Nicole M Iverson

Nicole M Iverson [email protected] University of Nebraska Lincoln work: 402-472-0884 233 L. W. Chase Hall cell: 732-648-3319 Lincoln, NE 68583

EDUCATION:

Rutgers University and University of Medicine and Dentistry of New Jersey Ph. D. in Biomedical Engineering 2010 M.S. in Biomedical Engineering 2005

University of Minnesota, Institute of Technology, Minneapolis, MN 2003 B.S. in Biomedical Engineering Minors in Mathematics and Chemistry Institute of Technology Honors

HONORS AND AWARDS

Massachusetts Institute of Technology  NIH Postdoctoral Fellowship 2010 – 2013  Listed on CNN’s Top 10 Ideas 2013  Center for Environmental Health Sciences poster competition award 2013  MIT Post Doctorate Association poster competition award 2013  Aspen Cancer Conference, invited participant 2013  MIT Biological Engineering Retreat, invited participant 2013  Articles describing novel in vivo sensor in NanotechWeb, Neue Zuricher Zeitung, MIT News 2013  Incorporation of sensor technology into exhibit, MIT Museum 2013

Rutgers University  American Heart Association Fellowship 2008 – 2009  NIH Biotechnology Fellowship 2005 – 2008  GAANN Fellowship 2004 – 2005  Whitaker Foundation Fellowship 2003 – 2004

University of Minnesota  Lillehei Heart Association Grant 2002 – 2003  National Merit Scholarship 1999 – 2003  Iron Range Scholarship 1999 – 2003  American Heart Association Grant 1999

RESEARCH EXPERIENCE:

Massachusetts Institute of Technology 2010 – present NIH Postdoctoral Fellow Advisors: Michael Strano, Gerald Wogan, John Essigmann  Delivery, monitoring and analysis of in vivo nanoparticles that act as biological sensors  Encapsulate, optimize and analyze DNA-wrapped single wall carbon nanotubes in alginate microparticles  Modified chemical structure of nanoparticle to enable non-invasive, intravenous delivery  Spearheaded NIH grant writing effort  Trained students and peers in proper in vivo techniques Nicole Iverson Page 1 of 5 Rutgers University 2003 – 2010 NIH Research Fellow Advisors: Prabhas Moghe, Kathryn Uhrich, Gary Nackman Graduate Thesis: Multifunctional nanoassemblies that increase highly oxidized LDL efflux while inhibiting highly oxidized LDL uptake, cytokine signaling and matrix metalloproteinase activation  Developed protocol and independently perform animal study to test the in vitro findings in an in vivo model  Tested and analyzed biological effects of anionic nanoparticles on a cultured cell line with multiple biochemical, genetic, and fluorometric assays  Designed and implemented RT2-PCR and PCR microarray based gene expression studies; specifically, analyzed atherosclerotic and inflammatory pathways  Synthesized, purified and analyzed multifaceted nanoparticles  Trained new students in proper lab technique and testing procedures  Assist in writing grants for NSF, NIH and AHA

Mayo Clinic 2006 Research Internship Advisor: Gary Sieck  Established protocol and mastered technique to label and capture different cell types with laser capture microdissection  Mastered quantitative RT-PCR procedure and analysis

University of Minnesota 2002 – 2003 Undergraduate Research Assistant Advisor: Jay Zhang  Observed and assisted with live animal operations for multiple protocols  Researched and tested new techniques of stem cell delivery through a fibrinogen patch into the heart  Interpreted data and wrote papers to explain the research for submission as journal articles  Cultured cells from research animal

University of Minnesota 2001 Undergraduate Research Assistant Advisor: Natalia Tretyakova  Formulated and customized interstrand DNA cross-linking methods with multiple carcinogenic agents  Optimized digestion methods for different compounds  Created and ran gel electrophoresis and MALDI-TOF analyses to determine DNA sequences and carcinogenic interference points

Fairview University Hospital, Pharmacy, Minneapolis, MN 2000 Pharmaceutical Assistant Advisor: Kathy Johnson  Maintained accurate counts and labeling of drug quantities and distribution of pharmaceutical products in double blind clinical trials

Hennepin County Medical Center, Minneapolis, MN 1999 Student Observer Advisor: Timothy Henry

Nicole Iverson Page 2 of 5  Observed human subjects and assisted medical professionals with multiple medical procedures and experimental protocols to investigate cardiac catheterization treatments TEACHING EXPERIENCE: Pre-Calculus Instructor 2008 Rutgers University  Created class syllabus, lesson plans and testing material  Instructed and advised 30 students in lecture setting as well as one-on-one and small group sessions

Teaching Assistant – Algebra I and II 2000 – 2002 University of Minnesota Talented Youth Math Program  Facilitated study sessions and provided personal assistance for students  Evaluated and recorded weekly homework and quiz results  Conducted weekly quizzes and examinations

PUBLICATIONS:

Iverson NM, Biskar G, Farias E, Ivanov V, Wogan GN, Strano MS, Carbon nanotube sensor encapsulation platform – characterization and optimization. Journal of Biomedical Nanotechnology. In Press.

Giraldo JP, Landry MP, Kwak S, Jain R, Wong MH, Iverson NM, Ben-Naim M, Strano MS, A Ratiometric Sensor Using Single Chirality Near-Infrared Fluorescent Carbon Nanotubes: Application to In Vitro Monitoring. Small. 2015 11(32):3973-3984.

Iverson NM, Strano MS, Wogan GN, In Vivo Delivery of Nitric Oxide Sensing Single Walled Carbon Nanotubes. Current Protocols in Chemical Biology. 2015 7:93-102.

Biskar G, Iverson NM, Ahn J, Strano MS, A Pharmacokinetic Model of a Tissue Implantable Insulin Sensor. Advanced Healthcare Materials. Advanced Healthcare Materials. 2015 4(1):87- 97.

Landry MP, Kruss S, Nelson JT, Bisker G, Iverson NM, Reuel NF, Strano MS, Experimental Tools to Study Molecular Recognition within the Nanoparticle Corona. Sensors 2014 14(9):16196-16211.

Ulissi ZW, Sen F, Gong X, Sen S, Iverson NM, Boghossian A, Godoy L, Wogan GN, Mukhopadhyay, Strano MS, Spatiotemporal Intracellular Nitric Oxide Signaling Captured using Internalized, Near Infrared Fluorescent Carbon Nanotube Nanosensors. Nano Letters. 2014 14(8):4887-4894.

Giraldo JP, Landry MP, Faltermeier S, McNicholas TP, Iverson NM, Boghossian AA, Reuel NF, Hilmer AJ, Sen F, Brew J Strano MS, Plant nanobionics approach to augment photosynthesis and biochemical sensing. Nature Materials 2014 13(4):400-408.

Iverson NM, Barone PW, Shandell M, Trudell LJ, Sen S, Sen F, Ivanov V, Atolia E, Farias E, McNicholas TP, Reuel N, Parry NMA, Wogan GN, Strano MS, In vivo biosensing via tissue localizable near-infrared fluorescent single walled carbon nanotubes. Nature Nanotechnology 2013 8(11):873-880.

Iverson NM, Plourde NM, Sparks SM, Wang J, Patel EN, Shah PS, Lewis DR, Zablocki KR, Nackman GB, Uhrich KE, Moghe PV, Dual use of amphiphilic macromolecules as cholesterol

Nicole Iverson Page 3 of 5 efflux triggers and inhibitors of macrophage athero-inflammation. Biomaterials 2011 32(32):8319-8327.

Iverson NM, Sparks SM, Demirdirek B, Uhrich KE, Moghe PV, Controllable inhibition of cellular uptake of oxidized low density lipoprotein: structure-function relationships for nanoscale amphiphilic polymers. Acta Biomaterials 2010 6(8):3081-3091.

Iverson N, Plourde N, Chnari E, Nackman G, Moghe PV, Convergence of nanotechnology and cardiovascular medicine: progress and emerging prospects. BioDrugs 2008 22(1):1-10.

Wang J, Plourde N, Iverson N, Moghe PV, Uhrich KE, Nanoscale amphiphilic macromolecules as lipoprotein inhibitors: the role of charge and architecture. International Journal of Nanomedicine 2007 2(4):697-705.

Zhang J, Gong G, Ye Y, Guo T, Mansoor A, Hu Q, Ochiai K, Liu J, Wang X, Cheng Y, Iverson N, Lee J, From AH, Ugurbil K, Bache RJ. Nitric oxide regulation of myocardial O2 consumption and HEP metabolism. American Journal of Physiology, Heart and Circulatory Physiology 2005 288(1):H310-H316.

PATENTS:

Iverson NM, Strano MS, Reuel NF, McNicholas TP. Near-infrared Fluorescent Single Walled Carbon Nanotubes as Tissue Localizable Biosensors. 61/878,303 Filing Date: Sept. 16 2013.

Uhrich KE, Moghe PV, Sparks S, Hehir S, Gu L, Iverson N, Plourde NP. Polymeric Micelles for Reducing LDL In Vivo. US 20120219598 A1. Publication Date: Aug. 30 2012.

Moghe PV, Uhrich KE, Iverson N, Plourde N, Wang JZ. Compositions and Methods for Treating Cardiovascular Conditions. US 20110008396 A1. Publication Date: Jan. 13 2011.

CONFERENCE PROCEEDINGS AND PRESENTATIONS:

Nicole M Iverson, Carbon Nanotubes as In Vivo Nitric Oxide Sensors. Massachusetts Institute of Technology Biological Engineering Retreat 2013.

Nicole M Iverson, Paul W Barone, Mia Shandell, Laura J Trudel, Selda Sen, Fatih Sen, Vsevolod Ivanov, Esha Atolia, Edgardo Farias, Thomas P McNicholas, Nigel Reuel, Nicola M A Parry, Gerald N Wogan and Michael S Strano, In Vivo Utilization of Near Infrared Fluorescent Single Walled Carbon Nanotubes as Tissue Localizable Biosensors. Aspen Cancer Conference 2013.

Nicole M Iverson, Paul W Barone, Mia Shandell, Laura J Trudel, Selda Sen, Fatih Sen, Vsevolod Ivanov, Esha Atolia, Edgardo Farias, Thomas P McNicholas, Nigel Reuel, Nicola M A Parry, Gerald N Wogan and Michael S Strano, In Vivo Utilization of Near Infrared Fluorescent Single Walled Carbon Nanotubes as Tissue Localizable Biosensors. Massachusetts Institute of Technology Center for Environmental Health Sciences Meeting 2013.

Nicole M Iverson, In vivo Delivery of Single-Walled Carbon Nanotubes Acting as Nitric Oxide Sensors. DNA Repair and Mutagenesis Seminar 2013.

Nicole M Iverson, Paul W Barone, Mia Shandell, Laura J Trudel, Selda Sen, Fatih Sen, Vsevolod Ivanov, Esha Atolia, Edgardo Farias, Thomas P McNicholas, Nigel Reuel, Nicola M A Parry, Gerald N Wogan and Michael S Strano, In vivo Utilization of Near Infrared Fluorescent Single Walled Carbon Nanotubes as Tissue Localizable Biosensors. Massachusetts Institute of Technology Post Doctorate Association Meeting 2013. Nicole Iverson Page 4 of 5 Nicole Iverson, Nicole Plourde, Sarah Sparks, Jinzhong Wang, Kathryn Uhrich and Prabhas V Moghe, Nanoscale Assembled Polymers for Nuclear Targeted Biomolecular Delivery in Macrophages: Multifunctional Biomaterial Candidates for Management of Atherosclerosis. Society of Biomaterials 2009.

Nicole Iverson, Nicole Plourde, Jinzhong Wang, Sarah Sparks, Kathryn Uhrich and Prabhas V Moghe, Bifunctional Nanoparticles Targeting Cells Leading to the Progression of Inflammation. Biomedical Engineering Society 2008.

Nicole Iverson, Nicole Plourde, Jinzhong Wang, Kathryn Uhrich and Prabhas V Moghe, Bifunctional Nanoparticles Targeting Scavenger Receptors and Nuclear Receptors. Biomedical Engineering Society 2007.

Nicole Iverson, Nicole Plourde, Jinzhong Wang, Kathryn Uhrich and Prabhas V Moghe, Design of Nanoparticles for Scavenger Receptor-Targeted Inhibition of Low Density Lipoproteins. Biomedical Engineering Society 2006.

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