Product Datasheet

GRB10 (Phospho-Ser501) Antibody

Catalog No: #12849

Package Size: #12849-1 50ul #12849-2 100ul Orders: [email protected] Support: [email protected]

Description

Product Name GRB10 (Phospho-Ser501) Antibody

Host Species Rabbit

Clonality Polyclonal

Applications WB

Species Reactivity Hu Ms Rt

Specificity Phospho-GRB10 (S501) Antibody detects endogenous levels of GRB10 only when phosphorylated at S501

Immunogen Type Peptide-KLH

Immunogen Description A synthesized peptide derived from human GRB10 (Phospho-Ser501)

Other Names grb 10 antibody

GRB IR antibody

grb-10 antibody

GRB10 adapter protein antibody

GRB10 adaptor protein antibody

GRB10 antibody

GRB10_HUMAN antibody

GRBIR antibody

Growth factor receptor bound protein 10 antibody

Growth factor receptor-bound protein 10 antibody

Insulin receptor binding protein antibody

Insulin receptor binding protein GRB IR antibody

Insulin receptor-binding protein Grb-IR antibody

IRBP antibody

KIAA0207 antibody

Maternally expressed gene 1 antibody

MEG1 antibody

RSS antibody

Accession No. Swiss-Prot#:Q13322 NCBI Gene ID2887

Calculated MW 76

Concentration 1.0mg mL

Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) pH 7.4 150mM NaCl 0.02% sodium azide

and 50% glycerol.

Storage Store at -20°C

Application Details

WB dilution:1:1000

Images

Address: 8400 Baltimore Ave., Suite 302, College Park, MD 20740, USA http://www.sabbiotech.com 1 Western blot analysis GRB10 (Phospho-Ser501) using EGF treated HeLa whole cell lysates

Product Description

Recently GRB10 was shown to be a direct substrate of mTORC1 (5). It is phosphorylated by mTORC1 at Ser150, Ser428, and Ser476 upon insulin stimulation (5).The GRB7 family of adaptor proteins consist of GRB7, GRB10 and GRB14, which all contain an amino-terminal proline-rich SH3 binding domain, followed by PH, PBS, and SH2 domains. Each member of the family has several splice variants (1). It has been reported that GRB10 interacts with many receptor tyrosine kinases (RTKs) as well as downstream signal molecules including Raf, Akt, and Nedd4 (1,2). Although it was originally thought that GRB10 is exclusively phosphorylated at serine residues (3), Src kinase family members have been shown to phosphorylate GRB10 at Tyr67 (4).

Note: This product is for in vitro research use only and is not intended for use in humans or animals.

Address: 8400 Baltimore Ave., Suite 302, College Park, MD 20740, USA http://www.sabbiotech.com 2