Β-Amyloid Deposition in AD Compared to Controls

Β-Amyloid Deposition in AD Compared to Controls

<p>Table e-1 </p><p>β-amyloid deposition in AD compared to controls</p><p>APOE ε4-positive AD > Controls APOE ε4-negative AD > Controls</p><p>Stereotactic Gyrus (cluster- z-score Stereotactic Gyrus (cluster- z-score coordinates maximum) coordinates maximum) x y z (mm) x y z (mm) -58 -14 -16 L Mid Temp 6.96 -2 -62 48 L Precuneus 6.23 -58 -22 -8 L Mid Temp 6.85 52 -62 20 R Mid Temp 5.00 62 -40 18 R Sup Temp 6.50 42 12 2 R Insula 4.77 -36 -10 -38 L Inf Temp 2.71 -42 14 22 L Inf Frontal 3.39</p><p>β-amyloid deposition in ε4-positive compared to ε4-negative AD-patients</p><p>APOE ε4-positive AD > ε4-negative AD APOE ε4-positive AD > ε4-negative AD (without PVE-correction) (following PVE-correction)</p><p>Stereotactic Gyrus (cluster- z-score Stereotactic Gyrus (cluster- z-score coordinates maximum) coordinates maximum) x y z (mm) x y z (mm)</p><p>62 -36 6 R Mid Temp 5.03 42 26 52 R Mid Frontal 5.15 -22 54 -6 L Sup Orbital 4.67 62 -30 30 R Supramargin 4.92 30 -48 -14 R Fusiform 3.74 -8 8 48 L SMA 4.82 -8 -46 42 L Precuneus 3.55 -8 -56 42 L Precuneus 4.04 12 -40 46 R Mid Cing Ctx 3.55 -60 -26 -2 L Mid Temp 3.98 -8 26 36 L Sup Medial 3.38 -46 -2 52 L Precentral 3.91 38 2 -40 R Inf Temp 3.38 -36 22 56 L Mid Frontal 3.81 -24 12 -30 L Temp Pole 3.28 32 8 68 R Sup Frontal 3.79 8 20 -16 R Rectal 3.18 42 2 -44 R Inf Temp 3.16</p><p>All reported clusters survived a significance threshold of p< 0.05, FDR corrected. Only cluster maxima are listed. AD: Alzheimer’s disease, APOE: apolipoprotein E, Cing: cingulate, Ctx: cortex, ε: epsilon allele, Inf: inferior, L: left, Mid: middle, PVE: partial volume effect, R: right, SMA: supplementary motor area, Sup: superior, Supramargin: supramarginal, Temp: temporal </p>

View Full Text

Details

  • File Type
    pdf
  • Upload Time
    -
  • Content Languages
    English
  • Upload User
    Anonymous/Not logged-in
  • File Pages
    1 Page
  • File Size
    -

Download

Channel Download Status
Express Download Enable

Copyright

We respect the copyrights and intellectual property rights of all users. All uploaded documents are either original works of the uploader or authorized works of the rightful owners.

  • Not to be reproduced or distributed without explicit permission.
  • Not used for commercial purposes outside of approved use cases.
  • Not used to infringe on the rights of the original creators.
  • If you believe any content infringes your copyright, please contact us immediately.

Support

For help with questions, suggestions, or problems, please contact us