Suppl. Table 1. SiRNA library used for centriole overduplication screen.

Entrez Gene Id NCBI gene symbol siRNA Target Sequence 1070 CETN3 TTGCGACGTGTTGCTAGAGAA 1070 CETN3 AAGCAATAGATTATCATGAAT 55722 CEP72 AGAGCTATGTATGATAATTAA 55722 CEP72 CTGGATGATTTGAGACAACAT 80071 CCDC15 ACCGAGTAAATCAACAAATTA 80071 CCDC15 CAGCAGAGTTCAGAAAGTAAA 9702 CEP57 TAGACTTATCTTTGAAGATAA 9702 CEP57 TAGAGAAACAATTGAATATAA 282809 WDR51B AAGGACTAATTTAAATTACTA 282809 WDR51B AAGATCCTGGATACAAATTAA 55142 CEP27 CAGCAGATCACAAATATTCAA 55142 CEP27 AAGCTGTTTATCACAGATATA 85378 TUBGCP6 ACGAGACTACTTCCTTAACAA 85378 TUBGCP6 CACCCACGGACACGTATCCAA 54930 C14orf94 CAGCGGCTGCTTGTAACTGAA 54930 C14orf94 AAGGGAGTGTGGAAATGCTTA 5048 PAFAH1B1 CCCGGTAATATCACTCGTTAA 5048 PAFAH1B1 CTCATAGATATTGAACAATAA 2802 GOLGA3 CTGGCCGATTACAGAACTGAA 2802 GOLGA3 CAGAGTTACTTCAGTGCATAA 9662 CEP135 AAGAATTTCATTCTCACTTAA 9662 CEP135 CAGCAGAAAGAGATAAACTAA 153241 CCDC100 ATGCAAGAAGATATATTTGAA 153241 CCDC100 CTGCGGTAATTTCCAGTTCTA 80184 CEP290 CCGGAAGAAATGAAGAATTAA 80184 CEP290 AAGGAAATCAATAAACTTGAA 22852 ANKRD26 CAGAAGTATGTTGATCCTTTA 22852 ANKRD26 ATGGATGATGTTGATGACTTA 10540 DCTN2 CACCAGCTATATGAAACTATA 10540 DCTN2 AACGAGATTGCCAAGCATAAA 25886 WDR51A AAGTGATGGTTTGGAAGAGTA 25886 WDR51A CCAGTGATGACAAGACTGTTA 55835 CENPJ CTCAAGTTAAACATAAGTCAA 55835 CENPJ CACAGTCAGATAAATCTGAAA 84902 CCDC123 AAGGATGGAGTGCTTAATAAA 84902 CCDC123 ACCCTGGTTGTTGGATATAAA 79598 LRRIQ2 CACAAGAGAATTCTAAATTAA 79598 LRRIQ2 AAGGATAATATCGTTTAACAA 51143 DYNC1LI1 TTGGATTTGTCTATACATATA 51143 DYNC1LI1 TAGACTTAGTATATAAATACA 2302 FOXJ1 CAGGACAGACAGACTAATGTA 2302 FOXJ1 CACCCTGTCGGCCATCTACAA 11064 CEP110 CAGCTATAATCTAATAGGGAA 11064 CEP110 AACAATTGAACTGGTAGCCCA 55363 HEMGN AACATACAGCTTAATAGTTTA 55363 HEMGN CACCTGAAACGTATCAAGAAA 9814 SFI1 AAGGATGGTGCAGTTAAGAAA 9814 SFI1 AAGCAAGTACTCATTACAGAA 8451 CUL4A ACCCATATTATTAGTGATAAA 8451 CUL4A CTAGAGATTGTTAATATTGTA 11258 DCTN3 CTGGACAGTGCTCACATCAAA 11258 DCTN3 GAGGGTGAAGATTCTCTACAA 203068 TUBB CAGTTGGTAGAGAATACTGAT 203068 TUBB CCGCAAGTTGGCAGTCAACAT 22995 CEP152 CAGGAACTTAAAGAAACTGAA 22995 CEP152 ATGAAGAAACTCGAAATTGAA 9738 CP110 AAAGGGCTATATAATAATAAA 9738 CP110 CCCGAAATTATGCCAAAGTTA 132320 SCLT1 CAGCTGGAAATGGCAAATGAA 132320 SCLT1 TAGAAGTGTATTGAAATGGTA 54801 FAM29A AAGGAACACTGTCAAACTATA 54801 FAM29A TTGGAGAACTACCTAATTTAA 7317 UBE1 CTGGGATGTCACGAAGTTAAA 7317 UBE1 CTGAATCCTAATAAAGAATTA 51199 NIN CTGGAAGACCTAAGAAATGTA 51199 NIN AACGGGAACAAGAGAAGTTTA 9857 CAP350 CTGGGACAAAGAATTAATAAA 9857 CAP350 CAGCATTATGCAGAAACTGAA 8450 CUL4B AATGATGATTTCAAACATAAA 8450 CUL4B TGGCAGCACTATTGTAATTAA 10383 TUBB2C CCGGGCAGTGCGGCAACCAAA 10383 TUBB2C GAGCAAATGCTTAATGTCCAA 22897 CEP164 CAGGTGACATTTACTATTTCA 22897 CEP164 ACCTACATTCCTAGTGAGCAA 56890 MDM1 ATGAGGGTGTAACAAACCATA 56890 MDM1 CTGGACTTAGATCAGATCAAT 79959 CEP76 AACGATGAATCCAAATGGAAA 79959 CEP76 TTGGATCATGTTTGCTTGTAA 10142 AKAP9 CAGCCTATCAGTGAACATCAA 10142 AKAP9 CAGCTTCAAAGGGATATACAA 29922 NME7 CCCGGCATTTACGCCCTGGAA 29922 NME7 TTCATGTAGATCACCAGTCAA 1019 CDK4 AAGCCTCTCTTCTGTGGAAAC 1019 CDK4 AAGGTAACCCTGGTGTTTGAG 995 CDC25C CCAGGGAGCCTTAAACTTATA 995 CDC25C GAGCTGCAATCTAGTTAACTA 993 CDC25A CTGGCCAAATAGCAAAGACAA 993 CDC25A AAGGGTTATCTCTTTCATACA 1017 CDK2 CAGGTTATATCCAATAGTAGA 1017 CDK2 GACGGAGCTTGTTATCGCAAA 5519 PPP2R1B CTGACGTTCGTTTGAATATCA 5519 PPP2R1B CAGAAGTTAGGTCAAGATGAA 6502 SKP2 AAGTGATAGTGTCATGCTAAA 6502 SKP2 ACCCTTCAACTGTTAAAGGAA 983 CDC2 CTCTGGTACAGATCTCCAGAA 983 CDC2 AAGGGGTTCCTAGTACTGCAA 84131 CEP78 AAGGCTGTTTAAGTATATCAA 84131 CEP78 TAGGAAGTGGTCACAAAGGAA 23644 EDC4 AACATTGAGAAATTCAATTAA 23644 EDC4 CAGGTGATAGTACCTCAGCAA 1069 CETN2 CAGAACGACTTTAGACAAGCA 1069 CETN2 AAGCACATGTAACTAGATTTA 23177 CEP68 CGGCAATTTAAGAAAGATATA 23177 CEP68 ACCGAAGATGATCCATCCCTA 7532 YWHAG CCGATTAGGCCTGGCTCTTAA 7532 YWHAG AAGAGCTATATCCTTAACCAT 8481 OFD1 CCGCCCGGGCTGGGCACTAAA 8481 OFD1 ATCGATCGTTCTGTCAATGGA 54820 NDE1 AGCCGAGAATATGAAGCTGAA 54820 NDE1 ACGCAGCTGCAACAAATTGAA 10464 PIBF1 CAGAGCCAATTCGCTATTAAA 10464 PIBF1 CTCGTTAAGATGCATAGTAAA 163786 SASS6 CTCCACTATTAGAGAACTTAA 163786 SASS6 CAGGCACAGGTTCAATATCAA 152185 CCDC52 TTAGCAGAATTTAATAATTAA 152185 CCDC52 CAGCTGTTAAATAAAGTGAAA 5108 PCM1 CAGGCTTTAACTAATTATGGA 5108 PCM1 CAGTATCACATCTGAACTAAA 10382 TUBB4 CTGACCTTGCCTCACCTTTAA 10382 TUBB4 TGAGCCCTAATTTATCTTTAA 10987 COPS5 CTGGACTAAGGATCACCATTA 10987 COPS5 TAGGACATACCCAAAGGGCTA 11190 CEP250 ACGCCACTTCCTGGAAATGAA 11190 CEP250 CAGATTCAAACTGTCACTCAA 64005 MYO1G CAGGTACAAGATGACCTGTGA 64005 MYO1G CCCGCCAGCGCTGCAAATAAA 10426 TUBGCP3 CACGACTCGCATGGACTTTAA 10426 TUBGCP3 CCACTACCTAAGAGTATTTAA 1781 DYNC1I2 CTCGATCGTGTCAGTTTGTAA 1781 DYNC1I2 CAGGTGCTAAACTGTCATTAA 114791 TUBGCP5 CACGTTATATAGCGTATCAGA 114791 TUBGCP5 CTGGATGATGTTCATGATCCA 10806 SDCCAG8 AAGGAAGAATGCTGTACATTA 10806 SDCCAG8 AACAGGGATCTTGAAATTAAA 27229 TUBGCP4 CAGCGGTAAACAAACAATATA 27229 TUBGCP4 CTGGATGTTACCACCAAGTAA 80321 CEP70 CAGGAGCTTATAGAAACTAAT 80321 CEP70 CAGGCATTTACTAATGATCTA 4957 ODF2 AAGGATCTTTATGTCGCTGAA 4957 ODF2 AAGAGGATTCTGAAAGACTAA 7840 ALMS1 CTGGAACAAAGTGGTGATTAA 7840 ALMS1 TCGGAAGTTAGTGAAGCTTTA 10121 ACTR1A CAGGACCATTTGAGATTGGAA 10121 ACTR1A CTGAGTGAAGTGAAGAAACTA 55125 CEP192 CAGAAGTTAGTAGATATGAAA 55125 CEP192 AACAGTGAATGTGCAAGTAAA 116840 CNTROB AAGCATATCTTTGAGATGGAA 116840 CNTROB CTGGTGGAAACCTTTCCTCTA 5116 PCNT CAGGGTGAATTTGGAAGTGAA 5116 PCNT CACGAGCTTGAAGGTCATATA 80709 AKNA AAGAATGAATATTGATCTTAA 80709 AKNA CCGGACTGTGGTATCTGGCAA 85444 LRRCC1 CTGCATAAACATGCAAATGAA 85444 LRRCC1 AAGATCTGACCTGTATGGTAA 22994 AZI1 CAGCACGAGCTGGAGATTAAA 22994 AZI1 CCGGGAGAAGTGGATCAGTGA 8452 CUL3 AACAACTTTCTTCAAACGCTA 8452 CUL3 AAGAATCCTTCTCATAGTGAA 3320 HSP90AA1 ATGGCATGACAACTACTTTAA 3320 HSP90AA1 AACCCTGACCATTCCATTATT 79659 DYNC2H1 AAGGAATTGAATACTCTTCAA 79659 DYNC2H1 AAGCTCGTTGGGACCAACTAA 8655 DYNLL1 CTAGTTTGTCGTGGTTATAAA 8655 DYNLL1 AGGGAACATCTCGATGTTTGA 9696 CROCC CCCAGAGATCTCTCCGCCTTA 9696 CROCC GAGCCACTGTAGATCATTAAA 9859 CEP170 CAGAATATTATTTAAAGACAA 9859 CEP170 AAACATGATGATGGTACGCAA 80254 CEP63 AAGAAACTACATGAAGAATTA 80254 CEP63 ATGGAAGCACATAACAATGAA 55294 FBXW7 CCCTAAAGAGTTGGCACTCTA 55294 FBXW7 AAACATATGATGCAAGTGATA 7531 YWHAE CTCCGCTGAAATGTTGCTGAA 7531 YWHAE AAGCATCTAAGAGAGAGGTTA 145508 C14orf145 AAGCTTGGAACAATCAATCGA 145508 C14orf145 GCGGGTGCGATAGAACATTTA 10844 TUBGCP2 CAGCGTCTGGATCAGCAACAA 10844 TUBGCP2 CCAGGAGGATTACAACGACAA 85459 KIAA1731 CAGCATGAACTTAGTGCTATA 85459 KIAA1731 AACAATTACTTGAATATCAAA 388554 LOC388554 CACGGCCTTTGTGAAAGCCAA 388554 LOC388554 CACCCTGGACCTGCTGACCTA 10376 TUBA1B TCCATCATATCTCAAAGTAAA 10376 TUBA1B CAGCTTAACTGACAGACGTTA 7846 TUBA1A CCGCCTAAGAGTCGCGCTGTA 7846 TUBA1A TCCAACCTATACTAACCTGAA 11178 LZTS1 CCAGACGGAGGTGAACGCCAA 11178 LZTS1 CACCGTGGCACTAGAATGCAA 1778 DYNC1H1 CAGGAGGTAATTGCAGACAAA 1778 DYNC1H1 CAGGTGGGTGTACATTACGAA 153090 DAB2IP CAGGGATAGGCTAAGGAGTAA 153090 DAB2IP AACGATCTTTCCGGTCTGATA 23332 CLASP1 AAGCGTAATGTTACACTTTAA 23332 CLASP1 CAGGACTTTGCTAACAATAAT 79441 C4orf15 CAGCGACGTAATAAATGTCAA 79441 C4orf15 AACAAGATTATTATACAGCAA 201255 LRRC45 CTCCATCATCAACGCTCTCAA 201255 LRRC45 CCGCACTCACGTCCTCAGCAA 49856 WDR8 TCCCAAGATAGTGGTGTATAA 49856 WDR8 CTCGATGGCCCTCCTCAGCAA 95681 TSGA14 CAGTATTAGTCTAATTGAGTA 95681 TSGA14 CACTGGTAACAGTATGACTAA 1639 DCTN1 TCGGCCCAACTTATGGAGCAA 1639 DCTN1 AGCGATGAATGAGATGAACGA 23354 KIAA0841 CAGGCACGTCAGCACACTCAA 23354 KIAA0841 CAGAGTTTACAAGATAAGGAA 5518 PPP2R1A CTGGTGTCCGATGCCAACCAA 5518 PPP2R1A ACGGCTGAACATCATCTCTAA 5577 PRKAR2B ACGAACATGGATATTGTTGAA 5577 PRKAR2B CACGCCATTGGGACTGTCAAA 7277 TUBA4A CCGCCGCAACCTAGACATCGA 7277 TUBA4A GAGGATGAGGGAGAAGAATAA 10769 PLK2 CACCTTTCAGGTGAATTTCTA 10769 PLK2 CAGATTGTGTCTGGACTGAAA 3796 KIF2A AAGAACCAAGATTGTTCTAAA 3796 KIF2A ACCATATAACATGTGATTATA 22919 MAPRE1 CCAGTTATCCCGAAATTTCTA 22919 MAPRE1 CAGAGCAACATCGGAATTCTT 4738 NEDD8 CTCATAATGAGGCATCATATA 4738 NEDD8 ATGCCCAGTAATGTATGTCTA 8453 CUL2 CGGCACAATGCCCTTATTCAA 8453 CUL2 TACATCGGATGTATACAGATA 5576 PRKAR2A AACGGCATGTCTCTCCAACAA 5576 PRKAR2A AACTTGAAAGTCAGCACTAAA 9793 CKAP5 CAGGTATTATTAATGACGCAA 9793 CKAP5 AAGGGTCGACTCAATGATTCA 5566 PRKACA CAGAAGGTGGTGAAACTGAAA 5566 PRKACA CAAGGACAACTCAAACTTATA 7283 TUBG1 CCGAGGGAAATCATCACCCTA 7283 TUBG1 CTCCTCTTATGAGACTATTTA 8636 SSNA1 TGGCCTGTGATTATGAATAAA 8636 SSNA1 CTCCTTCACCACAGAACCCAA 1263 PLK3 CTGCATCAAGCAGGTTCACTA 1263 PLK3 CAGAAAGACTGTGCACTACAA 10733 PLK4 AAGGACTTGGTCTTACAACTA 10733 PLK4 CAGACATATAAGTTTAATAAA 11116 FGFR1OP AAGATGTTGCATAGACACGAA 11116 FGFR1OP CCAGATGAAGATGATATGGAA 994 CDC25B CCCAGTCTGTTGAGTTAGTTA 994 CDC25B CAGGAGGCTGAGGAACCTAAA 1454 CSNK1E GTGGTTGTTAATTTGAAGTAA 1454 CSNK1E GAGCTTTATCGTGGTTGTTAA 1453 CSNK1D CCGGTCTAGGATCGAAATGTT 1453 CSNK1D CTCCCTGACGATTCCACTGTA 8454 CUL1 AACGTAGTTATCAGCGATTCA 8454 CUL1 ACCGACAGCACTCAAATTAAA 1021 CDK6 AAGACTCAAGGTGGTCAGTAA 1021 CDK6 TCTGAAGTGTTTGACATTTAA 5347 PLK1 CCGGATCAAGAAGAATGAATA 5347 PLK1 CGCGGGCAAGATTGTGCCTAA 121441 NEDD1 CAGGTTTGCCTCGAAGCATAA 121441 NEDD1 CACAGTGTAACCACTAATTTA 9134 CCNE2 AAGAAGAGTATTAAATATATA 9134 CCNE2 CTCCAAGTTGATGCTCTTAAA 898 CCNE1 AAGGCAAACGTGACCGTTTTT 898 CCNE1 CAGGGTATCAGTGGTGCGACA 55755 CDK5RAP2 ATCCGTGATCTTAGAAATGAA 55755 CDK5RAP2 CAGAAGGAGAATGACAAATTA 134359 C5orf37 CAGGATGTTTATGAAGGTAAA 134359 C5orf37 CAGCAACAAATTCTAGTCATA 4751 NEK2 TTACGAGGATGTTAAACTTAA 4751 NEK2 TACGAGGATGTTAAACTTAAA