11-cis Retinol Dehydrogenase (RDH5), Homo sapiens, Genbank entry: U43559 Recent update: 20.2.05 Nucleotide numbering is given in Blue Aminoacid numbering is given in green Colour coding of the mutations indicates the following disorders |Fundus albipunctatus; |Fundus albipunctatus + COD; |Fundus albipunctatus + Macular Dystrophy; |Polymorphism Numbers in brackets indicate the references at the end of the document Mutations have been adjusted to the most recent nucleotide and codon numbering. L = Ligand-binding (8) C = Co-factor-binding (8) S = SDR-conserved (8)
-1030 -1020 -1010 -1000 -990 -980 -970 -960 acaga gcagt gcagc tgcca tcctt gacag ctccc tcctc cttgg agacc atgac ataga tggtc aggaa cccag tgtct cgtca cgtcg acggt aggaa ctgtc gaggg aggag gaacc tctgg tactg tatct accag tcctt gggtc
-950 -940 -930 -920 -910 -900 -890 gctga gaaag acagc caagg ggtgg gggga gccta ggcaa atctg gcctc tgcca agtcc tggct tcagc caggc cgact ctttc tgtcg gttcc ccacc cccct cggat ccgtt tagac cggag acggt tcagg accga agtcg gtccg
-870 -860 -850 -840 -830 -820 -810 -800 aagct ccagc ctccc tggct cctcc tcctc ctcag tccta tcccc accct gtcac acata cactt aatac gcctg ttcga ggtcg gaggg accga ggagg aggag gagtc aggat agggg tggga cagtg tgtat gtgaa ttatg cggac
-790 -780 -770 -760 -750 -740 -730 gcatc caagt ccacc cactc cggac tttgg cctta gcagt agtta gtgtg ggagg ctggg aagac tggga gcagt cgtag gttca ggtgg gtgag gcctg aaacc ggaat cgtca tcaat cacac cctcc gaccc ttctg accct cgtca
-720 -710 -700 -690 -680 -670 -660 -650 ctctt aaaca aaagc aaaag aataa gcttc gggcg ctgta gtacc tgcca gcttt cgcca cagga ggtaa gtgga gagaa tttgt tttcg ttttc ttatt cgaag cccgc gacat catgg acggt cgaaa gcggt gtcct ccatt cacct
-640 -630 -620 -610 -600 -590 -580 tctgg gagct ggggg aactg agaag actag ccaga tatta catgt attgc caact caaaa ctttc agctt ttaac agacc ctcga ccccc ttgac tcttc tgatc ggtct ataat gtaca taacg gttga gtttt gaaag tcgaa aattg
-570 -560 -550 -540 -530 -520 -510 -500 atgct tcctc acaca ttatc ccctt tgatc ctcca caact ctgag gtgga cctgg tgggt cttag cccca cttgg tacga aggag tgtgt aatag gggaa actag gaggt gttga gactc cacct ggacc accca gaatc ggggt gaacc
-490 -480 -470 -460 -450 -440 -430 tagat gagaa aatag gttga gagag acagt gagat gctca gtatc acaca gcaaa cctct tggcc ctata catca atcta ctctt ttatc caact ctctc tgtca ctcta cgagt catag tgtgt cgttt ggaga accgg gatat gtagt
-420 -410 -400 -390 -380 -370 -360 -350 ttcca aacac aagac ccagg ttgca tatag aaggt tcagt gtccc tggtt tagaa ggaga ggtgg tgtga ggcaa aaggt ttgtg ttctg ggtcc aacgt atatc ttcca agtca caggg accaa atctt cctct ccacc acact ccgtt
-340 -330 -320 -310 -300 -290 -280 gcaag aagat gcctc tgctg cactc cagcc tgggc gacag agtga gactc catct caaaa aaaaa aaaaa acgat cgttc ttcta cggag acgac gtgag gtcgg acccg ctgtc tcact ctgag gtaga gtttt ttttt ttttt tgcta
-270 -260 -250 -240 -230 -220 -210 -200 gcctc tgctc catac agcag gtctg tacac aggat ctggc tcatg tggtt ttagt taagt tagcc acaaa tacag cggag acgag gtatg tcgtc cagac atgtg tccta gaccg agtac accaa aatca attca atcgg tgttt atgtc
-190 -180 -170 -160 -150 -140 -130 ggtct gccca catct ttgct ttgaa cagat gagcc atggt tggcc aatta tctgc caacc agata atttc tcaat ccaga cgggt gtaga aacga aactt gtcta ctcgg tacca accgg ttaat agacg gttgg tctat taaag agtta
-120 -110 -100 -90 -80 -70 -60 -50 RD2/1f (1) |------> atgct cacac cagat gcttc cagct aggga gggta ttagg ggaaa gggct tgagg gccac agtaa actgg acaag tacga gtgtg gtcta cgaag gtcga tccct cccat aatcc ccttt cccga actcc cggtg tcatt tgacc tgttc
IVS 1
-40 -30 -20 -10 1 15 ttttt ctgcc cagcc taggc tgcca cctgt aggtc acttg ggctc cagct ATG TGG CTG CCT CTT CTG CTG aaaaa gacgg gtcgg atccg acggt ggaca tccag tgaac ccgag gtcga TAC ACC GAC GGA GAA GAC GAC Met Trp Leu Pro Leu Leu Leu M W L P L L L 1 5
30 45 60 75 |------> RD2/2f (1) GGT GCC TTA CTC TGG GCA GTG CTG TGG TTG CTC AGG GAC CGG CAG AGC CTG CCC GCC AGC AAT GCC CCA CGG AAT GAG ACC CGT CAC GAC ACC AAC GAG TCC CTG GCC GTC TCG GAC GGG CGG TCG TTA CGG < Gly Ala Leu Leu Trp Ala Val Leu Trp Leu Leu Arg Asp Arg Gln Ser Leu Pro Ala Ser Asn Ala G A L L W A V L W L L R D R Q S L P A S N A 10 15 20 25
G=Val (1) | A=Ser (2) del (7) 90 | | 120 | 135 150 | | |------> RD2/3f(1) TTT GTC TTC ATC ACC GGC TGT GAC TCA GGC TTT GGG CGC CTT CTG GCA CTG CAG CTG GAC CAG AGA AAA CAG AAG TAG TGG CCG ACA CTG AGT CCG AAA CCC GCG GAA GAC CGT GAC GTC GAC CTG GTC TCT ------| RD2/1r (1) <------Phe Val Phe Ile Thr Gly Cys Asp Ser Gly Phe Gly Arg Leu Leu Ala Leu Gln Leu Asp Gln Arg F V F I T G C D S G F G R L L A L Q L D Q R CCCCCCCCCCCCCCCCCCCCCCCCCCC 30 35 40 45 50
(1,13,15) Phe=T (7) ins GTGG | 165 180 195 210 | | GGC TTC CGA GTC CTG GCC AGC TGC CTG ACC CCC TCC GGG GCC GAG GAC CTG CAG CGG GTG GCC TCC CCG AAG GCT CAG GAC CGG TCG ACG GAC TGG GGG AGG CCC CGG CTC CTG GAC GTC GCC CAC CGG AGG ------| RD2/2r (1) Gly Phe Arg Val Leu Ala Ser Cys Leu Thr Pro Ser Gly Ala Glu Asp Leu Gln Arg Val Ala Ser G F R V L A S C L T P S G A E D L Q R V A S 55 60 65 70
225 240 255 270 285 TCC CGC CTC CAC ACC ACC CTG TTG GAT ATC ACT GAT CCC CAG AGC GTC CAG CAG GCA GCC AAG TGG AGG GCG GAG GTG TGG TGG GAC AAC CTA TAG TGA CTA GGG GTC TCG CAG GTC GTC CGT CGG TTC ACC Ser Arg Leu His Thr Thr Leu Leu Asp Ile Thr Asp Pro Gln Ser Val Gln Gln Ala Ala Lys Trp S R L H T T L L D I T D P Q S V Q Q A A K W 75 80 85 90 95
300 310 GTG GAG ATG CAC GTT AAG GAA GCA G gtaag tatgg tagac cacca ggaat atggt gtggg gtgtc ctgat CAC CTC TAC GTG CAA TTC CTT CGT C cattc atacc atctg gtggt cctta tacca caccc cacag gacta Val Glu Met His Val Lys Glu Ala Gly <------| RD2/3r (1) V E M H V K E A G 100 104 cccca cagtc acccc aggag tcacc tgcaa gggct gtggt aagct aaagg gacaa tttga ggaga agcag ttttc ggggt gtcag tgggg tcctc agtgg acgtt cccga cacca ttcga tttcc ctgtt aaact cctct tcgtc aaaag
IVS 2
|------> RD3/1f(1) agat gctcc cagga agaag aggga gctgt gggag tgcct cacct acccc cagca tcctt ttcat ctccc cacag tcta cgagg gtcct tcttc tccct cgaca ccctc acgga gtgga tgggg gtcgt aggaa aagta gaggg gtgtc C=Arg (6,13,15) 312 315 | 330 345 360 375 GG CTT TTT GGT CTG GTG AAT AAT GCT GGT GTG GCT GGT ATC ATC GGA CCC ACA CCA TGG CTG ACC CC GAA AAA CCA GAC CAC TTA TTA CGA CCA CAC CGA CCA TAG TAG CCT GGG TGT GGT ACC GAC TGG Gly Leu Phe Gly Leu Val Asn Asn Ala Gly Val Ala Gly Ile Ile Gly Pro Thr Pro Trp Leu Thr G L F G L V N N A G V A G I I G P T P W L T SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 105 110 115 120 125
A=Met (6,14) T=Ile (1) 390 | 405 420 | 435 | |------> Rd3/2f (1) CGG GAC GAT TTC CAG CGG GTG CTG AAT GTG AAC ACA ATG GGT CCC ATC GGG GTC ACC CTT GCC CTG GCC CTG CTA AAG GTC GCC CAC GAC TTA CAC TTG TGT TAC CCA GGG TAG CCC CAG TGG GAA CGG GAC Arg Asp Asp Phe Gln Arg Val Leu Asn Val Asn Thr Met Gly Pro Ile Gly Val Thr Leu Ala Leu R D D F Q R V L N V N T M G P I G V T L A L 130 135 140 145
T=Trp (3) T=Phe (12) A=His (11) 450 465 | 480 | 495 | CTG CCT CTG CTG CAG CAA GCC CGG GGC CGG GTG ATC AAC ATC ACC AGC GTC CTG GGT CGC CTG GCA GAC GGA GAC GAC GTC GTT CGG GCC CCG GCC CAC TAG TTG TAG TGG TCG CAG GAC CCA GCG GAC CGT <------| Rd3/1r (1) Leu Pro Leu Leu Gln Gln Ala Arg Gly Arg Val Ile Asn Ile Thr Ser Val Leu Gly Arg Leu Ala L P L L Q Q A R G R V I N I T S V L G R L A 150 155 160 165
C=Gly (9) 510 525 | 540 555 569 GCC AAT GGT GGG GGC TAC TGT GTC TCC AAA TTT GGC CTG GAG GCC TTC TCT GAC AGC CTG AG CGG TTA CCA CCC CCG ATG ACA CAG AGG TTT AAA CCG GAC CTC CGG AAG AGA CTG TCG GAC TC Ala Asn Gly Gly Gly Tyr Cys Val Ser Lys Phe Gly Leu Glu Ala Phe Ser Asp Ser Leu Arg A N G G G Y C V S K F G L E A F S D S L R LLLLLLLLLLLLLLLLLLL 170 175 180 185 190 gtgag gggta caggg ctctg ggttc cagga ctaac agcag cccac tcaac aaacg tgggc cagca gaggt ggtta cactc cccat gtccc gagac ccaag gtcct gattg tcgtc gggtg agttg tttgc acccg gtcgt ctcca ccaat <------| RD3/2r (1) aaata cagca cattg gaata gttaa aaaga gacag tttag ggcta aactt catgg gttca atgaa gtcta ccctt tttat gtcgt gtaac cttat caatt tttct ctgtc aaatc ccgat ttgaa gtacc caagt tactt cagat gggaa atgta agctt tgtga ccata agtag attac ttctc tttac ccatt tttaa cgtgt ttgtt ttttg ttttt tgaga tacat tcgaa acact ggtat tcatc taatg aagag aaatg ggtaa aaatt gcaca aacaa aaaac aaaaa actct tggag tcttg ctctg tcgcc aggct ggagt gcagt ggcgc gatct tggct cacca caatt tccac ccccg gggtt acctc agaac gagac agcgg tccga cctca cgtca ccgcg ctaga accga gtggt gttaa aggtg ggggc cccaa caagc gattc tcctg cctca gcctc ccgag tagct gggac tacag gcatg cgcca ccatg cctgg ctaat ttttg gttcg ctaag aggac ggagt cggag ggctc atcga ccctg atgtc cgtac gcggt ggtac ggacc gatta aaaac tattt ttagt agaga caggg tttca ctatg ttggc caggt tggtc tcaaa ctcct gacct cgtga tccgc ccacc ataaa aatca tctct gtccc aaagt gatac aaccg gtcca accag agttt gagga ctgga gcact aggcg ggtgg tcagc ctccc aaagt gctgg gatta caggt gtgag ccacc acgcc cggcc ttgcc tctcg tcttt aaaca ataag agtcg gaggg tttca cgacc ctaat gtcca cactc ggtgg tgcgg gccgg aacgg agagc agaaa tttgt tattc gttca aagtt ccgtg ggagc acaaa ggaga catga tgagg acaac gggag ttagg gcctg agttt ttttg gtttt caagt ttcaa ggcac cctcg tgttt cctct gtact actcc tgttg ccctc aatcc cggac tcaaa aaaac caaaa ttttt tttaa gcgtt ttgct cttgt tgcct aggct ggagt gcaat ggcga gatct cagct cacag caacc cctgc aaaaa aaatt cgcaa aacga gaaca acgga tccga cctca cgtta ccgct ctaga gtcga gtgtc gttgg ggacg ctctc aggtt catgt gattc tcctg cctca gcctc ccgat tagct gggct tacag gcacg tgcca ccact cccag gagag tccaa gtaca ctaag aggac ggagt cggag ggcta atcga cccga atgtc cgtgc acggt ggtga gggtc ctaaa ttttt aggta gagat ggagt ttata ccatg tggcc agggt gggtt tgaat tcctg acctc acctg atcca gattt aaaaa tccat ctcta cctca aatat ggtac accgg tccca cccaa actta aggac tggag tggac taggt ccgga ccggc cttcc caaag tgctg ggatt acagg catga gccac cacac acggc ccaag gcctg agttc ttagc ggcct ggccg gaagg gtttc acgac cctaa tgtcc gtact cggtg gtgtg tgccg ggttc cggac tcaag aatcg aggag tataa ggcgc ctaag cttag tctac cttct aagga agcct gcgtt tgtca ccatc actca gcaaa taacc tcctc atatt ccgcg gattc gaatc agatg gaaga ttcct tcgga cgcaa acagt ggtag tgagt cgttt attgg ggaat tgtct cctgt ctctc agcct taatt tttca ggcag catca tggga cacat acttt tagtt ttgag acaag cctta acaga ggaca gagag tcgga attaa aaagt ccgtc gtagt accct gtgta tgaaa atcaa aactc tgttc gcctt gctct caccc agggt ggagt gcagt ggtgc agtca cggcc cactg aactt caaac tccta ggctc aagca cggaa cgaga gtggg tccca cctca cgtca ccacg tcagt gccgg gtgac ttgaa gtttg aggat ccgag ttcgt gctca agcga tatcc gcctc agcct cctga gtagc tgaga ccaca ggcgc gtgcc agcat gcctg gctag tattt cgagt tcgct atagg cggag tcgga ggact catcg actct ggtgt ccgcg cacgg tcgta cggac cgatc ataaa
tttta cagat ggggt cttgc tgtgg tgacc agact tgtct ccaac tcccg gcctc aagcg atgct tccgc ctggg aaaat gtcta cccca gaacg acacc actgg tctga acaga ggttg agggc cggag ttcgc tacga aggcg gaccc cctcc caaag tgttg ggatt atagg tgtga gccac tgcat actgg aacac atact ttata cttga atttt ttttt ggagg gtttc acaac cctaa tatcc acact cggtg acgta tgacc ttgtg tatga aatat gaact taaaa aaaaa atccc cttcc ttcgt gctcc taacc tatac ttgga tttct acatc tgtgc caggg cagtg ggatg tatcc ccact taggg gaagg aagca cgagg attgg atatg aacct aaaga tgtag acacg gtccc gtcac cctac atagg ggtga ttccc catca gctta ccctc cagca aatac gagac tatac ccttc aatat ccagc actca gggct caacc atgtg aaggg gtagt cgaat gggag gtcgt ttatg ctctg atatg ggaag ttata ggtcg tgagt cccga gttgg tacac ttttg ggagc aaggg aatgg ggttc ctcta ggtca ggaat cggca aactc agtac tcaag ccaga tttgg ccagc aaaac cctcg ttccc ttacc ccaag gagat ccagt cctta gccgt ttgag tcatg agttc ggtct aaacc ggtcg
IVS 3 tgcct acaag ctgat aatgg ttttt tttat tttta aatgg ttaca ttgta aactg ttata taagt acctg ataat acgga tgttc gacta ttacc aaaaa aaata aaaat ttacc aatgt aacat ttgac aatat attca tggac tatta atcat taatt ttgtt tcttg gcctg ccatg cttaa aatat taact ctctg gccct ttaag aaaaa aacgt gctga tagta attaa aacaa agaac cggac ggtac gaatt ttata attga gagac cggga aattc ttttt ttgca cgact cccct gctct agatc aaaga aaaca aacct caaaa atact ttcct ccctc taccc cactt gaccc ttgtc ccggg gggga cgaga tctag tttct tttgt ttgga gtttt tatga aagga gggag atggg gtgaa ctggg aacag ggccc gcagt aggca tctcc gtcaa aactc ttgtc cctgg tctgt ggtaa ctttc tcagc tcccc aaccc atgtc cctca cgtca tccgt agagg cagtt ttgag aacag ggacc agaca ccatt gaaag agtcg agggg ttggg tacag ggagt 570 585 |------> RD4f (1) aagtc ccctc cctat agggc aagaa cccag caact tcgct ctgcc ccgac tctag G CGG GAT GTA GCT CAT ttcag gggag ggata tcccg ttctt gggtc gttga agcga gacgg ggctg agatc C GCC CTA CAT CGA GTA Arg Arg Asp Val Ala His R R D V A H 190 195
A/T/G=V200V (1,4) 600| 615 630 645 TTT GGG ATA CGA GTC TCC ATC GTG GAG CCT GGC TTC TTC CGA ACC CCT GTG ACC AAC CTG GAG AGT AAA CCC TAT GCT CAG AGG TAG CAC CTC GGA CCG AAG AAG GCT TGG GGA CAC TGG TTG GAC CTC TCA Phe Gly Ile Arg Val Ser Ile Val Glu Pro Gly Phe Phe Arg Thr Pro Val Thr Asn Leu Glu Ser F G I R V S I V E P G F F R T P V T N L E S 200 205 210 215
insG (6) T=Trp (1,5) 660 675 690 705 | CTG GAG AAA ACC CTG CAG GCC TGC TGG GCA CGG CTG CCT CCT GCC ACA CAG GCC CAC TAT GGG GGG GAC CTC TTT TGG GAC GTC CGG ACG ACC CGT GCC GAC GGA GGA CGG TGT GTC CGG GTG ATA CCC CCC Leu Glu Lys Thr Leu Gln Ala Cys Trp Ala Arg Leu Pro Pro Ala Thr Gln Ala His Tyr Gly Gly L E K T L Q A C W A R L P P A T Q A H Y G G 220 225 230 235
720 733 GCC TTC CTC ACC AAG T gtgag tagcc aggcc cacac agggg cacat gaagg gaaac aagta ccaga aaggc CGG AAG GAG TGG TTC A cactc atcgg tccgg gtgtg tcccc gtgta cttcc ctttg ttcat ggtct ttccg Ala Phe Leu Thr Lys Tyr <------| RD4r (1) A F L T K Y 240 245 cagtc ctgca taagc ctgct aggag gtggg tgggg caccc agggc agggt tgagg gtgaa cagga tgtta caa gtcag gacgt attcg gacga tcctc caccc acccc gtggg tcccg tccca actcc cactt gtcct acaat gtt
IVS 4 agt gccca ggcca tgtgg aacct gccca ctccc cacac tgagg agggg actga gggtg acaag cccag ggccc tca cgggt ccggt acacc ttgga cgggt gaggg gtgtg actcc tcccc tgact cccac tgttc gggtc ccggg
|------> RD5/1f (1) caaaa aacag tacct aanat gggct ggagt gagga aggga aactg attgc aacca cctat ggggc tgcag gtttt ttgtc atgga ttnta cccga cctca ctcct tccct ttgac taacg ttggt ggata ccccg acgtc
735 750 765 780 795 RD5/2f (1) |------AC CTG AAA ATG CAA CAG CGC ATC ATG AAC CTG ATC TGT GAC CCG GAC CTA ACC AAG GTG AGC CGA TG GAC TTT TAC GTT GTC GCG TAG TAC TTG GAC TAG ACA CTG GGC CTG GAT TGG TTC CAC TCG GCT Tyr Leu Lys Met Gln Gln Arg Ile Met Asn Leu Ile Cys Asp Pro Asp Leu Thr Lys Val Ser Arg Y L K M Q Q R I M N L I C D P D L T K V S R 245 250 255 260 265
A=His (5,9,10) G=Trp (7) | C=His (6) | 810 825 | | 855 ->| | | TGC CTG GAG CAT GCC CTG ACT GCT CGA CAC CCC CGA ACC CGC TAC AGC CCA GGT TGG GAT GCC AAG ACG GAC CTC GTA CGG GAC TGA CGA GCT GTG GGG GCT TGG GCG ATG TCG GGT CCA ACC CTA CGG TTC <------Cys Leu Glu His Ala Leu Thr Ala Arg His Pro Arg Thr Arg Tyr Ser Pro Gly Trp Asp Ala Lys C L E H A L T A R H P R T R Y S P G W D A K 270 275 280 285
C=Pro (5) (16,11,13,6,2) insGAAG/del 870 | 885 900 915 | CTG CTC TGG CTG CCT GCC TCC TAC CTG CCA GCC AGC CTG GTG GAT GCT GTG CTC ACC TGG GTC CTT GAC GAG ACC GAC GGA CGG AGG ATG GAC GGT CGG TCG GAC CAC CTA CGA CAC GAG TGG ACC CAG GAA ------| RD5/1r (1) Leu Leu Trp Leu Pro Ala Ser Tyr Leu Pro Ala Ser Leu Val Asp Ala Val Leu Thr Trp Val Leu L L W L P A S Y L P A S L V D A V L T W V L 290 295 300 305 310
945 957 967 977 987 997 CCC AAG CCT GCC CAA GCA GTC TAC TGA atcca gcctt ccagc aagag attgt ttttc aagga caagg acttt GGG TTC GGA CGG GTT CGT CAG ATG ACT taggt cggaa ggtcg ttctc taaca aaaag ttcct gttcc tgaaa Pro Lys Pro Ala Gln Ala Val Tyr ter <------| RD5/2r (1) P K P A Q A V Y X 315 319
1007 1017 1027 1037 1047 1057 1067 1077 gattt atttc tgccc ccacc ctggt actgc ctggt gcctg ccaca aaata agcac taaca aaagt gtatt gttta ctaaa taaag acggg ggtgg gacca tgacg gacca cggac ggtgt tttat tcgtg attgt tttca cataa caaat
1087 1097 1107 1117 1127 1137 1147 aaaaa taaaa agaag gtggg cagaa atgtg cccag tggaa ggctg acccc attta agtgc caact actcc aaacc ttttt atttt tcttc caccc gtctt tacac gggtc acctt ccgac tgggg taaat tcacg gttga tgagg tttgg
1157 1167 1177 1187 1197 1207 1217 1227 gacat gctca cggtc tctgg cctgt tcagt ccctg caaaa cagct agcac ccaca gtggg gcgcc aggga actgc ctgta cgagt gccag agacc ggaca agtca gggac gtttt gtcga tcgtg ggtgt caccc cgcgg tccct tgacg
1237 1247 1257 1267 1277 1287 1297 ctcac atcta cagct gcacg tcggg gagtg gccat caaag ggcac tttaa tacat ttccc ttatt ttctg aaggg gagtg tagat gtcga cgtgc agccc ctcac cggta gtttc ccgtg aaatt atgta aaggg aataa aagac ttccc
1307 1317 1327 1337 1347 1357 1367 1377 gagta aggtt gcaat tcagt gtctg tactg ggaat ggtct tcata tttct tgggg gagaa gagca ggtga tgagg ctcat tccaa cgtta agtca cagac atgac cctta ccaga agtat aaaga acccc ctctt ctcgt ccact actcc
1387 1397 1407 1417 1427 1437 1447 gttct gggcc aggct gggtg gcttc catgg aagaa aaggc aatat tcaca taaat tctcc tgcta aggac actga caaga cccgg tccga cccac cgaag gtacc ttctt ttccg ttata agtgt attta agagg acgat tcctg tgact
1457 1467 1487 1497 1507 1517 1527 1537 ccaca caggt gtgca aggca actta tcata cttcg aaagg agctg gatcc cttga ggatt ggcca ggaag ggagg ggtgt gtcca cacgt tccgt tgaat agtat gaagc tttcc tcgac ctagg gaact cctaa ccggt ccttc cctcc
1547 1557 1567 tgctg ggccc ttagc ggtgc acaga aggcc aggaa g acgac ccggg aatcg ccacg tgtct tccgg tcctt c
(1)= [1] (5)= [5] (9)= [9] (13)= [13] (2)= [2] (6)= [6] (10)= [10] (14)= [14] (3)= [3] (7)= [7] (11)= [11] (15)= [15] (4)= [4] (8)= [8] (12)= [12] (16)= [16]
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