Β-Amyloid Deposition in AD Compared to Controls

Table e-1

β-amyloid deposition in AD compared to controls

APOE ε4-positive AD > Controls APOE ε4-negative AD > Controls

Stereotactic Gyrus (cluster- z-score Stereotactic Gyrus (cluster- z-score coordinates maximum) coordinates maximum) x y z (mm) x y z (mm) -58 -14 -16 L Mid Temp 6.96 -2 -62 48 L Precuneus 6.23 -58 -22 -8 L Mid Temp 6.85 52 -62 20 R Mid Temp 5.00 62 -40 18 R Sup Temp 6.50 42 12 2 R Insula 4.77 -36 -10 -38 L Inf Temp 2.71 -42 14 22 L Inf Frontal 3.39

β-amyloid deposition in ε4-positive compared to ε4-negative AD-patients

APOE ε4-positive AD > ε4-negative AD APOE ε4-positive AD > ε4-negative AD (without PVE-correction) (following PVE-correction)

Stereotactic Gyrus (cluster- z-score Stereotactic Gyrus (cluster- z-score coordinates maximum) coordinates maximum) x y z (mm) x y z (mm)

62 -36 6 R Mid Temp 5.03 42 26 52 R Mid Frontal 5.15 -22 54 -6 L Sup Orbital 4.67 62 -30 30 R Supramargin 4.92 30 -48 -14 R Fusiform 3.74 -8 8 48 L SMA 4.82 -8 -46 42 L Precuneus 3.55 -8 -56 42 L Precuneus 4.04 12 -40 46 R Mid Cing Ctx 3.55 -60 -26 -2 L Mid Temp 3.98 -8 26 36 L Sup Medial 3.38 -46 -2 52 L Precentral 3.91 38 2 -40 R Inf Temp 3.38 -36 22 56 L Mid Frontal 3.81 -24 12 -30 L Temp Pole 3.28 32 8 68 R Sup Frontal 3.79 8 20 -16 R Rectal 3.18 42 2 -44 R Inf Temp 3.16

All reported clusters survived a significance threshold of p< 0.05, FDR corrected. Only cluster maxima are listed. AD: Alzheimer’s disease, APOE: apolipoprotein E, Cing: cingulate, Ctx: cortex, ε: epsilon allele, Inf: inferior, L: left, Mid: middle, PVE: partial volume effect, R: right, SMA: supplementary motor area, Sup: superior, Supramargin: supramarginal, Temp: temporal