* Number of Patients in Each Group According to Lysholn Score, with Cutpoints 60 and 90 Units

Bartlett 2005 Basad 2004 Bentley 2003 Dozin 2005 Gooding 2006 Horas 2003 Knutsen 2004 Knutsen 2007 Saris 2008 Saris 2009 Visna 2004 ACI-C MACI MACI MF ACI MP ACI-P MP ACI-P ACI-C ACI-P MP ACI-P MF ACI-P MF CCI MF CCI MF ACT abration N 44 47 10 9 58 42 22 22 33 35 20 20 40 40 40 40 57 61 57 61 25 25 s

h 59/6, t 51/6,12 n

o Clinical 44/12 47/12 58/12 42/12 19/10 18/10 33/24 35/24 40/3,6,12,24 80/12,24 80/60 57/12, 39/36 43/36 25/12 25/12 44/18 m

/ 51/18

r Arthrosc 31/12 29/12 e

t 24/12 18/12 37/12 23/12 77/24 4/3-5 e

l opy 9/24 11/24 p 14/12 13/12 m Biopsy 14/12 11/12 19/12 6 5 32/24 35/24 25/12 38/12 o

c 3/24 7/24 14/12 13/12 pre 14/12 11/12 19/12 24.9 28.45 57.4 55.4 47.6 52.6 3/24 7/24

5 m 1 l , o 0

2 27.6/3 28/3,53.5/6 77.2/5 , h 1 78/12

0 s , 45.8/6 68.3/12 69.2/12 86.5/12 69.2/5 5 y 5

post +48 +15 75.4/24 p= 0.23 9 L ,

2 57.5/12 72.7/24 70.8/24 p<0.001/1 74.5/12 1 . p=0.092 * 0 66.8/24 p<0.05/all 2 = p pre 1.6 1.6 3.28 3.16 3.2** 2.3***

n 1.6/3, 3.6/6

g 1.6/3, 3/6, 4.36/60 6/12

e post +1.6 +0 5/6, 5.2/24 4.05/60 4.2/12

T 4.3/6, 5.1/24 p=0.3 p<0.01 p>0.05 15,19,7, Modified 10,16,10 23,28,7,0 10,12,7,4/ 12,14,5,4 6 9,20,6,7 Cincinnati ,8 p$=0.28 12 p$>0.05/12 p$=0.32 pre 53.9 53.7

S 40.3/12 A 35.5/12

V post -1.7 -1.9 35.2/24 p=0.278 31.3/24 p=0.292 pre 7.2 7.85 s

r 7.9/3, 3.8/6, e 8.5/3, 12.1/6, y 15.9/12, a post + 6.5 +1.9 4.2/12,

M 16.8/24 15.9/24 p>0.05

d pre 56.3 59.5 e S i f i O 70.6/6, 72.6/6, +21.25 +15.8 d O o post 73.3/12, 73.10/12, p=0.05 K M 74.7/18 75/18 pre 41.1 37.4 6 3

- 42.9/12,

F 42.6/12,

S post 46/24 P=0.054 42/24 p=0.004

0 , 2 2 5 l 4 4 , 1 l 1 / / 2 2 a 5 / / / 1 1 S 1 1 , , 1 0 , , 5

, , 9.1/12

  . R 5 5 4 5 , ,

6,24,6,1 0,8,10,5 3 2

post , 0 8.1/12  $ 8.5 , , C 2 0 8 3 I

> p =0.170

$ 5 8 , . 2 2 $ , , p <0.01 , , 4 0 p 0 1  3 3 =   $ p hyaline like 4/12 3/12 7/12 2/12, 1/24 3/12, 1/24 6/24 4/24 y

s mixed 2/12 1/12 7/12 4/12, 2/24 6/12, 4/24 10/24 6/24 p o i Fibro

B 8/12 7/12 5/12 8/12, 0/24 4/12, 2/24 11/24 18/24 cartilage Fibrous 5/24 7/24 pre 41.3 45 C

D 67/5,76.5/12 62.3/5,

K post I p<0.05/12 68.1/12 Stanmore post -0.8 -0.6 Appendix Table. Data as reported in studies included in the review. The mean values at each follow-up in months are reported (mean/months) for Lysholm, Tegner, VAS, Mayers, KOOS, SF-36, ICRS, IKDC and Stanmore scores. For biopsies counts/months are reported. Cincinatti score and ICRS in three studies are reported as number of participants in categories excellent, good, fair, poor. P-values refer to comparisons between arms and are printed in the arm they favour.

* Number of patients in each group according to Lysholn score, with cutpoints 60 and 90 units ** retrospectively measured at 12 patients ***retrospectively measured at 10 patients  Modified Cincinnati is classified as excellent, good, fair, and poor and refers to postoperative values only. Similarly for ICRS in three trials. $ p values refer to comparison between good or excellent group versus fair and poor.  Estimated from four patients only