<p>Author, year, Data source Population Follow- Malignancies reported country (N) up, years (N) Abasolo et al. EMECAR cohort Prevalent Median Overall excluding non-</p><p>2007, RA (789) 3.95; melanoma skin (25) </p><p>Spain [3] Maximum Non-Hodgkin’s </p><p>6.04 lymphoma (3)</p><p>Lung (7)</p><p>Colorectal (1)</p><p>Breast (2) Askling et al. Swedish Inpatient Prevalent Mean: Overall solid (prevalent </p><p>2005, Register, Early RA (53,067); prevalent 3379, early RA 138, anti-</p><p>Sweden [4,5] Arthritis Register, early RA cohort TNF 67)</p><p>TNF antagonist (3,703); 5.6, early Lymphoma (prevalent </p><p> register, and TNF- RA 3.6, 319, early RA 11, anti-</p><p> other Swedish antagonist anti-TNF TNF 9)</p><p> registers treated 2.3; Lung (prevalent 330, </p><p>(4,160) overall early RA 23; anti-TNF </p><p> range 0- 10)</p><p>13 Colorectal (prevalent </p><p>342, early RA 18, anti-</p><p>TNF 10)</p><p>Breast (prevalent 471, </p><p> early RA 13, anti-TNF 8) Cibere et al. Rheumatic Prevalent Mean Overall (136)</p><p>1997, Canada disease referral RA (862) 17.4; Non-Hodgkin’s [6] center and cancer range lymphoma (3)</p><p> registry 0.6-35 Hodgkin’s disease (0)</p><p>Lung (16)</p><p>Colorectal (10)</p><p>Breast (18) Ekstrom et al. National hospital Prevalent Mean 9.6 Overall (8,898)</p><p>2003, discharge register RA (76,527) Lymphoma (535)</p><p>Sweden [7] and other Non-Hodgkin’s (458)</p><p>Swedish registers Hodgkin’s (77) Franklin et al. Norfolk Arthritis Early RA Mean 7.5 Overall excluding non-</p><p>2006, Register (1,237) melanoma skin (92)</p><p>United Lymphoma (9)</p><p>Kingdom [8,9]</p><p>Geborek et al. Community- RA cohort Mean: Overall (without anti-</p><p>2005, based RA cohort, without anti- without TNF 69; anti-TNF 16)</p><p>Sweden [10] South Swedish TNF (800); anti-TNF Lymphoma (without anti-</p><p>Arthritis anti-TNF- 5.5, anti- TNF 2; anti-TNF 5) </p><p>Treatment Group treated RA TNF 2.1; </p><p> register, and (757) overall </p><p> other population range </p><p> registers 1.3-5.5 Gridley et al. Swedish Hospital Prevalent Mean 8.6 Overall (840)</p><p>1993, Inpatient Register RA (11,683) Lymphoma (48)</p><p>Sweden [11] and other Non-Hodgkin’s (36) population Hodgkin’s (12)</p><p> registers Lung (68)</p><p>Colorectal (72)</p><p>Breast (106) Kauppi et al. Finnish hospitals’ Prevalent Mean 6.9 Lung (73)</p><p>1996, Finland national RA (8,920)</p><p>[12] discharge registry</p><p> and other </p><p> population </p><p> registers Kauppi et al. Finnish hospitals’ Prevalent Mean 6.9 Overall (540)</p><p>1996, 1997, national RA (9,469) Non-Hodgkin’s </p><p>Finland discharge registry lymphoma (34)</p><p>[13,14] and other Hodgkin’s disease (4)</p><p> population Colorectal (30)</p><p> registers Mariette et al. French Prevalent Max 3 Non-Hodgkin’s </p><p>2002, France rheumatology RA treated lymphoma (18)</p><p>[15] centers and local with Hodgkin’s disease (7)</p><p> oncology methotrexate</p><p> departments (30,000 </p><p> estimated) Matteson et Rheumatoid Prevalent Mean 3 Overall excluding non- al. 1991, Arthritis RA treated melanoma skin (20)</p><p>Canada [16] Azathioprine with Lung (6) Registry DMARDs </p><p>(530) McKendry et Rheumatic Prevalent Mean 5.6 Lung (4) al. 1993, disease clinic RA treated </p><p>Canada [17] records with </p><p> methotrexate</p><p>(144) Mellemkjaer Danish Hospital Prevalent Mean 7; Overall excluding et al. 1996, Discharge RA (20,669) range 1- lymphatic and </p><p>Denmark [18] Register and 15 hematopoietic (1832)</p><p> other population Non-Hodgkin’s </p><p> registries lymphoma (85)</p><p>Hodgkin’s disease (14)</p><p>Lung (308)</p><p>Colorectal (204)</p><p>Breast (186) Moritomo et Single health care Prevalent Mean 6.1 Overall (26) al. 1995, center and cancer RA (655) Lung (0) </p><p>Japan [19] registry Colorectal (2)</p><p>Breast (3) Setoguchi et Administrative Prevalent Mean 4 Non-Hodgkin’s al. 2006, databases (2 US RA treated lymphoma (58)</p><p>United States states, 1 with biologic Lung (169) and Canada Canadian DMARDs or Colorectal (118)</p><p>[20] province) methotrexate Breast (112) (7,830) Thomas et al. Inpatient records Prevalent Mean 5.7 Overall (2,029)</p><p>2000, and Scottish RA (26,623) Non-Hodgkin’s </p><p>Scotland [21] Cancer Registry lymphoma (101)</p><p>Hodgkin’s disease (17)</p><p>Lung (472)</p><p>Colorectal (188)</p><p>Breast (249) Wolfe et al. National Data Prevalent Mean 4.6 Lymphoma (95)</p><p>2007, United Bank of RA (19,591)</p><p>States Rheumatic </p><p>[22] Diseases Wolfe et al. National Data Prevalent Mean 3.5 Overall excluding non-</p><p>2007, United Bank of RA (13,869) melanoma skin (543)</p><p>States Rheumatic Non-Hodgkin’s </p><p>[23] Diseases lymphoma (42)</p><p>Hodgkin’s disease (4)</p><p>Lung (112)</p><p>Colon (37)</p><p>Breast (102)</p>