regenerativemedicine.osu.edu

Center for Regenerative Medicine and Cell Based Therapies (CRMCBT) 2st Annual Retreat Friday and Saturday, July 26 to 27th, 2013 Mohican State Park Lodge Friday, 7/26/12

8:30 AM – 9:00AM Welcome and Opening Remarks

Chandan Sen, Ph.D. Director, Center for Regenerative Medicine and Cell Based Therapies Associate Dean, Translational & Applied Research Professor and Vice-Chairman, Surgery Director, OSU Comprehensive Wound Center Deputy Director, Davis Heart and Lung Research Institute CRMCBT The Ohio State University

David B Williams, Ph.D. Dean, College of Engineering CRMCBT The Ohio State University

Robert Higgins, M.D., MSHA Professor and Chairman, Department of Surgery, John H. and Mildred C. Lumley Medical Research Chair Surgeon-in-Chief, Wexner Medical Center, Executive Director, Comprehensive Transplant Center Wexner Medical Center The Ohio State University Mariesa Malinoski Executive Director, National Center for Regenerative Medicine (NCRM) Case Western Reserve University

9:00AM to 12:00PM First Session

9:00AM to 10:00AM 9:00-9:07 Christopher Breuer, M.D., Deputy Vice Chair, Research, Director, Tissue Engineering Program CRMCBT The Ohio State University Co-Director, Tissue Engineering Program Nationwide Children’s Hospital Cardiovascular Tissue Engineering Page 1 of 10 regenerativemedicine.osu.edu

9:08-9:15 Toshiharu Shinoka, M.D. Professor, Department of Surgery CRMCBT The Ohio State University Director, Cardiovascular Tissue Engineering Program, Department of Cardiothoracic Surgery, The Heart Center, Nationwide Children's Hospital Vessel Bioengineering: The Development and Translation of Tissue Engineered Vascular Grafts

9:16-9:23 Gail E. Besner, M.D. Chief, Department of Pediatric Surgery Principal Investigator, Center for Perinatal Research Director, Pediatric Surgery Training Program Associate Burn Director College of Medicine CRMCBT The Ohio State University Nationwide Children's Hospital Production of Tissue Engineered Intestine

9:24-9:31 Jed Johnson, Ph.D. Chief Technology Officer Nanofiber Solutions Clinical Translation of Synthetic Tissue Engineering

9:32-9:39 David Dean, Ph.D. Associate Professor Director, Imaging Laboratory Dept. Neurological Surgery, HH5, MS 5042 Case Western Reserve University Tissue Engineered Bone Grafts

9:40AM to 10:00AM Panel Discussion

10:00AM to 11:00PM 10:00-10:07 Matthew L. Becker, Ph.D. Associate Professor Department of Polymer Science Co-Director, Akron Functional Materials Center Lead, Center for Biomaterials in Medicine of the Austen Bioinnovation Institute in Akron University of Akron Highly tailorable polymers for regenerative medicine.

10:08-10:15 Page 2 of 10 regenerativemedicine.osu.edu Jianjun Guan, Ph.D. Assistant Professor Department of Materials Science and Engineering College of Engineering CRMCBT The Ohio State University Novel biomaterials for cell transplantation and tissue regeneration

10:16-10:23 Ali Dhinojwala, Ph.D. Department Chair H. A. Morton Professor of Polymer Science Akron University "Probing surfaces of biomaterials using nonlinear optical spectroscopy"

10:24-10:31 Derek Hansford, Ph.D. Associate Professor, Biomedical Engineering, Associate Professor, Materials Science CRMCB The Ohio State University Micro- and Nanofabricated Polymer Structures for Tissue Engineering and Cell Biology

10:32-10:39 Rebecca Kuntz Willits, Ph.D. Margaret F. Donovan Endowed Chair for Women in Engineering Associate Department Chair for Graduate Studies, BME Associate Professor of Biomedical Engineering The University of Akron Off the shelf materials for personalized medicine

10:40-10:47 Kristy Ainslie’s Lab: Hassan Borteh Post Doc Researcher Division of Pharmaceutics College of Pharmacy CRMCBT The Ohio State University Electrospun Acetalated Dextran Scaffolds for Temporal Release of Therapeutic s

10:48AM to 11:00AM Panel Discussion 11:00AM to 12:00PM 11:00-11:07 Panagiotis A. Tsonis, Ph.D. Professor, Department of Biology and Joint Appointment in Bioengineering Program Director, Center for Tissue Regeneration and Engineering at Dayton (TREND) University of Dayton “What netws can teach us about regenerative biology and medicine” 11:08-11:15 Nic D. Leipzig, Ph.D. Page 3 of 10 regenerativemedicine.osu.edu Iredell Chair Assistant Professor Chemical and Biomolecular Engineering College of Engineering University of Akron Guided regeneration via oxygenated biomaterial-growth factor platforms

11:16-11:23 Richard T. Hart, Ph.D. Edgar C. Hendrickson Designated Professor Chair, Department of Biomedical Engineering College of Engineering CRMCBT The Ohio State University Biomedical Engineering: Focus on Modeling and Imaging as Collaborative Tools

11:24-11:31 Michael Miller, M.D. Professor of Plastic Surgery Chair, Department of Plastic Surgery College of Medicine CRMCBT The Ohio State University Collaborative Research in the Department of Plastic Surgery

11:32-11:39 Binnaz Leblebicioglu, DDS, MS, Ph.D. Diplomate, American Board of Periodontology Associate Professor Division of Periodontology College of Dentistry The Ohio State University Regenerative Medicine in Dentistry

11:40-11:47 Katia Del Rio-Tsonis, Ph.D. Professor of Zoology Miami University, Oxford, OH Retina Regeneration: Trans differentiation and stem cell activation

11:48AM to 12:00PM Panel Discussion

12:00PM to 1:00PM Lunch

1:00PM to 3:15PM Second Session

1:00PM to 2:00PM 1:00-1:07 Alicia L. Bertone, DVM, Ph.D., Diplomate ACVS Equine Orthopedic Surgeon and Trueman Family Endowed Chair and Professor, Veterinary Clinical Sciences CRMCBT The Ohio State University Synovial MSCs for cartilage restoration Page 4 of 10 regenerativemedicine.osu.edu

1:08-1:15 Brian Kaspar, Ph.D. Associate Professor Department of Pediatrics and Children's Research Institute CRMCBT The Ohio State University Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS

1:16-1:23 J. Gary Meszaros, Ph.D. Associate Professor Physiology and Pharmacology Department of Integrative Medical Sciences Northeast Ohio Medical University (formerly NEOUCOM) Paradoxical effects of collagen VI deletion in cardiac remodeling…less is more!

1:24-1:31 Hiranmoy Das, Ph.D. Associate Professor, Cardiovascular and Internal Medicine CRMCBT The Ohio State University Preclinical Evaluation of Hematopoietic Stem Cell in Regenerative Medicine

1:32-1:39 Mahmood Khan, M.Pharm., Ph.D. Assistant Professor of Internal Medicine Division of Cardiology Davis Heart and Lung Research Institute CRMCBT The Ohio State University Human Induced Pluripotent Stem Cells-Derived Cardiomyocytes for Cardiac Repair

1:40PM to 2:00PM Panel Discussion

2:00PM to 3:15PM 2:00-2:07 Michael Knopp, MD, Ph.D. Vice Chair of Research Professor Novartis Chair of Imaging Research Director, Wright Center of Innovation in Biomedical Imaging Division of Imaging Science Current concepts and opportunities of Imaging in Regenerative Medicine

2:08-2:15 Zhenghong Lee, Ph.D. Associate Professor of Radiology Biomedical Engineering Case Center for Imaging Research National Center for Regenerative Medicine Comparing strategies for imaging stem cell differentiation Page 5 of 10 regenerativemedicine.osu.edu

2:16-2:23 Raghu Machiraju, Ph.D. Professor, Computer Science and Engineering College of Engineering Courtesy Appointments: Biomedical Informatics, Program of Solid Tumor Biology, CCC CRMCBT The Ohio State University Informatics Research for Regenerative Medicine and Cell Based Therapies

2:24-2:31 Kun Huang, Ph.D. Associate Professor in Biomedical Informatics Co-Director of OSUCCC Biomedical Informatics Shared Resource CRMCBT The Ohio State University Data Integration for Disease Gene and Biomarker Discovery

2:32-2:39 B. Rita Alevriadou, Ph.D. Associate Professor Department of Biomedical Engineering Department of Internal Medicine (Cardiovascular Medicine) CRMCBT The Ohio State University Mechanical Forces, Oxidative Stress, and the Endothelium

2:40-2:47 Gayle Gordillo, M.D., FACS Associate Professor of Plastic Surgery CRMCBT The Ohio State University Translating Investigator Initiated Research: how to cross the valley of “No”

2:48-2:55 Avner Friedman, Ph.D. Professor, Mathematical Biosciences Institute CRMCBT The Ohio State University Report on the workshop "Stem Cells and Regeneration" held in Paris, June25-28, 2013

2:56PM to 3:15PM Panel Discussion

3:30PM Group Picture (Location will be given at close of last session)

4:00PM to 4:30PM CRMCBT Operations Committee Meeting (Committee Members Only)

4:00PM to 5:00PM Freshen Up, Relax in Lodge or Room Page 6 of 10 regenerativemedicine.osu.edu

6:00PM to 8:00PM Cookout

8:00PM Evening Open Networking and Free Time Outdoor Patio/Lodge/Boxers Lounge Saturday, 7/27/13

7:30AM to 8:00AM Breakfast

8:00AM to 11:00AM Third Session

8:00AM to 9:00 AM 8:00-8:15 Stan Gerson, M.D. Director Case Comprehensive Cancer Center, CWRU Director, Seidman Cancer Center University Hospitals Case Medical Center Director, National Center for Regenerative Medicine, CWRU

8:16-8:23 Jose Otero, M.D., Ph.D. Assistant Professor Department of Pathology Division of Neuropathology College of Medicine CRMCBT The Ohio State University Stem cell biology and engineering: A promising approach to pathobiology research

8:24-8:31 Carmen Cantemir-Stone, Ph.D. Research Scientist The Ohio State University Department of Internal Medicine Division of Pulmonary Medicine The role of mesenchymal tissue in healthy aging and tissue regeneration

8:32-8:39 Juliana Woda, Ph.D. Manager Translational Research Juventas Therapuetics, Inc Exploring Novel Factor Based Therapies for Regenerative Medicine

8:40-8:47 Sudha Agarwal, Ph.D. Professor Division of Oral Biology ,College of Dentistry Department of Orthopedics, College of Medicine Department of Biomedical Engineering, College of Engineering

Page 7 of 10 regenerativemedicine.osu.edu CRMCBT The Ohio State University Biomechanical signals in regenerative medicine

8:48AM to 9:00AM Panel Discussion

9:00AM to 10:00 AM 9:00-9:07 L. James Lee, Ph.D. Professor, Helen C. Kurtz Chair Chemical & Biomolecular Eng College of Engineering CRMCBT The Ohio State University High precision cell transfection and reprogramming by Nanochannel Electroporation (NEP)

9:08-9:15 Srinagesh Kumar Potluri, Ph.D. Chief Scientist Zyyex Technologies Application of Functionalized CNTs

9:16-9:23 Robert J. Lee, Ph.D. Professor of Pharmaceutics College of Pharmacy (NCI) OSU Comprehensive Cancer Center (OSUCCC) (NSF) Nanoscale Science and Engineering Center (NSEC) CRMCBT The Ohio State University Lipid nanoparticles for oligonucleotide delivery

9:24-9:31 Shang-Tian Yang, Ph.D. Professor Chemical & Biomolecular Engineering College of Engineering CRMCBT The Ohio State University Stem cell tissue engineering for regenerative medicine and drugdiscovery

9:32-9:39 Nicanor I. Moldovan, Ph.D. Research Associate Professor, Department of Internal Medicine College of Medicine and Public Health Investigator, Davis Heart and Lung Research Institute Bio-Engineering of an Advanced Coating for Tissue Integration

9:40-9:47 Christopher A. Adin, DVM, DACVS Page 8 of 10 regenerativemedicine.osu.edu Associate Professor College of Veterinary Medicine Dual Encapsulation of Insulin-Producing Cells CRMCBT The Ohio State University Dual Encapsulation of Insulin-Producing Cells

9:48AM to 10:00AM Panel Discussion

10:00AM to 11:00 AM 10:00-10:07 Sashwati Roy, Ph.D. Associate Professor Department of Surgery Director, Laser Capture Molecular Core CRMCBT The Ohio State University miRNA in wound inflammation

10:08-10:15 Daria A. Narmoneva, Ph.D. Associate Professor Biomedical Engineering School of Energy, Environmental, Biological and Medical Engng University of Cincinnati Engineered Microenvironments for Regenerative Wound Healing

10:16-10:23 Sundeep G Keswani, M.D. Pediatric Surgeon, Division of General, Thoracic and Fetal Surgery Fetal Surgeon, Fetal Care Center of Cincinnati Director, Pediatric Advanced Wound Care and Skin Services Assistant Professor, UC Department of Surgery Novel Mechanisms of IL-10 in Regenerative Wound Healing

10:24-1031 Douglas Kniss, Ph.D. Professor, SBS-Biomedical Informatics Professor, Obstetrics & Gynecology Professor, Pediatrics College of Medicine CRMCBT The Ohio State University "TRIMing the FER: A new collaboration to investigate interactions between TRIM and FER proteins in wound healing and cancer biology"

10:32-10:39 Michael Gilkey, MBA, MS Marketing and Operations Manager National Center for Regenerative Medicine Case Western Reserve University OH-Alive

Page 9 of 10 regenerativemedicine.osu.edu 10:40-10:47 Leodis D. Gupton, Ph.D. Technology Licensing Officer CRMCBT The Ohio State University Technology Commercialization and Knowledge Transfer

10:48AM to 11:00AM Panel Discussion

11:00 AM Closing Remarks Chandan Sen, Ph.D.

11:00AM to 12:00PM Lunch and Open Networking Before Leaving

Thank you for attending the 2nd Annual Center for Regenerative Medicine and Cell Based Therapies Retreat at Mohican

Our intent is to foster new team formation and collaborations, please keep Brent Toto ([email protected]) updated on new partnerships to validate success and continue the event. Feedback on how to improve the event is desired.

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