PHS 398 (Rev. 9/04), Biographical Sketch Format Page s9

Principal Investigator/Program Director (Last, First, Middle): Yeates, Todd O.

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Todd O. Yeates Professor eRA COMMONS USER NAME

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) University of California, Los Angeles, CA B. S. 1983 Biochemistry University of California, Los Angeles, CA Ph.D. 1988 Biochemistry

A. Positions and Honors Professional Positions 1988-1990 Postdoctoral, Research Institute of Scripps Clinic 1996-present Adjunct Assistant to Adjunct Associate Professor, The Scripps Research Institute 1990-present Assistant Professor, then Professor in Biochemistry, Univ. of California, Los Angeles Awards and Honors 1984-1987 NIH/USPHS – National Research Service Award 1991-1996 NSF Presidential Young Investigator Award 1993 Sidhu Award – Pittsburgh Diffraction Society 2002 Fellow, American Association for the Advancement of Science 2004 Hanson-Dow Award for Excellence in Teaching – UCLA 2006 Plenary Lecture – German Crystallographic Society 2006 Jacob Marschak Lecture – UCLA Panels and Service (since 2003) Cal State LA Bioinformatics Institute – SAB and Mentor (2003-2005); DOE Genomes to Life Program, Protein Structure Prediction - panel member (2003); NIH, Physical Biochemistry study section – ad hoc (2003); NSF, Biological Databases and Informatics – program reviewer (2003); DOE-GTL Cellular Interactions - panel chair (2004); Joint Center for Structural Genomics - Scientific Advisory Board (2004- 2006); NIH Computational Biophysics Special Emphasis Panel (2004, 2005); Protein Science – Editorial Advisory Board (2006-); NIH MSFC study section (ad hoc) (2006); NIH Computational Biophysics Special Emphasis Panel, BCMB-Q (2006); Co-Editor, Acta Crystallographica, sect. D (2006-); NIH MSFB study section (ad hoc) (2006); Editorial Board, Protein Engineering Design and Selection; NIH MSFD study section (ad hoc) (6/2007, 10/2007)

B. Selected Research Publications (out of approximately 100) King, N.P., Yeates, E.O., Yeates, T.O. (2007). Identification of Rare Slipknots in Proteins and Their Implications for Stability and Folding. J. Mol. Biol. 373, 153-66. Tsai, Y., Sawaya, M.R., Cannon, G.C., Cai, F., Williams, E.B., Heinhorst, S., Kerfeld, C.A., and Yeates, T.O. (2007). Structural analysis of CsoS1A and the protein shell of the Halothiobacillus neapolitanus carboxysome. PLoS Biol. 5, e144. Yeates, T.O., Tsai, Y., Tanaka, S., Sawaya, M.R., Kerfeld, C.A. (2007). Self-assembly in the carboxysome: a viral capsid-like protein shell in bacterial cells. Biochem. Soc. Trans. 35, 508-11. Yeates, T.O. and Beeby, M. (2007). Biochemistry. Proteins in a small world. Science 314, 1882-3. Boutz, D.R., Cascio, D., Whitelegge, J., Perry, L.J., and Yeates, T.O. (2007). Discovery of a thermophilic protein complex stabilized by topologically interlinked chains. J. Mol. Biol. 368, 1332-44.

PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page 6 Biographical Sketch Format Page Principal Investigator/Program Director (Last, First, Middle): Yeates, Todd O. Banatao D.R., Cascio D., Crowley C.S., Fleissner M.R., Tienson H.L., and Yeates, T.O. (2006). An approach to crystallizing proteins by synthetic symmetrization. Proc. Natl.Acad. Sci. USA, 103, 16230-5. Norcross, T.S. and Yeates, T.O. 2006. A framework for describing topological frustration in models of protein folding. J. Mol. Biol. 362, 605-21. Kerfeld, C.A., Sawaya, M.R., Tanaka, S., Nguyen, C.V., Phillips, M., Beeby, M., Yeates, T.O. 2005. Protein structures forming the shell of primitive bacterial organelles. Science 309, 936-8. Beeby, M., O'connor, B.D., Ryttersgaard, C., Boutz, D.R., Perry, L.J., Yeates, T.O. 2005. The Genomics of Disulfide Bonding and Protein Stabilization in Thermophiles. PLoS Biol. 3, PLoS Biol. 3, 1549-58. Kudryashov, D.S., Sawaya, M.R., Adisetiyo, H., Norcross, T., Hegyi, G., Reisler, E., Yeates, T.O. 2005. The Crystal Structure of a Cross-linked Actin Dimer Suggests a Detailed Molecular Interface in F-Actin. Proc Natl Acad Sci USA 102, 13105-14110. Chaudhuri, B.N. and Yeates, T.O. 2005. A computational method to predict genetically encoded rare amino acids in proteins. Genome Biol. 6, R79. Bowers, P.M., Cokus, S.J., Eisenberg, D., and Yeates, T.O. 2004. Use of logic relationships to decipher protein network organization. Science. 306, 2246-9. Padilla, J.E., and Yeates, T.O. 2003. A statistic for local intensity differences: robustness to anisotropy and pseudo-centering and utility for detecting twinning. Acta Cryst. D 59, 1124-30. Chaudhuri, B.N., Sawaya, M.R., Kim, C.Y., Waldo, G.S., Park, M.S., Terwilliger, T.C., and Yeates, T.O. 2003. The crystal structure of the first enzyme in the pantothenate biosynthetic pathway, ketopantoate hydroxymethyltransferase, from M. tuberculosis. Structure 11, 753-64. Kerfeld C.A., Sawaya, M.R., Brahmandam, V., Cascio, D., Ho, K.K., Trevithick-Sutton, C.C., Krogmann, D.W., and Yeates, T.O. 2003. The Crystal Structure of a Cyanobacterial Water-Soluble Carotenoid Binding Protein. Structure 11, 55-65. Yeates, T.O. and Padilla, J.P. 2002. Designing Supramolecular Protein Assemblies. 2002. Curr. Op. Struct. Biol. 12, 464-470. Mallick, P., Boutz, D.R., Eisenberg, D., and Yeates, T.O. 2002. Genomic Evidence that the Intracellular Proteins of Archaeal Microbes Contain Disulfide Bonds. Proc. Natl. Acad. Sci. USA 99, 9679-9684. Serag, A.A., Altenbach, C., Gingery, M., Hubbell, W.L., and Yeates, T.O. 2002. Arrangement of Subunits and Ordering of -Strands in an Amyloid Sheet. Nature Struct. Biol. 9, 734-739. Griffith, S.C., Sawaya, M.R., Boutz, D.R., Thapar, N., Katz, J.E., Clarke, S., and Yeates, T.O. 2002. Crystal Structure of a Protein Repair Methyltransferase from Pyrococcus furiosus with its L-Isoaspartyle Peptide Substrate. J.Mol.Biol., 313, 1103-1116. Padilla, J.E., Colovos, C., and Yeates, T.O. Nanohedra: 2001. Using Symmetry to Design Self-Assembling Protein Cages, Layers, Crystals and Filaments, Proc Natl Acad Sci USA, 98, 2217-2221. Serag, A.A., Altenbach, C., Gingery, M., Hubbell, W.L., and Yeates, T.O. 2001. Identification of A Subunit Interface In Transthyretin Amyloid Fibrils: Evidence for Assembly From Oligomeric Building Blocks. Biochem. 40, 9089-96. Toth, E.A. and Yeates, T.O. 2000. The Structure of Adenylosuccinate Lyase, an Enzyme with Dual Activity in the de novo Purine Biosynthetic Pathway. Structure, 8, 163-174. Eisenberg, D., Marcotte, E.M., Xenarios, I., and Yeates, T. 2000. Protein Function in the Post-Genomic Era. Nature, 405, 823-826. Toth, E.A., Worby, C., Dixon, J.E., Goedken, E.R., Marqusee, S., and Yeates, T.O. 2000. The Crystal Structure of Adenylosuccinate Lyase from Pyrobaculum aerophilum Reveals an Intracellular Protein with Three Disulfide Bonds. J. Mol. Biol., 301, 433-450. Pellegrini, M., Marcotte, E.M., Thompson, M.J., Eisenberg, D., and Yeates, T.O. 1999. Assigning Protein Functions by Comparative Genome Analysis: Protein Phylogenetic Profiles. PNAS, 96, 4285-4288. Yeates, T.O. 1997. Detecting and Overcoming Crystal Twinning. Meth. Enzymol. 276, 344-358. Wukovitz, S. W. and Yeates, T. O. 1995. Why Protein Crystals Favour Some Space Groups Over Others. Nature Structural Biology 2, 1062-1067.

PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page 7 Biographical Sketch Format Page