Supplemental Table 1. Relative Differential Gene Expressions in Submandibular Glands From

Supplemental Table 1. Relative differential gene expressions in submandibular glands from 12 weeks old C57BL/6.NOD-Aec1Aec2 mice versus 8 weeks old C57BL/6.NOD-Aec1Aec2 mice

Gene/Function Gene Old symbol New symbol Gene Description

Signal transduction

Ltbp1 Latent transforming growth factor beta binding protein 1

Rgds Ralgds Ral guanine nucleotide dissociation stimulator

Admr Adrenomedullin receptor Fgf17 Fibroblast growth factor 17 Il18R1 Interleukin 18 receptor 1 Regulation of transcription D16Ertd465e Carhsp1 Calcium regulated heat stable protein 1 2610510G03Rik Gtf3c2 General transcription factor IIIC, polypeptide 2, beta Neo1 Neogenin Utf1 Undifferentiated embryonic cell transcription factor 1 Cited1 Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 Zfp28 Zinc finger protein 28 Magoh Mago-nashi homolog, proliferation-associated Dnajb11 DnaJ (Hsp40) homolog, subfamily B, member 11 Ssb Sjögren’s syndrome antigen B Humoral immune response Scya1 Ccl1 Chemokine (C-C motif) ligand 1 Hunk Hormonally upregulated Neu-associated kinase Tyki Thymidylate kinase family LPS-inducible member Igl-5 Igll1 Immunoglobulin lambda-like polypeptide 1 Protein transport/biosynthesis 1200003O06Rik Mfsd1 Major facilitator superfamily domain containing 1 Dbil5 Diazepam binding inhibitor-like 5 Stx18 Syntaxin 18 Abcc5a Abcc5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 Dnaja2 DnaJ (Hsp40) homolog, subfamily A, member 2 Rpl10 Ribosomal protein 10 Uros Uroporphyrinogen III synthase Pin1 Protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 Rps29 Ribosomal protein S29 Ap3b1 Adaptor-related protein complex 3, beta 1 subunit Rab14 RAB14, member RAS oncogene family Central nervous system development Nog Noggin Gfra2 Glial cell line derived neurotrophic factor family receptor alpha 2 Cstb Cystatin B Pcdh13 Pcdhga12 Protocadherin gamma subfamily A, 12 Mpz Myelin protein zero Mesdc1 Mesoderm development candidate 1 Top2b Topoisomerase (DNA) II beta Structural development 4921513D09Rik Ccdc81 Coiled-coil domain containing 81 Vcam1 Vascular cell adhesion molecule 1 Gabarapl1 Gamma-aminobutyric acid (GABA(A)) receptor-associated protein-like 1 Mtap4 Microtubule-associated protein 4 Col13a1 Procollagen, type XIII, alpha 1 Col17a1 Procollagen, type XVII, alpha 1 Prkcz Protein kinase C, zeta Anxa2 Annexin A2 C81457 4833439L19Rik RIKEN cDNA 4833439L19 gene Metabolism 9130017L10Rik Gdpd2 Glycerophosphodiester phosphodiesterase domain containing 2 Allc Allantoicase 1810029C22Rik Cd209f CD209f antigen Apoc4 Apolipoprotein C-IV Insrr Insulin receptor-related receptor Lipc Lipase, hepatic Hnrpdl Heterogeneous nuclear ribonucleoprotein D-like Chst3 Carbohydrate (chondroitin 6/keratan) sulfotransferase 3 Tbxas1 Thromboxane A synthase 1, platelet 4921521K07Rik RIKEN cDNA 4921521K07 gene Cell cycle/DNA replication Ddx19 Ddx19a DEAD (Asp-Glu-Ala-Asp) box polypeptide 19a Cdk12 Crkrs Cdc2-related kinase, arginine/serine-rich Npm1 Nucleophosmin 1 Ion transport 2410003H12Rik Zswim1 Zinc finger, SWIM domain containing 1 Cacng4 Calcium channel, voltage-dependent, gamma subunit 4 Gsr Glutathione reductase 1 Slc23a2 Solute carrier family 23 (nucleobase transporters), member 2 Ubiquitin pathway Rnf11 Ring finger protein 11 Ube2n Ubiquitin-conjugating enzyme E2N Unknown biological function 1200008N06Rik Synapse defective 1, Rho GTPase N4wbp4 Tmepai Transmembrane, prostate androgen induced RNA 2900074C18Rik Ttc9b Tetratricopeptide repeat domain 9B CTXL Vsig2 V-set and immunoglobulin domain containing 2 Cegf1 Scube2 Signal peptide, CUB domain, EGF-like 2 2810432L12Rik RIKEN cDNA 0610010F05 gene 3100002J23Rik RIKEN cDNA 3100002J23 gene 1700001C19Rik RIKEN cDNA 1700001C19 gene 3322402L07Rik RIKEN cDNA 3322402L07 gene 2600001A11Rik RIKEN cDNA 2600001A11 gene 5430420K21Rik RIKEN cDNA 2310047D13 gene 4930417G10Rik RIKEN cDNA 4930417G10 gene 5730528L13Rik RIKEN cDNA 5730528L13 gene 1700006A11Rik RIKEN cDNA 1700006A11 gene 1700011I03Rik N/A LOC 208943 N/A Cacnα4 N/A 1700029K01Rik Ccdc46 N/A