ESM 1 Table 4: Dystonic Side Movements: Whole Brain PFWE-Corr<0.05; MNI Coordinates

Pat Clusters Side MNI (x,y, z) t- z Cluster P-value statisti volume cluster level c (mm3) FWE corrected 1 Frontal Inf Gyrus IL 40, 35, 3 6.73 5.60 541.73 <0.001 2 Cerebellum (Lob VIIb) CL -24, -69, -50 7.63 6.12 640.22 0.002 Cerebell (Lob VIIa Crus II) CL -35, -51, -43 6.88 5.70 1477.44 <0.001 3 NS NS 4 Lingual G CL -23, -95, -16 6.98 5.75 2064.62 <0.001 5 Precentral G (BA6) CL -21, -22, 74 8.25 6.46 8667.65 <0.001 Paracentral Lob (BA6) CL -6, -15, 74 7.34 5.96 Sup Parietal Lob CL -42, -47, 63 6.93 5.72 Cerebellum Lob VI IL 30, -40, -28 6.61 5.53 443.23 <0.001 Amygdala CL -13, -4, -20 5.64 4.90 344.74 <0.001 Cerebell (Lob VIIa Crus II) CL -39, -90, -39 5.80 5.01 689.47 <0.001 6 Postcentral G (BA3b) CL -35, -33, 59 9.22 6.93 5860.51 <0.001 Premotor (BA6) CL -10, -26, 51 8.14 6.40 5121.79 <0.001 SMA CL -3, -11, 59 6.56 5.50 Postcentral G (BA2) IL 30, -44, 59 7.67 6.15 1477.44 <0.001 Sup Parietal Lob IL 19, -47, 66 5.82 5.03 Amygdala CL -28,-4, -24 6.73 5.61 984.96 <0.001 Insula CL -28, 14, -20 6.31 5.34 SMA IL 15, -19, 66 6.38 5.39 640.22 <0.001 7 Precentral G (BA6) CL -35, -19, 63 12.56 Inf 20191.68 <0.001 Sup Parietal Lob (5L) CL -21, -40, 74 9.96 7.27 Sup Parietal Lob (7A) IL 23, -47, 74 8.65 6.66 6008.26 <0.001 Sup Frontal G (BA6) IL 33, -11, 59 7.27 5.92 Postcentral G (BA1) IL 33, -47, 70 6.72 5.60 Thalamus (visual) CL -28, -33, 3 7.98 6.31 2560.9 <0.001 Mid Cingulate G IL 15, -15, 40 7.03 5.78 344.74 0.001 Vermis Lob (VIIIa) 1,-65, -35 7.00 5.77 1822.18 <0.001 Cerebellum (Lob VI) IL 8, -62, -9 5.74 4.97 Vermis 1, -55, 6 6.72 5.60 787.97 <0.001 Thalamus (temporal) IL 8, -22, 21 6.74 5.61 492.48 <0.001 8 Cerebell (Lob VIIa Crus II) IL 8, -94, -43 7.63 6.12 837.22 <0.001 9 Cerebell (Lob VIIa Crus II) IL -28, -83, -39 7.16 5.86 2265.41 <0.001 Cerebell (Lob VIIa Crus I) IL -42, -73, -43 6.20 5.28 10 Precuneus SPL (5L, 7A) CL 8, -58, 70 8.78 6.72 2166.91 <0.001 Cerebellum (Lob VI) CL 15, -55, -13 8.19 6.42 935.71 <0.001 Cerebell (Lob VIIa Crus II) CL 23, -90, -50 7.83 6.23 787.97 <0.001 Postcentral G (BA3b) CL 19, -33, 59 7.43 6.01 6303.74 <0.001 Precentral G (BA6) IL -24, -11, 63 6.60 5.52 SMA IL -3, -8, 63 6.58 5.51 Postcentral G (BA1) IL -28, -44, 78 7.36 5.97 1477.44 <0.001 Vermis (Lob VI) 5, -73, -13 7.24 5.91 1181.95 <0.001 Sup Frontal G (BA6) CL 33, -11, 70 6.84 5.67 1625.18 <0.001 Supramarginal G CL 55, -29, 29 6.27 5.32 787.97 <0.001 Cerebell (Lob VIIa Crus I) CL 44, -80, -35 6.21 5.28 393.98 <0.001 11 Premotor (BA6) CL -13, -22, 59 11.23 7.78 25017.98 <0.001 SMA CL -17, -8, 66 8.79 6.73 Precentral G (BA4p) CL -31, -25, 51 8.24 6.45 Superior Orbital G IL 15, 14, -20 10.84 7.64 4383.07 <0.001 Rectus G IL -10, 14, -20 8.30 6.48 SMA IL 15, -11, 70 9.69 7.15 28120.61 <0.001 Supramarginal G IL 58, -26, 25 7.54 6.07 3939.84 <0.001 Sup Parietal Lob (5L) IL 15, -47, 78 6.57 5.51 1083.46 <0.001 Mid Occipital G (hOC4v) IL 40, -83, 6 6.38 5.39 1132.71 <0.001

ESM_1 Table 4: Dystonic side movements: Whole brain PFWE-corr<0.05; MNI coordinates of significant clusters; NS: Non- significant activity; Side: CL: contralateral or IL: ipsilateral to the movement; Sup: superior; Inf: inferior; Mid: middle; G: gyrus; Lob: lobule; BA: Brodmann area; SMA: supplementary motor area; SPL: superior parietal lobule; Cerebell: cerebellum; C: cortex; Pat: Patient

Pat Clusters Side MNI (x,y, z) t- z Cluster P-value statisti volume cluster c (mm3) level FWE corrected 1 Postcentral G(BA3b) CL 30, -40, 66 6.13 5.23 147.74 0.003 2 Precentral G (BA4a) CL 33, -29, 63 9.82 7.20 7682.69 <0.001 Postcentral G (BA2) CL 33, -44, 59 7.67 6.14 3 Cuneus (BA17) CL -3, -102, 6 5.83 5.03 1365.61 0.001 4 Cerebell (Lob VIIa Crus CL 25, -91, -39 10.08 7.32 4524.58 <0.001 II) CL 29, -98, -13 6.84 5.67 307.49 0.001 Inf Occipital C (BA17) IL 5, -95, -13 5.88 5.06 439.28 <0.001 Occipital C (BA17) 5 Postcentral G (BA1) CL 37, -33, 66 9.63 7.12 3792.1 <0.001 6 Precentral G (BA4a) CL 30, -29, 63 11.53 Inf 10982.30 <0.001 Precentral G (BA6) CL 26, -22, 70 9.15 6.90 23, -15, 66 8.66 6.67 Cerebellum Lob V IL -6, -55, -9 6.18 5.26 590.98 <0.001 7 Precentral G (BA4a) CL 30, -33, 63 11.44 Inf 14872.90 <0.001 Premotor (BA6) CL 30, -19, 59 11.17 7.75 CL 23, -29, 74 9.04 6.86 Cerebellum (Lob V) IL -6, -58, -16 8.87 6.76 5023.3 <0.001 Cerebellum (Lob VI) IL -21, -47,-24 8.51 6.59 Occipital C (BA18) CL 19, -90, 44 7.76 6.19 1969.92 <0.001 SMA CL 12,-19, 55 7.09 5.82 886.46 <0.001 Vermis (Lob VIIIb) -3, -65, -39 6.80 5.64 344.74 <0.001 8 Occipital C (hOC3v) CL 44, -90, -9 9.02 6.84 7436.45 <0.001 Mid Temporal G CL 66, -69, -16 8.36 6.51 Cerebell (Lob VIIa Crus CL 23, -90, -46 8.66 6.66 4136.83 <0.001 II) CL 30, -19, 78 7.35 5.97 935.71 <0.001 Premotor (BA6) IL 1, -101, -9 6.68 5.57 2413.15 <0.001 Occipital C (BA17) IL -28, -58,-35 7.10 5.82 1034.21 <0.001 Cerebellum (Lob VI) -3, -65, -43 6.79 5.64 2068.42 <0.001 Vermis (Lob VIIIb) IL -6, -58, -16 6.79 5.64 Cerebellum (Lob V) CL 40, -55, -46 7.03 5.78 295.49 0.001 Cerebell (Lob VIIa Crus CL 44, -76, -50 6.78 5.63 295.49 0.001 I) CL 19, -62, 3 6.12 5.22 640.22 <0.001 Cerebell (Lob VIIa Crus II) Lingual G (BA17) 9 Precuneus (SPL 7p) IL 8, -76, 33 5.84 5.04 246.24 0.001 Inf Parietal C CL 46, -87, 14 5.55 4.84 196.99 0.002 Precuneus (SPL 7p) CL -10, -80, 33 5.53 4.83 147.74 0.003 10 Cerebellum (Lob V) IL 26, -40, -28 7.24 5.91 393.98 <0.001 Cerebellum (Lob VI) IL 19, -62, -20 6.68 5.57 541.73 <0.001 Precentral G (BA6) CL -28, -19, 74 6.61 5.53 1181.95 <0.001 11 Cerebellum (Lob VI) IL -31, -44,-28 10.90 7.66 6156 <0.001 Cerebellum (Lob V) IL -28, -33,-31 7.55 6.08 Mid Orbital G IL -24, 42, -13 7.23 5.90 1132.70 <0.001 Middle Occipital G CL 44, -87, 3 9.46 7.04 3348.86 <0.001 Inf Temp G CL 55, -73, -9 7.30 5.94 Rectus G IL -10, 17, -16 8.95 6.80 738.72 <0.001 Sup Orbital G CL 23, 17, -16 8.83 6.75 1231.2 <0.001 15, 60, -13 7.18 5.87 837.22 <0.001 Vermis (Lob VI) 5, -76, -16 7.81 6.22 1625.18 <0.001 Occipital G (BA17) IL -13,-108,-13 7.18 5.87 2511.65 <0.001 Middle Frontal G IL -31, 39, 18 6.65 5.55 1428.19 <0.001 Middle Temporal G IL -64, -37,-13 6.69 5.58 984.96 <0.001 Sup Frontal G CL 15, 60, 21 6.95 5.74 541.73 <0.001 Sup Temporal G CL 62, -1, 3 6.42 5.42 295.49 0.001

ESM_1 Table 5: Non-dystonic side movements: Whole brain PFWE-corr<0.05; anatomic MNI coordinates of significant clusters; Side: CL: contralateral or IL: ipsilateral to the movement; Sup: superior; Inf: inferior; Mid: middle; G: gyrus; Lob: lobule; BA: Brodmann area; SMA: supplementary motor area; SPL: superior parietal lobule; Cerebell: cerebellum; C: cortex; Pat: patient