Curriculum Vitae s73

CURRICULUM VITAE Kristine M. Garza

WORK: (915) 747-6562 Univ. Texas at El Paso FAX: (915) 747-5808 500 W. University Ave. e-mail: [email protected] El Paso, TX 79968-0519

EDUCATION: B.S. Biology, May 1991 St. Mary’s University, San Antonio, TX Graduated with Honors and Summa cum laude

Ph.D. Microbiology, January 1998 University of Virginia, Charlottesville, VA Mentor: Kenneth S. K. Tung, M.D. Dissertation: The Role of Peptide Self Antigen in the Induction of Autoimmunity and Tolerance

EMPLOYMENT 2006 – present Univ. of Texas at El Paso (UTEP) Dept. of Biological Sciences and Border Biomedical Research Center, Associate Professor

2000 – 2006 Univ. of Texas at El Paso (UTEP) Dept. of Biological Sciences and Border Biomedical Research Center, Assistant Professor

1998 – 2000 Ontario Cancer Institute Dept. Immunology, Postdoctoral Fellow (with Pamela S. Ohashi)

RESEARCH FUNDING 2007-2011 MBRS SCORE Individual Research Grant (PI - $492,678) 2006-2008 NIAID R15 (Co-PI - $200,000) 2005-2008 NIEHS-ARCH Project (Co-PI - $148,179) 2005–2006 EPA-SCERP Pilot Project (Co-PI - $42,475) 2004-2005 Tobacco Settlement Fund Award (Co-PI - $18,000) 2003.2007 MBRS SCORE Individual Research Subproject Grant (PI - $427,280) 2003-2004 Tobacco Settlement Fund Award (PI - $14,000) 2001.2003 MBRS SCORE Individual Research Subproject Grant (PI - $233,000) 2000.2001 UTEP – University Research Institute Grant (PI - $5000)

FUNDING for RESEARCH TRAINING and MENTORING 2009-2012 NSF-Research Experience for Undergraduates Program (PI, Program Director - $320,413) 2008 LI-COR Bioscience Genomics Education Matching Funds Grant (PI - $50,000) 2007-2011 Howard Hughes Undergraduate Science Program (Co-PI, Program Director - $1,500,000) 2004-2008 NSF-Research Experience for Undergraduates Program (PI, Program Director - $433,766) 2002.2004 NSF-Research Experience for Undergraduates Program (PI, Program Director - $140,000) 2000.2002 UTEP – Model Institutions for Excellence Initiative Grant (PI - $10,000) DOCTORATE/POST-DOCTORATE FUNDING 1999 - 2000 NSF-NATO Postdoctoral Fellowship ($35,000) 1999 Medical Research Council of Canada Postdoctoral Fellowship ($25,000) 1998 Amgen/Ontario Cancer Institute Fellowship ($22,000) 1995 - 1997 NIGMS Minority Access to Research Careers Predoctoral Fellowship ($30,000) 1991 - 1994 National Science Foundation Minority Predoctoral Fellowship ($45,000)

MEMBERSHIPS 1989 – present Society for the Advancement of Chicanos and Native Americans in Science 2000 – present American Association of Immunologists 2004 – present American Society for Cell Biologists

HONORS AND AWARDS 2009 Distinguished Achieve Award for Service to the College of Science 2008-2009 National Academies Education Mentor in the Life Sciences 2008 Jack Bristol Distinguished Achievement Award in Teaching 2008-2010 UTEP’s Center for Hispanic Entrepreneurship Fellow (CfHE Fellow) 2007-2008 National Academies Education Fellow in the Life Sciences 2007 National Academies Summer Institute on Undergraduate Education in Biology 2006 FASEB-AAI Minority Scientist Travel Award 2005 Selected to serve as a Fellow for the Center for Effective Teaching and Learning (CETaL) 2005 Appointed to the Minority Affairs Committee for the American Association of Immunology 2004 Nominated for the Jack R. Bristol for Teaching Excellence Award 2004 ASCB Minority Scientist Travel Award 2004 Fellow of the IMPACT and Leadership Summer Institute 2004 FASEB/MARC Mentor/Minority Trainee Travel Award 2003-2004 Sigma Xi – UTEP Chapter President 2002 AAI Minority Scientist Travel Award 2001 SACNAS Junior Faculty Travel Award 2001 Inducted into the UTEP Chapter of Sigma Xi, the Scientific Research Society 1997 Michael J. Peach Outstanding Graduate Student Award 1991 Graduated Summa Cumme Laude 1989 National Science Foundation Recognition Award 1989-1991 Minority Access to Research Careers Fellow 1988-1991 National Chicano Council for Higher Education Fellow

PUBLICATIONS since 2000 (*undergraduate and **graduate student authors): 1. **Ramirez, O., *L.B. Motta-Mena, *B. Barrow, *S. Garcia, T.P. Primm, L.E. Martinez, and K.M. Garza (2009). Napthoquinone compounds induce apoptosis of murine fibroblasts using multiple mechanisms. Bioorg. Med. Chem. Submitted.

2. **Ramirez, O., *C. Perez, and K.M. Garza (2009). Leptin-deficiency in vivo enhances ability of splenic dendritic cells to activate T cells. Cellular Immunology. Submitted.

3. Murr, L.E. and K.M. Garza (2009). Natural and anthropogenic environmental nanoparticlates: Their microstructual characterization and respiratory health implications. Atmospheric Env. 43:2683-2692. 4. *Ramos, E., L. Krauth-Siege, K.M. Garza, J. Bader, L. Martinez, and R.A. Maldonado (2008). 2,3- diphenyl-1,4-napthoquinone: A potential chemotherapeutic agent against trypanosoma cruzi. Antimicrobial Agents & Chemotherapy. (MS#TMP00412-08).

5. Garza, K.M., **K.F. Soto, and L.E. Murr (2008). Cytotoxicity and reactive oxygen specifis generation for aggregate carbon and carbonaceous particulate materials. Int. J. Nanomedicine. 3(1):1-12.

6. Calzascia, T., M. Pellegrini, A. Lin, K.M. Garza, A.R. Elford, A. Shahinian, P.S. Ohashi, and T.W. Mak (2008). CD4 T cells,lymphopenia, and IL-7 in multistep pathway to autoimmunity. PNAS, 105:2999- 3005.

7. Garza, K.M., **K.F. Soto, and L.E. Murr (2008). Direct contact cytotoxicity assays for filter-collected, carbonaceous (soot) nanoparticulate material and observations of lung cell response. Atmospheric Environ. 42:1970-1982.

8. **Soto, K.F., K.M. Garza, and L.E. Murr (2008). Cytotoxic and potential respiratory health effecs of carbon and carbonaceous nonpartulates in the El Paso del Norte airshed environment. Int. j. Env. Res. Pub. Health.

9. **Soto, K.F., Murr, L.E., and K.M. Garza (2007) Cytotoxic response for carbon nanotubes and aggregates: the role of in vitro biological assays in nanomaterial evaluations. Acta Biomaterialia. 3:351- 358.

10. Murr, L.E., **K.F. Soto, K.M. Garza, P.A. Guerrero, F. Martinez, D.A. Ramirez, Y.Shi, J.J. Bang, and J. Venzor, III (2006) Combustion-generated nanoparticulates in the El Paso, TX USA / Juarez, Mexico metroplex: Their comparatiave characterization and potential for adverse health effects. Int. J. Env. Res. Publ. Health. 3:48-66.

11. Murr, L.E., K.M. Garza, *A. Carrasco, **K.F. Soto, P.A. Guerrero, D.A. Lopez, D.A. Ramirez, and J. Venzor, III (2005) Cytotoxicity assessment of carbon nanotubes and related carbon nanoparticle aggregates and the implications for anthropogenic carbon nanotube aggregates in the environment. Int. J. Env. Res. Publ. Health. 2:31-42.

12. **Soto, K.F., *A. Carrasco, T.G. Powell, K.M. Garza, and L.E. Murr (2005) Comparative in vitro cytotoxicity assessment of manufactured nanoparticulate materials characterized by transmission electron microscopy. J. Nanopart. Res. 2:145-169.

13. *Montoya, J., A. Varela-Ramirez, *A. Estrada, L.E. Martinez, K.M. Garza, and R.J. Aguilera (2004) Flourescence-based rapid screening assay for cytotoxic compounds. Biochem. Biophy. Res. Comm. 325:1517-1523.

14. Millar, D.G., K.M. Garza, B. Odermatt, A. R. Elford, O. Nobuyuki, Z. Li, P.S. Ohashi; (2003) Hsp 70 promotes antigen presenting function and converts T cell tolerance to autoimmunity in vivo. Nat. Med. 9:1469-1476.

15. **Villa, R., C.E. Ortiz, *S. Tapia, G. Gonzalez, E. Trillo, K.M. Garza, S. W. Stafford, and L.E. Murr (2002) In vitro biocompatibility studies of fibroblast cells on Ti-Ta alloys. Mat. Trans. 43:1-4.

16. Garza, K.M., K. McKall-Fainza, and P.S. Ohashi. (2002) Enhanced T cell responses contribute to the genetic predisposition of CD8-mediated spontaneous autoimmunity. Eur. J. Immunol. 32:885-894. 17. Nguyen LT, Elford AR, Murakami K, Garza KM, Schoenberger SP, Odermatt B, Speiser DE, Ohashi PS. (2002) Tumor Growth Enhances Cross-Presentation Leading to Limited T Cell Activation without Tolerance. J Exp Med. 195:423-435.

18. Tung, K.S.K., P. Alard, K.M. Garza, S.S. Agersborg, and Y.-H. Lou. (2001) The impact of regulatory T cell, endogenous antigen, and neonatal environment in the prevention and induction of autoimmune disease. Immunol. Rev. 182: 135-148.

19. Okkenhaug, K., L. Wu, K. M. Garza, J. La Rose, W. Khoo, B. Odermatt, T. W. Mak, P. S. Ohashi & R. Rottapel (2001); A point mutation in CD28 distinguishes proliferative signals from survival signals. Nature Immunology 2:325 – 332.

20. Garza, K.M., L.T. Nguyen, R.G. Jones, and P.S. Ohashi. (2001) Factors contributing to autoimmune disease. Adv. Exp. Med. Biol. 490:7-19.

21. Agersborg, S.S., K.M. Garza, and K.S.K. Tung. (2001) Intestinal parasitism terminate self tolerance and enhances neonatal induction of autoimmune disease and memory. Eur. J. Immunol. 31:851-859.

22. Garza, K.M., V.S.F. Chan, and P.S. Ohashi. (2000) T cell tolerance and autoimmunity. Rev. Immunogen. 2:2-17.

23. Garza, K.M., *S. Chang, R. Suri, B. Odermatt, S. Schoenberger, and P.S. Ohashi. (2000) Role of antigen presenting cell in mediating tolerance and autoimmunity. J. Exp. Med. 191:2021-2027.

24. Garza, K.M., S.S. Agersborg, E. Baker, and K.S.K. Tung. (2000). Persistence of physiological self antigen is required for the regulation of self tolerance. J. Immunol. 164:3982-3989.

25. Tung, K.S.K, S.S. Agersborg, H. Bagavant, K.M. Garza, and K. Wei. (1999). Autoimmune ovarian disease induced by immunization with zona pellucida (ZP3) peptide). In: Current Protocols in Immunology (Unit 15.17). John Wiley & Sons, Inc.

26. Garza, K.M., Y.-H. Lou, and K.S.K. Tung. (1998). Mechanism of ovarian autoimmunity: induction of T cell and antibody responses by T cell epitope mimicry and epitope spreading. J. Reprod. Immunol. 37:87-101.

27. Tung, K.S.K., K.M. Garza, and Y.-H. Lou. (1998). Induction of pathogenic autoimmune T cell and autoantibody responses through T cell epitope spreading. In: Pathogenic autoimmune reactions. Ed. Sudhir Paul, Humana Press, Totowa NT.

28. Garza, K.M., N.D. Griggs, and K.S.K. Tung. (1997). Neonatal injection of an ovarian peptide induces autoimmune ovarian disease in female mice: Requirement of endogenous neonatal ovaries. Immunity 6:89-96.

29. Tung, K.S.K., Y.-H. Lou, K.M. Garza, C. Tuescher. (1997). Autoimmune ovarian disease: Mechanism of prevention and induction. Curr. Opin. Immunol. 9:839-845.

30. Lou, Y.H., F.M. McElveen, K.M. Garza, and K.S.K. Tung. (1995). Rapid induction of auto-antibodies by native endogenous antigens and antigen primed T cells: Implications in autoimmune pathogenesis and B cell tolerance. J. Immunol. 156:3535-3540. 31. Garza, K.M., and K.S.K. Tung. (1995). Frequency of molecular mimicry among T cell peptides as the basis for autoimmune disease and autoantibody induction. J. Immunol. 155:5444-5448.

32. Luo, A.M., K.M. Garza, D. Hunt, and K.S.K. Tung. (1993). Antigen mimicry in autoimmune disease: Sharing of amino acid residues critical for pathogenic T cell activation. J. Clin. Invest. 92:2117-2123.

RECENT INVITED SEMINARS:  Guest seminar speaker, California State University at San Marcos, “Leptin and optimal dendritic cell function.” Feb. 26, 2009.  Keynote Speaker, Purdue University, SACNAS Midwest Regional Meeting, “The making of a Chicana Immunologist”. Feb. 21, 2009.  Guest seminar speaker, University of Virginia, 2009 Summer Research Internship Program. “Navigating graduate school as a person of color” June 16, 2009.  Keynote Speaker, Univ. of Colorado at Denver (Aurora Campus), The Rocky Mountain Regional SACNAS Meeting, “The making of a Chicana Immunologist”. Aug. 28-29, 2009.

RECENT SERVICE ACTIVITIES  Chair , search committee for an Animal Facilities Manager  Member of the Biological Safety Level 3 (BSL3) Advisory Board for UTEP  Member of the Advisory Board for the Medical Profession Institute at UTEP  Serve as a mentor to two 2nd-year female faculty (one in physics and another in chemistry) as part of the UTEP Faculty Mentoring Program for Women  Advisory Board Member for the UTEP Minority Access to Research Careers (MARC) Program  Site visitor and review panelist for the NIGMS Minority Program Research Committee, Panel A  Program Committee member for the Society for the Advancement of Chicanos and Native Americans in Science (SACNAS)  Chair of the Student Presentations Committee and the Student Programs Committee for SACNAS

RECENT LEADERSHIP ACTIVITIES  Member of the Biology Research Experience for Undergraduates Leadership Council Steering Committee (Bio REU LC) (the committee was established by the Biology Directorate of NSF in 2007)  Director of the UTEP Summer Research Experience for Undergraduates Program in Molecular and Cellular Biology: 2002–2012  Chair, Dept. of Biological Sciences Advisory Board  Chair, Research Committee (subcommittee of the Faculty Senate): 2007 - present  Chair, Institutional Animal Care and Use Committee: 2008 - present  Faculty advisor for the UTEP Student Chapter of SACNAS “El Paso del Norte SACNAS Chapter”: 2005 – present  Member of the Board of Directors for the Society for the Advancement of Chicanos and Native Americans in Science (SACNAS)  Member of the Executive Committee for SACNAS (serve as secretary)

TEACHING/EDUCATIONAL ACTIVITIES . Teaching Responsibilities: Molecular Cell Biology (BIOL 3414) (undergraduate course – responsible for lecture section as well as all teaching laboratory sections) and Current Concepts in Cell Biology (BIOL 5326) (graduate course – responsible for teaching the entire course) . Co-PI of “Development of Curricular and Team Research in Biomedicine” (HHMI) and Director of the HHMI Undergraduate Research Teaching Laboratory (responsible for operations of the facility and for designing and directing all the undergraduate research teaching programs that utilize this facility) . Attended The National Academies Summer Institutes on Undergraduate Education in Biology in Madison, WI – June 23 – 28, 2008 as a team facilitator:  “The Howard Hughes Medical Institute and the National Academies invite research university faculty to build teaching skills and transform the undergraduate biology classroom at a week-long gathering in beautiful Madison, Wisconsin. This unique Summer Institute on Undergraduate Education in Biology is crafted to model the scientific teaching principles on which it is founded and draws on the expertise of both participants and presenters. Current and seminal research, active learning, assessment, and diversity weave through the week, creating a foundation for participants to share ideas and develop innovative instructional materials which they implement when they return to their own campuses.”