANIMALS OTHER ARTHROPODS How many kinds of insects are there in the world? • 1,000,0001,000,000 speciesspecies knownknown Possibly 3,000,000 unidentified species Insects & Relatives 100,000 species in N America 1,000 in a typical backyard Mostly beneficial or harmless Pollination Food for birds and fish Produce honey, wax, shellac, silk Less than 3% are pests Destroy food crops, ornamentals Attack humans and pets Transmit disease Classification of Japanese Beetle Kingdom Animalia Phylum Arthropoda Class Insecta Order Coleoptera Family Scarabaeidae Genus Popillia Species japonica Arthropoda (jointed foot) Arachnida -Spiders, Ticks, Mites, Scorpions Xiphosura -Horseshoe crabs Crustacea -Sowbugs, Pillbugs, Crabs, Shrimp Diplopoda - Millipedes Chilopoda - Centipedes Symphyla - Symphylans Insecta - Insects Shared Characteristics of Phylum Arthropoda - Segmented bodies are arranged into regions, called tagmata (in insects = head, thorax, abdomen). - Paired appendages (e.g., legs, antennae) are jointed. - Posess chitinous exoskeletion that must be shed during growth. - Have bilateral symmetry. - Nervous system is ventral (belly) and the circulatory system is open and dorsal (back). Arthropod Groups Mouthpart characteristics are divided arthropods into two large groups •Chelicerates (Scissors-like) •Mandibulates (Pliers-like) Arthropod Groups Chelicerate Arachnida -Spiders, -
ALLERGIC REACTIONS/ANAPHYLAXIS Connie J
Northwest Community EMS System Paramedic Education Program ALLERGIC REACTIONS/ANAPHYLAXIS Connie J. Mattera, M.S., R.N., EMT-P Reading assignments Text-Vol.1 pp. 235, 1272-1276 SOP: Allergic Reactions/ Anaphylactic Shock Assumed knowledge: Drugs: Epinephrine 1:1,000, 1:10,000; albuterol, ipratropium, dopamine, glucagon KNOWLEDGE OBJECTIVES Upon reading the assigned text assignments and completion of the class and homework questions, each participant will independently do the following with at least an 80% degree of accuracy and no critical errors: 1. Define allergic reaction. 2. Describe the incidence, morbidity and mortality of allergic reactions and anaphylaxis. 3. Identify risk factors that predispose a patient to anaphylaxis. 4. Explain the physiology of the immune system following exposure to an allergen including activation of histamine receptors and the formation of antibodies. 5. Discuss the pathophysiology of allergic reactions and anaphylaxis. 6. Describe the common modes by which allergens enter the body. 7. Compare and contrast natural and acquired and active vs. passive immunity. 8. Identify antigens most frequently associated with anaphylaxis. 9. Differentiate the clinical presentation and severity of risk for a mild, moderate and severe allergic reaction with an emphasis on recognizing an anaphylactic reaction. 10. Integrate the pathophysiologic principles of anaphylaxis with treatment priorities. 11. Sequence care per SOP for patients with mild, moderate and severe allergic reactions. CJM: S14 NWC EMSS Paramedic Education Program ALLERGIC REACTIONS/ANAPHYLAXIS Connie J. Mattera, M.S., R.N., EMT-P I. Immune system A. Principal body system involved in allergic reactions. Others include the cutaneous, cardiovascular, respiratory, nervous, and gastrointestinal systems. -
Violent Incidents Between Humans and Orcas in Captivity
Violent incidents between humans and orcas in captivity Several accounts of violent incidents with humans have appeared in books and news clips, with little information on the dates or details of those incidents. Other descriptions have made headlines, and some were captured on video tape. There are also anecdotal reports of incidents that were never officially documented. NO. DATE AQUARIUM WHALEs INCIDENT SOURCE early years New York When water level was lowered for pool cleaning, young female Lupa sent Edward R. Riciuti, , New #1 1968 Lupa York, Walker & Co., 1973, Aquarium, USA trainers scrambling from the pool, snapping her jaws threatening. pp. 227-228. Edward R. Riciuti, Killers of the Sea, New York, Young male Cuddles became so increasingly aggressive, having a hold of at Walker & Co., 1973, pp. Flamingo Park, least two trainers, that keepers had to clean the pool from the protection of a 227-228; Reading #2 1969-1970 Cuddles England shark cage. Cuddles also dragged keeper Don Robinson into the pool when he Eagle, August 15, was at Dudley Zoo but that was possibly a PR stunt. 1971; Doug Cartlidge, personal communication, March 2010. Karen Pryor writes, "I have since heard... of at least one killer whale which Karen Pryor, Lads Before the Wind, New York, #3 1970s unknown unknown launched an unprovoked attack on a favorite trainer, in normal circumstances, Harper & Row, 1976, p. savaged him very badly, and nearly killed him." 220. Vancouver Trainer Doug Pemberton described young female Skana as the dominant Cranky killer whales put trainers through their #4 1970's Aquarium, Skana animal in the pool. -
Arthropod Envenomations: Immunologic and Toxicologic Considerations Cyrus Rangan, MD, FAAP, ACMT
Emergency Department Evaluation and Treatment for Children With Arthropod Envenomations: Immunologic and Toxicologic Considerations Cyrus Rangan, MD, FAAP, ACMT Arthropod envenomations are a significant cause of environmental injury in children. Bees, wasps, and spiders inflict injury via specialized venoms with a broad range of components, mechanisms, and potential treatments. Immunologic and toxicologic considerations in the evaluation and management of arthropod envenomations are important for the under- standing of the progression of envenomations, prompt diagnosis of severe conditions including anaphylaxis, and the use of antivenom in selected cases. Clin Ped Emerg Med 8:104-109 ª 2007 Published by Elsevier Inc. KEYWORDS envenomation, arthropod, arachnida, hymenoptera rthropod bites and stings accounted for more than ever, clinical symptoms of envenomation and treatment A75000 reports to poison control centers in the are similar. Bees are attracted to carbon dioxide (hence, United States in 2005 [1]. The phylum Arthropoda the predilection for bees to fly around the facial area), includes 2 clinically important classes: Insecta (order: bright colors (ie, clothing), and sweet odors (ie, Hymenoptera—bees, wasps, yellow jackets, and ants), perfumes, fragrances). Children commonly believe that and Arachnida (ticks, scorpions, and spiders). Virtually bees are aggressive insects, but they are mostly docile all arthropods possess some form of venom for immobi- creatures; indeed, the sometimes fearful behavior of lization and digestion of prey, yet only a select few species children around a nearby bee may increase the risk of a have developed venom delivery mechanisms capable of sting. Mass envenomations may occur when a hive is poisoning humans [2]. Pathophysiologic mechanisms of physically disturbed by children throwing rocks or other venom vary considerably among arthropods, and clinical objects at the hive [3]. -
Tarantulas in the Pacific Northwest1
WSU Puyallup REC PLS-108 Updated July 2003 Tarantulas in the Pacific Northwest1 Tarantulas (Fig. 1) in the Pacific Northwest? Well, maybe not like the hairy monsters of the tropics, but some very interesting "atypical" species do occur here. Our species belong to the family Antrodiaetidae. One of our most common spiders is the folding-door spider, Antrodiaetus pacificus (Simon). It is a fairly large species, females ranging from 11 to 13 millimeters in length, males slightly smaller. They are generally dark brown to almost black in color with the abdomen purplish brown. Males are characterized by their long legs, slim bodies, and three tergites (hardened plates) on the abdomen. Females (Fig. 2) are more robust with only one tergite. These spiders excavate burrows in the soil or in damp, rotten wood, digging with a row of spines on each chelicer, known as a ratellum. The six to ten inch deep vertical shafts are lined with silk. The webbing extends beyond ground level as a short collar of camouflaged silk. The turret’s two sides may be drawn in by the occupant, forming two "doors" which meet in the middle. At night, Antrodiaetus assumes a foraging posture with its pedipalps and first pair of legs just touching the rim of silk at the mouth of the tube. In this position, the folding door spider can readily detect an insect moving above ground. The spider will leap out of its burrow with lightning speed, seize its victim, and drop back down, like a terrorizing Jack-in-the-box. When finished with its meal, it will add the insect's dry, dismembered body to a silk-covered trash pile at the bottom of its burrow. -
Awareness, Prevention and Treatment of World-Wide Marine Stings and Bites
Awareness, Prevention and Treatment of world-wide marine stings and bites Dr Peter Fenner Honorary Medical Officer, Surf Life Saving Australia International Life Saving Federation Medical/Rescue Conference Proceedings September 1997 Abstract The most common world-wide first aid treatment used by the average lifesaver/lifeguard is the treatment of marine envenomation, especially the treatment of jellyfish stings. It is important to use the correct first aid treatment for each type of envenomation. This study provides a simplified protocol for: - 1. Awareness of the geographical distribution and possibilities of envenomation enabling: - 2. Preventative strategies to reduce morbidity and mortality from marine envenomation 3. First aid treatment of marine envenomation by jellyfish or other marine animals This discussion is based on protocols developed for Surf Life Saving Australia and other first aid providers in Australia over the past ten years. Their success has been proven by a 30% reduction in the number of stings over the past 10 years (statistics from the author’s records). Information for this article has been taken from: - 1. Venomous and poisonous marine animals: a medical and biological handbook produced by Surf Life Saving Queensland 2. The global problem of cnidarian stinging. MD Thesis by the author for the University of London. Introduction The global problem of marine envenomation is not fully appreciated. Each year hundreds of deaths occur from poisoning (by ingestion or eating) or by envenomation (stinging by jellyfish, or biting by venomous marine animals). The morbidity is even greater with jellyfish stings world-wide being numbered in their millions. Each summer it is estimated that up to half a million stings occur on the east coast of the United States from the Portuguese man-o’-war (Physalia physalis). -
Approach and Management of Spider Bites for the Primary Care Physician
Osteopathic Family Physician (2011) 3, 149-153 Approach and management of spider bites for the primary care physician John Ashurst, DO,a Joe Sexton, MD,a Matt Cook, DOb From the Departments of aEmergency Medicine and bToxicology, Lehigh Valley Health Network, Allentown, PA. KEYWORDS: Summary The class Arachnida of the phylum Arthropoda comprises an estimated 100,000 species Spider bite; worldwide. However, only a handful of these species can cause clinical effects in humans because many Black widow; are unable to penetrate the skin, whereas others only inject prey-specific venom. The bite from a widow Brown recluse spider will produce local symptoms that include muscle spasm and systemic symptoms that resemble acute abdomen. The bite from a brown recluse locally will resemble a target lesion but will develop into an ulcerative, necrotic lesion over time. Spider bites can be prevented by several simple measures including home cleanliness and wearing the proper attire while working outdoors. Although most spider bites cause only local tissue swelling, early species identification coupled with species-specific man- agement may decrease the rate of morbidity associated with bites. © 2011 Elsevier Inc. All rights reserved. More than 100,000 species of spiders are found world- homes and yards in the southwestern United States, and wide. Persons seeking medical attention as a result of spider related species occur in the temperate climate zones across bites is estimated at 50,000 patients per year.1,2 Although the globe.2,5 The second, Lactrodectus, or the common almost all species of spiders possess some level of venom, widow spider, are found in both temperate and tropical 2 the majority are considered harmless to humans.