Table 2: Clincal and Laboratory Data of Patients with Cerebrovascular Complications After

Additional table 1: Clincal and laboratory data of patients with cerebrovascular complications after orthotopic liver transplantation

Case Sex Age primary OLT Operative Previous Introperative Introperative Platelet (y) liver disease to persistent abdominal Retrans- blood blood counts PT APTT Introperative ICH time (h) surgery plantation loss transfusion ① ② ① ② ① ② hypotention (d) (ml) (ml) (×109/L) (S) 1 F 63 primary 28 5.7 No No 3000 2300 51 176 14.4 12.5 38.8 26.1 Yes hepatic carcinoma 2 M 59 PHC 8 5.5 Yes No 2000 3000 84 60 12.4 22.0 31.3 58.6 Yes

3 F 50 cirrhosis 7 6.5 Yes No 3500 6200 114 294 13.4 10.8 36.1 27.6 No

4 M 51 PHC 28 7.0 No No 2000 2900 17 210 17.0 9.8 51.0 31.5 No 5 M 61 cirrhosis 34 6.0 No No 1500 3100 47 34 35.0 22.6 60.9 29.0 No 6 M 40 cirrhosis 5 5.5 No No 1500 2950 131 5.5 23.8 13.6 57.9 28.4 Yes 7 M 67 cirrhosis 12 6.0 Yes No 6000 2000 36 35 24.3 18.8 64.7 38.1 Yes 8 F 59 cirrhosis 1 8.0 Yes No 15000 8700 54 62 17.8 20.1 119.8 46.0 Yes 9 M 46 PHC 6 11.5 Yes No 38000 30000 47 8 13.0 22.8 25.8 42.5 Yes 10 F 59 PHC 58 11.5 No No 8000 5300 22 169 22.2 12.4 63.8 28.1 No (Continued) Case Postoperative Infection Immunosuppre Cran- hypotention ssive drugs Clinical signs Brain CT scan findings iectomy Outcome 1 Yes bacteria pneumonia FK506, CysA, sudden vomiting, right left cerebral hemisphere basal gangliar, frontal No death steroids hemiparalysis and coma and temporal lobe hematomas, with intraventricular hematomas extension and midline shift 2 No bacteria pneumonia FK506, CysA, sudden aphasia and righ left basal gangliar with intraventricular hematomas Yes death steroids themiparalysis, 2 days later coma extension and midline shift and subarachnoid hematomas 3 No bacteria pneumonia , FK506, Cys A, sudden coma, left hemiparalysis, massive right parietal lobe hematoma No Survive urinary tract infection steroids awakened, headache 4 No No FK506, Cys A, onset seizures, loss of left parietal lobe hematoma No Survive steroids consciousness, awakened 5 No aspergillus FK506, Cys A, hypnody, then coma left temporal and parietal lobe hematomas with No death pneumonia steroids midline shift 6 No bacteria pneumonia FK506, Cys A, sudden loss of consciousness, left frontal lobe hematoma No death steroids A hypnody, coma 7 No bacteria pneumonia FK506, Cys A, restlessness, aphasia, drowsiness, left temple and frontal lobe subdural hematomas No Survive steroids right paraparesis 8 Yes Candida tropicalis and FK506, Cys A, coma, onset seizures, right left temple, frontal and parietal lobe subdural Yes death aspergillus steroids hemiparalysis hematomas with midline shift pneumonia 9 Yes bacteria pneumonia FK506, Cys A, restlessness, onset seizures, left basal gangliar lacunar infarction No death steroids persistent coma 10 No Candidiasis albicans FK506, Cys A, apathy, barylalia right basal gangliar lacunar and cerebellum infarctions No survive pneumonia steroids APTT: activated partial prothrombin time; CT: Brain computed tomography; Cys A:cyclosporine A; F: Female; M: Male; OLT: orthotopic liver transplantation; PHC: Primary hepatic carcinoma; PT: prothrombin time. ①：At the time of appearance of intracranial hemorrhage, ②: postoperative time.