Author, Year, Country

Author, year, Data source Population Follow- Malignancies reported country (N) up, years (N) Abasolo et al. EMECAR cohort Prevalent Median Overall excluding non-

2007, RA (789) 3.95; melanoma skin (25)

Spain [3] Maximum Non-Hodgkin’s

6.04 lymphoma (3)

Lung (7)

Colorectal (1)

Breast (2) Askling et al. Swedish Inpatient Prevalent Mean: Overall solid (prevalent

2005, Register, Early RA (53,067); prevalent 3379, early RA 138, anti-

Sweden [4,5] Arthritis Register, early RA cohort TNF 67)

TNF antagonist (3,703); 5.6, early Lymphoma (prevalent

register, and TNF- RA 3.6, 319, early RA 11, anti-

other Swedish antagonist anti-TNF TNF 9)

registers treated 2.3; Lung (prevalent 330,

(4,160) overall early RA 23; anti-TNF

range 0- 10)

13 Colorectal (prevalent

342, early RA 18, anti-

TNF 10)

Breast (prevalent 471,

early RA 13, anti-TNF 8) Cibere et al. Rheumatic Prevalent Mean Overall (136)

1997, Canada disease referral RA (862) 17.4; Non-Hodgkin’s [6] center and cancer range lymphoma (3)

registry 0.6-35 Hodgkin’s disease (0)

Lung (16)

Colorectal (10)

Breast (18) Ekstrom et al. National hospital Prevalent Mean 9.6 Overall (8,898)

2003, discharge register RA (76,527) Lymphoma (535)

Sweden [7] and other Non-Hodgkin’s (458)

Swedish registers Hodgkin’s (77) Franklin et al. Norfolk Arthritis Early RA Mean 7.5 Overall excluding non-

2006, Register (1,237) melanoma skin (92)

United Lymphoma (9)

Kingdom [8,9]

Geborek et al. Community- RA cohort Mean: Overall (without anti-

2005, based RA cohort, without anti- without TNF 69; anti-TNF 16)

Sweden [10] South Swedish TNF (800); anti-TNF Lymphoma (without anti-

Arthritis anti-TNF- 5.5, anti- TNF 2; anti-TNF 5)

Treatment Group treated RA TNF 2.1;

register, and (757) overall

other population range

registers 1.3-5.5 Gridley et al. Swedish Hospital Prevalent Mean 8.6 Overall (840)

1993, Inpatient Register RA (11,683) Lymphoma (48)

Sweden [11] and other Non-Hodgkin’s (36) population Hodgkin’s (12)

registers Lung (68)

Colorectal (72)

Breast (106) Kauppi et al. Finnish hospitals’ Prevalent Mean 6.9 Lung (73)

1996, Finland national RA (8,920)

[12] discharge registry

and other

population

registers Kauppi et al. Finnish hospitals’ Prevalent Mean 6.9 Overall (540)

1996, 1997, national RA (9,469) Non-Hodgkin’s

Finland discharge registry lymphoma (34)

[13,14] and other Hodgkin’s disease (4)

population Colorectal (30)

registers Mariette et al. French Prevalent Max 3 Non-Hodgkin’s

2002, France rheumatology RA treated lymphoma (18)

[15] centers and local with Hodgkin’s disease (7)

oncology methotrexate

departments (30,000

estimated) Matteson et Rheumatoid Prevalent Mean 3 Overall excluding non- al. 1991, Arthritis RA treated melanoma skin (20)

Canada [16] Azathioprine with Lung (6) Registry DMARDs

(530) McKendry et Rheumatic Prevalent Mean 5.6 Lung (4) al. 1993, disease clinic RA treated

Canada [17] records with

methotrexate

(144) Mellemkjaer Danish Hospital Prevalent Mean 7; Overall excluding et al. 1996, Discharge RA (20,669) range 1- lymphatic and

Denmark [18] Register and 15 hematopoietic (1832)

other population Non-Hodgkin’s

registries lymphoma (85)

Hodgkin’s disease (14)

Lung (308)

Colorectal (204)

Breast (186) Moritomo et Single health care Prevalent Mean 6.1 Overall (26) al. 1995, center and cancer RA (655) Lung (0)

Japan [19] registry Colorectal (2)

Breast (3) Setoguchi et Administrative Prevalent Mean 4 Non-Hodgkin’s al. 2006, databases (2 US RA treated lymphoma (58)

United States states, 1 with biologic Lung (169) and Canada Canadian DMARDs or Colorectal (118)

[20] province) methotrexate Breast (112) (7,830) Thomas et al. Inpatient records Prevalent Mean 5.7 Overall (2,029)

2000, and Scottish RA (26,623) Non-Hodgkin’s

Scotland [21] Cancer Registry lymphoma (101)

Lung (472)

Colorectal (188)

Breast (249) Wolfe et al. National Data Prevalent Mean 4.6 Lymphoma (95)

2007, United Bank of RA (19,591)

States Rheumatic

[22] Diseases Wolfe et al. National Data Prevalent Mean 3.5 Overall excluding non-

2007, United Bank of RA (13,869) melanoma skin (543)

States Rheumatic Non-Hodgkin’s

[23] Diseases lymphoma (42)

Lung (112)

Colon (37)

Breast (102)