Table 1: Clinical Characteristics of 11 Patients with Bloodstream and Endovascular Infections

Table 1: Clinical characteristics of 11 patients with bloodstream and endovascular infections due to Abiotrophia defectiva and Granulicatella spp.

Case Sex/Age Clinical 16 SrRNA Genbank Mono-/ Underlying Predisposing Antibimicrobial therapy Outcome no. diagnosis identification accession polymicrobial conditions factors number bacteraemia 1 F/58 Mitral A. defectiva AY879306 Monomicrobial Rheumatic fever None Amoxicillin/clavulanate and Cured endocarditis and in childhood amikacin for 1w, then ceftriaxone sacroileitis for 3w 2 M/55 Aortic A. defectiva AY879307 Monomicrobial None None Ceftriaxone for 6w and amikacin for Cured endocarditis 4w 3 M/67 Aortic graft A. defectiva AY879308 Polymicrobial Aorto-femoral Aortoenteric fistula Amoxicillin/clavulanate for 2w, then No long term follow-up infection (+ Escherichia coli) vascular graft ciprofloxacin for > 24w (vascular graft not removed) 4 F/58 Primary G. adiacens AY879300 Monomicrobial Chronic Neutropenia Cefepime for 2d, then Death bacteraemia lymphocytic piperacillin/tazobactam for 3d , then (gastrointestinal bleeding/ leukaemia ceftriaxone and gentamicin for 10d refractory thrombopenia) 5 F/56 Primary G. adiacens AY879302 Polymicrobial Acute Neutropenia Cefepime and vancomycin for 2d, Cured bacteraemia (+ Staphylococcus lymphoblastic Oral mucositis then imipenem for 2w epidermidis) leukaemia 6 M/62 Primary G. adiacens AY879299 Polymicrobial Small cell lung Neutropenia Cefepime for 4d, then amoxicillin Cured bacteraemia (+ Clostridium cancer Autologous BMT for 10d sordellii) Oral and intestinal mucositis 7 M/1 Primary “G. para- AY879301 Monomicrobial Acute myeloid Neutropenia Ceftriaxone and amikacin for 5d, Cured bacteraemia adiacens” leukaemia Oral mucositis then vancomycin for 10d 8 F/56 Primary G. adiacens AY879303 Monomicrobial Multiple Neutropenia Cefepime and vancomycin for 5d, Cured bacteraemia myeloma Autologous BMT then amoxicillin for 10d Oral mucositis 9 M/62 Primary G. adiacens AY879304 Polymicrobial Metastatic Ulcerous Amoxicilline/clavulanate for 8d, Death bacteraemia (+ Lactobacillus oesophageal oesophageal lesions then imipenem for 2d (advanced metastatic cancer) rhamnosus) cancer 10 F/35 Primary “G. para- AY879298 Monomicrobial Hypertrophic Cardiac allograft Amoxicilline/clavulanate for 4d, Cured bacteraemia adiacens” cardiomyopathy then cefepime for 2d, then ceftriaxone for 2w 11 F/39 Primary G. adiacens AY879305 Monomicrobial Lymphoma Neutropenia Cefepime and vancomycin for 1w, Cured bacteraemia Autologous BMT gentamicin for 4d, then imipenem for 1w

M, male; F, female; BMT, Bone Marrow Transplant; d, day; w, week; m, month