The Final Risk Score MERIS

The final risk score MERIS

Risk factor: Intervals Points Max. no of drugs that counts

Reduced renal function: eGFR > 60 ml/min 0 60 > eGFR >30 ml/min 5 eGFR<30 ml/min 10.6

No. of drugs: 0-5 0 6-11 5 > 12 10.6

No of drugs with: Low risk of harm 0.25 3 Medium risk of harm 0,5 8 High risk of harm 1 7 Low + medium risk of interaction 0.25 12 High risk of interaction 0.5 2

Drugs with a low, medium and high risk of causing harm or interactions.

Drugs with a low risk, medium risk and high risk of Drugs with a low risk, medium risk and high risk of causing harm causing interactions Low risk Low risk Metoclopramide Other antidepressants Metoclopramide Azathioprin Ondansetron Disulfiram Insulin NSAID Calciumantagonists exc. Nitrofurantoin COX-2 inhibitors Verapamil Statins High risk Paracetamol Allopurinol Fibrates Insulin Ondansetron Antipsychotics exc. lithium Vitamin K antagonists Benzodiazepines Medium risk Other oral anticoagulants Medium risk SSRI, exc. fluvoxamine and fluoxetine Oral antidiabetics Digoxin Oral antidiabetics Fluvoxamine Xanthines Amiodarone Potassium Fluoxetine Potassium Propafenone Other oral anticoagulants Other antidepressants Low molecular heparines Flecainide Low molecular heparins Disulfiram Antithrombotics Glucocorticoids Antitrombotics Xanthines Alphablockers Cyclophosphamide Digoxin Opioids Thiazides Methotrexate Propafenone Loop diuretics Calcineurin inhibitors Flecainide High risk Potassium sparing diuretics Azathioprine Alphablockers Vitamin K antagonists Betablockers NSAID Thiazides Amiodarone Verapamil COX-inhibitors Loop diuretics Erythromycin Renin-angiotensin system Opioids Potassium sparing diuretics Calcineurin inhibitors inhibitors Viagra Antipsychotics Betablockers Antiepileptics Erythromycin Lithium Calcium antagonists exc. TCA verapamil Ciprofloxacin Benzodiazepines Verapamil MAO-inhibitors Nitrofurantoin TCA Renin-angiotensin system Rifamycin inhibitors Antimycotics Statins Lithium Rifamycins Fibrates Isoniazide Viagra Protease inhibitors Glucocorticoids Allopurinol Macrolides exc. erythromycin Paracetamol Ciprofloxacin Antiepileptics Antimycotics SSRI, exc. fluvoxamine, Isoniazide fluoxetine Fluvoxamine Protease inhibitors Fluoxetine Cyclophosphamide MAO-inhibitors Methotrexate