Mouse Anti-Human Desmoglein-3 (EC2 Domain) Monoclonal Antibody, Clone QWC39 (CABT-L2646) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Mouse Anti-Human desmoglein-3 (EC2 domain) monoclonal antibody, clone QWC39 (CABT-L2646) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview Recombinant monoclonal antibody to desmoglein-3. Variable regions (i.e. specificity) from the EBV transformed human B cell clone QWC39. Made by immortalizing IgG-expressing B cells from Pemphigus vulgaris (PV) patients.

Specificity This antibody specifically recognizes a conformational epitope in the EC2 domain of human desmoglein-3 (DSG). This antibody was isolated as a human IgG4 from a patient with mucocutaneous pemphigus vulgaris. This antibody has in vitro and in vivo pathogenic activity, as assessed in a keratinocyte dissociation assay and by the formation of microscopic blisters in newborn mice. This antibody crossreacts with murine DSG-3.

Immunogen Desmoglein-3

Isotype IgG1, κ

Source/Host Mouse

Species Reactivity Human

Clone QWC39

Purification Protein A affinity purified

Conjugate Unconjugated

Applications IA

Format Liquid

Concentration 1 mg/ml

Size 200 ug; 1 mg

Buffer PBS

Preservative See individual product datasheet

Storage Store at -20 or -70°C upon receipt. Divide antibody into aliquots prior usage. Avoid multiple freeze-thaw cycles.

Ship Wet ice

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

BACKGROUND

Introduction Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.

Keywords DSG3; desmoglein 3; PVA; CDHF6; desmoglein-3; cadherin family member 6; pemphigus vulgaris antigen; 130-kD pemphigus vulgaris antigen; 130 kDa pemphigus vulgaris antigen;

GENE INFORMATION

Official Symbol desmoglein 3

Entrez Gene ID 1830

Protein Refseq NP_001935

UniProt ID P32926

Chromosome Location 18q12.1

Pathway Apoptosis; Apoptotic cleavage of cell adhesion proteins; Apoptotic cleavage of cellular proteins; Apoptotic execution phase; Programmed Cell Death;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]