GRB10 (Phospho-Ser501) Antibody

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Product Datasheet GRB10 (Phospho-Ser501) Antibody Catalog No: #12849 Package Size: #12849-1 50ul #12849-2 100ul Orders: [email protected] Support: [email protected] Description Product Name GRB10 (Phospho-Ser501) Antibody Host Species Rabbit Clonality Polyclonal Applications WB Species Reactivity Hu Ms Rt Specificity Phospho-GRB10 (S501) Antibody detects endogenous levels of GRB10 only when phosphorylated at S501 Immunogen Type Peptide-KLH Immunogen Description A synthesized peptide derived from human GRB10 (Phospho-Ser501) Other Names grb 10 antibody GRB IR antibody grb-10 antibody GRB10 adapter protein antibody GRB10 adaptor protein antibody GRB10 antibody GRB10_HUMAN antibody GRBIR antibody Growth factor receptor bound protein 10 antibody Growth factor receptor-bound protein 10 antibody Insulin receptor binding protein antibody Insulin receptor binding protein GRB IR antibody Insulin receptor-binding protein Grb-IR antibody IRBP antibody KIAA0207 antibody Maternally expressed gene 1 antibody MEG1 antibody RSS antibody Accession No. Swiss-Prot#:Q13322 NCBI Gene ID2887 Calculated MW 76 Concentration 1.0mg mL Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) pH 7.4 150mM NaCl 0.02% sodium azide and 50% glycerol. Storage Store at -20°C Application Details WB dilution:1:1000 Images Address: 8400 Baltimore Ave., Suite 302, College Park, MD 20740, USA http://www.sabbiotech.com 1 Western blot analysis GRB10 (Phospho-Ser501) using EGF treated HeLa whole cell lysates Product Description Recently GRB10 was shown to be a direct substrate of mTORC1 (5). It is phosphorylated by mTORC1 at Ser150, Ser428, and Ser476 upon insulin stimulation (5).The GRB7 family of adaptor proteins consist of GRB7, GRB10 and GRB14, which all contain an amino-terminal proline-rich SH3 binding domain, followed by PH, PBS, and SH2 domains. Each member of the family has several splice variants (1). It has been reported that GRB10 interacts with many receptor tyrosine kinases (RTKs) as well as downstream signal molecules including Raf, Akt, and Nedd4 (1,2). Although it was originally thought that GRB10 is exclusively phosphorylated at serine residues (3), Src kinase family members have been shown to phosphorylate GRB10 at Tyr67 (4). Note: This product is for in vitro research use only and is not intended for use in humans or animals. Address: 8400 Baltimore Ave., Suite 302, College Park, MD 20740, USA http://www.sabbiotech.com 2.

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Chemoresistance in Human Ovarian Cancer: the Role of Apoptotic
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