nanomaterials Article Iron Hydroxide/Oxide-Reduced Graphene Oxide Nanocomposite for Dual-Modality Photodynamic and Photothermal Therapy In Vitro and In Vivo Wei-Jane Chiu 1, Yi-Chun Chen 2, Chih-Ching Huang 1,3,4 , Lingyan Yang 5 , Jiantao Yu 5, Shih-Wei Huang 6,7,8 and Chia-Hua Lin 2,* 1 Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung 20224, Taiwan;
[email protected] (W.-J.C.);
[email protected] (C.-C.H.) 2 Department of Biotechnology, National Formosa University, Yunlin 63208, Taiwan;
[email protected] 3 Center of Excellence for the Oceans, National Taiwan Ocean University, Keelung 20224, Taiwan 4 School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan 5 Key Laboratory of Nano-Bio Interface, Suzhou Key Laboratory for Nanotheranostics, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China;
[email protected] (L.Y.);
[email protected] (J.Y.) 6 Department of Electronics, Cheng Shiu University, Kaohsiung 83347, Taiwan;
[email protected] 7 Center for Environmental Toxin and Emerging-Contaminant Research, Cheng Shiu University, Kaohsiung 83347, Taiwan 8 Super Micro Research and Technology Center, Cheng Shiu University, Kaohsiung 83347, Taiwan * Correspondence:
[email protected]; Tel.: +886-5-6315-558 Citation: Chiu, W.-J.; Chen, Y.-C.; Abstract: Minimal invasive phototherapy utilising near-infrared (NIR) laser to generate local reactive Huang, C.-C.; Yang, L.; Yu, J.; Huang, oxygen species (ROS) and heat has few associated side effects and is a precise treatment in cancer S.-W.; Lin, C.-H.